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Infectious Pleural Effusion

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Practical Manual of Pleural Pathology
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Abstract

The clinical pictures with which infectious pleural effusions can occur are simple pleural effusion, complicated pleural effusion and pleural empyema. An infectious pleural effusion can be accompanied by a pulmonary infection (pneumonia or lung abscess) and therefore can be a parapneumonic pleural effusion, or it can be present as an entity in its own right and therefore a ‘primary empyema’.

Pleural empyema is characterised by a high mortality. The diagnosis of infectious pleural effusion is clinical-radiological, confirmed by thoracentesis. Chest ultrasound is indispensable. In the presence of a pleural effusion of suspected infectious origin, thoracentesis must always be performed immediately. Thoracentesis provides fundamental and indispensable information to know the characteristics of the pleural fluid, to establish whether it is a simple or complicated effusion and to perform all possible tests: physico-chemical, microbiological, cytological examination with differential cell count and pH measurement. The characteristics of the pleural fluid guide the therapeutic choices, which must be adopted quickly to prevent possible complications.

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References

  1. Dyrhovden R, Nygaard RM, Patel R, Ulvestad E, Kommedal Ø. The bacterial aetiology of pleural empyema. A descriptive and comparative metagenomic study. Clin Microbiol Infect. 2019;25(8):981–6. https://doi.org/10.1016/j.cmi.2018.11.030. Epub 2018 Dec 21. PMID: 30580031.

    Article  CAS  PubMed  Google Scholar 

  2. Brims F, Popowicz N, Rosenstengel A, Hart J, Yogendran A, Read CA, Lee F, Shrestha R, Franke A, Lewis JR, Kay I, Waterer G, Lee YCG. Bacteriology and clinical outcomes of patients with culture-positive pleural infection in Western Australia: a 6-year analysis. Respirology. 2019;24(2):171–8. https://doi.org/10.1111/resp.13395. Epub 2018 Sep 6. PMID: 30187976.

    Article  PubMed  Google Scholar 

  3. Marston BJ, Plouffe JF, File TM Jr, Hackman BA, Salstrom SJ, Lipman HB, Kolczak MS, Breiman RF. Incidence of community-acquired pneumonia requiring hospitalization. Results of a population-based active surveillance Study in Ohio. The Community-Based Pneumonia Incidence Study Group. Arch Intern Med. 1997;157(15):1709–18. PMID: 9250232.

    Article  CAS  PubMed  Google Scholar 

  4. Falguera M, Carratalà J, Bielsa S, García-Vidal C, Ruiz-González A, Chica I, Gudiol F, Porcel JM. Predictive factors, microbiology and outcome of patients with parapneumonic effusion. Eur Respir J. 2011;38(5):1173–9. https://doi.org/10.1183/09031936.00000211. Epub 2011 May 12. PMID: 21565916.

    Article  CAS  PubMed  Google Scholar 

  5. Burgos J, Falcó V, Pahissa A. The increasing incidence of empyema. Curr Opin Pulm Med. 2013;19(4):350–6. https://doi.org/10.1097/MCP.0b013e3283606ab5. PMID: 23508113.

    Article  PubMed  Google Scholar 

  6. Finley C, Clifton J, Fitzgerald JM, Yee J. Empyema: an increasing concern in Canada. Can Respir J. 2008;15(2):85–9. https://doi.org/10.1155/2008/975312. PMID: 18354748; PMCID: PMC2677840.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Nayak R, Lougheed MD, Brogly S, Lajkosz K, Petsikas D. Thoracic empyema - 20 year trends in management and outcomes in Ontario, Canada. Am J Respir Crit Care Med. 2018;197:A4215.

    Google Scholar 

  8. Lehtomäki A, Nevalainen R, Ukkonen M, Nieminen J, Laurikka J, Khan J. Trends in the incidence, etiology, treatment, and outcomes of pleural infections in adults over a decade in a Finnish University Hospital. Scand J Surg. 2020;109(2):127–32. https://doi.org/10.1177/1457496919832146. Epub 2019 Feb 21. PMID: 30791827.

