Abstract
Melanocytic nevi represent the most common benign lesion of the skin and human body overall. They are extremely common in Caucasians and can arise in any anatomic site. Nevi are classified into congenital and acquired nevi. The former can be present at birth or develop within the first 2 years of life or early in childhood. The latter arise later in life, manifest a wide clinical and histological variation, and they are further categorized into several entities such as common acquired nevus, atypical (dysplastic) nevus, blue nevus, Spitz/Reed nevus, and halo nevus. The link between nevi and melanoma remains one of the most challenging subjects in the field of dermato-oncology. Up-to-date knowledge shows that melanocytic nevi are not precursors of melanoma. However, the presence of a large number of nevi or special types of nevi (i.e., atypical nevi, giant congenital nevi) is associated with a higher risk for the development of melanoma. Preventive surgical excision is not required, and this therapeutic choice is selected only for lesions in the gray zone clinico-dermatoscopically between the nevus and melanoma. Thus, melanocytic nevi at special anatomic sites, atypical nevi, and lesions with an intriguing clinical/dermatoscopic presentation should be followed up by means of dermatoscopy in a more regular basis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Further Reading
Ackerman AB, Milde P. Naming acquired melanocytic nevi. Common and dysplastic, normal and atypical, or Unna, Miescher, spitz, and Clark? Am J Dermatopathol. 1992;14(5):447–53.
Alikhan A, Ibrahimi OA, Eisen DB. Congenital melanocytic nevi: where are we now? Part I. clinical presentation, epidemiology, pathogenesis, histology, malignant transformation, and neurocutaneous melanosis. J Am Acad Dermatol. 2012;67(4):495.e1–17; quiz 512–14. https://doi.org/10.1016/j.jaad.2012.06.023.
Barnhill RL, Barnhill MA, Berwick M, Mihm MC Jr. The histologic spectrum of pigmented spindle cell nevus: a review of 120 cases with emphasis on atypical variants. Hum Pathol. 1991;22(1):52–8.
Barnhill RL, Argenyi ZB, From L, et al. Atypical spitz nevi/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome. Hum Pathol. 1999;30(5):513–20.
Bauer J, Curtin J, Pinkel D, Bastian BC. Congenital melanocytic nevi frequently harbor NRAS but no BRAF mutations. J Invest Dermatol. 2007;127(1):179–82.
Bett BJ. Large or multiple congenital melanocytic nevi: occurrence of cutaneous melanoma in 1008 persons. J Am Acad Dermatol. 2005;52(5):793–7.
Bevona C, Goggins W, Quinn T, Fullerton J, Tsao H. Cutaneous melanomas associated with nevi. Arch Dermatol. 2003;139(12):1620–4; discussion 1624.
Casso EM, Grin-Jorgensen CM, Grant-Kels JM. Spitz nevi. J Am Acad Dermatol. 1992;27(6 Pt 1):901–13.
Celebi JT, Ward KM, Wanner M, Polsky D, Kopf AW. Evaluation of germline CDKN2A, ARF, CDK4, PTEN, and BRAF alterations in atypical mole syndrome. Clin Exp Dermatol. 2005;30(1):68–70.
Charbel C, Fontaine RH, Malouf GG, et al. NRAS mutation is the sole recurrent somatic mutation in large congenital melanocytic nevi. J Invest Dermatol. 2014;134(4):1067–74.
Clarke LE. Dysplastic nevi. Clin Lab Med. 2011;31(2):255–65.
De Snoo FA, Kroon MW, Bergman W, ter Huurne JE, Houwing-Duistermaat JJ, van Mourik L, et al. From sporadic atypical nevi to familial melanoma: risk analysis for melanoma in sporadic atypical nevus patients. J Am Acad Dermatol. 2007;56:748–52.
DeDavid M, Orlow SJ, Provost N, et al. A study of large congenital melanocytic nevi and associated malignant melanomas: review of cases in the New York University registry and the world literature. J Am Acad Dermatol. 1997;36(3 Pt 1):409–16.
Ferrara G, Argenziano G, Soyer HP, et al. The spectrum of spitz nevi: a clinicopathologic study of 83 cases. Arch Dermatol. 2005a;141(11):1381–7.
Ferrara G, Argenziano G, Soyer HP, et al. The spectrum of spitz nevi: a clinicopathologic study of 83 cases. Arch Dermatol. 2005b;141(11):1381–7.
Gallagher RP, McLean DI. The epidemiology of acquired melanocytic nevi. A brief review. Dermatol Clin. 1995;13(3):595–603.
Gelbard SN, Tripp JM, Marghoob AA, et al. Management of Spitz nevi: a survey of dermatologists in the United States. J Am Acad Dermatol. 2002;47(2):224–30.
Geller AC, Swetter SM, Brooks K, Demierre MF, Yaroch AL. Screening, early detection, and trends for melanoma: current status (2000-2006) and future directions. J Am Acad Dermatol. 2007;57(4):555–72; quiz 573–6.
Haenssle HA, Korpas B, Hansen-Hagge C, Buhl T, Kaune KM, Johnsen S, Rosenberger A, Schön MP, Emmert S. Selection of patients for long-term surveillance with digital dermoscopy by assessment of melanoma risk factors. Arch Dermatol. 2010;146(3):257–64. https://doi.org/10.1001/archdermatol.2009.370.
Harrison SL, MacLennan R, Buettner PG. Sun exposure and the incidence of melanocytic nevi in young Australian children. Cancer Epidemiol Biomark Prev. 2008;17(9):2318–24.
Ibrahimi OA, Alikhan A, Eisen DB. Congenital melanocytic nevi: where are we now? Part II. Treatment options and approach to treatment. J Am Acad Dermatol. 2012;67(4):515.e1–13; quiz 528–30. https://doi.org/10.1016/j.jaad.2012.06.022.
Kincannon J, Boutzale C. The physiology of pigmented nevi. Pediatrics. 1999;104(4 Pt 2):1042–5.
Krengel S, Hauschild A, Schafer T. Melanoma risk in congenital melanocytic naevi: a systematic review. Br J Dermatol. 2006;155(1):1–8.
Krengel S, Scope A, Dusza SW, Vonthein R, Marghoob AA. New recommendations for the categorization of cutaneous features of congenital melanocytic nevi. J Am Acad Dermatol. 2013;68(3):441–51.
Lambert WC, Brodkin RH. Nodal and subcutaneous cellular blue nevi. A pseudometastasizing pseudomelanoma. Arch Dermatol. 1984;120(3):367–70.
Lovett A, Maari C, Decarie JC, et al. Large congenital melanocytic nevi and neurocutaneous melanocytosis: one pediatric center’s experience. J Am Acad Dermatol. 2009;61(5):766–74.
Marghoob AA. Congenital melanocytic nevi. Evaluation and management. Dermatol Clin. 2002;20(4):607–16.
Marghoob AA, Schoenbach SP, Kopf AW, Orlow SJ, Nossa R, Bart RS. Large congenital melanocytic nevi and the risk for the development of malignant melanoma. A prospective study. Arch Dermatol. 1996;132:170–5.
Marinkovic M, Janjic Z, Nikolic J. Dysplastic nevus—a risk factor of developing skin melanoma clinical and epidemiological study with retrospective review of literature. Med Pregl. 2011;64(5–6):315–8.
Menzies SW, Stevenson ML, Altamura D, Byth K. Variables predicting change in benign melanocytic nevi undergoing short-term dermoscopic imaging. Arch Dermatol. 2011;147(6):655–9.
Monteagudo B, Labandeira J, Acevedo A, et al. Prevalence and clinical features of congenital melanocytic nevi in 1,000 Spanish newborns. Actas Dermosifiliogr. 2011;102(2):114–20.
Murali R, McCarthy SW, Scolyer RA. Blue nevi and related lesions: a review highlighting atypical and newly described variants, distinguishing features and diagnostic pitfalls. Adv Anat Pathol. 2009;16(6):365–82.
Phadke PA, Rakheja D, Le LP, Selim MA, Kapur P, Davis A, et al. Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 cases. Am J Surg Pathol. 2011;35:656.
Rodriguez HA, Ackerman LV. Cellular blue nevus. Clinicopathologic study of forty-five cases. Cancer. 1968;21(3):393–405.
Sepehr A, Chao E, Trefrey B, et al. Long-term outcome of spitz-type melanocytic tumors. Arch Dermatol. 2011;147(10):1173–9.
Van Geel N, Vandenhaute S, Speeckaert R, et al. Prognostic value and clinical significance of halo naevi regarding vitiligo. Br J Dermatol. 2011;164(4):743–9.
Wu J, Rosenbaum E, Begum S, Westra WH. Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis. Am J Dermatopathol. 2007;29(6):534–7.
Zaal LH, Mooi WJ, Klip H, van der Horst CM. Risk of malignant transformation of congenital melanocytic nevi: a retrospective nationwide study from The Netherlands. Plast Reconstr Surg. 2005;116(7):1902–9.
Zalaudek I, Schmid K, Marghoob AA, et al. Frequency of dermoscopic nevus subtypes by age and body site: a cross-sectional study. Arch Dermatol. 2011;147(6):663–70.
Zeff RA, Freitag A, Grin CM, Grant-Kels JM. The immune response in halo nevi. J Am Acad Dermatol. 1997;37(4):620–4.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Katoulis, A.C., Sgouros, D., Stavrianeas, N.G. (2023). Nevi (Benign Melanocytic). In: Katsambas, A.D., Lotti, T.M., Dessinioti, C., D'Erme, A.M. (eds) European Handbook of Dermatological Treatments. Springer, Cham. https://doi.org/10.1007/978-3-031-15130-9_63
Download citation
DOI: https://doi.org/10.1007/978-3-031-15130-9_63
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-15129-3
Online ISBN: 978-3-031-15130-9
eBook Packages: MedicineMedicine (R0)