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The Spinal Cord in Diabetic Neuropathy

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Diabetic Neuropathy

Part of the book series: Contemporary Diabetes ((CDI))

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Abstract

The spinal cord is not only a conduit for the flow of afferent information from the periphery to the higher central nervous system, but also a complex sensorimotor processing interface. The spinal cord is the first site of integration of sensory input from the periphery and the last site of descending control of sensory and motor systems, therefore disruption of its function may impede appropriate CNS control systems and contribute to apparent peripheral neuropathy. In diabetes, the focus on the function and contribution of the spinal cord to neuropathy has increased, particularly in the domain of inflammation, molecular mechanisms, spinal disinhibition and stimulation. Numerous preclinical studies in rodents demonstrated the clear contributing role of the spinal cord to diabetic peripheral neuropathy and painful neuropathy. For the patients with diabetes this translates to few approved drugs, progress in spinal cord stimulation to benefit intractable pain and a new method of detection of pain generation site to benefit determination of appropriate treatment and future successful clinical trials.

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Authors and Affiliations

  1. Musculoskeletal Biology, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK

    Andrew G. Marshall

  2. Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

    Anne Worthington

  3. University of California San Diego, La Jolla, CA, USA

    Corinne G. Jolivalt

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  1. Andrew G. Marshall
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  2. Anne Worthington
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  3. Corinne G. Jolivalt
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Correspondence to Corinne G. Jolivalt .

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Editors and Affiliations

  1. Royal Hallamshire Hospital, Sheffield Teaching Hospitals and the University of Sheffield Director of Diabetes Research, Sheffield, UK

    Solomon Tesfaye

  2. Beth Israel Deaconess Medical Center, Boston, MA, USA

    Christopher H. Gibbons

  3. Weill Cornell Medicine, Cornell University, Doha, Qatar

    Rayaz Ahmed Malik

  4. Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Aristidis Veves

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Marshall, A.G., Worthington, A., Jolivalt, C.G. (2023). The Spinal Cord in Diabetic Neuropathy. In: Tesfaye, S., Gibbons, C.H., Malik, R.A., Veves, A. (eds) Diabetic Neuropathy. Contemporary Diabetes. Humana, Cham. https://doi.org/10.1007/978-3-031-15613-7_20

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