Abstract
Hair cells are the sensory receptors of the vertebrate inner ear that detect sound vibrations (to initiate hearing) and head movements (to facilitate balance). In humans, injury or loss of these cells can cause permanent hearing impairment, disequilibrium, and/or improper visual reflexes. For this reason, the development of methods to promote the regeneration of lost hair cells is a topic of great translational interest. The demonstration that the ears of nonmammalian vertebrates can regenerate hair cells after injury has led to considerable research focused on understanding the biological basis of this regenerative process. Other work has attempted to induce repair in the mammalian inner ear via gene therapy or introduction of stem cells. Such research is still ongoing, and it is not clear which approaches will ultimately yield clinical strategies for restoring hearing and motion perception. This chapter provides a brief history of this discipline and summarizes the contents of this volume.
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References
Adler HJ, Raphael Y (1996) New hair cells arise from supporting cell conversion in the acoustically damaged chick inner ear. Neurosci Lett 205:17–20. https://doi.org/10.1016/0304-3940(96)12367-3
Altman J (1969) Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J Comp Neurol 137:433–457. https://doi.org/10.1002/cne.901370404. PMID: 5361244
Baird RA, Burton MD, Lysakowski A, Fashena DS, Naeger RA (2000) Hair cell recovery in mitotically blocked cultures of the bullfrog saccule. Proc Natl Acad Sci U S A. 97(22):11722–11729. https://doi.org/10.1073/pnas.97.22.11722
Brockes JP, Kumar A (2008) Comparative aspects of animal regeneration. Annu Rev Cell Dev Biol 24:525–549. https://doi.org/10.1146/annurev.cellbio.24.110707.175336. PMID: 18598212
Bucks SA, Cox BC, Vlosich BA, Manning JP, Nguyen TB, Stone JS (2017) Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice. 6:e18128. https://doi.org/10.7554/eLife.18128. PMID: 28263708; PMCID: PMC5338920
Burns JC, Corwin JT (2013) A historical to present-day account of efforts to answer the question: “what puts the brakes on mammalian hair cell regeneration?”. Hear Res. 297:52–67. https://doi.org/10.1016/j.heares.2013.01.005. Epub 2013 Jan 17.
Corwin JT (1977) Morphology of the macula neglecta in sharks of the genus Carcharhinus. J Morphol 152:341–362. https://doi.org/10.1002/jmor.1051520306. PMID: 875041
Corwin JT (1981) Postembryonic production and aging in inner ear hair cells in sharks. J Comp Neurol 201:541–553. https://doi.org/10.1002/cne.902010406. PMID: 7287934
Corwin JT (1983) Postembryonic growth of the macula neglecta auditory detector in the ray, Raja clavata: continual increases in hair cell number, neural convergence, and physiological sensitivity. J Comp Neurol 217:345–356. https://doi.org/10.1002/cne.902170309. PMID: 6886057
Corwin JT (1985) Perpetual production of hair cells and maturational changes in hair cell ultrastructure accompany postembryonic growth in an amphibian ear. Proc Natl Acad Sci U S A 82:3911–3915. https://doi.org/10.1073/pnas.82.11.3911. PMID: 3923484; PMCID: PMC397899
Corwin JT, Cotanche DA (1988) Regeneration of sensory hair cells after acoustic trauma. Science 240:1772–1774. https://doi.org/10.1126/science.3381100. PMID: 3381100
Cotanche DA (1987) Regeneration of hair cell stereociliary bundles in the chick cochlea following severe acoustic trauma. Hear Res 30:181–195. https://doi.org/10.1016/0378-5955(87)90135-3. PMID: 3680064
Cotanche DA, Saunders JC, Tilney LG (1988) Hair cell damage produced by acoustic trauma in the chick cochlea. Hear Res 25:267–286. https://doi.org/10.1016/0378-5955(87)90098-0. PMID: 3558135
Cruz RM, Lambert PR, Rubel EW (1987) Light microscopic evidence of hair cell regeneration after gentamicin toxicity in chick cochlea. Arch Otolaryngol Head Neck Surg 113:1058–1062. https://doi.org/10.1001/archotol.1987.01860100036017. PMID: 3620125
Cruz IA, Kappedal R, Mackenzie SM, Hailey DW, Hoffman TL, Schilling TF, Raible DW (2015) Robust regeneration of adult zebrafish lateral line hair cells reflects continued precursor pool maintenance. Dev Biol. 402(2):229–238. https://doi.org/10.1016/j.ydbio.2015.03.019. Epub 2015 Apr 11. PMID: 25869855; PMCID: PMC4450121
Farbman AI (1980) Renewal of taste bud cells in rat circumvallate papillae. Cell Tissue Kinet 13:349–357. https://doi.org/10.1111/j.1365-2184.1980.tb00474.x. PMID: 7428010
Fernald RD (1990) Teleost vision: Seeing while growing. J Exp Zool Suppl 5:167–180. https://doi.org/10.1002/jez.1402560521. PMID: 1982493
Fettiplace R (2020) Diverse mechanisms of sound frequency discrimination in the vertebrate cochlea. Trends Neurosci 43:88–102. https://doi.org/10.1016/j.tins.2019.12.003. Epub 2020 Jan 15. PMID: 31954526; PMCID: PMC7015066
