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The Epidemiology of Diabetic Neuropathy

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Diabetic Neuropathy

Part of the book series: Contemporary Diabetes ((CDI))

Abstract

Diabetic neuropathy is one of the most common complications to diabetes that is associated with substantial negative individual and socioeconomic consequences. Diabetic neuropathy encompasses a heterogeneous group of neuropathic syndromes with varying clinical manifestations. The most common forms of diabetic neuropathy are: distal symmetric polyneuropathy (DSPN) and cardiovascular autonomic neuropathy (CAN).

Estimating prevalence and incidence rate is challenging as diagnostic criteria for the complications vary between studies and depending on the geographical origin of studies. In addition, scares data is available from longitudinal studies, which restricts the ability to present substantial data on incidence rates and disease progression.

Based on reviews of major studies of diabetic neuropathy from the last four decades, we present data on the global prevalence and incidence of DSPN and CAN.

In summary, the prevalence of clinical DSPN varies between 20% and 30% for both type 1 and type 2 diabetes, with significant variability between studies and geographical regions. Approximately, 15% of people with diabetes suffer from painful DSPN. A common risk maker for DSPN and painful DSPN is diabetes duration. The incidence of DSPN is generally higher in type 2 diabetes than in type 1 diabetes. CAN prevalence in type 1 diabetes and type 2 diabetes also varies by geographical region. Estimates vary between 10 and 30% with a tendency to higher prevalence in non-Western regions. CAN prevalence increases with age. No apparent changes in prevalence have been observed from the 1990s to the present.

In summary, diabetic neuropathies are common and variations in prevalence are related to geographical region. Prevalence estimates are possibly subjected to inaccuracies due to varying diagnostic modalities and criteria.

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Authors and Affiliations

  1. Steno Diabetes Center Copenhagen, Herlev, Denmark

    Christian Stevns Hansen

  2. Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

    Laura L. Määttä

  3. Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark

    Laura L. Määttä & Morten H. Charles

  4. Steno Diabetes Center Aarhus, Regional Hospital Gødstrup, Herning, Denmark

    Signe Toft Andersen

  5. Department of Public Health, Aarhus University, Aarhus, Denmark

    Morten H. Charles

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  1. Christian Stevns Hansen
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  2. Laura L. Määttä
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  3. Signe Toft Andersen
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  4. Morten H. Charles
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Editors and Affiliations

  1. Royal Hallamshire Hospital, Sheffield Teaching Hospitals and the University of Sheffield Director of Diabetes Research, Sheffield, UK

    Solomon Tesfaye

  2. Beth Israel Deaconess Medical Center, Boston, MA, USA

    Christopher H. Gibbons

  3. Weill Cornell Medicine, Cornell University, Doha, Qatar

    Rayaz Ahmed Malik

  4. Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Aristidis Veves

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Hansen, C.S., Määttä, L.L., Andersen, S.T., Charles, M.H. (2023). The Epidemiology of Diabetic Neuropathy. In: Tesfaye, S., Gibbons, C.H., Malik, R.A., Veves, A. (eds) Diabetic Neuropathy. Contemporary Diabetes. Humana, Cham. https://doi.org/10.1007/978-3-031-15613-7_2

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