Abstract
Benign vocal fold lesions, such as vocal nodule, laryngeal polyp, mucosal hemorrhage, Reinke’s edema, intrachordal cyst, and sulcus vocalis, usually occur as a result of incorrect and excessive use of the voice. Excessive and irregular vibration of the vocal folds creates microtrauma and causes changes in the structure of the vocal folds. Although the most common cause is vibratory injury, the exact cause of benign pathologies of the larynx is not well known yet.
References
Remacle M, Friedrich G, Dikkers FG, de Jong F. Phonosurgery of the vocal folds: a classification proposal. Eur Arch Otorhinolaryngol. 2003;260:1–6. https://doi.org/10.1007/s00405-002-0507-5.
Sulica L. Laryngoscopy, stroboscopy and other tools for the evaluation of voice disorders. Otolaryngol Clin N Am. 2013;46:21–30. https://doi.org/10.1016/j.otc.2012.09.001.
Kunduk M, McWhorter AJ. True vocal fold nodules: the role of differential diagnosis. Curr Opin Otolaryngol Head Neck Surg. 2009;17:449–52. https://doi.org/10.1097/MOO.0b013e3283328b6d.
Tavares ELM, Martins RHG. Vocal evaluation in teachers with or without symptoms. J Voice. 2007;21:407–14. https://doi.org/10.1016/j.jvoice.2006.04.001.
Sataloff RT. Structural abnormalities of the larynx. In: Sataloff RT, editor. Clinical assessment of voice. 2nd ed. San Diego: Plural Publishing; 2017. p. 589–642.
Birchall MA, Carding P. Vocal nodules management. Clin Otolaryngol. 2019;44:497–501. https://doi.org/10.1111/coa.13324.
Naunheim MR, Carroll TL. Benign vocal fold lesions: update on nomenclature, cause, diagnosis, and treatment. Curr Opin Otolaryngol Head Neck Surg. 2017;25:453–8. https://doi.org/10.1097/MOO.0000000000000408.
Selçuk A. Larinksin Benign Lezyonları. In: Koç C, editor. Kulak Burun Boğaz Hastalıkları ve Baş Boyun Cerrahisi. 3rd ed. Ankara: Güneş Tıp Kitapevleri; 2019. p. 1125–9.
Miaśkiewicz B, Panasiewicz A, Gos E, et al. Voice aspects in sulcus coexisting with benign lesions of the vocal folds. Acta Otorhinolaryngol Ital. 2020;40:262–9. https://doi.org/10.14639/0392-100X-N0555.
Mansuri B, Tohidast SA, Soltaninejad N, et al. Nonmedical treatments of vocal fold nodules: a systematic review. J Voice. 2018;32:609–20. https://doi.org/10.1016/j.jvoice.2017.08.023.
Santa Maria C, Sung C-K, Baird BJ, Erickson-DiRenzo E. Vocal hygiene in collegiate singers-does formal training relate to practices? J Voice. 2020;S0892-1997(20):30106–5. https://doi.org/10.1016/j.jvoice.2020.03.014.
Bastian RW, Wingo ML. Benign vocal fold mucosal disorders. In: Flint PW, Haughey BH, Lund VJ, et al., editors. Cummings otolaryngology- head and neck surgery. 7th ed. Philadelphia: Elsevier; 2021. p. 868–96.
Lechien JR, Saussez S, Nacci A, et al. Association between laryngopharyngeal reflux and benign vocal folds lesions: a systematic review. Laryngoscope. 2019;129:E329–41. https://doi.org/10.1002/lary.27932.
Kaneko M, Sugiyama Y, Mukudai S, Hirano S. Effect of voice therapy using semioccluded vocal tract exercises in singers and nonsingers with dysphonia. J Voice. 2020;34:963.e1–9. https://doi.org/10.1016/j.jvoice.2019.06.014.
Hartnick C, Ballif C, De Guzman V, et al. Indirect vs direct voice therapy for children with vocal nodules: a randomized clinical trial. JAMA Otolaryngol Head Neck Surg. 2018;144:156–63. https://doi.org/10.1001/jamaoto.2017.2618.
Béquignon E, Bach C, Fugain C, et al. Long-term results of surgical treatment of vocal fold nodules. Laryngoscope. 2013;123:1926–30. https://doi.org/10.1002/lary.23768.