    Article  PubMed  Google Scholar 

  9. Maskell NA, Batt S, Hedley EL, Davies CW, Gillespie SH, Davies RJ. The bacteriology of pleural infection by genetic and standard methods and its mortality significance. Am J Respir Crit Care Med. 2006;174(7):817–23. https://doi.org/10.1164/rccm.200601-074OC. Epub 2006 Jul 13. PMID: 16840746.

    Article  PubMed  Google Scholar 

  10. Farjah F, Symons RG, Krishnadasan B, Wood DE, Flum DR. Management of pleural space infections: a population-based analysis. J Thorac Cardiovasc Surg. 2007;133(2):346–51. https://doi.org/10.1016/j.jtcvs.2006.09.038. Epub 2006 Dec 29. PMID: 17258562.

    Article  PubMed  Google Scholar 

  11. Colice GL, Curtis A, Deslauriers J, Heffner J, Light R, Littenberg B, Sahn S, Weinstein RA, Yusen RD. Medical and surgical treatment of parapneumonic effusions : an evidence-based guideline. Chest. 2000;118(4):1158–71. https://doi.org/10.1378/chest.118.4.1158. Erratum in: Chest 2001;119(1):319. PMID: 11035692.

    Article  CAS  PubMed  Google Scholar 

  12. Shen KR, Bribriesco A, Crabtree T, Denlinger C, Eby J, Eiken P, Jones DR, Keshavjee S, Maldonado F, Paul S, Kozower B. The American Association for Thoracic Surgery consensus guidelines for the management of empyema. J Thorac Cardiovasc Surg. 2017;153(6):e129–46. https://doi.org/10.1016/j.jtcvs.2017.01.030. Epub 2017 Feb 4. PMID: 28274565.

    Article  PubMed  Google Scholar 

  13. Lisboa T, Waterer GW, Lee YC. Pleural infection: changing bacteriology and its implications. Respirology. 2011;16(4):598–603. https://doi.org/10.1111/j.1440-1843.2011.01964.x. PMID: 21382129.

    Article  PubMed  Google Scholar 

  14. Corcoran JP, Wrightson JM, Belcher E, DeCamp MM, Feller-Kopman D, Rahman NM. Pleural infection: past, present, and future directions. Lancet Respir Med. 2015;3(7):563–77. https://doi.org/10.1016/S2213-2600(15)00185-X. PMID: 26170076.

    Article  PubMed  Google Scholar 

  15. Bedawi EO, Hassan M, McCracken D, Rahman NM. Pleural infection: a closer look at the etiopathogenesis, microbiology and role of antibiotics. Expert Rev Respir Med. 2019;13(4):337–47. https://doi.org/10.1080/17476348.2019.1578212. Epub 2019 Feb 20. PMID: 30707629.

    Article  CAS  PubMed  Google Scholar 

  16. Tu CY, Hsu WH, Hsia TC, Chen HJ, Chiu KL, Hang LW, Shih CM. The changing pathogens of complicated parapneumonic effusions or empyemas in a medical intensive care unit. Intensive Care Med. 2006;32(4):570–6. https://doi.org/10.1007/s00134-005-0064-7. Epub 2006. PMID: 16479377.

    Article  PubMed  Google Scholar 

  17. Insa R, Marín M, Martín A, Martín-Rabadán P, Alcalá L, Cercenado E, Calatayud L, Liñares J, Bouza E. Systematic use of universal 16S rRNA gene polymerase chain reaction (PCR) and sequencing for processing pleural effusions improves conventional culture techniques. Medicine (Baltimore). 2012;91(2):103–10. https://doi.org/10.1097/MD.0b013e31824dfdb0. PMID: 22391472.

