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A School Goes into Depth

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Exercise, Respiratory and Environmental Physiology

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Abstract

This chapter is on breath-holding and breath-hold diving. The involvement of the School of Milano in diving is a consequence of the strong connection with Buffalo. Therefore, an analysis of the work carried out at Buffalo is initially presented. This includes the early studies on alveolar gas composition after breath-holding and the projects on the physiology of Korean diving women. The School of Milano entered the game with the Maiorca study, carried out in collaboration with Buffalo. Concepts such as gas exchange and energy expenditure during diving, the cardiovascular responses during diving, including the first demonstration of the occurrence of a diving response in humans, and the respiratory adaptation to breath-hold diving are discussed. An analysis of the limits of deep breath-hold diving is performed, including the effects of lung volumes. Finally, the most recent studies on cardiovascular dynamics during breath-holding and the role of baroreflexes are discussed.

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References

  • Agostoni E (1963) Diaphragm activity during breath holding: factors related to its onset. J Appl Physiol 18:30–36

    Article  CAS  PubMed  Google Scholar 

  • Andersen HT (1966) Physiological adaptations in diving vertebrates. Physiol Rev 46:212–243

    Article  CAS  PubMed  Google Scholar 

  • Andersson J, Schagatay E (1998) Effects of lung volume and involuntary breathing movements on the human diving response. Eur J Appl Physiol 77:19–24

    Article  CAS  Google Scholar 

  • Arborelius M Jr, Balldin UI, Lilja B, CEG L (1972) Hemodynamic changes in man during immersion with the head above water. Aerospace Med 43:592–598

    PubMed  Google Scholar 

  • Asmussen E, Kristiansson NG (1968) The “diving bradycardia” in exercising man. Acta Physiol Scand 73:527–535

    Article  CAS  PubMed  Google Scholar 

  • Åstrand PO (1960) Breath holding during and after muscular exercise. J Appl Physiol 15:220–224

    Article  PubMed  Google Scholar 

  • Bakovic D, Valic Z, Eterovic D, Vukovic I, Obad A, Marinovic-Terzic I, Dujic Z (2003) Spleen volume and blood flow response to repeated breath-hold apneas. J Appl Physiol 95:1460–1466

    Article  PubMed  Google Scholar 

  • Bjertnaes L, Hange A, Kjekshus J, Soyland E (1984) Cardiovascular responses to face immersion and apnea during steady-state muscle exercise. Acta Physiol Scand 120:605–612

    Article  CAS  PubMed  Google Scholar 

  • Blix AS, Folkow B (1983) Cardiovascular adjustments to diving in mammals and birds. In: Shephard JT, Abboud FM (eds) Handbook of Physiology. The cardiovascular system III, vol 3. American Physiological Society, sect. 2, Bethesda, MD, pp 917–945

    Google Scholar 

  • Brick I (1966) Circulatory responses to immersing the face in water. J Appl Physiol 21:33–36

    Article  CAS  PubMed  Google Scholar 

  • Bringard A, Adami A, Fagoni N, Fontolliet T, Lador F, Moia C, Tam E, Ferretti G (2017) Dynamics of the RR-interval versus blood pressure relationship at exercise onset in humans. Eur J Appl Physiol 117:619–630

    Article  PubMed  Google Scholar 

  • Burton AC, Bazett HC (1936) A study of the average temperature of the tissues, and of the exchanges of heat and vasomotor responses in man by means of a bath calorimeter. Am J Phys 117:36–54

    Article  Google Scholar 

  • Butler PJ, Jones DR (1997) Physiology of diving of birds and mammals. Physiol Rev 77:837–899

    Article  CAS  PubMed  Google Scholar 

  • Chapin JL (1955) Relationship between lung volume and breath-holding breaking point. J Appl Physiol 8:88–90

    Article  CAS  PubMed  Google Scholar 

  • Christmas KM, Bassingthwaighte JB (2017) Equations for O2 and CO2 solubilities in saline and plasma: combining temperature and density dependences. J Appl Physiol 122:1313–1320

    Article  PubMed  PubMed Central  Google Scholar 

  • Costalat G, Coquart J, Castres I, Joulia F, Sirost O, Clua E, Lemaître F (2017) The oxygen-conserving potential of the diving response: a kinetic-based analysis. J Sports Sci 35:678–687

