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Palliative Treatment in Lung Cancer

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Airway diseases

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Abstract

Lung cancer is a quite common disease throughout the world, which still is the first among the causes of cancer-related mortality, even though the treatment options have been increasing in recent years. While the expected 5-year survival rate is only 18.5% regarding all cases with lung cancer, in stage 4 non-small cell lung carcinoma (NSCLC), this rate decreases to 0–10% [1, 2]. Besides mortality, lung cancer also has significant morbidity. The burden, complications, and treatment side effects of cancer can seriously reduce the quality of life in patients with lung cancer. The median ages at the time of diagnosis and death are 70 and 72 years, respectively, increasing the likelihood of patients with lung cancer to encounter additional comorbidities.

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References

  1. Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE, Nicholson AG, Groome P, Mitchell A, Bolejack V, International Association for the Study of Lung Cancer S, Prognostic Factors Committee AB, Participating I, International Association for the Study of Lung Cancer S, Prognostic Factors Committee Advisory B, Participating I. The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 2016;11(1):39–51.

    Article  PubMed  Google Scholar 

  2. USCS. data visualizations. https://gis.cdc.gov/grasp/USCS/DataViz.html.

  3. Bhattacharya P, Dessain SK, Evans TL. Palliative Care in Lung Cancer: when to start. Curr Oncol Rep. 2018;20(11):90.

    Article  PubMed  Google Scholar 

  4. Iyer S, Roughley A, Rider A, Taylor-Stokes G. The symptom burden of non-small cell lung cancer in the USA: a real-world cross-sectional study. Support Care Cancer. 2014;22(1):181–7.

    Article  PubMed  Google Scholar 

  5. Yates P, Schofield P, Zhao I, Currow D. Supportive and palliative care for lung cancer patients. J Thorac Dis. 2013;5(Suppl 5):S623–8.

    PubMed  PubMed Central  Google Scholar 

  6. Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ. Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med. 2010;363(8):733–42.

    Article  CAS  PubMed  Google Scholar 

  7. Shinde AM, Dashti A. Palliative Care in Lung Cancer. Cancer Treat Res. 2016;170:225–50.

    Article  PubMed  Google Scholar 

  8. (WHO) WHO Definition of palliative care.

    Google Scholar 

  9. Blum T, Schonfeld N. The lung cancer patient, the pneumologist and palliative care: a developing alliance. Eur Respir J. 2015;45(1):211–26.

    Article  PubMed  Google Scholar 

  10. Meier DE, Bishop TF (2011) Palliative care; benefits, services, and models of care.

    Google Scholar 

  11. Quill TE, Abernethy AP (2013) Generalist plus specialist palliative care--creating a more sustainable model. N Engl J Med 368 (13):1173–1175.

    Google Scholar 

  12. Kelley AS, Morrison RS. Palliative Care for the Seriously ill. N Engl J Med. 2015;373(8):747–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Temel JS, Greer JA, El-Jawahri A, Pirl WF, Park ER, Jackson VA, Back AL, Kamdar M, Jacobsen J, Chittenden EH, Rinaldi SP, Gallagher ER, Eusebio JR, Li Z, Muzikansky A, Ryan DP. Effects of early integrated palliative Care in Patients with Lung and GI cancer: a randomized clinical trial. J Clin Oncol. 2017;35(8):834–41.

    Article  PubMed  Google Scholar 

  14. Aragon KN. Palliative Care in Lung Cancer. Clin Chest Med. 2020;41(2):281–93.

    Article  PubMed  Google Scholar 

  15. IASP. http://www.iasp-pain.org/terms-p.htlm.pain.

  16. Caraceni A, Brunelli C, Martini C, Zecca E, De Conno F. Cancer pain assessment in clinical trials. A review of the literature (1999-2002). J Pain Symptom Manag. 2005;29(5):507–19.

    Article  Google Scholar 

  17. Vainio A, Auvinen A. Prevalence of symptoms among patients with advanced cancer: an international collaborative study. Symptom prevalence group. J Pain Symptom Manag. 1996;12(1):3–10.