    Article  CAS  PubMed  Google Scholar 

  18. Davies HE, Davies RJ, Davies CW, BTS Pleural Disease Guideline Group. Management of pleural infection in adults: British Thoracic Society Pleural Disease Guideline 2010. Thorax. 2010;65(Suppl 2):ii41–53. https://doi.org/10.1136/thx.2010.137000. PMID: 20696693.

    Article  PubMed  Google Scholar 

  19. Menzies SM, Rahman NM, Wrightson JM, Davies HE, Shorten R, Gillespie SH, Davies CW, Maskell NA, Jeffrey AA, Lee YC, Davies RJ. Blood culture bottle culture of pleural fluid in pleural infection. Thorax. 2011;66(8):658–62. https://doi.org/10.1136/thx.2010.157842. Epub 2011 Apr 1. PMID: 21459855.

    Article  PubMed  Google Scholar 

  20. Pedro-Botet ML, Sabria-Leal M, Haro M, Rubio C, Gimenez G, Sopena N, Tor J. Nosocomial and community-acquired Legionella pneumonia: clinical comparative analysis. Eur Respir J. 1995;8(11):1929–33. https://doi.org/10.1183/09031936.95.08111929. PMID: 8620964.

    Article  CAS  PubMed  Google Scholar 

  21. Tan MJ, Tan JS, Hamor RH, File TM Jr, Breiman RF. The radiologic manifestations of Legionnaire’s disease. The Ohio Community-Based Pneumonia Incidence Study Group. Chest. 2000;117(2):398–403. https://doi.org/10.1378/chest.117.2.398. PMID: 10669681.

    Article  CAS  PubMed  Google Scholar 

  22. Porta G, Rodríguez-Carballeira M, Gómez L, Salavert M, Freixas N, Xercavins M, Garau J. Thoracic infection caused by Streptococcus milleri. Eur Respir J. 1998;12(2):357–62. https://doi.org/10.1183/09031936.98.12020357. PMID: 9727785.

    Article  CAS  PubMed  Google Scholar 

  23. Ahmed RA, Marrie TJ, Huang JQ. Thoracic empyema in patients with community-acquired pneumonia. Am J Med. 2006;119(10):877–83. https://doi.org/10.1016/j.amjmed.2006.03.042. PMID: 17000220.

    Article  PubMed  Google Scholar 

  24. Hassan M, Cargill T, Harriss E, Asciak R, Mercer RM, Bedawi EO, McCracken DJ, Psallidas I, Corcoran JP, Rahman NM. The microbiology of pleural infection in adults: a systematic review. Eur Respir J. 2019;54(3):1900542. https://doi.org/10.1183/13993003.00542-2019. PMID: 31248959.

    Article  CAS  PubMed  Google Scholar 

  25. Godfrey MS, Bramley KT, Detterbeck F. Medical and surgical management of empyema. Semin Respir Crit Care Med. 2019;40(3):361–74. https://doi.org/10.1055/s-0039-1694699. Epub 2019 Sep 16. PMID: 31525811.

    Article  PubMed  Google Scholar 

  26. Boyanova L, Djambazov V, Gergova G, Iotov D, Petrov D, Osmanliev D, Minchev Z, Mitov I. Anaerobic microbiology in 198 cases of pleural empyema: a Bulgarian study. Anaerobe. 2004;10(5):261–7. https://doi.org/10.1016/j.anaerobe.2004.06.001. PMID: 16701526.

    Article  PubMed  Google Scholar 

  27. Scarascia A. Infezioni del cavo pleurico. Utilità delle metodiche della Pneumologia Interventistica. Tesi di Specializzazione in Pneumologia. Anno Accademico 2012-13. Università di Parma.

    Google Scholar 

  28. Heffner JE, Klein JS, Hampson C. Diagnostic utility and clinical application of imaging for pleural space infections. Chest. 2010;137(2):467–79. https://doi.org/10.1378/chest.08-3002. PMID: 20133295.