    Article  PubMed  Google Scholar 

  • Costalat G, Coquart J, Castres I, Tourny C, Lemaître F (2013) Hemodynamic adjustments during breath-holding in trained divers. Eur J Appl Physiol 113:2523–2529

    Article  CAS  PubMed  Google Scholar 

  • Costalat G, Pichon A, Joulia F, Lemaître F (2015) Modeling the diving bradycardia: toward an oxygen-conserving breaking point? Eur J Appl Physiol 115:1475–1484

    Article  PubMed  Google Scholar 

  • Craig AB Jr (1961) Causes of loss of consciousness during underwater swimming. J Appl Physiol 16:583–586

    Article  PubMed  Google Scholar 

  • Craig AB Jr (1963) Heart rate responses to apneic underwater diving and to breath holding in man. J Appl Physiol 18:854–862

    Article  PubMed  Google Scholar 

  • Craig AB Jr (1968) Depth limits in breath-hold diving (an example of Fennology). Respir Physiol 5:14–22

    Article  PubMed  Google Scholar 

  • Craig FN, Cummings EG (1958) Breath holding during exercise. J Appl Physiol 13:30–34

    Article  CAS  PubMed  Google Scholar 

  • Cross TJ, Breskovic T, Sabapathy S, Zubin Maslov P, Johnson BD, Dujic Z (2013) Respiratory muscle pressure development during breath-holding in apnea divers. Med Sci Sports Exerc 45:93–101

    Article  PubMed  Google Scholar 

  • Curran-Everett D (2006) A classic learning opportunity from Fenn, Rahn, and Otis (1946): the alveolar gas equation. Adv Physiol Educ 30:58–62

    Article  PubMed  Google Scholar 

  • Dejours P, Girard F, Labrousse Y, Teillac A (1959) Etude de la régulation de la ventilation de repos chez l’homme en haute altitude. Rev Franc Etud Clin Biol 4:115–127

    CAS  PubMed  Google Scholar 

  • Dejours P, Puccinelli R, Armand J, Dicharry M (1965) Concept and measurement of ventilatory sensitivity to carbon dioxide. J Appl Physiol 20:890–897

    Article  CAS  PubMed  Google Scholar 

  • di Prampero PE (1981) Energetics of muscular exercise. Rev Physiol Biochem Pharmaco 89:143–222

    Article  Google Scholar 

  • di Prampero PE, Ferretti G (1999) The energetics of anaerobic muscle metabolism: a reappraisal of older and recent concepts. Respir Physiol 118:103–115

    Article  PubMed  Google Scholar 

  • Douglas CG, Haldane JS (1909) The causes of periodic or Cheyne-stokes breathing. J Physiol Lond 38:401–419

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eichinger M, Walterspacher S, Scholz T, Tetzlaff R, Puderbach M, Tetzlaff K, Kopp-Schneider A, Ley S, Choe K, Kauczor HU, Sorichter S (2010) Glossopharyngeal insufflation and pulmonary hemodynamics in elite breath hold divers. Med Sci Sports Exerc 42:1688–1695

    Article  PubMed  Google Scholar 

  • Espersen K, Frandsen H, Lorentzen T, Kanstrup IL, Christensen NJ (2002) The human spleen as an erythrocyte reservoir in diving-related interventions. J Appl Physiol 92:2071–2079

    Article  PubMed  Google Scholar 

  • Fagoni N, Sivieri A, Antonutto G, Moia C, Taboni A, Bringard A, Ferretti G (2015) Cardiovascular responses to dry resting apneas in elite divers while breathing pure oxygen. Respir Physiol Neurobiol 219:1–8

    Article  PubMed  Google Scholar 

  • Fagoni N, Taboni A, Vinetti G, Bottarelli S, Moia C, Bringard A, Ferretti G (2017) Alveolar gas composition during maximal and interrupted apneas in ambient air and pure oxygen. Respir Physiol Neurobiol 235:45–51

    Article  PubMed  Google Scholar 

  • Farhi LE (1990) World War II and respiratory physiology: the view from Rochester, New York. J Appl Physiol 69:1565–1570

    Article  CAS  PubMed  Google Scholar 

  • Farhi LE, Rahn H (1955) Gas stores of the body and the unsteady state. J Appl Physiol 7:472–484

