Skip to main content

Sex Hormones, Menstrual Cycle, and Resistance Exercise

  • Chapter
  • First Online:
Sex Hormones, Exercise and Women
  • 892 Accesses

Abstract

There have been a number of studies about the effects and influence of the menstrual cycle on aerobic and anaerobic performance, but most studies that investigated muscle strength responses to resistance exercise over the menstrual cycle have not found any changes. However, since there are many factors that can influence exercise performance, the effect of the menstrual cycle on muscle strength is probably very individual specific, and hence, the effect of menstrual cycle status on the response to acute resistance exercise is not clear. To this end, some studies have demonstrated that the responses of anabolic hormones to acute resistance exercise in women vary with menstrual cycle status. Women with menstrual disorders associated with low serum estradiol and progesterone levels have an attenuated anabolic hormone response to acute resistance exercise, suggesting that menstrual disorders characterized by low ovarian hormone levels may affect exercise-induced changes in anabolic hormones in women. It has also been suggested that estrogen may be protective against exercise-induced muscle damage, and that recovery from exercise-induced muscle damage may differ between the menstrual cycle phases. These differences might critically affect long-term adaptations to resistance training; however, to date there is little data available to examine this point. Further studies are needed to demonstrate the short-term and long-term effects of changes in skeletal muscle response to resistance exercise by menstrual cycle status in women.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aizawa K, Akimoto T, Inoue H, et al. Resting serum DHEAS level increases after 8-week resistance training among young. Eur J Appl Physiol. 2003;90:575–80.

    Google Scholar 

  • Aizawa K, Hayashi K, Mesaki N. Relationship of muscle strength with dehydroepiandrosterone sulfate (DHEAS), testosterone and insulin-like growth factor-I in male and female athletes. Adv Exerc Sports Physiol. 2006;12:29–34.

    Google Scholar 

  • Aizawa K, Iemitsu M, Otsuki T, Maeda S, Miyauchi T, Mesaki N. Sex differences in steroidogenesis in skeletal muscle following a single bout of exercise in rats. J Appl Physiol. 2008;104(1):67–74.https://doi.org/10.1152/japplphysiol.00558.2007.

  • Bambaeichi E, Reilly T, Cable NT, et al. The isolated and combined effects of menstrual cycle phase and time-of-day on muscle strength of eumenorrheic females. Chronobiol Int. 2004;21:645–60.

    Google Scholar 

  • Baulieu EE. Dehydroepiandrosterone (DHEA): a fountain of youth? J Clin Endocrinol Metab. 1996;81:3147–51.

    Google Scholar 

  • Consitt LA, Copeland JL, Tremblay MS. Hormone responses to resistance vs. endurance exercise in premenopausal females. Can J Appl Physiol. 2001;26:574–87.

    Google Scholar 

  • Consitt LA, Copeland JL, Tremblay MS. Endogenous anabolic hormone responses to endurance versus resistance exercise and training in women. Sports Med. 2002;32:1–22.

    Google Scholar 

  • Constantini NW, Dubnov G, Lebrun CM. The menstrual cycle and sport performance. Clin Sports Med. 2005;24:e51–82.

    Google Scholar 

  • Copeland JL, Consitt LA, Tremblay MS. Hormonal responses to endurance and resistance exercise in females aged 19–69 years. J Gerontol A Biol Sci Med Sci. 2002;57:B158–65.

    Google Scholar 

  • De Crée C. Sex steroid metabolism and menstrual irregularities in the exercising female. A review. Sports Med. 1998;25:369–406.

    Google Scholar 

  • Elliott KJ, Cable NT, Reilly T, et al. Effect of menstrual cycle phase on the concentration of bioavailable 17-beta oestradiol and testosterone and muscle strength. Clin Sci (Lond). 2003;105:663–9.

    Google Scholar 

  • Enea C, Boisseau N, Ottavy M, et al. Effects of menstrual cycle, oral contraception, and training on exercise-induced changes in circulating DHEA-sulphate and testosterone in young women. Eur J Appl Physiol. 2009;106:365–73.https://doi.org/10.1007/s00421-009-1017-6.

  • Enea C, Boisseau N, Fargeas-Gluck MA. Circulating androgens in women: exercise-induced changes. Sports Med. 2011;41:1–15.https://doi.org/10.2165/11536920-000000000-00000.

  • Enns DL, Tiidus PM. The influence of estrogen on skeletal muscle: sex matters. Sports Med. 2010;40:41–58.https://doi.org/10.2165/11319760-000000000-00000.

  • Faria AC, Bekenstein LW, Booth Jr RA, et al. Pulsatile growth hormone release in normal women during the menstrual cycle. Clin Endocrinol (Oxf). 1992;36:591–6.

    Google Scholar 

  • Fleck SJ, Kraemer WJ. Designing resistance training programs. 4th ed. Champaign, IL: Human Kinetics; 2014.

    Google Scholar 

  • Fridén C, Hirschberg AL, Saartok T. Muscle strength and endurance do not significantly vary across 3 phases of the menstrual cycle in moderately active premenopausal women. Clin J Sport Med. 2003;13:238–41.