    Article  PubMed  Google Scholar 

  29. Sahn SA. Pleural disease. ACCP Pulmonary Medicine Board Review. 25th ed. Glenview, IL: ACCP; 2009. p. 513–46.

    Book  Google Scholar 

  30. Rahman NM, Mishra EK, Davies HE, Davies RJ, Lee YC. Clinically important factors influencing the diagnostic measurement of pleural fluid pH and glucose. Am J Respir Crit Care Med. 2008;178(5):483–90. https://doi.org/10.1164/rccm.200801-062OC. Epub 2008 Jun 12. PMID: 18556632; PMCID: PMC2643213.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Maskell NA, Gleeson FV, Darby M, Davies RJ. Diagnostically significant variations in pleural fluid pH in loculated parapneumonic effusions. Chest. 2004;126(6):2022–4. https://doi.org/10.1378/chest.126.6.2022. PMID: 15596709.

    Article  PubMed  Google Scholar 

  32. Fitzgerald DB, Leong SL, Budgeon CA, Murray K, Rosenstengal A, Smith NA, Bielsa S, Clive AO, Maskell NA, Porcel JM, Lee YCG. Relationship of pleural fluid pH and glucose: a multi-centre study of 2,971 cases. J Thorac Dis. 2019;11(1):123–30. https://doi.org/10.21037/jtd.2018.12.101. PMID: 30863580; PMCID: PMC6384369.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Valdés L, San José ME, Pose A, Gude F, González-Barcala FJ, Alvarez-Dobaño JM, Sahn SA. Diagnosing tuberculous pleural effusion using clinical data and pleural fluid analysis A study of patients less than 40 years-old in an area with a high incidence of tuberculosis. Respir Med. 2010;104(8):1211–7. https://doi.org/10.1016/j.rmed.2010.02.025. Epub 2010 Mar 26. PMID: 20347287.

    Article  PubMed  Google Scholar 

  34. Heffner JE, McDonald J, Barbieri C, Klein J. Management of parapneumonic effusions. An analysis of physician practice patterns. Arch Surg. 1995;130(4):433–8. https://doi.org/10.1001/archsurg.1995.01430040095021. PMID: 7710346.

    Article  CAS  PubMed  Google Scholar 

  35. Ashbaugh DG. Empyema thoracis. Factors influencing morbidity and mortality. Chest. 1991;99(5):1162–5. https://doi.org/10.1378/chest.99.5.1162. PMID: 2019172.

    Article  CAS  PubMed  Google Scholar 

  36. Sasse S, Nguyen TK, Mulligan M, Wang NS, Mahutte CK, Light RW. The effects of early chest tube placement on empyema resolution. Chest. 1997;111(6):1679–83. https://doi.org/10.1378/chest.111.6.1679. PMID: 9187193.

    Article  CAS  PubMed  Google Scholar 

  37. Davies CW, Kearney SE, Gleeson FV, Davies RJ. Predictors of outcome and long-term survival in patients with pleural infection. Am J Respir Crit Care Med. 1999;160(5 Pt 1):1682–7. https://doi.org/10.1164/ajrccm.160.5.9903002. PMID: 10556140.

    Article  CAS  PubMed  Google Scholar 

  38. Teixeira LR, Sasse SA, Villarino MA, Nguyen T, Mulligan ME, Light RW. Antibiotic levels in empyemic pleural fluid. Chest. 2000;117(6):1734–9. https://doi.org/10.1378/chest.117.6.1734. PMID: 10858410.

    Article  CAS  PubMed  Google Scholar 

  39. Birkenkamp K, O’Horo JC, Kashyap R, Kloesel B, Lahr BD, Daniels CE, Nichols FC III, Baddour LM. Empyema management: a cohort study evaluating antimicrobial therapy. J Infect. 2016;72(5):537–43. https://doi.org/10.1016/j.jinf.2016.02.009. Epub 2016 Mar 15. PMID: 26987740.