    Article  CAS  PubMed  Google Scholar 

  • Feiner JR, Bickler PE, Severinghaus JW (1995) Hypoxic ventilatory response predicts the extent of maximal breath-holds in man. Respir Physiol 100:213–222

    Article  CAS  PubMed  Google Scholar 

  • Fenn WO (1962) Born fifty years too soon. Annu Rev Physiol 24:1–10

    Article  CAS  PubMed  Google Scholar 

  • Fenn WO, Rahn H, Otis AB (1950) Respiratory system. Annu Rev Physiol 12:179–204

    Article  CAS  PubMed  Google Scholar 

  • Ferretti G (2001) Extreme human breath-hold diving. Eur J Appl Physiol 84:254–271

    Article  CAS  PubMed  Google Scholar 

  • Ferretti G (2018) The O2-CO2 diagram. A revolution in respiration physiology. pH 2:36–57

    Google Scholar 

  • Ferretti G, Costa M (2003) Diversity in and adaptation to breath-hold diving in humans. Comp Biochem Physiol 136:205–213

    Article  Google Scholar 

  • Ferretti G, Costa M, Ferrigno M, Grassi B, Marconi C, Lundgren CEG, Cerretelli P (1991) Alveolar gas composition and exchange during deep breath-hold diving and dry breath holds in elite divers. J Appl Physiol 70:794–802

    Article  CAS  PubMed  Google Scholar 

  • Ferretti G, Costa M, Moroni R, Ranieri P, Butti F, Sponsiello N (2012) Lung volumes of extreme breath-hold divers. Sport Sci Health 7:55–59

    Article  Google Scholar 

  • Ferretti G, Veicsteinas A, Rennie DW (1986) Regional heat flows of resting and exercising men immersed in cool water. J Appl Physiol 64:1239–1248

    Article  Google Scholar 

  • Ferretti G, Veicsteinas A, Rennie DW (1989) Conductive and convective heat flows of exercising humans in cold water. J Appl Physiol 67:2473–2480

    Article  CAS  PubMed  Google Scholar 

  • Ferrigno M, Ferretti G, Ellis A, Warkander D, Costa M, Cerretelli P, Lundgren CEG (1997) Cardiovascular changes during deep breath-hold dives in a pressure chamber. J Appl Physiol 83:1282–1290

    Article  CAS  PubMed  Google Scholar 

  • Ferrigno M, Grassi B, Ferretti G, Costa M, Marconi C, Cerretelli P, Lundgren CEG (1991) Electrocardiogram during deep breath-hold dives by elite divers. Undersea Biomed Res 18:81–91

    CAS  PubMed  Google Scholar 

  • Fitz-Clarke JR (2018) Breath-hold diving. Compr Physiol 8:585–630

    Article  PubMed  Google Scholar 

  • Foster GE, Sheel AW (2005) The human diving response, its function, and its control. Scand J Med Sci Sports 15:3–12

    Article  CAS  PubMed  Google Scholar 

  • Gayeski TEJ, Honig CR (1983) Direct measurement of intracellular O2 gradients: role of convection and myoglobin. Adv Exp Med Biol 159:613–621

    Article  CAS  PubMed  Google Scholar 

  • Gooden BA (1994) Mechanism of the human diving response. Integr Physiol Behav Sci 29:6–16

    Article  CAS  PubMed  Google Scholar 

  • Grassi B, Ferretti G, Costa M, Ferrigno M, Panzacchi A, Lundgren CEG, Marconi C, Cerretelli P (1994) Ventilatory responses to hypercapnia and hypoxia in elite breath-hold divers. Respir Physiol 97:323–332

    Article  CAS  PubMed  Google Scholar 

  • Harashima S (1965) Gito Teruoka: his life and work. In: Rahn H, Yokoyama T (eds) Physiology of breath-hold diving and the ama of Japan. DC, NAS-NRC Publ, Washington, p 1341

    Google Scholar 

  • Harding PE, Roman D, Whelan RF (1965) Diving bradycardia in man. J Physiol 181:401–409

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Heistad DD, Aboud FM, Eckstein JW (1968) Vasoconstrictor response to simulated diving in men. J Appl Physiol 25:542–549