    Google Scholar 

  • Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev. 1998;19:717–97.

    Google Scholar 

  • Hackney AC, Viru A. Research methodology: endocrinologic measurements in exercise science and sports medicine. J Athl Train. 2008;43:631–9.

    Google Scholar 

  • Häkkinen K, Pakarinen A. Acute hormonal responses to heavy resistance exercise in men and women at different ages. Int J Sports Med. 1995;16:507–13.

    Google Scholar 

  • Häkkinen K, Pakarinen A, Kraemer WJ, et al. Basal concentrations and acute responses of serum hormones and strength development during heavy resistance training in middle-aged and elderly men and women. J Gerontol A Biol Sci Med Sci. 2000;55:B95–105.

    Google Scholar 

  • Hansen M, Kjaer M. Influence of sex and estrogen on musculotendinous protein turnover at rest and after exercise. Exerc Sport Sci Rev. 2014;42:183–92.https://doi.org/10.1249/JES.0000000000000026.

  • Haines M, McKinley-Barnard SK, Andre TL, et al. Skeletal muscle estrogen receptor activation in response to eccentric exercise up-regulates myogenic-related gene expression independent of differing serum estradiol levels occurring during the human menstrual cycle. J Sports Sci Med. 2018;17:31-39.

    Google Scholar 

  • Hicks KM, Onambélé-Pearson G, Winwood K, Morse CI. Oral contraceptive pill use and the susceptibility to markers of exercise-induced muscle damage. Eur J Appl Phys 2017;117(7):1393-1402.https://doi.org/10.1007/s00421-017-3629-6.

  • Hornum M, Cooper DM, Brasel JA, et al. Exercise-induced changes in circulating growth factors with cyclic variation in plasma estradiol in women. J Appl Physiol. 1997;82:1946–51.

    Google Scholar 

  • Jabbour HN, Kelly RW, Fraser HM, et al. Endocrine regulation of menstruation. Endocr Rev. 2006;27:17–46.

    Google Scholar 

  • Janse de Jonge XA. Effects of the menstrual cycle on exercise performance. Sports Med. 2003;33:833–51.

    Google Scholar 

  • Jenkins PJ. Growth hormone and exercise. Clin Endocrinol (Oxf). 1999;50:683–9.

    Google Scholar 

  • Johnson LG, Kraemer RR, Haltom R, et al. Effects of estrogen replacement therapy on dehydroepiandrosterone, dehydroepiandrosterone sulfate, and cortisol responses to exercise in postmenopausal women. Fertil Steril. 1997;68:836–43.

    Google Scholar 

  • Kahn SM, Hryb DJ, Nakhla AM, et al. Sex hormone-binding globulin is synthesized in target cells. J Endocrinol. 2002;175:113–20.

    Google Scholar 

  • Kanaley JA, Giannopoulou I, Collier S, et al. Hormone-replacement therapy use, but not race, impacts the resting and exercise-induced GH response in postmenopausal women. Eur J Endocrinol. 2005;153:527–33.

    Google Scholar 

  • Koziris LP, Hickson RC, Chatterton Jr RT, et al. Serum levels of total and free IGF-I and IGFBP-3 are increased and maintained in long-term training. J Appl Physiol. 1999;86:1436–42.

    Google Scholar 

  • Kraemer WJ, Ratamess NA. Hormonal responses and adaptations to resistance exercise and training. Sports Med. 2005;35:339–61.

    Google Scholar 

  • Kraemer WJ, Gordon SE, Fleck SJ, et al. Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females. Int J Sports Med. 1991;12:228–35.

    Google Scholar 

  • Kraemer WJ, Fleck SJ, Dziados JE, et al. Changes in hormonal concentrations after different heavy-resistance exercise protocols in women. J Appl Physiol. 1993;75:594–604.

    Google Scholar 

  • Kraemer RR, Heleniak RJ, Tryniecki JL, et al. Follicular and luteal phase hormonal responses to low-volume resistive exercise. Med Sci Sports Exerc. 1995;27:809–17.

    Google Scholar 

  • Kraemer RR, Johnson LG, Haltom R, et al. Effects of hormone replacement on growth hormone and prolactin exercise responses in postmenopausal women. J Appl Physiol. 1998;84:703–8.

    Google Scholar 

  • Labrie F, Belanger A, Cusan L, et al. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab. 1997;82:2396–402.

    Google Scholar 

  • Lane AR, O'Leary CB, Hackney AC. Menstrual cycle phase effects free testosterone responses to prolonged aerobic exercise. Acta Physiol Hung. 2015;102(3):336–41.

    Google Scholar 

  • Lebrun CM. The effect of the phase of the menstrual cycle and the birth control pill on athletic performance. Clin Sports Med. 1994;13:419–41.

    Google Scholar 

  • Markofski MM, Braun William A. Influence of menstrual cycle on indices of contraction-induced muscle damage. J Strength Conditioning Res. 2014;28(9):2649–2656.https://doi.org/10.1519/JSC.0000000000000429.