    Article  PubMed  Google Scholar 

  40. Chatzika K, Manika K, Kontou P, Pitsiou G, Papakosta D, Zarogoulidis K, Kioumis I. Moxifloxacin pharmacokinetics and pleural fluid penetration in patients with pleural effusion. Antimicrob Agents Chemother. 2014;58(3):1315–9. https://doi.org/10.1128/AAC.02291-13. Epub 2013 Dec 9. PMID: 24323477; PMCID: PMC3957872.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Dan M, Torossian K, Weissberg D, Kitzes R. The penetration of ciprofloxacin into bronchial mucosa, lung parenchyma, and pleural tissue after intravenous administration. Eur J Clin Pharmacol. 1993;44(1):101–2. https://doi.org/10.1007/BF00315290. PMID: 8436147.

    Article  CAS  PubMed  Google Scholar 

  42. Migliori GB, Langendam MW, D’Ambrosio L, Centis R, Blasi F, Huitric E, Manissero D, van der Werf MJ. Protecting the tuberculosis drug pipeline: stating the case for the rational use of fluoroquinolones. Eur Respir J. 2012;40(4):814–22. https://doi.org/10.1183/09031936.00036812. Epub 2012 May 31. PMID: 22653774; PMCID: PMC3461345.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Migliori GB, Zellweger JP, Abubakar I, Ibraim E, Caminero JA, De Vries G, D’Ambrosio L, Centis R, Sotgiu G, Menegale O, Kliiman K, Aksamit T, Cirillo DM, Danilovits M, Dara M, Dheda K, Dinh-Xuan AT, Kluge H, Lange C, Leimane V, Loddenkemper R, Nicod LP, Raviglione MC, Spanevello A, Thomsen VØ, Villar M, Wanlin M, Wedzicha JA, Zumla A, Blasi F, Huitric E, Sandgren A, Manissero D. European union standards for tuberculosis care. Eur Respir J. 2012;39(4):807–19. https://doi.org/10.1183/09031936.00203811. PMID: 22467723; PMCID: PMC3393116.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Chen TC, Lu PL, Lin CY, Lin WR, Chen YH. Fluoroquinolones are associated with delayed treatment and resistance in tuberculosis: a systematic review and meta-analysis. Int J Infect Dis. 2011;15(3):e211–6. https://doi.org/10.1016/j.ijid.2010.11.008. Epub 2010 Dec 30. PMID: 21195001.

    Article  CAS  PubMed  Google Scholar 

  45. Casalini AG, Cusmano F, Sverzellati N, Mori PA, Majori M. An undiagnosed pleural effusion with surprising consequences. Respir Med Case Rep. 2017;22:53–6. https://doi.org/10.1016/j.rmcr.2017.05.007. PMID: 28702335; PMCID: PMC5487223.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Tagarro A, Otheo E, Baquero-Artigao F, Navarro ML, Velasco R, Ruiz M, Penín M, Moreno D, Rojo P, Madero R, CORTEEC Study Group. Dexamethasone for parapneumonic pleural effusion: a randomized, double-blind, clinical trial. J Pediatr. 2017;185:117–123.e6. https://doi.org/10.1016/j.jpeds.2017.02.043. Epub 2017 Mar 28. PMID: 28363363.

    Article  CAS  PubMed  Google Scholar 

  47. Fitzgerald DB, Waterer GW, Read CA, Fysh ET, Shrestha R, Stanley C, Muruganandan S, Lan NSH, Popowicz ND, Peddle-McIntyre CJ, Rahman NM, Gan SK, Murray K, Lee YCG. Steroid therapy and outcome of parapneumonic pleural effusions (STOPPE): Study protocol for a multicenter, double-blinded, placebo-controlled randomized clinical trial. Medicine (Baltimore). 2019;98(43):e17397. https://doi.org/10.1097/MD.0000000000017397. PMID: 31651842; PMCID: PMC6824804.