    Article  CAS  Google Scholar 

  18. Simone CB 2nd, Vapiwala N, Hampshire MK, Metz JM. Palliative care in the management of lung cancer: analgesic utilization and barriers to optimal pain management. J Opioid Manag. 2012;8(1):9–16.

    Article  PubMed  Google Scholar 

  19. Di Maio M, Gridelli C, Gallo C, Manzione L, Brancaccio L, Barbera S, Robbiati SF, Ianniello GP, Ferrau F, Piazza E, Frontini L, Rosetti F, Carrozza F, Bearz A, Spatafora M, Adamo V, Isa L, Iaffaioli RV, Di Salvo E, Perrone F. Prevalence and management of pain in Italian patients with advanced non-small-cell lung cancer. Br J Cancer. 2004;90(12):2288–96.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Bruera Eea. Textbook of palliative medicine. New York: Oxford University Press; 2006.

    Google Scholar 

  21. Simmons CP, Macleod N, Laird BJ. Clinical management of pain in advanced lung cancer. Clin Med Insights Oncol. 2012;6:331–46.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Organization WH (2018) WHO guidelines for the pharmacological and radio therapeutic management of cancer pain in adults and adolescents.

    Google Scholar 

  23. Adult Cancer Pain: NCCN clinical practice guidelines in oncology (2015).

    Google Scholar 

  24. Colleau SM. Appraising the WHO analgesic ladder on its 20th anniversary. Cancer Pain Release. 2006;19:13–20.

    Google Scholar 

  25. Bandieri E, Romero M, Ripamonti CI, Artioli F, Sichetti D, Fanizza C, Santini D, Cavanna L, Melotti B, Conte PF, Roila F, Cascinu S, Bruera E, Tognoni G, Luppi M, Early Strong Opioid Treatment Study I. Randomized trial of low-dose morphine versus weak opioids in moderate cancer pain. J Clin Oncol. 2016;34(5):436–42.

    Article  CAS  PubMed  Google Scholar 

  26. Wiffen PJ, Derry S, Moore RA. Tramadol with or without paracetamol (acetaminophen) for cancer pain. Cochrane Database Syst Rev. 2017;5:CD012508.

    PubMed  Google Scholar 

  27. Thapa D, Rastogi V, Ahuja V. Cancer pain management-current status. J Anaesthesiol Clin Pharmacol. 2011;27(2):162–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Yuan CS. Methylnaltrexone mechanisms of action and effects on opioid bowel dysfunction and other opioid adverse effects. Ann Pharmacother. 2007;41(6):984–93.

    Article  CAS  PubMed  Google Scholar 

  29. Gülhan M. Palliative treatment in lung cancer. Türkiye Klinikleri J Thor Surg - special topics. 2017;8(1):296–301.

    Google Scholar 

  30. Barghi K, Edmonds KP, Ajayi TA, Atayee RS. Prescribing trends of palliative care Team's use of dexamethasone for cancer-related pain. J Pain Palliat Care Pharmacother. 2018;32(1):37–43.

    Article  PubMed  Google Scholar 

  31. Fairchild A. Palliative radiotherapy for bone metastases from lung cancer: evidence-based medicine? World J Clin Oncol. 2014;5(5):845–57.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Berenson JR. Recommendations for zoledronic acid treatment of patients with bone metastases. Oncologist. 2005;10(1):52–62.

    Article  CAS  PubMed  Google Scholar 

  33. Balboni TA, Hui KP, Kamal AH. Supportive Care in Lung Cancer: improving value in the era of modern therapies. Am Soc Clin Oncol Educ Book. 2018;38:716–25.

    Article  PubMed  Google Scholar 

  34. Dyspnea. Mechanisms, assessment, and management: a consensus statement. American Thoracic Society. Am J Respir Crit Care Med. 1999;159(1):321–40.

    Google Scholar 

  35. Kathiresan G, Clement RF, Sankaranarayanan MT. Dyspnea in lung cancer patients: a systematic review. Lung Cancer (Auckl). 2010;1:141–50.

    PubMed  Google Scholar 

  36. Currow DC, Smith J, Davidson PM, Newton PJ, Agar MR, Abernethy AP. Do the trajectories of dyspnea differ in prevalence and intensity by diagnosis at the end of life? A consecutive cohort study. J Pain Symptom Manag. 2010;39(4):680–90.

    Article  Google Scholar 

  37. Molassiotis A, Lowe M, Blackhall F, Lorigan P. A qualitative exploration of a respiratory distress symptom cluster in lung cancer: cough, breathlessness and fatigue. Lung Cancer. 2011;71(1):94–102.

    Article  CAS  PubMed  Google Scholar 

  38. Cheville AL, Novotny PJ, Sloan JA, Basford JR, Wampfler JA, Garces YI, Jatoi A, Yang P. The value of a symptom cluster of fatigue, dyspnea, and cough in predicting clinical outcomes in lung cancer survivors. J Pain Symptom Manag. 2011;42(2):213–21.

    Article  Google Scholar 

  39. Tiep B, Sun V, Koczywas M, Kim J, Raz D, Hurria A, Hayter J. Pulmonary rehabilitation and palliative Care for the Lung Cancer Patient. J Hosp Palliat Nurs. 2015;17(5):462–8.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Claessens MT, Lynn J, Zhong Z, Desbiens NA, Phillips RS, Wu AW, Harrell FE Jr, Connors AF Jr. Dying with lung cancer or chronic obstructive pulmonary disease: insights from SUPPORT. Study to understand prognoses and preferences for outcomes and risks of treatments. J Am Geriatr Soc. 2000;48(S1):S146–53.

    Article  CAS  PubMed  Google Scholar 

  41. Ekstrom M, Johnson MJ, Schioler L, Kaasa S, Hjermstad MJ, Currow DC. Who experiences higher and increasing breathlessness in advanced cancer? The longitudinal EPCCS study. Support Care Cancer. 2016;24(9):3803–11.

    Article  CAS  PubMed  Google Scholar 

  42. Akgun KM. Palliative and end-of-life Care for Patients with malignancy. Clin Chest Med. 2017;38(2):363–76.

    Article  PubMed  Google Scholar 

  43. Parshall MB, Schwartzstein RM, Adams L, Banzett RB, Manning HL, Bourbeau J, Calverley PM, Gift AG, Harver A, Lareau SC, Mahler DA, Meek PM, O'Donnell DE, American Thoracic Society Committee on D. An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med. 2012;185(4):435–52.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Bausewein C, Farquhar M, Booth S, Gysels M, Higginson IJ. Measurement of breathlessness in advanced disease: a systematic review. Respir Med. 2007;101(3):399–410.

    Article  CAS  PubMed  Google Scholar 

  45. Dudgeon (2011) End of life care: Dyspnea.

    Google Scholar 

  46. Jantarakupt P, Porock D. Dyspnea management in lung cancer: applying the evidence from chronic obstructive pulmonary disease. Oncol Nurs Forum. 2005;32(4):785–97.

    Article  PubMed  Google Scholar 

  47. Bruera E, de Stoutz N, Velasco-Leiva A, Schoeller T, Hanson J. Effects of oxygen on dyspnoea in hypoxaemic terminal-cancer patients. Lancet. 1993;342(8862):13–4.

    Article  CAS  PubMed  Google Scholar 

  48. Campbell ML, Yarandi H, Dove-Medows E. Oxygen is nonbeneficial for most patients who are near death. J Pain Symptom Manag. 2013;45(3):517–23.