    Article  CAS  PubMed  Google Scholar 

  • Hong SK, Kim PK, Pak HK, Kim JK, Yoo MJ, Rennie DW (1969a) Maximal aerobic power of Korean women divers. Fed Proc 28:1284–1288

    CAS  PubMed  Google Scholar 

  • Hong SK, Lee CK, Kim JK, Song SH, Rennie DW (1969b) Peripheral blood flow and heat flux of Korean women divers. Fed Proc 28:1143–1148

    CAS  PubMed  Google Scholar 

  • Hong SK, Lin YC, Lally DA, Yim BJB, Kominami N, Hong PW, Moore TO (1971) Alveolar gas exchange and cardiovascular function during breath holding with air. J Appl Physiol 30:540–547

    Article  CAS  PubMed  Google Scholar 

  • Hong SK, Rahn H (1967) The diving women of Korea and Japan. Sci Am 216:34–43

    Article  CAS  PubMed  Google Scholar 

  • Hong SK, Rahn H, Kang DH, Song SH, Kang BS (1963) Diving pattern, lung volumes and alveolar gas of the Korean diving women (ama). J Appl Physiol 18:457–465

    Article  CAS  PubMed  Google Scholar 

  • Hong SK, Rennie DW, Park YS (1986) Cold acclimatization and deacclimatization in Korean women divers. Exercise Sports Sci Rev 14:231–268

    Article  CAS  Google Scholar 

  • Hong SK, Song SH, Kim PK, Suh CS (1967) Seasonal observations on the cardiac rhythm during diving in the Korean ama. J Appl Physiol 23:18–22

    Article  CAS  PubMed  Google Scholar 

  • Hurford WE, Hong SK, Park YS, Ahn DW, Shiraki K, Mohri M, Zapol WM (1990) Splenic contraction during breath-hold diving in the Korean ama. J Appl Physiol 69:932–936

    Article  CAS  PubMed  Google Scholar 

  • Ilardo MA, Moltke I, Korneliussen TS, Cheng J, Stern AJ, Racimo F, de Barros DP, Sikora M, Seguin-Orlando A, Rasmussen S et al (2018) Physiological and genetic adaptations to diving in sea nomads. Cell 173:569–580

    Article  CAS  PubMed  Google Scholar 

  • Jansson E, Sylvén C, Nordevang E (1982) Myoglobin in the quadriceps femoris muscle of competitive cyclists and untrained men. Acta Physiol Scand 114:627–629

    Article  CAS  PubMed  Google Scholar 

  • Jouasset D (1960) Normalisation des épreuves fonctionnelles respiratoires dans les pays de la Communauté Européenne du Charbon et de l’Acier. Poumon Coeur 10:1145–1159

    Google Scholar 

  • Kang BS, Han DS, Paik KS, Park YS, Kim JK, Kim CS, Rennie DW, Hong SK (1970) Calorigenic action of norepinephrine in the Korean women divers. J Appl Physiol 29(6–9):1970

    Google Scholar 

  • Kang BS, Song SH, Suh CS, Hong SK (1963) Changes in body temperature and basal metabolic rate of the ama. J Appl Physiol 18:483–488

    Article  CAS  PubMed  Google Scholar 

  • Kardos A, Watterich G, de Menezes R, Csanady M, Casadei B, Rudas L (2001) Determinants of spontaneous baroreflex sensitivity in a healthy working population. Hypertension 37:911–916

    Article  CAS  PubMed  Google Scholar 

  • Klocke FJ, Rahn H (1959) Breath holding after breathing oxygen. J Appl Physiol 14:689–693

    Article  CAS  PubMed  Google Scholar 

  • Kooyman GL, Ponganis PJ (1998) The physiological basis of diving to depth: birds and mammals. Annu Rev Physiol 60:19–32

    Article  CAS  PubMed  Google Scholar 

  • Lambertsen CJ (1960) Carbon dioxide and respiration in acid base homeostasis. Anesthesiology 21:642–651

    Article  CAS  PubMed  Google Scholar 

  • Lanphier EH, Rahn H (1963) Alveolar gas exchange during breath-holding with air. J Appl Physiol 18:478–482

    Article  CAS  PubMed  Google Scholar 

  • Lemaître F, Clua E, Andréani B, Castres I, Chollet D (2010) Ventilatory function in breath-hold divers: effect of glossopharyngeal insufflation. Eur J Appl Physiol 108:741–747