    Article  CAS  PubMed  Google Scholar 

  48. Maskell NA, Davies CW, Nunn AJ, Hedley EL, Gleeson FV, Miller R, Gabe R, Rees GL, Peto TE, Woodhead MA, Lane DJ, Darbyshire JH, Davies RJ, First Multicenter Intrapleural Sepsis Trial (MIST1) Group. U.K. Controlled trial of intrapleural streptokinase for pleural infection. N Engl J Med. 2005;352(9):865–74. https://doi.org/10.1056/NEJMoa042473. Erratum in: N Engl J Med. 2005;352(20):2146. PMID: 15745977.

    Article  CAS  PubMed  Google Scholar 

  49. Cameron R, Davies HR. Intra-pleural fibrinolytic therapy versus conservative management in the treatment of adult parapneumonic effusions and empyema. Cochrane Database Syst Rev. 2008;(2):CD002312. https://doi.org/10.1002/14651858.CD002312.pub3. Update in: Cochrane Database Syst Rev. 2019;2019(10): PMID: 18425881.

  50. Rahman NM, Maskell NA, West A, Teoh R, Arnold A, Mackinlay C, Peckham D, Davies CW, Ali N, Kinnear W, Bentley A, Kahan BC, Wrightson JM, Davies HE, Hooper CE, Lee YC, Hedley EL, Crosthwaite N, Choo L, Helm EJ, Gleeson FV, Nunn AJ, Davies RJ. Intrapleural use of tissue plasminogen activator and DNase in pleural infection. N Engl J Med. 2011;365(6):518–26. https://doi.org/10.1056/NEJMoa1012740. PMID: 21830966.

    Article  CAS  PubMed  Google Scholar 

  51. Nie W, Liu Y, Ye J, Shi L, Shao F, Ying K, Zhang R. Efficacy of intrapleural instillation of fibrinolytics for treating pleural empyema and parapneumonic effusion: a meta-analysis of randomized control trials. Clin Respir J. 2014;8(3):281–91. https://doi.org/10.1111/crj.12068. Epub 2014 Jan 16. PMID: 24428897.

    Article  CAS  PubMed  Google Scholar 

  52. Altmann ES, Crossingham I, Wilson S, Davies HR. Intra-pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult parapneumonic effusions and empyema. Cochrane Database Syst Rev. 2019;2019(10):CD002312. https://doi.org/10.1002/14651858.CD002312.pub4. PMID: 31684683; PMCID: PMC6819355.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Porcel JM. Dual intracavitary therapy for pleural infections: leaving reluctance behind. Eur Respir J. 2019;54(2):1901001. https://doi.org/10.1183/13993003.01001-2019. PMID: 31371440.

    Article  CAS  PubMed  Google Scholar 

  54. Luengo-Fernandez R, Penz E, Dobson M, Psallidas I, Nunn AJ, Maskell NA, Rahman NM. Cost-effectiveness of intrapleural use of tissue plasminogen activator and DNase in pleural infection: evidence from the MIST2 randomised controlled trial. Eur Respir J. 2019;54(2):1801550. https://doi.org/10.1183/13993003.01550-2018. PMID: 31097519.

    Article  PubMed  Google Scholar 

  55. Hooper CE, Edey AJ, Wallis A, Clive AO, Morley A, White P, Medford AR, Harvey JE, Darby M, Zahan-Evans N, Maskell NA. Pleural irrigation trial (PIT): a randomised controlled trial of pleural irrigation with normal saline versus standard care in patients with pleural infection. Eur Respir J. 2015;46(2):456–63. https://doi.org/10.1183/09031936.00147214. Epub 2015 May 28. PMID: 26022948.

    Article  PubMed  Google Scholar 

  56. Bedawi EO. A randomised controlled trial of the feasibility of early administration of clot-busting medication through a chest tube versus early surgery in pleural infection. ISRCTN registry; 2019. Report No.: ISRC TN18192121. http://www.isrctn.com/ISRCTN18192121. Accessed 3 Jul 2020.

  57. Reynard C, Frey JG, Tschopp JM. Thoracoscopie en anesthésie locale dans le traitement des empyèmes: une technique efficace et peu invasive. Med Hyg. 2004;62:2138–43.

