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Pathophysiology of Gastric Neuromuscular Disorders

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The AFS Textbook of Foregut Disease

Abstract

Patients with gastric neuromuscular disorders can present with a multitude of symptoms including nausea, vomiting, bloating, early satiety/postprandial fullness, and/or abdominal pain. These symptoms are often disruptive to daily life and can result in diminished quality of life. Care of this patient population is frequently challenging, partially influenced by a complex underlying pathophysiology. In this chapter, we review the epidemiology, symptom profile, and the pathophysiology of patients with gastric neuromuscular disorders. Additionally, we discuss how knowledge of the pathophysiology can guide future treatment decisions of this patient population.

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References

  1. Stanghellini V, Chan FK, Hasler WL, et al. Gastroduodenal disorders. Gastroenterology. 2016;150:1380–92.

    Article  PubMed  Google Scholar 

  2. Pasricha PJ, Grover M, Yates KP, et al. Functional dyspepsia and gastroparesis in tertiary care are interchangeable syndromes with common clinical and pathologic features. Gastroenterology. 2021;160:2006–17.

    Article  CAS  PubMed  Google Scholar 

  3. Jung HK, Choung RS, Locke GR III, et al. The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006. Gastroenterology. 2009;136:1225–33.

    Article  PubMed  Google Scholar 

  4. Ye Y, Jiang B, Manne S, et al. Epidemiology and outcomes of gastroparesis, as documented in general practice records, in the United Kingdom. Gut. 2021;70:644–53.

    Article  PubMed  Google Scholar 

  5. Oshima T, Siah KTH, Kim YS, et al. Knowledge, attitude, and practice survey of gastroparesis in Asia by Asian Neurogastroenterology and Motility Association. J Neurogastroenterol Motil. 2021;27:46–54.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Soykan I, Sivri B, Sarosiek I, et al. Demography, clinical characteristics, psychological and abuse profiles, treatment, and long-term follow-up of patients with gastroparesis. Dig Dis Sci. 1998;43:2398–404.

    Article  CAS  PubMed  Google Scholar 

  7. Parkman HP, Wilson LA, Hasler WL, et al. Abdominal pain in patients with gastroparesis: associations with gastroparesis symptoms, etiology of gastroparesis, gastric emptying, somatization, and quality of life. Dig Dis Sci. 2019;64:2242–55.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Pasricha PJ, Yates KP, Nguyen L, et al. Outcomes and factors associated with reduced symptoms in patients with gastroparesis. Gastroenterology. 2015;149:1762–1774.e4.

    Article  PubMed  Google Scholar 

  9. El-Serag HB, Talley NJ. The prevalence and clinical course of functional dyspepsia. Aliment Pharmacol Ther. 2004;19:643–54.

    Article  CAS  PubMed  Google Scholar 

  10. Agréus L, Svärdsudd K, Nyrén O, et al. Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time. Gastroenterology. 1995;109:671–80.

    Article  PubMed  Google Scholar 

  11. Agréus L, Svärdsudd K, Talley NJ, et al. Natural history of gastroesophageal reflux disease and functional abdominal disorders: a population-based study. Am J Gastroenterol. 2001;96:2905–14.

    Article  PubMed  Google Scholar 

  12. Ford AC, Forman D, Bailey AG, et al. Initial poor quality of life and new onset of dyspepsia: results from a longitudinal 10-year follow-up study. Gut. 2007;56:321–7.

    Article  PubMed  Google Scholar 

  13. Halder SL, Locke GR III, Schleck CD, et al. Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study. Gastroenterology. 2007;133:799–807.

    Article  PubMed  Google Scholar 

  14. Olafsdottir LB, Gudjonsson H, Jonsdottir HH, et al. Natural history of functional dyspepsia: a 10-year population-based study. Digestion. 2010;81:53–61.

    Article  PubMed  Google Scholar 

  15. Kindt S, Van Oudenhove L, Mispelon L, et al. Longitudinal and cross-sectional factors associated with long-term clinical course in functional dyspepsia: a 5-year follow-up study. Am J Gastroenterol. 2011;106:340–8.

    Article  PubMed  Google Scholar 

  16. Hirsch W, Nee J, Ballou S, et al. Emergency department burden of gastroparesis in the United States, 2006 to 2013. J Clin Gastroenterol. 2019;53:109–13.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Wang YR, Fisher RS, Parkman HP. Gastroparesis-related hospitalizations in the United States: trends, characteristics, and outcomes, 1995–2004. Am J Gastroenterol. 2008;103:313–22.

    Article  PubMed  Google Scholar 

  18. Qayed E, Muftah M. Frequency of hospital readmission and care fragmentation in gastroparesis: a nationwide analysis. World J Gastrointest Endosc. 2018;10:200–9.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Hasler WL, Wilson LA, Nguyen LA, et al. Opioid use and potency are associated with clinical features, quality of life, and use of resources in patients with gastroparesis. Clin Gastroenterol Hepatol. 2019;17:1285–1294.e1.

    Article  CAS  PubMed  Google Scholar 

  20. Talley NJ, Ford AC. Functional dyspepsia. N Engl J Med. 2015;373:1853–63.

    Article  CAS  PubMed  Google Scholar 

  21. Spiller R. Postinfectious functional dyspepsia and postinfectious irritable bowel syndrome: different symptoms but similar risk factors. Gastroenterology. 2010;138:1660–3.

    Article  PubMed  Google Scholar 

  22. Zhong L, Shanahan ER, Raj A, et al. Dyspepsia and the microbiome: time to focus on the small intestine. Gut. 2017;66:1168–9.

    Article  CAS  PubMed  Google Scholar 

  23. Koloski NA, Jones M, Talley NJ. Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study. Aliment Pharmacol Ther. 2016;44:592–600.

    Article  CAS  PubMed  Google Scholar 

  24. Talley NJ, Walker MM, Aro P, et al. Non-ulcer dyspepsia and duodenal eosinophilia: an adult endoscopic population-based case-control study. Clin Gastroenterol Hepatol. 2007;5:1175–83.

    Article  PubMed  Google Scholar 

  25. Futagami S, Shindo T, Kawagoe T, et al. Migration of eosinophils and CCR2-/CD68-double positive cells into the duodenal mucosa of patients with postinfectious functional dyspepsia. Am J Gastroenterol. 2010;105:1835–42.

    Article  PubMed  Google Scholar 

  26. Oshima T, Toyoshima F, Nakajima S, et al. Genetic factors for functional dyspepsia. J Gastroenterol Hepatol. 2011;26(Suppl 3):83–7.

    Article  CAS  PubMed  Google Scholar 

  27. Wood JD, Alpers DH, Andrews PL. Fundamentals of neurogastroenterology. Gut. 1999;45 Suppl 2:II6–II16.

    CAS  PubMed  Google Scholar 

  28. Camilleri M, Malagelada JR, Brown ML, et al. Relation between antral motility and gastric emptying of solids and liquids in humans. Am J Phys. 1985;249:G580–5.

    CAS  Google Scholar 

  29. Parkman HP, Jones MP. Tests of gastric neuromuscular function. Gastroenterology. 2009;136:1526–43.

    Article  PubMed  Google Scholar 

  30. Wang XJ, Burton DD, Breen-Lyles M, et al. Gastric accommodation influences proximal gastric and total gastric emptying in concurrent measurements conducted in healthy volunteers. Am J Physiol Gastrointest Liver Physiol. 2021;320:G759–67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Takahashi T. Interdigestive migrating motor complex - its mechanism and clinical importance. J Smooth Muscle Res. 2013;49:99–111.

    Article  PubMed  Google Scholar 

  32. Azpiroz F. Control of gastric emptying by gastric tone. Dig Dis Sci. 1994;39:18S–9S.

    Article  CAS  PubMed  Google Scholar 

  33. Takahashi T. Pathophysiological significance of neuronal nitric oxide synthase in the gastrointestinal tract. J Gastroenterol. 2003;38:421–30.

    Article  CAS  PubMed  Google Scholar 

  34. Thumshirn M, Camilleri M, Choi MG, et al. Modulation of gastric sensory and motor functions by nitrergic and alpha2-adrenergic agents in humans. Gastroenterology. 1999;116:573–85.

    Article  CAS  PubMed  Google Scholar 

  35. Gangula PR, Maner WL, Micci MA, et al. Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum. Am J Physiol Gastrointest Liver Physiol. 2007;292:G725–33.

    Article  CAS  PubMed  Google Scholar 

  36. Karamanolis G, Caenepeel P, Arts J, et al. Determinants of symptom pattern in idiopathic severely delayed gastric emptying: gastric emptying rate or proximal stomach dysfunction? Gut. 2007;56:29–36.

    Article  CAS  PubMed  Google Scholar 

  37. Thumshirn M, Bruninga K, Camilleri M. Simplifying the evaluation of postprandial antral motor function in patients with suspected gastroparesis. Am J Gastroenterol. 1997;92:1496–500.

    CAS  PubMed  Google Scholar 

  38. Camilleri M, Brown ML, Malagelada JR. Relationship between impaired gastric emptying and abnormal gastrointestinal motility. Gastroenterology. 1986;91:94–9.

    Article  CAS  PubMed  Google Scholar 

  39. Samsom M, Jebbink RJ, Akkermans LM, et al. Abnormalities of antroduodenal motility in type I diabetes. Diabetes Care. 1996;19:21–7.

    Article  CAS  PubMed  Google Scholar 

  40. Fraser RJ, Horowitz M, Maddox AF, et al. Hyperglycaemia slows gastric emptying in type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1990;33:675–80.

    Article  CAS  PubMed  Google Scholar 

  41. Goyal RK, Cristofaro V, Sullivan MP. Rapid gastric emptying in diabetes mellitus: pathophysiology and clinical importance. J Diabetes Complicat. 2019;33:107414.

    Article  Google Scholar 

  42. Snape WJ, Lin MS, Agarwal N, et al. Evaluation of the pylorus with concurrent intraluminal pressure and EndoFLIP in patients with nausea and vomiting. Neurogastroenterol Motil. 2016;28:758–64.

    Article  CAS  PubMed  Google Scholar 

  43. Mearin F, Camilleri M, Malagelada JR. Pyloric dysfunction in diabetics with recurrent nausea and vomiting. Gastroenterology. 1986;90:1919–25.

    Article  CAS  PubMed  Google Scholar 

  44. Friedenberg FK, Palit A, Parkman HP, et al. Botulinum toxin A for the treatment of delayed gastric emptying. Am J Gastroenterol. 2008;103:416–23.

    Article  CAS  PubMed  Google Scholar 

  45. Arts J, Holvoet L, Caenepeel P, et al. Clinical trial: a randomized-controlled crossover study of intrapyloric injection of botulinum toxin in gastroparesis. Aliment Pharmacol Ther. 2007;26:1251–8.

    Article  CAS  PubMed  Google Scholar 

  46. Pouderoux P, Veyrac M, Michel H. Sham feeding disrupts phase III of the duodenal migrating motor complex in humans. Neurogastroenterol Motil. 1995;7:139–44.

    Article  CAS  PubMed  Google Scholar 

  47. Fraser R, Horowitz M, Maddox A, et al. Dual effects of cisapride on gastric emptying and antropyloroduodenal motility. Am J Phys. 1993;264:G195–201.

    CAS  Google Scholar 

  48. Nguyen L, Wilson LA, Miriel L, et al. Autonomic function in gastroparesis and chronic unexplained nausea and vomiting: relationship with etiology, gastric emptying, and symptom severity. Neurogastroenterol Motil. 2020;32:e13810.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Kumar A, Attaluri A, Hashmi S, et al. Visceral hypersensitivity and impaired accommodation in refractory diabetic gastroparesis. Neurogastroenterol Motil. 2008;20(6):635–42.

    Article  CAS  PubMed  Google Scholar 

  50. Camilleri M, Coulie B, Tack JF. Visceral hypersensitivity: facts, speculations, and challenges. Gut. 2001;48:125–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Holzer P. TRPV1: a new target for treatment of visceral pain in IBS? Gut. 2008;57:882–4.

    Article  CAS  PubMed  Google Scholar 

  52. Hammer J, Fuhrer M, Pipal L, et al. Hypersensitivity for capsaicin in patients with functional dyspepsia. Neurogastroenterol Motil. 2008;20:125–33.

    CAS  PubMed  Google Scholar 

  53. Ashat M, Lewis A, Liaquat H, et al. Intravenous immunoglobulin in drug and device refractory patients with the symptoms of gastroparesis-an open-label study. Neurogastroenterol Motil. 2018;30. https://doi.org/10.1111/nmo.13256.

  54. Flanagan EP, Saito YA, Lennon VA, et al. Immunotherapy trial as diagnostic test in evaluating patients with presumed autoimmune gastrointestinal dysmotility. Neurogastroenterol Motil. 2014;26:1285–97.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Grover M, Farrugia G, Lurken MS, et al. Cellular changes in diabetic and idiopathic gastroparesis. Gastroenterology. 2011;140:1575–85.e8.

    Article  CAS  PubMed  Google Scholar 

  56. Grover M, Bernard CE, Pasricha PJ, et al. Clinical-histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium. Neurogastroenterol Motil. 2012;24:531–9, e249.

    Article  CAS  PubMed  Google Scholar 

  57. Gottfried-Blackmore A, Namkoong H, Adler E, et al. Gastric mucosal immune profiling and dysregulation in idiopathic gastroparesis. Clin Transl Gastroenterol. 2021;12:e00349.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Vijayvargiya P, Jameie-Oskooei S, Camilleri M, et al. Association between delayed gastric emptying and upper gastrointestinal symptoms: a systematic review and meta-analysis. Gut. 2019;68:804–13.

    Article  PubMed  Google Scholar 

  59. Stanghellini V, Tack J. Gastroparesis: separate entity or just a part of dyspepsia? Gut. 2014;63:1972–8.

    Article  PubMed  Google Scholar 

  60. Aurora SK, Shrewsbury SB, Ray S, et al. A link between gastrointestinal disorders and migraine: insights into the gut-brain connection. Headache. 2021;61:576–89.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Lobrano A, Minocha A, Abell T, et al. The presence of overlap syndromes in patients with gastroparesis and correlation with hypercoagulable states in gastroparesis. J Investig Med. 2006;54:S289.

    Article  Google Scholar 

  62. Grover M, Gibbons SJ, Nair AA, et al. Transcriptomic signatures reveal immune dysregulation in human diabetic and idiopathic gastroparesis. BMC Med Genet. 2018;11:62.

    Google Scholar 

  63. Abell TL, Familoni B, Voeller G, et al. Electrophysiologic, morphologic, and serologic features of chronic unexplained nausea and vomiting: lessons learned from 121 consecutive patients. Surgery. 2009;145:476–85.

    Article  PubMed  Google Scholar 

  64. Abell TL, Kedar A, Stocker A, et al. Pathophysiology of gastroparesis syndromes includes anatomic and physiologic abnormalities. Dig Dis Sci. 2021;66(4):1127–41.

    Article  CAS  PubMed  Google Scholar 

  65. Grover M, Bernard CE, Pasricha PJ, et al. Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum. Neurogastroenterol Motil. 2017;29 https://doi.org/10.1111/nmo.13018.

  66. Meier B, Schmidt A, Glaser N, et al. Endoscopic full-thickness resection of gastric subepithelial tumors with the gFTRD-system: a prospective pilot study (RESET trial). Surg Endosc. 2020;34:853–60.

    Article  PubMed  Google Scholar 

  67. Orthey P, Yu D, Van Natta ML, et al. Intragastric meal distribution during gastric emptying scintigraphy for assessment of fundic accommodation: correlation with symptoms of gastroparesis. J Nucl Med. 2018;59:691–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Alvarez W. The electrogastrogram and what it shows. J Am Med Assoc. 1922;78:1116–9.

