Abstract
In recent years, deep learning techniques have been applied with great success in the healthcare industry, such as disease prediction and drug recommendation. However, existing works on drug recommendation either do not take the critical impact of doses on treatment outcomes into account, or neglect the patient’s personalized history and drug-drug interactions, resulting in suboptimal recommendation results. To fill these gaps, we propose a novel Temporal Prescription Generation (TPG) model in this paper. Specifically, we first utilize a message passing neural network to capture the interaction between drugs, combined with a decomposed long and short-term memory (LSTM-DE) to characterize patient’s general information. Then, we design a prescription generator based on recurrent neural network to generate drugs and estimate doses simultaneously. Experimental results on a real-world dataset clearly demonstrate that the proposed model is superior to the best existing models in terms of drug recommendation and dose estimation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Barragán-Montero, A.M.: Three-dimensional dose prediction for lung IMRT patients with deep neural networks: robust learning from heterogeneous beam configurations. Med. Phys. 46(8), 3679–3691 (2019)
Baytas, I.M., Xiao, C., Zhang, X., Wang, F., Jain, A.K., Zhou, J.: Patient subtyping via time-aware lstm networks. In: Proceedings of the 23rd ACM SIGKDD international conference on knowledge discovery and data mining, pp. 65–74 (2017)
Chen, L., Liu, Y., He, X., Gao, L., Zheng, Z.: Matching user with item set: collaborative bundle recommendation with deep attention network. In: IJCAI, pp. 2095–2101 (2019)
Choi, E., Bahadori, M.T., Schuetz, A., Stewart, W.F., Sun, J.: Doctor ai: predicting clinical events via recurrent neural networks. In: Machine Learning for Healthcare Conference, pp. 301–318. PMLR (2016)
Choi, E., Bahadori, M.T., Sun, J., Kulas, J., Schuetz, A., Stewart, W.: Retain: an interpretable predictive model for healthcare using reverse time attention mechanism. In: Advances in Neural Information Processing Systems, vol. 29 (2016)
Gilmer, J., Schoenholz, S.S., Riley, P.F., Vinyals, O., Dahl, G.E.: Neural message passing for quantum chemistry. In: International Conference on Machine Learning, pp. 1263–1272. PMLR (2017)
He, K., Zhang, X., Ren, S., Sun, J.: Delving deep into rectifiers: surpassing human-level performance on imagenet classification. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 1026–1034 (2015)
Jin, B., Yang, H., Sun, L., Liu, C., Qu, Y., Tong, J.: A treatment engine by predicting next-period prescriptions. In: Proceedings of the 24th ACM SIGKDD International Conference on Knowledge Discovery & Data Mining, pp. 1608–1616 (2018)
Le, H., Tran, T., Venkatesh, S.: Dual memory neural computer for asynchronous two-view sequential learning. In: Proceedings of the 24th ACM SIGKDD International Conference on Knowledge Discovery & Data Mining, pp. 1637–1645 (2018)
Lipton, Z.C., Kale, D.C., Elkan, C., Wetzel, R.: Learning to diagnose with LSTM recurrent neural networks. arXiv preprint. arXiv:1511.03677 (2015)
Liu, S., et al.: A hybrid method of recurrent neural network and graph neural network for next-period prescription prediction. Int. J. Mach. Learn. Cybern. 11(12), 2849–2856 (2020)
Liu, Y., et al.: Dose prediction using a three-dimensional convolutional neural network for nasopharyngeal carcinoma with tomotherapy. Front. Oncol. 11, 752007–752007 (2021)
Shang, J., Xiao, C., Ma, T., Li, H., Sun, J.: Gamenet: graph augmented memory networks for recommending medication combination. In: proceedings of the AAAI Conference on Artificial Intelligence, vol. 33, pp. 1126–1133 (2019)
Yang, P., Sun, X., Li, W., Ma, S., Wu, W., Wang, H.: SGM: sequence generation model for multi-label classification. arXiv preprint. arXiv:1806.04822 (2018)
Zhang, Y., Chen, R., Tang, J., Stewart, W.F., Sun, J.: Leap: learning to prescribe effective and safe treatment combinations for multimorbidity. In: proceedings of the 23rd ACM SIGKDD International Conference on Knowledge Discovery and data Mining, pp. 1315–1324 (2017)
Zheng, Z., et al.: Drug package recommendation via interaction-aware graph induction. In: Proceedings of the Web Conference 2021, pp. 1284–1295 (2021)
Zheng, Z., et al.: Interaction-aware drug package recommendation via policy gradient. In: ACM Transactions on Information Systems (TOIS) (2022)
Acknowledgement
This work was supported by the grants from National Natural Science Foundation of China (No. 62072423), and the USTC Research Funds of the Double First-Class Initiative (No. YD2150002009).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Wang, C., Zheng, Z., Xu, T., Yin, Z., Chen, E. (2022). Interaction-Aware Temporal Prescription Generation via Message Passing Neural Network. In: Fang, L., Povey, D., Zhai, G., Mei, T., Wang, R. (eds) Artificial Intelligence. CICAI 2022. Lecture Notes in Computer Science(), vol 13605. Springer, Cham. https://doi.org/10.1007/978-3-031-20500-2_18
Download citation
DOI: https://doi.org/10.1007/978-3-031-20500-2_18
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-20499-9
Online ISBN: 978-3-031-20500-2
eBook Packages: Computer ScienceComputer Science (R0)