    Google Scholar 

  58. Tassi GF, Marchetti GP. Il versamento parapneumonico e l’empiema. In: Casalini AG, editor. Pneumologia Interventistica. Milan: Springer; 2007.

    Google Scholar 

  59. Tassi GF, Marchetti GP, Aliprandi PL. Advanced medical thoracoscopy. Monaldi Arch Chest Dis. 2011;75:99–101.

    CAS  PubMed  Google Scholar 

  60. Wait MA, Sharma S, Hohn J, Dal Nogare A. A randomized trial of empyema therapy. Chest. 1997;111(6):1548–51. https://doi.org/10.1378/chest.111.6.1548. PMID: 9187172.

    Article  CAS  PubMed  Google Scholar 

  61. Brutsche MH, Tassi GF, Györik S, Gökcimen M, Renard C, Marchetti GP, Tschopp JM. Treatment of sonographically stratified multiloculated thoracic empyema by medical thoracoscopy. Chest. 2005;128(5):3303–9. https://doi.org/10.1378/chest.128.5.3303. PMID: 16304276.

    Article  PubMed  Google Scholar 

  62. Ravaglia C, Gurioli C, Tomassetti S, Casoni GL, Romagnoli M, Gurioli C, Agnoletti V, Poletti V. Is medical thoracoscopy efficient in the management of multiloculated and organized thoracic empyema? Respiration. 2012;84(3):219–24. https://doi.org/10.1159/000339414. Epub 2012 Jul 24. PMID: 22832393.

    Article  PubMed  Google Scholar 

  63. Casalini AG. Il versamento pleurico infettivo. Rassegna di Patologia dell’Apparato Respiratorio. 2017;32:39–47. https://www.aiporassegna.it/article/view/212.

    Google Scholar 

  64. Sumalani KK, Rizvi NA, Asghar A. Role of medical thoracoscopy in the management of multiloculated empyema. BMC Pulm Med. 2018;18(1):179. https://doi.org/10.1186/s12890-018-0745-y. PMID: 30486876; PMCID: PMC6264615.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Redden MD, Chin TY, van Driel ML. Surgical versus non-surgical management for pleural empyema. Cochrane Database Syst Rev. 2017;3(3):CD010651. https://doi.org/10.1002/14651858.CD010651.pub2. PMID: 28304084; PMCID: PMC6464687.

    Article  PubMed  Google Scholar 

  66. Scarci M, Abah U, Solli P, Page A, Waller D, van Schil P, Melfi F, Schmid RA, Athanassiadi K, Sousa Uva M, Cardillo G. EACTS expert consensus statement for surgical management of pleural empyema. Eur J Cardiothorac Surg. 2015;48(5):642–53. https://doi.org/10.1093/ejcts/ezv272. Epub 2015 Aug 7. PMID: 26254467.

    Article  PubMed  Google Scholar 

  67. Solèr M, Wyser C, Bolliger CT, Perruchoud AP. Treatment of early parapneumonic empyema by “medical” thoracoscopy. Schweiz Med Wochenschr. 1997;127(42):1748–53. PMID: 9383821.

    Google Scholar 

  68. Tscheikuna J, Silairatana S, Sangkeaw S, Nana A. Outcome of medical thoracoscopy. J Med Assoc Thai. 2009;92(Suppl 2):S19-23. PMID: 19562981.

    Google Scholar 

  69. Abo-El-maged AHA, Elsamadony MF, El-Shamly MM, Hablas WR. Safety and efficacy of medical thoracoscopy in the management of loculated thoracic empyema. Egyptian J Chest Dis.Tuberc. 2017;66(3):445–51. ISSN 0422-7638. https://doi.org/10.1016/j.ejcdt.2016.12.013.

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Casalini, A.G. (2023). Infectious Pleural Effusion. In: Casalini, A.G. (eds) Practical Manual of Pleural Pathology. Springer, Cham. https://doi.org/10.1007/978-3-031-20312-1_10

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