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Neurodevelopmental Pediatrics

Genetic and Environmental Influences

  • Textbook
  • © 2023

Overview

Editors:
  1. David D. Eisenstat

    1. Department of Paediatrics, University of Melbourne, Parkville, Australia

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  2. Dan Goldowitz

    1. Department of Medical Genetics, University of British Columbia, Vancouver, Canada

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  3. Tim F. Oberlander

    1. Department of Pediatrics and School of Population and Public Health, University of British Columbia, Vancouver, Canada

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  4. Jerome Y. Yager

    1. Department of Pediatrics, University of Alberta, Edmonton, Canada

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  • Explores the interrelationship of genetics, the environment, or both
  • Integrates clinical and research topics, including disease models, for each disorder
  • Provides an overview of the biology, genetics, and epigenetics of brain development

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Table of contents (50 chapters)

  1. Front Matter

    Pages i-xxi
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  2. Overview of CNS Development and Disorders

    1. Front Matter

      Pages 1-1
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    2. Overview of CNS Organization and Development

      • Richard E. Brown
      Pages 3-28

    3. Neural Induction and Regionalization

      • Jeffrey T. Wigle, David D. Eisenstat
      Pages 29-38

    4. Neural Stem Cells, Differentiation, and Migration

      • Jessica M. Livingston, Emily A. B. Gilbert, Donna Gao, Cindi M. Morshead
      Pages 39-54

    5. Neurotrophins and Cell Death

      • Arman Shekari, Crystal Mahadeo, Nisha Sanwalka, Margaret Fahnestock
      Pages 55-75

    6. Synaptogenesis

      • Margaret H. Hastings, James Gilbert, Yuda Huo, Heng-Ye Man
      Pages 77-92

    7. Axonal Guidance

      • Mikaela Nevin, Janine Gallego, David D. Eisenstat
      Pages 93-106

    8. Myelination

      • Janine Gallego, Mikaela Nevin, David D. Eisenstat
      Pages 107-121

    9. Epigenetics

      • Helena Biasibetti-Brendler, Michael Steffen Kobor
      Pages 123-145

    10. The Impact of an Adverse Intrauterine Environment on Neurodevelopment

      • Sindhu Ramachandra, Michelle Low, Nethra Madurai, Maide Ozen, Yuma Kitase, Shenandoah Robinson et al.
      Pages 147-163

    11. Stress as a Determinant of Neurodevelopmental Outcomes

      • Bona Kim, Stephen G. Matthews
      Pages 165-178

    12. Sex Differences in Neurodevelopment and Its Disorders

      • Richard E. Brown
      Pages 179-212

  3. Autism Spectrum Disorders

    1. Front Matter

      Pages 213-213
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    2. The History of Autism Spectrum Disorder

      • Alexandra Jackman, Lonnie Zwaigenbaum
      Pages 215-226

    3. Epidemiology

      • Mayada Elsabbagh
      Pages 227-241

    4. An Approach to the Diagnosis of Autism Spectrum

      • Cecilia Lee, Melanie Penner
      Pages 243-251

    5. Autism Spectrum Disorder: Cognition

      • Elizabeth Kelley, Alison Dodwell
      Pages 253-268

    6. The Neuroradiology of Autism: Framing Neuroimaging Investigations of the Autistic Brain Based on the US NIMH Research Domain Criteria

      • Hsiang-Yuan Lin, Meng-Chuan Lai
      Pages 269-282

    7. Neuropathology of Autism

      • Yarden Kezerle
      Pages 283-291
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Keywords

About this book

This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.  

Editors and Affiliations

  • Department of Paediatrics, University of Melbourne, Parkville, Australia

    David D. Eisenstat

  • Department of Medical Genetics, University of British Columbia, Vancouver, Canada

    Dan Goldowitz

  • Department of Pediatrics and School of Population and Public Health, University of British Columbia, Vancouver, Canada

    Tim F. Oberlander

  • Department of Pediatrics, University of Alberta, Edmonton, Canada

    Jerome Y. Yager

About the editors

David D. Eisenstat, MD, MA, FRCPC; Professor, Department of Paediatrics, University of Melbourne; Parkville, Victoria 


Dan Goldowitz, PhD; Scientific Director, NeuroDevNet National Centres of Excellence; Professor and Canada Research Chair; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute; Department of Medical Genetics; University of British Columbia; 950 West 28th Avenue; Vancouver, British Columbia V5Z 4H4


Tim Oberlander, MD, FRCPC; Professor, Department of Pediatrics; BC Children’s Hospital and Child and Family Research Institute; University of British Columbia; 4480 Oak Street; Vancouver, British Columbia V6H 3V4





Jerome Y. Yager, MD, FRCPC; Professor, Department of Pediatrics; Stollery Children’s Hospital; Faculty of Medicine and Dentistry; University ofAlberta

8440 112 Street, NW; Edmonton, Alberta T6G 2R7











Bibliographic Information

  • Book Title: Neurodevelopmental Pediatrics

  • Book Subtitle: Genetic and Environmental Influences

  • Editors: David D. Eisenstat, Dan Goldowitz, Tim F. Oberlander, Jerome Y. Yager

  • DOI: https://doi.org/10.1007/978-3-031-20792-1

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2023

  • Hardcover ISBN: 978-3-031-20791-4Published: 23 February 2023

  • Softcover ISBN: 978-3-031-20794-5Published: 24 February 2024

  • eBook ISBN: 978-3-031-20792-1Published: 22 February 2023

  • Edition Number: 1

  • Number of Pages: XXI, 832

  • Number of Illustrations: 31 b/w illustrations, 103 illustrations in colour

  • Topics: Pediatrics, Neurology, Human Genetics

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