  • Marx JO, Ratamess NA, Nindl BC, et al. Low-volume circuit versus high-volume periodized resistance training in women. Med Sci Sports Exerc. 2001;33:635–43.

    Google Scholar 

  • Mauras N, Rogol AD, Veldhuis JD. Increased hGH production rate after low-dose estrogen therapy in prepubertal girls with Turner’s syndrome. Pediatr Res. 1990;28:626–30.

    Google Scholar 

  • McMurray RG, Hackney AC. Endocrine responses to exercise and training. In: Garrett W, Kirkendall DT, editors. Exercise and sport science. Philadelphia, PA: Lippincott, Williams & Wilkins; 2000. p. 135–61.

    Google Scholar 

  • Meczekalski B, Tonetti A, Monteleone P, et al. Hypothalamic amenorrhea with normal body weight: ACTH, allopregnanolone and cortisol responses to corticotropin-releasing hormone test. Eur J Endocrinol. 2000;142:280–5.

    Google Scholar 

  • Minahan C, Joyce S, Bulmer AC, Cronin N, Sabapathy S. The influence of estradiol on muscle damage and leg strength after intense eccentric exercise. Eur J Appl Phys. 2015;115(7):1493–1500.https://doi.org/10.1007/s00421-015-3133-9.

  • Nakamura Y, Aizawa K, Imai T, et al. Hormonal responses to resistance exercise during different menstrual cycle states. Med Sci Sports Exerc. 2011;43:967–73.https://doi.org/10.1249/MSS.0b013e3182019774.

  • Oosthuyse T, Bosch AN. The effect of the menstrual cycle on exercise metabolism: implications for exercise performance in eumenorrhoeic women. Sports Med. 2010;40:207–27.https://doi.org/10.2165/11317090-000000000-00000.

  • Ovesen P, Vahl N, Fisker S, et al. Increased pulsatile, but not basal, growth hormone secretion rates and plasma insulin-like growth factor I levels during the periovulatory interval in normal women. J Clin Endocrinol Metab. 1998;83:1662–7.

    Google Scholar 

  • Reis E, Frick U, Schmidtbleicher D. Frequency variations of strength training sessions triggered by the phases of the menstrual cycle. Int J Sports Med. 1995;16:545–50.

    Google Scholar 

  • Riechman SE, Fabian TJ, Kroboth PD, et al. Steroid sulfatase gene variation and DHEA responsiveness to resistance exercise in MERET. Physiol Genomics. 2004;17:300–6.

    Google Scholar 

  • Roth SM, Gajdosik R, Ruby BC, Effects of circulating estradiol on exercise-induced creatine kinase activity. J Exerc Physiol 2001;4:10–7.

    Google Scholar 

  • Sakamaki-Sunaga M, Min S, Kamemoto K, et al. Effects of menstrual phase-dependent resistance training frequency on muscular hypertrophy and strength. J Strength Cond Res. 2015;30(6):1727–34.

    Google Scholar 

  • Staron RS, Karapondo DL, Kraemer WJ, et al. Skeletal muscle adaptations during early phase of heavy-resistance training in men and women. J Appl Physiol. 1994;76:1247–55.

    Google Scholar 

  • Sung E, Han A, Hinrichs T, et al. Effects of follicular versus luteal phase-based strength training in young women. SpringerPlus. 2014;3:668.https://doi.org/10.1186/2193-1801-3-668.

  • Thompson B, Almarjawi A, Sculley D, Janse de Jonge X. The effect of the menstrual cycle and oral contraceptives on acute responses and chronic adaptations to resistance training: a systematic review of the literature. Sports Med. 2020;50(1):171–85.https://doi.org/10.1007/s40279-019-01219-1.

  • Vingren JL, Kraemer WJ, Ratamess NA, et al. Testosterone physiology in resistance exercise and training: the up-stream regulatory elements. Sports Med. 2010;40:1037–53.https://doi.org/10.2165/11536910000000000-00000.

  • Waters DL, Qualls CR, Dorin R, et al. Increased pulsatility, process irregularity, and nocturnal trough concentrations of growth hormone in amenorrheic compared to eumenorrheic athletes. J Clin Endocrinol Metab. 2001;86:1013–9.

    Google Scholar 

  • Wikström-Frisén L, Boraxbekk CJ, Henriksson-Larsén K. Effects on power strength and lean body mass of menstrual/oral contraceptive cycle based resistance training. J Sports Med Phys Fitness. 2017;57(1–2).https://doi.org/10.23736/S0022-4707.16.05848-5.

  • Yahiro J, Glass AR, Fears WB, et al. Exaggerated gonadotropin response to luteinizing hormone-releasing hormone in amenorrheic runners. Am J Obstet Gynecol. 1987;156:586–91.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yuki Nakamura .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Nakamura, Y., Aizawa, K. (2023). Sex Hormones, Menstrual Cycle, and Resistance Exercise. In: Hackney, A.C. (eds) Sex Hormones, Exercise and Women. Springer, Cham. https://doi.org/10.1007/978-3-031-21881-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-21881-1_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-21880-4

  • Online ISBN: 978-3-031-21881-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics