Abstract
Psoriasis is a chronic, inflammatory, immune-mediated disease triggered by external insults (infections, trauma, drugs, and psychological stress) in genetically susceptible individuals. Various classes of T cells (with IL23/Th17 axis playing a central role), interacting with dendritic cells, neutrophils and keratinocytes, are responsible for the development of an inflammatory cascade, leading to uncontrolled keratinocyte proliferation. Plaque psoriasis (with erythematous lesions covered by white silvery scales) is the most common clinical form of the disease, but several clinical variants have been described. Psoriatic arthritis is a common association together with metabolic syndrome, depression, or cardiovascular disease. Mild forms of psoriasis are usually treated with topical therapies or phototherapy, whereas moderate-to-severe psoriasis usually requires systemic therapies with traditional or biological therapies.
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Chiricozzi, A., Pirro, F. (2023). Dermatologic Diseases: Psoriasis and Psoriatic Arthritis. In: Katsambas, A.D., Lotti, T.M., Dessinioti, C., D'Erme, A.M. (eds) European Handbook of Dermatological Treatments. Springer, Cham. https://doi.org/10.1007/978-3-031-15130-9_78
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