    Article  Google Scholar 

  69. O’Grady GO, Abell TL. Low- and high-resolution mapping of gastric electrical activity. Gastroenterol Clin N Am. 2015;44:169–84.

    Article  Google Scholar 

  70. Angeli TR, Cheng LK, Du P, et al. Loss of interstitial cells of cajal and patterns of gastric dysrhythmia in patients with chronic unexplained nausea and vomiting. Gastroenterology. 2015;149:56–66.e5.

    Article  PubMed  Google Scholar 

  71. Wauters L, Talley NJ, Walker MM, et al. Novel concepts in the pathophysiology and treatment of functional dyspepsia. Gut. 2020;69:591–600.

    Article  CAS  PubMed  Google Scholar 

  72. Greenwood-Van Meerveld B, Johnson AC, Grundy D. Gastrointestinal physiology and function. In: Greenwood-Van Meerveld B, editor. Gastrointestinal pharmacology. Cham: Springer International Publishing; 2017. p. 1–16.

    Chapter  Google Scholar 

  73. Raghav S, Kipp D, Watson J, et al. Gastroparesis with multiple sclerosis. Mult Scler J. 2006;12:243–4.

    Article  CAS  Google Scholar 

  74. Parkman HP. Migraine and gastroparesis from a gastroenterologist’s perspective. Headache. 2013;53:4–10.

    Article  PubMed  Google Scholar 

  75. Camilleri M. Diabetic gastroparesis. N Engl J Med. 2007;356:820–9.

    Article  CAS  PubMed  Google Scholar 

  76. Dabby R, Sadeh M, Broitman Y, et al. Painful small fiber neuropathy with gastroparesis: a new phenotype with a novel mutation in the SCN10A gene. J Clin Neurosci. 2016;26:84–8.

    Article  CAS  PubMed  Google Scholar 

  77. Tu Y, Abell TL, Raj SR, et al. Mechanisms and management of gastrointestinal symptoms in postural orthostatic tachycardia syndrome. Neurogastroenterol Motil. 2020;32:e14031.

    Article  PubMed  Google Scholar 

  78. Seabrook N, Kedar A, Bills G, et al. Inflammatory markers and mortality in diabetic versus idiopathic gastroparesis. Am J Med Sci. 2022;363(3):218–23.

    Article  PubMed  Google Scholar 

  79. Abell TL, Kedar A, Stocker A, et al. Gastroparesis syndromes: response to electrical stimulation. Neurogastroenterol Motil. 2019;31:e13534.

    Article  PubMed  Google Scholar 

  80. Soota K, Kedar A, Nikitina Y, et al. Immunomodulation for treatment of drug and device refractory gastroparesis. Results Immunol. 2016;6:11–4.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Luo J, Al-Juburi A, Rashed H, et al. Gastric electrical stimulation is associated with improvement in pancreatic exocrine function in humans. Pancreas. 2004;29:e41–4.

    Article  PubMed  Google Scholar 

  82. Pørksen N, Hollingdal M, Juhl C, et al. Pulsatile insulin secretion: detection, regulation, and role in diabetes. Diabetes. 2002;51:S245–54.

    Article  PubMed  Google Scholar 

  83. Ahuja NK, Clarke JO. Pyloric therapies for gastroparesis. Curr Treat Opt Gastroenterol. 2017;15:230–40.

    Article  Google Scholar 

  84. Gourcerol G, Tissier F, Melchior C, et al. Impaired fasting pyloric compliance in gastroparesis and the therapeutic response to pyloric dilatation. Aliment Pharmacol Ther. 2015;41:360–7.

    Article  CAS  PubMed  Google Scholar 

  85. Malik Z, Sankineni A, Parkman HP. Assessing pyloric sphincter pathophysiology using EndoFLIP in patients with gastroparesis. Neurogastroenterol Motil. 2015;27:524–31.

    Article  CAS  PubMed  Google Scholar 

  86. Jehangir A, Parkman HP. Reflux symptoms in gastroparesis: correlation with gastroparesis symptoms, gastric emptying, and esophageal function testing. J Clin Gastroenterol. 2020;54:428–38.