    Article  PubMed  Google Scholar 

  • Lin YC (1982) Breath hold diving in terrestrial mammals. Exerc Sports Sci Rev 10:270–307

    Article  CAS  Google Scholar 

  • Lin YC, Hong SK (1996) Hyperbaria: breath-hold diving. In: Fregly MJ, Blatteis CM (eds) Handbook of physiology. Environmental physiology. Oxford University Press, New York, pp 979–995

    Google Scholar 

  • Lin YC, Lally DA, Moore TO, Hong SK (1974) Physiological and conventional breath-hold breaking points. J Appl Physiol 37:291–296

    Article  CAS  PubMed  Google Scholar 

  • Lin YC, Shida KK, Hong SK (1983) Effects of hypercapnia, hypoxia and rebreathing on circulatory response to apnea. J Appl Physiol 54:172–177

    Article  CAS  PubMed  Google Scholar 

  • Lindholm P, Linnarsson D (2002) Pulmonary gas exchange during apnea in exercising men. Eur J Appl Physiol 86:487–491

    Article  CAS  PubMed  Google Scholar 

  • Lindholm P, Lundgren CEG (2009) The physiology and pathophysiology of human breath-hold diving. J Appl Physiol 106:284–292

    Article  PubMed  Google Scholar 

  • Lindholm P, Nyren S (2005) Studies on inspiratory and expiratory glossopharyngeal breathing in breath-hold divers employing magnetic resonance imaging and spirometry. Eur J Appl Physiol 94:646–651

    Article  PubMed  Google Scholar 

  • Lindholm P, Sundblad P, Linnarsson D (1999) Oxygen-conserving effects of apnea in exercising men. J Appl Physiol 87:2122–2127

    Article  CAS  PubMed  Google Scholar 

  • Lloyd BB, Jukes MGM, Cunningham DJC (1958) The relation between the alveolar oxygen pressure and the respiratory response to carbon dioxide in man. Q J Exp Physiol 43:214–227

    Article  CAS  PubMed  Google Scholar 

  • Loring SH, O’Donnell CR, Butler JP, Lindholm P, Jacobson F, Ferrigno M (2007) Transpulmonary pressures and lung mechanics with glossopharyngeal insufflation and exsufflation beyond normal lung volumes in competitive breath-hold divers. J Appl Physiol 102:841–846

    Article  PubMed  Google Scholar 

  • Lundgren CGE, Ferrigno M (1987) The physiology of breath-hold diving. Undersea and Hyperbaric Medical Society, Bethesda MD, USA

    Google Scholar 

  • Majorca E (1987) Depth records: practical considerations. In: Lundgren CEG, Ferrigno M (eds) The physiology of breath—hold diving. Undersea and Hyperbaric Medicine Society, Bethesda, MD, pp 291–294

    Google Scholar 

  • Manley L (1990) Apnoeic heart rate responses in humans. A review Sports Med 9:286–310

    Article  CAS  PubMed  Google Scholar 

  • Marabotti C, Belardinelli A, L'Abbate A, Scalzini A, Chiesa F, Cialoni D, Passera M, Bedini R (2008) Cardiac function during breath-hold diving in humans: an echocardiographic study. Undersea Hyperb Med 35:83–90

    CAS  PubMed  Google Scholar 

  • Marabotti C, Scalzini A, Cialoni D, Passera M, Ripoli A, L'Abbate A, Bedini R (2009) Effect of depth and chest volume on cardiac output during breath-hold diving. Eur J Appl Physiol 106:683–689

    Article  PubMed  Google Scholar 

  • Massion J, Meulders M, Colle J (1960) Fonction posturale des muscles respiratoires. Arch Int Physiol Biochim 68:314–326

    CAS  PubMed  Google Scholar 

  • Masuda Y, Yoshida A, Hayashi F, Sasaki K, Honda Y (1981) The ventilatory responses to hypoxia and hypercapnia in the Ama. Jpn J Physiol 31:187–197

    Article  CAS  PubMed  Google Scholar 

  • Masuda Y, Yoshida A, Hayashi F, Sasaki K, Honda Y (1982) Attenuated ventilatory responses to hypercapnia and hypoxia in assisted breath-hold divers (funado). Jpn J Physiol 32:327–336