    Article  Google Scholar 

  49. Abernethy AP, McDonald CF, Frith PA, Clark K, Herndon JE 2nd, Marcello J, Young IH, Bull J, Wilcock A, Booth S, Wheeler JL, Tulsky JA, Crockett AJ, Currow DC. Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double-blind, randomised controlled trial. Lancet. 2010;376(9743):784–93.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Mahler DA, Selecky PA, Harrod CG, Benditt JO, Carrieri-Kohlman V, Curtis JR, Manning HL, Mularski RA, Varkey B, Campbell M, Carter ER, Chiong JR, Ely EW, Hansen-Flaschen J, O'Donnell DE, Waller A. American College of Chest Physicians consensus statement on the management of dyspnea in patients with advanced lung or heart disease. Chest. 2010;137(3):674–91.

    Article  PubMed  Google Scholar 

  51. Hui D, Morgado M, Chisholm G, Withers L, Nguyen Q, Finch C, Frisbee-Hume S, Bruera E. High-flow oxygen and bilevel positive airway pressure for persistent dyspnea in patients with advanced cancer: a phase II randomized trial. J Pain Symptom Manag. 2013;46(4):463–73.

    Article  Google Scholar 

  52. Nava S, Ferrer M, Esquinas A, Scala R, Groff P, Cosentini R, Guido D, Lin CH, Cuomo AM, Grassi M. Palliative use of non-invasive ventilation in end-of-life patients with solid tumours: a randomised feasibility trial. Lancet Oncol. 2013;14(3):219–27.

    Article  PubMed  Google Scholar 

  53. Yeow ME, Szmuilowicz E. Practical aspects of using noninvasive positive pressure ventilation at the end of life #231. J Palliat Med. 2010;13(9):1150–1.

    Article  PubMed  Google Scholar 

  54. Bausewein C, Booth S, Gysels M, Higginson I. Non-pharmacological interventions for breathlessness in advanced stages of malignant and non-malignant diseases. Cochrane Database Syst Rev. 2008;2:CD005623.

    Google Scholar 

  55. Bausewein C, Booth S, Gysels M, Kuhnbach R, Higginson IJ. Effectiveness of a hand-held fan for breathlessness: a randomised phase II trial. BMC Palliat Care. 2010;9:22.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Barnes H, McDonald J, Smallwood N, Manser R. Opioids for the palliation of refractory breathlessness in adults with advanced disease and terminal illness. Cochrane Database Syst Rev. 2016;3:CD011008.

    PubMed  Google Scholar 

  57. Jennings AL, Davies AN, Higgins JP, Gibbs JS, Broadley KE. A systematic review of the use of opioids in the management of dyspnoea. Thorax. 2002;57(11):939–44.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Mahler DA, O'Donnell DE. Recent advances in dyspnea. Chest. 2015;147(1):232–41.

    Article  PubMed  Google Scholar 

  59. Zeppetella G. Nebulized morphine in the palliation of dyspnoea. Palliat Med. 1997;11(4):267–75.

    Article  CAS  PubMed  Google Scholar 

  60. Thomas JR, von Gunten CF. Clinical management of dyspnoea. Lancet Oncol. 2002;3(4):223–8.

    Article  CAS  PubMed  Google Scholar 

  61. Clemens KE, Klaschik E. Dyspnoea associated with anxiety--symptomatic therapy with opioids in combination with lorazepam and its effect on ventilation in palliative care patients. Support Care Cancer. 2011;19(12):2027–33.

    Article  PubMed  Google Scholar 

  62. Viola R, Kiteley C, Lloyd NS, Mackay JA, Wilson J, Wong RK, Supportive Care Guidelines Group of the Cancer Care Ontario Program in Evidence-Based C. The management of dyspnea in cancer patients: a systematic review. Support Care Cancer. 2008;16(4):329–37.

    Article  PubMed  Google Scholar 

  63. Simon ST, Higginson IJ, Booth S, Harding R, Weingartner V, Bausewein C. Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults. Cochrane Database Syst Rev. 2016;10:CD007354.

    PubMed  Google Scholar 

  64. Elsayem A, Bruera E. High-dose corticosteroids for the management of dyspnea in patients with tumor obstruction of the upper airway. Support Care Cancer. 2007;15(12):1437–9.

