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Experimental Pancreas Transplantation

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Transplantation of the Pancreas

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Abstract

Animal research has played an important role in our understanding of diabetes mellitus and metabolism, transplant immunology, organ preservation, developmental biology, and surgical technique. Advances in diabetes care have changed pancreas transplantation. Improved blood glucose monitoring, continuous insulin pumps, and improvements in care for chronic kidney disease have modified the indications and timing of pancreas transplantation, yet pancreas transplantation remains the only clinical modality that reliably replaces diabetic insulin insufficiency in the long term. Built upon a solid foundation of basic and clinical research, the field of transplantation has advanced remarkably to the point where success is the norm and often taken for granted. Despite successful transplant outcomes and other medical advancements, experimental pancreas transplantation remains relevant today, able to address important questions in organ preservation and reperfusion injury, transplant immunology, autoimmunity, metabolism, and tissue regeneration. In the previous edition of this book, experimental models of pancreas transplantation were reviewed in two separate sections: small animal and large animal. Here, small and large animal models are combined as a single topic to show how they complement each other and how research in small animals (with a focus on immunology) and large animals (with a focus on surgical techniques and preservation) has advanced the field as a whole.

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Authors and Affiliations

  1. Surgery, Abdominal Organ Transplant Program, Wake Forest Baptist Health, Winston Salem, NC, USA

    Alan C. Farney

  2. Division of Transplantation Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA

    Mikel Prieto

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  1. Department of Surgery, State University of New York (SUNY), Downstate Health Sciences University, Brooklyn, NY, USA

    Rainer W. G. Gruessner

  2. Department of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY, USA

    Angelika C. Gruessner

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Farney, A.C., Prieto, M. (2023). Experimental Pancreas Transplantation. In: Gruessner, R.W.G., Gruessner, A.C. (eds) Transplantation of the Pancreas. Springer, Cham. https://doi.org/10.1007/978-3-031-20999-4_6

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