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History of Vascularized Composite Allotransplantation

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Reconstructive Transplantation

Abstract

Restoration of devastating tissue losses is challenging for reconstructive surgeons. This problem has already been addressed in mythology. The quote of the ancient Greek physician Hippocrates: “War is the only proper school for surgeons” is still applicable in the modern history and applies to the vascularized composite allotransplantation (VCA) which has its roots in World War II, where severe multi-tissue injuries introduced novel approaches for skin grafting and reconstruction of composite tissue defects.

In late 1990s VCA emerged as a new field of reconstructive transplantation and became integrated into transplant immunology, pharmacology, reconstructive surgery, and regenerative medicine. In past decade VCA has marked many historical achievements of the first hand, face, larynx, abdominal wall, and other VCA transplantations; however, there are still challenges which need to be overcome in order to introduce VCA to the routine clinical practice which is the ultimate goal for the new field of VCA transplantation.

This chapter reviews the origin, the progress, and the true success story on the VCA transplantation.

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Authors and Affiliations

  1. Department of Orthopaedics, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA

    Maria Z. Siemionow

  2. Department of Surgery, Wake Forest University Health Sciences, Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, USA

    Hülya Kapucu & Fatih Zor

Authors
  1. Maria Z. Siemionow
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  2. Hülya Kapucu
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  3. Fatih Zor
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Corresponding author

Correspondence to Maria Z. Siemionow .

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Editors and Affiliations

  1. Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA

    Raffi Gurunian

  2. Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA

    Antonio Rampazzo

  3. Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA

    Frank Papay

  4. Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA

    Bahar Bassiri Gharb

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Siemionow, M.Z., Kapucu, H., Zor, F. (2023). History of Vascularized Composite Allotransplantation. In: Gurunian, R., Rampazzo, A., Papay, F., Bassiri Gharb, B. (eds) Reconstructive Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-031-21520-9_1

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  • DOI: https://doi.org/10.1007/978-3-031-21520-9_1

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