    Article  PubMed  Google Scholar 

  65. Molassiotis A, Bailey C, Caress A, Brunton L, Smith J. Interventions for cough in cancer. Cochrane Database Syst Rev. 2010;9:CD007881.

    Google Scholar 

  66. Harle AS, Blackhall FH, Smith JA, Molassiotis A. Understanding cough and its management in lung cancer. Curr Opin Support Palliat Care. 2012;6(2):153–62.

    Article  PubMed  Google Scholar 

  67. Kvale PA, Selecky PA, Prakash UB, American College of Chest P. Palliative care in lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 2007;132(3 Suppl):368S–403S.

    Article  PubMed  Google Scholar 

  68. Beckles MA, Spiro SG, Colice GL, Rudd RM. Initial evaluation of the patient with lung cancer: symptoms, signs, laboratory tests, and paraneoplastic syndromes. Chest. 2003;123(1 Suppl):97S–104S.

    Article  PubMed  Google Scholar 

  69. Molassiotis A, Smith JA, Bennett MI, Blackhall F, Taylor D, Zavery B, Harle A, Booton R, Rankin EM, Lloyd-Williams M, Morice AH. Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough. Cough. 2010;6:9.

    Article  PubMed  PubMed Central  Google Scholar 

  70. Simoff MJ, Lally B, Slade MG, Goldberg WG, Lee P, Michaud GC, Wahidi MM, Chawla M. Symptom management in patients with lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):e455S–97S.

    Article  CAS  PubMed  Google Scholar 

  71. Luporini G, Barni S, Marchi E, Daffonchio L. Efficacy and safety of levodropropizine and dihydrocodeine on nonproductive cough in primary and metastatic lung cancer. Eur Respir J. 1998;12(1):97–101.

    Article  CAS  PubMed  Google Scholar 

  72. Matthys H, Bleicher B, Bleicher U. Dextromethorphan and codeine: objective assessment of antitussive activity in patients with chronic cough. J Int Med Res. 1983;11(2):92–100.

    Article  CAS  PubMed  Google Scholar 

  73. Doona M, Walsh D. Benzonatate for opioid-resistant cough in advanced cancer. Palliat Med. 1998;12(1):55–8.

    Article  CAS  PubMed  Google Scholar 

  74. Kvale PA. Chronic cough due to lung tumors: ACCP evidence-based clinical practice guidelines. Chest. 2006;129(1 Suppl):147S–53S.

    Article  PubMed  Google Scholar 

  75. Speiser BL, Spratling L. Remote afterloading brachytherapy for the local control of endobronchial carcinoma. Int J Radiat Oncol Biol Phys. 1993;25(4):579–87.

    Article  CAS  PubMed  Google Scholar 

  76. Numico G, Russi E, Merlano M. Best supportive care in non-small cell lung cancer: is there a role for radiotherapy and chemotherapy? Lung Cancer. 2001;32(3):213–26.

    Article  CAS  PubMed  Google Scholar 

  77. Yoneda KY, Colt H, Stollenwerk NS. Lung cancer emergencies. In: Ball DB, Scagliotti CV, editors. Pass HI, The IASLC Multidisciplinary approach to Thoracic Oncology. Colorado; 2014. p. 815–38.

    Google Scholar 

  78. Dweik RA, Stoller JK. Role of bronchoscopy in massive hemoptysis. Clin Chest Med. 1999;20(1):89–105.

    Article  CAS  PubMed  Google Scholar 

  79. Corey R, Hla KM. Major and massive hemoptysis: reassessment of conservative management. Am J Med Sci. 1987;294(5):301–9.

    Article  CAS  PubMed  Google Scholar 

  80. Shigemura N, Wan IY, Yu SC, Wong RH, Hsin MK, Thung HK, Lee TW, Wan S, Underwood MJ, Yim AP. Multidisciplinary management of life-threatening massive hemoptysis: a 10-year experience. Ann Thorac Surg. 2009;87(3):849–53.