Jo YS, Kim MY, So YK. Impact of remnant nodules on immediate and long-term outcomes of voice therapy for vocal fold nodules. J Voice. 2021;35:400–5. https://doi.org/10.1016/j.jvoice.2019.10.001.
Wang C-T, Lai M-S, Cheng P-W. Long-term surveillance following intralesional steroid injection for benign vocal fold lesions. JAMA Otolaryngol Head Neck Surg. 2017;143:589–94. https://doi.org/10.1001/jamaoto.2016.4418.
Martins RHG, Defaveri J, Domingues MAC, de Albuquerque e Silva R. Vocal polyps: clinical, morphological, and immunohistochemical aspects. J Voice. 2011;25:98–106. https://doi.org/10.1016/j.jvoice.2009.05.002.
Gu J, Huang Y. β-Defensin-2 is overexpressed in human vocal cord polyps. Eur Arch Otorhinolaryngol. 2017;274:901–7. https://doi.org/10.1007/s00405-016-4270-4.
Kraimer KL, Husain I. Updated medical and surgical treatment for common benign laryngeal lesions. Otolaryngol Clin N Am. 2019;52:745–57. https://doi.org/10.1016/j.otc.2019.03.017.
Dai Y-F, Tan J-J, Deng C-Q, et al. Association of pepsin and DNA damage in laryngopharyngeal reflux-related vocal fold polyps. Am J Otolaryngol. 2020;41:102681. https://doi.org/10.1016/j.amjoto.2020.102681.
Sahin M, Gode S, Dogan M, et al. Effect of voice therapy on vocal fold polyp treatment. Eur Arch Otorhinolaryngol. 2018;275:1533–40. https://doi.org/10.1007/s00405-018-4962-z.
Lee YS, Lee DH, Jeong G-E, et al. Treatment efficacy of voice therapy for vocal fold polyps and factors predictive of its efficacy. J Voice. 2017;31:120.e9–120.e13. https://doi.org/10.1016/j.jvoice.2016.02.014.
Ju YH, Jung K-Y, Kwon S-Y, et al. Effect of voice therapy after phonomicrosurgery for vocal polyps: a prospective, historically controlled, clinical study. J Laryngol Otol. 2013;127:1134–8. https://doi.org/10.1017/S0022215113002454.
Mizuta M, Hiwatashi N, Kobayashi T, et al. Comparison of vocal outcomes after angiolytic laser surgery and microflap surgery for vocal polyps. Auris Nasus Larynx. 2015;42:453–7. https://doi.org/10.1016/j.anl.2015.03.011.
Ma J, Fang R, Zhen R, et al. A 532-nm KTP laser for vocal fold polyps: efficacy and relative factors. Ear Nose Throat J. 2021;100:87S–93S. https://doi.org/10.1177/0145561320946153.
McGarey PO, Collins A, Dominguez LM, et al. Treatment of vocal fold polyps with in-office potassium titanyl phosphate (KTP) laser ablation in professional singers. J Voice. 2021;35:800–3. https://doi.org/10.1016/j.jvoice.2020.01.029.
Wang C-T, Liao L-J, Cheng P-W, et al. Intralesional steroid injection for benign vocal fold disorders: a systematic review and meta-analysis. Laryngoscope. 2013;123:197–203. https://doi.org/10.1002/lary.23551.
Wu C-H, Lo W-C, Liao L-J, et al. Vocal fold steroid injection for benign vocal lesions in professional voice users. J Voice. 2021;S0892-1997(21):00057–6. https://doi.org/10.1016/j.jvoice.2021.02.002.
Lee SW, Park KN. Long-term efficacy of percutaneous steroid injection for treating benign vocal fold lesions: a prospective study. Laryngoscope. 2016;126:2315–9. https://doi.org/10.1002/lary.25916.
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Becerik, Ç., Karaca, Ç.T. (2023). Vocal Fold Nodules and Polyps. In: Cingi, C., Yorgancıoğlu, A., Bayar Muluk, N., Cruz, A.A. (eds) Airway diseases. Springer, Cham. https://doi.org/10.1007/978-3-031-22483-6_123-1
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