Abstract
The double inlet left ventricle is a congenital cardiac abnormality, which means it exists from birth. The heart’s top collecting chambers, the right and the left atria (plural to atrium), are attached to similar bottom ventricle or, pumping chamber, under this scenario. One of the ventricles of the heart’s in some situations might be unusually small. Because neonates with common-inlet LV are extremely rare, those two concepts might be related to the development of the human heart and considered to be separate from septation of the atrioventricular canal apparently. The common-inlet right ventricle is a rare occurrence that usually arises in the context of heterotaxia syndrome. Benoit Bruneau, a developmental biologist, and his equals discovered molecular foundation related to the ventricular septum creation by an exclusive series of experiments. The presence of T-box Tbx5 (transcription factor) is connected to the creation of ventricular septum in mammals and humans (low in the right ventricle and high in the left one, and exactly in the location of the septum formation there is a sharp boundary of expression). The homozygous Tbx5 null mouse was found to be dead at 10.5 embryonic days with an LV that has severe hypoplasia and a slew of other abnormalities, highlighting the protein’s importance in so many facets of embryonic development.
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Al-Obaidi, A.D., Ali, A.M., Ahmad, S.S., Khalaf, A.K.s., Hashim, A.T., Mohammed, M.Q. (2023). Double Inlet Left Ventricle. In: Tagarakis, G., Gheni Sarfan, A., Hashim, H.T., Varney, J. (eds) Clinical and Surgical Aspects of Congenital Heart Diseases . Springer, Cham. https://doi.org/10.1007/978-3-031-23062-2_20
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DOI: https://doi.org/10.1007/978-3-031-23062-2_20
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