    Article  CAS  PubMed  Google Scholar 

  • Mithoefer JC (1959) Lung volume restriction as a ventilatory stimulus during breath-holding. J Appl Physiol 14:701–705

    Article  CAS  PubMed  Google Scholar 

  • Morelli L, Data PG (1991) Thoracic radiological changes during deep breath-hold diving (abstract). In: Data PG, Lahiri S (eds) Proceedings of the workshop on the physiology of deep breath-hold diving. Chieti, Italy, pp 28–30

    Google Scholar 

  • Nielsen M, Smith H (1952) Studies on the regulation of respiration in acute hypoxia; with an appendix on respiratory control during prolonged hypoxia. Acta Physiol Scand 24:293–313

    Article  CAS  PubMed  Google Scholar 

  • Novalija J, Lindholm P, Loring SH, Diaz E, Fox JA, Ferrigno M (2007) Cardiovascular aspects of glossopharyngeal insufflation and exsufflation. Undersea Hyperb Med 34:415–423

    CAS  PubMed  Google Scholar 

  • Olszowka AJ, Rahn H (1987) Breath-hold diving. In: Sutton JR, Houston CS, Coates G (eds) Hypoxia and cold. New York, Praeger, pp 417–428

    Google Scholar 

  • Otis AB (1964) Quantitative relationships in steady-state gas exchange. In: Fenn WO, Rahn H (eds) Handbook of physiology. Respiration. American Physiological Society, Washington, DC, pp 681–698

    Google Scholar 

  • Otis AB, Rahn H, Epstein MA, Fenn WO (1946) Performance as related to alveolar air. Am J Phys 146:207–221

    Article  CAS  Google Scholar 

  • Otis AB, Rahn H, Fenn WO (1948) Alveolar gas changes during breath holding. Am J Phys 152:674–686

    Article  CAS  Google Scholar 

  • Paik KS, Kang BS, Han DS, Rennie DW, Hong SK (1972) Vascular responses of Korean Ama to hand immersion in cold water. J Appl Physiol 32:446–450

    Article  CAS  PubMed  Google Scholar 

  • Palada I, Eterovic D, Obad A, Bakovic D, Valic Z, Ivancev V, Lojour M, Shoemaker JK, Dujic Z (2007) Spleen and cardiovascular function during short apneas in divers. J Appl Physiol 103:1958–1963

    Article  PubMed  Google Scholar 

  • Pappenheimer J (1996) Hermann Rahn: July 5, 1912-June 23, 1990. Biogr Mem Natl Acad Sci 69:242–267

    Google Scholar 

  • Park YS, Rennie DW, Lee SI, Park YD, Paik KS, Kang DH, Suh DJ, Lee SH, Hong SY, Hong SK (1983) Time course of deacclimatization to cold water immersion in Korean women divers. J Appl Physiol 54:1708–1716

    Article  CAS  PubMed  Google Scholar 

  • Parkes MJ (2006) Breath-holding and its break point. Exp Physiol 91:1–15

    Article  CAS  PubMed  Google Scholar 

  • Patrician A, Gasho C, Spajic B, Caldwell HG, Bakovic-Kramaric D, Barak O, Drviš I, Dujic Z, Ainslie PN (2021) Case studies in physiology: breath-hold diving beyond 100 meters – cardiopulmonary responses in world-champion divers. J Appl Physiol 130:1345–1350

    Article  PubMed  Google Scholar 

  • Paulev PE (1969) Respiratory and cardiovascular effects of breath-holding. Acta Physiol Scand Suppl 324:1–116

    CAS  PubMed  Google Scholar 

  • Pelizzari U (2005) Profondamente, 2nd edn. Mondadori, Milano

    Google Scholar 

  • Perini R, Gheza A, Moia C, Sponsiello N, Ferretti G (2010) Cardiovascular time course during prolonged immersed static apnea. Eur J Appl Physiol 110:277–283

    Article  PubMed  Google Scholar 

  • Perini R, Tironi A, Gheza A, Butti F, Moia C, Ferretti G (2008) Heart rate and blood pressure time courses during prolonged dry apnea in breath-hold divers. Eur J Appl Physiol 104:1–7

    Article  PubMed  Google Scholar 

  • Qvist J, Hurford WE, Park YS, Radermacher P, Falke KJ, Ahn DW, Guyton GP, Stanek KS, Hong SK, Weber RE, Zapol WM (1993) Arterial blood gas tensions during breath-hold diving in the Korean ama. J Appl Physiol 75:285–293

    Article  CAS  PubMed  Google Scholar 

  • Rahn H (1965) Gito Teruoka: his contribution to the physiology of the Ama. In: Physiology of breath-hold diving and the Ama of Japan, vol 1341. NAS-NRC Publ, Washington, DC, pp 9–10

    Google Scholar 

  • Rahn H (1979) Wallace Osgood Fenn: August 27,1893-September 20,1971. Biogr Mem Natl Acad Sci 50:140–173

    Google Scholar 

  • Rahn H, Bahnson HT, Muxworthy JF, Hagen JM (1953) Adaptation to high altitude: changes in breath-holding time. J Appl Physiol 6:154–157

    Article  CAS  PubMed  Google Scholar 

  • Rahn H, Farhi LE (1964) Ventilation, perfusion and gas exchange – the \( {\dot{V}}_A/\dot{Q} \)concept. In: Fenn WO, Rahn H (eds) Handbook of Physiology. Respiration. American Physiological Society, Washington, DC, pp 735–766

    Google Scholar 

  • Rahn H, Fenn WO (1955) A graphical analysis of the respiratory gas exchange, The O2-CO2 diagram. American Physiological Society, Washington, DC

    Google Scholar 

  • Rahn H, Otis AB (1949) Continuous analysis of alveolar gas composition during work, hyperpnea, hypercapnia and anoxia. J Appl Physiol 1:717–724

    Article  CAS  PubMed  Google Scholar 

  • Rahn H, Yokoyama T (1965) Physiology of breath-hold diving and the Ama of Japan. Washington, DC, NAS-NRC Publ 1341

    Google Scholar 

  • Rebuck AS, Slutsky AS, Mahutte CK (1977) A mathematical expression to describe the ventilatory response to hypoxia and hypercapnia. Respir Physiol 31:107–116

    Article  CAS  PubMed  Google Scholar 

  • Rennie DW, Covino BG, Howell BJ, Song SH, Kang BS, Hong SK (1962) Physical insulation of Korean diving women. J Appl Physiol 17:961–966

    Article  CAS  PubMed  Google Scholar 

  • Rodbard S (1947) The effect of oxygen, altitude and exercise on breath-holding time. Am J Phys 150:142–148

    Article  CAS  Google Scholar 

  • Schaefer KE, Allison RD, Dougherty JH Jr, Carey CR, Walker R, Yost F, Parker D (1968) Pulmonary and circulatory adjustments determining the limits of depth in breath-hold diving. Science 162:1020–1023

    Article  CAS  PubMed  Google Scholar 

  • Schagatay E, Andersson JP, Hallen M, Palsson B (2001) Selected contribution: role of spleen emptying in prolonging apneas in humans. J Appl Physiol 90:1623–1629

    Article  CAS  PubMed  Google Scholar 

  • Schagatay E, van Kampen M, Emanuelsson S, Holm B (2000) Effects of physical and apnea training on apneic time and the diving response in humans. Eur J Appl Physiol 82:161–169

    Article  CAS  PubMed  Google Scholar 

  • Schipke JD, Kelm M, Siegmund K, Muth T, Sievers B, Steinerd S (2015) Lung packing in breath hold-diving: an impressive case of pulmo–cardiac interaction. Respir Med Case Rep 16:120–121

    PubMed  PubMed Central  Google Scholar 

  • Scholander PF (1940) Experimental investigations on the respiratory function in diving mammals and birds, vol 22. Norske Videnskaps-Akademie Oslo, Hvalradets Skrifter, pp 1–131

    Google Scholar 

  • Sivieri A, Fagoni N, Bringard A, Capogrosso M, Perini R, Ferretti G (2015) A beat-by-beat analysis of cardiovascular responses to dry resting and exercise apneas in elite divers. Eur J Appl Physiol 115:119–128

    Article  PubMed  Google Scholar 

  • Song SH, Kang DH, Kang BS, Hong SK (1963) Lung volumes and ventilatory responses to high CO2 and low O2 in the Ama. J Appl Physiol 18:466–470

    Article  CAS  PubMed  Google Scholar 

  • Stanley NN, Altose MD, Kelsen SG, Ward CF, Cherniack NS (1975) Changing effect of lung volume on respiratory drive in man. J Appl Physiol 38:768–773

    Article  CAS  PubMed  Google Scholar 

  • Sterba JA, Lundgren CE (1988) Breath-hold duration in man and the diving response induced by face immersion. Undersea Biomed Res 15:361–375

    CAS  PubMed  Google Scholar 

  • Subramani S, Kanthakumar P, Maneksh D, Sidharthan A, Rao SV, Parasuraman V, Tharion E (2011) O2-CO2 diagram as a tool for comprehension of blood gas abnormalities. Adv Physiol Educ 35:314–320

    Article  PubMed  Google Scholar 

  • Taboni A, Fagoni N, Fontolliet T, Grasso G, Moia C, Vinetti A, Ferretti G (2020) Breath holding as an example of extreme hypoventilation: experimental testing of a new model describing alveolar gas pathways. Exp Physiol 105:2216–2225

    Article  CAS  PubMed  Google Scholar 

  • Taboni A, Vinetti G, Bruseghini P, Camelio S, D’Elia M, Moia C, Ferretti G, Fagoni N (2018) Cardiovascular responses to dry apneas at exercise in air and in pure oxygen. Respir Physiol Neurobiol 255:17–21

    Article  PubMed  Google Scholar 

  • Taboni A, Vinetti G, Fontolliet T, Grasso G, Tam E, Moia C, Ferretti G, Fagoni N (2021) Baroreflex responses during dry resting and exercise apneas in air and pure oxygen. Eur J Appl Physiol 121:539–547

    Article  CAS  PubMed  Google Scholar 

  • Teruoka G (1932) Die Ama und ihre Arbeit. Arbeitsphysiologie 5:239–251

    Google Scholar 

  • Tibes U, Stegemann J (1969) Behavior of the end tidal respiratory gas pressure, O2 uptake and CO2 output following simple apnea in water, on land and apneic diving. Pflugers Arch 311:300–311

    Article  CAS  PubMed  Google Scholar 

  • Tocco F, Crisafulli A, Melis F, Porru C, Pittau G, Milia R, Concu A (2012) Cardiovascular adjustments in breath-hold diving: comparison between divers and non-divers in simulated dynamic apnea. Eur J Appl Physiol 112:543–554

    Article  PubMed  Google Scholar 

  • Tocco F, Marongiu F, Pinna M, Roberto S, Pusceddu M, Angius L, Migliaccio GM, Milia R, Concu A, Crisafulli A (2013) Assessment of circulatory adjustments during underwater apnea in elite divers by means of a portable device. Acta Physiol 207:290–298

    Article  CAS  Google Scholar 

  • Veicsteinas A, Ferretti G, Rennie DW (1982) Superficial shell insulation in resting and exercising men in cold water. J Appl Physiol 52:1557–1564

    Article  CAS  PubMed  Google Scholar 

  • Veicsteinas A, Rennie DW (1982) Thermal insulation and shivering threshold in Greek sponge divers. J Appl Physiol 52:845–850

    Article  CAS  PubMed  Google Scholar 

  • Walterspacher S, Scholz T, Tetzlaff K, Sorichter S (2011) Breath-hold diving: respiratory function on the longer term. Med Sci Sports Exerc 43:1214–1219

    Article  PubMed  Google Scholar 

  • Warkander DE, Ferrigno M, Lundgren CEG, McCoy K (1996) Some physiological parameters in a breathhold dive to 107 msw (351 fsw) in the ocean. Undersea Hyperb Med 23:575

    Google Scholar 

  • West JB (2012) The physiological legacy of the Fenn, Rahn and Otis school. Am J Phys 303:L1845–L1851

    Google Scholar 

  • Zapol WM (1996) Diving physiology of the Weddel seal. In: Fregly MJ, Blatteis CM (eds) Handbook of physiology. Environmental physiology. Oxford University Press, New York, pp 1049–1056

    Google Scholar 

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Correspondence to Guido Ferretti .

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Ferretti, G. (2023). A School Goes into Depth. In: Ferretti, G. (eds) Exercise, Respiratory and Environmental Physiology. Perspectives in Physiology. Springer, Cham. https://doi.org/10.1007/978-3-031-19197-8_12

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