    Article  PubMed  Google Scholar 

  87. Parkman HP, Sharkey E, McCallum RW, et al. Constipation in patients with symptoms of gastroparesis: analysis of symptoms and gastrointestinal transit. Clin Gastroenterol Hepatol. 2022;20(3):546–558.e5.

    Article  PubMed  Google Scholar 

  88. Brzana RJ, Koch KL. Gastroesophageal reflux disease presenting with intractable nausea. Ann Intern Med. 1997;126:704–7.

    Article  CAS  PubMed  Google Scholar 

  89. Zhao Y, Ke M, Wang Z, et al. Pathophysiological and psychosocial study in patients with functional vomiting. J Neurogastroenterol Motil. 2010;16:274–80.

    Article  PubMed  PubMed Central  Google Scholar 

  90. Reddymasu SC, Lin Z, Sarosiek I, et al. Efficacy of gastric electrical stimulation in improving functional vomiting in patients with normal gastric emptying. Dig Dis Sci. 2010;55:983–7.

    Article  PubMed  Google Scholar 

  91. George NS, Sankineni A, Parkman HP. Small intestinal bacterial overgrowth in gastroparesis. Dig Dis Sci. 2014;59:645–52.

    Article  PubMed  Google Scholar 

  92. Tack J, Caenepeel P, Fischler B, et al. Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia. Gastroenterology. 2001;121:526–35.

    Article  CAS  PubMed  Google Scholar 

  93. Bisschops R, Karamanolis G, Arts J, et al. Relationship between symptoms and ingestion of a meal in functional dyspepsia. Gut. 2008;57:1495–503.

    Article  CAS  PubMed  Google Scholar 

  94. Van Oudenhove L, Vandenberghe J, Dupont P, et al. Abnormal regional brain activity during rest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: a H(2)(15)O-PET study. Am J Gastroenterol. 2010;105:913–24.

    Article  PubMed  Google Scholar 

  95. Cherian D, Sachdeva P, Fisher RS, et al. Abdominal pain is a frequent symptom of gastroparesis. Clin Gastroenterol Hepatol. 2010;8:676–81.

    Article  PubMed  Google Scholar 

  96. Jehangir A, Abdallah RT, Parkman HP. Characterizing abdominal pain in patients with gastroparesis into neuropathic and nociceptive components. J Clin Gastroenterol. 2019;53:427–33.

    Article  PubMed  Google Scholar 

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Acknowledgments

The authors would like to thank Catherine McBride for ongoing editorial assistance and Prateek Mathur for help with final manuscript review.

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Authors and Affiliations

  1. Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Aylin Tansel

  2. Division of Gastroenterology & Hepatology, Department of Medicine, Stanford University, Stanford, CA, USA

    Linda Nguyen

  3. Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Louisville, Louisville, KY, USA

    Thomas L. Abell

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  1. Aylin Tansel
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  2. Linda Nguyen
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  3. Thomas L. Abell
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Correspondence to Thomas L. Abell .

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Editors and Affiliations

  1. University of California, Irvine, Orange, CA, USA

    Ninh T. Nguyen

  2. Department of Gastroenterology & Hepatology, Stanford Digestive Health Clinic, Redwood City, CA, USA

    John O. Clarke

  3. Keck School of Medicine at USC, Los Angeles, CA, USA

    John C. Lipham

  4. Digestive Health Institute, University of California, Irvine, Orange, CA, USA

    Kenneth J. Chang

  5. Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York City, NY, USA

    Felice Schnoll-Sussman

  6. Institute of Esophageal & Reflux Surgery, Englewood, CO, USA

    Reginald C.W. Bell

  7. Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Peter J. Kahrilas

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Tansel, A., Nguyen, L., Abell, T.L. (2023). Pathophysiology of Gastric Neuromuscular Disorders. In: Nguyen, N.T., et al. The AFS Textbook of Foregut Disease. Springer, Cham. https://doi.org/10.1007/978-3-031-19671-3_41

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