Forge A, Li L, Corwin JT, Nevill G (1993) Ultrastructural evidence for hair cell regeneration in the mammalian inner ear. Science 259:1616–1619. https://doi.org/10.1126/science.8456284. PMID: 8456284
Graziadei GA, Graziadei PP (1979) Neurogenesis and neuron regeneration in the olfactory system of mammals. II. Degeneration and reconstitution of the olfactory sensory neurons after axotomy. J Neurocytol 8:197–213. https://doi.org/10.1007/BF01175561. PMID: 469573
Graziadei PP, Monti Graziadei GA (1985) Neurogenesis and plasticity of the olfactory sensory neurons. Ann N Y Acad Sci 457:127–142. https://doi.org/10.1111/j.1749-6632.1985.tb20802.x. PMID: 3913359
Johns PR (1982) Formation of photoreceptors in larval and adult goldfish. J Neurosci 2:178–198. https://doi.org/10.1523/JNEUROSCI.02-02-00178.1982. PMID: 7062105; PMCID: PMC6564304
Johns PR, Easter SS (1977) Growth of the adult goldfish eye. II. Increase in retinal cell number. J Comp Neurol 176:331–341. https://doi.org/10.1002/cne.901760303. PMID: 915041
Jørgensen JM, Mathiesen C (1988) The avian inner ear. Continuous production of hair cells in vestibular sensory organs, but not in the auditory papilla. Naturwissenschaften 75:319–320. https://doi.org/10.1007/BF00367330. PMID: 3205314
Kirkegaard M, Jørgensen JM (2000) Continuous hair cell turnover in the inner ear vestibular organs of a mammal, the Daubenton’s bat (Myotis daubentonii). Naturwissenschaften. 87(2):83–86. https://doi.org/10.1007/s001140050015. PMID: 10663140
Kujawa SG, Liberman MC (2006) Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth. J Neurosci 26(7):2115–2123. https://doi.org/10.1523/JNEUROSCI.4985-05.2006
Kujawa SG, Liberman MC (2009) Adding insult to injury: cochlear nerve degeneration after “temporary” noise-induced hearing loss. J Neurosci 29(45):14077–14085. https://doi.org/10.1523/JNEUROSCI.2845-09.2009
Li CW, Lewis ER (1979) Structure and development of vestibular hair cells in the larval bullfrog. Ann Otol Rhinol Laryngol 88:427–437. https://doi.org/10.1177/000348947908800323. PMID: 313736
Lippe W, Rubel EW (1983) Development of the place principle: tonotopic organization. Science 219:514–516. https://doi.org/10.1126/science.6823550. PMID: 6823550
Meyer RL (1978) Evidence from thymidine labeling for continuing growth of retina and tectum in juvenile goldfish. Exp Neurol 59:99–111. https://doi.org/10.1016/0014-4886(78)90204-2
Popper AN, Hoxter B (1984) Growth of a fish ear: 1. Quantitative analysis of hair cell and ganglion cell proliferation. Hear Res 15(2):133–142. https://doi.org/10.1016/0378-5955(84)90044-3
Raymond PA, Easter SS (1983) Postembryonic growth of the optic tectum in goldfish. I. Location of germinal cells and numbers of neurons produced. J Neurosci 3:1077–1091. https://doi.org/10.1523/JNEUROSCI.03-05-01077.1983. PMID: 6842282; PMCID: PMC6564515
Roberson DW, Rubel EW (1994) Cell division in the gerbil cochlea after acoustic trauma. Am J Otol 15(1):28–34.
Rubel EW (1978) Ontogeny of Structure and Function in the Vertebrate Auditory System. In: Jacobson M (ed) Development of Sensory Systems. Handbook of Sensory Physiology, vol 9. Springer, Berlin, Heidelberg
Rubel EW, Ryals BM (1983) Development of the place principle: acoustic trauma. Science 219:512–514. https://doi.org/10.1126/science.6823549
Ruben RJ (1967) Development of the inner ear of the mouse: a radioautographic study of terminal mitoses. Acta Otolaryngol: Suppl 220:1–44
Ryals BM, Rubel EW (1988) Hair cell regeneration after acoustic trauma in adult Coturnix quail. Science 240:1774–1776. https://doi.org/10.1126/science.3381101
Stone LS (1937) Further experimental studies of the development of lateral-line sense organs in the amphibians observed in living preparations. J Comp Neurol 68:83–115
Von Békésy G (1960) Experiments in hearing. McGraw Hill, New York
Warchol ME (2011) Sensory regeneration in the vertebrate inner ear: differences at the levels of cells and species. Hear Res 273(1–2):72–79. https://doi.org/10.1016/j.heares.2010.05.00
Warchol ME, Lambert PR, Goldstein BJ, Forge A, Corwin JT (1993) Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. Science 259:1619–1622. https://doi.org/10.1126/science.8456285
Weisleder P, Rubel EW (1993) Hair cell regeneration after streptomycin toxicity in the avian vestibular epithelium. J Comp Neurol 331:97–110. https://doi.org/10.1002/cne.903310106
Williams JA, Holder N (2000) Cell turnover in neuromasts of zebrafish larvae. Hear Res 143(1–2):171–181. https://doi.org/10.1016/s0378-5955(00)00039-3
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Warchol, M.E., Stone, J.S. (2023). Sensory Regeneration in the Inner Ear: History, Strategies, and Prospects. In: Warchol, M.E., Stone, J.S., Coffin, A.B., Popper, A.N., Fay, R.R. (eds) Hair Cell Regeneration. Springer Handbook of Auditory Research, vol 75. Springer, Cham. https://doi.org/10.1007/978-3-031-20661-0_1
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