    Article  PubMed  Google Scholar 

  81. Jean-Baptiste E. Clinical assessment and management of massive hemoptysis. Crit Care Med. 2000;28(5):1642–7.

    Article  CAS  PubMed  Google Scholar 

  82. Conlan AA, Hurwitz SS. Management of massive haemoptysis with the rigid bronchoscope and cold saline lavage. Thorax. 1980;35(12):901–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Fartoukh M, Khalil A, Louis L, Carette MF, Bazelly B, Cadranel J, Mayaud C, Parrot A. An integrated approach to diagnosis and management of severe haemoptysis in patients admitted to the intensive care unit: a case series from a referral Centre. Respir Res. 2007;8:11.

    Article  PubMed  PubMed Central  Google Scholar 

  84. Schols AM, Gosker HR. The pathophysiology of cachexia in chronic obstructive pulmonary disease. Curr Opin Support Palliat Care. 2009;3(4):282–7.

    Article  PubMed  Google Scholar 

  85. Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489–95.

    Article  PubMed  Google Scholar 

  86. van der Meij BS, Schoonbeek CP, Smit EF, Muscaritoli M, van Leeuwen PA, Langius JA. Pre-cachexia and cachexia at diagnosis of stage III non-small-cell lung carcinoma: an exploratory study comparing two consensus-based frameworks. Br J Nutr. 2013;109(12):2231–9.

    Article  PubMed  Google Scholar 

  87. Ross PJ, Ashley S, Norton A, Priest K, Waters JS, Eisen T, Smith IE, O'Brien ME. Do patients with weight loss have a worse outcome when undergoing chemotherapy for lung cancers? Br J Cancer. 2004;90(10):1905–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Aapro M, Arends J, Bozzetti F, Fearon K, Grunberg SM, Herrstedt J, Hopkinson J, Jacquelin-Ravel N, Jatoi A, Kaasa S, Strasser F, ESMO. Early recognition of malnutrition and cachexia in the cancer patient: a position paper of a European School of Oncology Task Force. Ann Oncol. 2014;25(8):1492–9.

    Article  CAS  PubMed  Google Scholar 

  89. Detsky AS, McLaughlin JR, Baker JP, Johnston N, Whittaker S, Mendelson RA, Jeejeebhoy KN. What is subjective global assessment of nutritional status? JPEN J Parenter Enteral Nutr. 1987;11(1):8–13.

    Article  CAS  PubMed  Google Scholar 

  90. Deng GE, Rausch SM, Jones LW, Gulati A, Kumar NB, Greenlee H, Pietanza MC, Cassileth BR. Complementary therapies and integrative medicine in lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):e420S–36S.

    Article  CAS  PubMed  Google Scholar 

  91. Stanga Z. Cancer treatment and nutrition. In: Van Halteren H, Jatoi A, editors. Nutrition and cancer. 2nd ed. Danvers: ESMO Press; 2013. p. 33–48.

    Google Scholar 

  92. Arends J, Bodoky G, Bozzetti F, Fearon K, Muscaritoli M, Selga G, van Bokhorst-de van der Schueren MA, von Meyenfeldt M, Dgem, Zurcher G, Fietkau R, Aulbert E, Frick B, Holm M, Kneba M, Mestrom HJ, Zander A, ESPEN (2006) ESPEN guidelines on enteral nutrition: non-surgical oncology. Clin Nutr 25 (2):245–259.

    Google Scholar 

  93. Illman J, Corringham R, Robinson D Jr, Davis HM, Rossi JF, Cella D, Trikha M. Are inflammatory cytokines the common link between cancer-associated cachexia and depression? J Support Oncol. 2005;3(1):37–50.

    CAS  PubMed  Google Scholar 

  94. Von Roenn JH, Paice JA. Control of common, non-pain cancer symptoms. Semin Oncol. 2005;32(2):200–10.

    Article  Google Scholar 

  95. Berenstein EG, Ortiz Z. Megestrol acetate for the treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2005;(2):CD004310.

    Google Scholar 

  96. Fearon KC, Barber MD, Moses AG, Ahmedzai SH, Taylor GS, Tisdale MJ, Murray GD. Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia. J Clin Oncol. 2006;24(21):3401–7.

    Article  CAS  PubMed  Google Scholar 

  97. van der Meij BS, Langius JA, Smit EF, Spreeuwenberg MD, von Blomberg BM, Heijboer AC, Paul MA, van Leeuwen PA. Oral nutritional supplements containing (n-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment. J Nutr. 2010;140(10):1774–80.

    Article  PubMed  Google Scholar 

  98. Del Fabbro E, Hui D, Dalal S, Dev R, Nooruddin ZI, Bruera E. Clinical outcomes and contributors to weight loss in a cancer cachexia clinic. J Palliat Med. 2011;14(9):1004–8.

    Article  PubMed  PubMed Central  Google Scholar 

  99. Baracos VE. Cancer-associated cachexia and underlying biological mechanisms. Annu Rev Nutr. 2006;26:435–61.

    Article  CAS  PubMed  Google Scholar 

  100. Temel JS, Abernethy AP, Currow DC, Friend J, Duus EM, Yan Y, Fearon KC. Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials. Lancet Oncol. 2016;17(4):519–31.

    Article  CAS  PubMed  Google Scholar 

  101. Argon A, Onat H. Kanserli hastada yorgunluk. In: Mandal MN, Onat H, editors. Kanser hastasına yaklaşım: Tanı tedavi takipte yaklaşım. Nobel Tıp; 2012. p. 513–7.

    Google Scholar 

  102. Cancer related fatigue - National Comprehensive Cancer Network (2014).

    Google Scholar 

  103. Cella DF, Bonomi AE, Lloyd SR, Tulsky DS, Kaplan E, Bonomi P. Reliability and validity of the Functional Assessment of Cancer Therapy-Lung (FACT-L) quality of life instrument. Lung Cancer. 1995;12(3):199–220.

    Article  CAS  PubMed  Google Scholar 

  104. Hollen PJ, Gralla RJ, Kris MG, Potanovich LM. Quality of life assessment in individuals with lung cancer: testing the Lung Cancer Symptom Scale (LCSS). Eur J Cancer. 1993;29A(Suppl 1):S51–8.

    Article  Google Scholar 

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Authors and Affiliations

  1. Medical Faculty, Department of Pulmonology, Aydın Adnan Menderes University, Aydın, Turkey

    Şule Taş Gülen

  2. Department of Pulmonology, Suat Seren Chest Diseases and Thoracic Surgery Research and Training Hospital, İzmir, Turkey

    Berna Kömürcüoğlu

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  1. Şule Taş Gülen
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Editors and Affiliations

  1. Department of Otorhinolaryngology, Eskişehir Osmangazi University, Eskisehir, Türkiye

    Cemal Cingi

  2. Department of Pulmonology, Celal Bayar University, Manisa, Türkiye

    Arzu Yorgancıoğlu

  3. Department of Otorhinolaryngology, Kırıkkale University, Kırıkkale, Türkiye

    Nuray Bayar Muluk

  4. Federal University of Bahia School of Medicine and ProAR Foundation, Salvador - Bahia, Brazil

    Alvaro A. Cruz

Section Editor information

  1. Department of Chest Disease, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey

    Muzaffer Metintaş MD

  2. Department of Chest Disease, Eskisehir Osmangazi University, Eskisehir, Turkey

    Guntulu Ak

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Gülen, Ş.T., Kömürcüoğlu, B. (2023). Palliative Treatment in Lung Cancer. In: Cingi, C., Yorgancıoğlu, A., Bayar Muluk, N., Cruz, A.A. (eds) Airway diseases. Springer, Cham. https://doi.org/10.1007/978-3-031-22483-6_76-1

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  • DOI: https://doi.org/10.1007/978-3-031-22483-6_76-1

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  • Print ISBN: 978-3-031-22482-9

  • Online ISBN: 978-3-031-22483-6

  • eBook Packages: MedicineReference Module Medicine

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