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Immune-Mediated Cerebellar Ataxias

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Essentials of Cerebellum and Cerebellar Disorders

Abstract

Immune-mediated cerebellar ataxias (IMCAs) have diverse etiologies. Paraneoplastic cerebellar degeneration, gluten ataxia, and primary autoimmune cerebellar ataxia are discussed in separate chapters. This chapter will discuss the clinical characteristics and pathoimmunological mechanisms of two other IMCAs: (1) postinfectious cerebellitis and Miller Fisher syndrome in which the autoimmunity is triggered by infection, and (2) anti-GAD, anti-VGCC, anti-mGluR1, anti-GluR delta, anti-Caspr2, and anti-DPPX ataxias, in which autoantibodies target synaptic machinery proteins or ion channels/ion channel-related proteins.

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Author information

Authors and Affiliations

  1. Academic Department of Neurosciences, Royal Hallamshire Hospital, Sheffield, UK

    Marios Hadjivassiliou

  2. Department of Medical Education, Tokyo Medical University, Tokyo, Japan

    Hiroshi Mitoma

Authors
  1. Marios Hadjivassiliou
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  2. Hiroshi Mitoma
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Corresponding author

Correspondence to Marios Hadjivassiliou .

Editor information

Editors and Affiliations

  1. Neuroscience Department, The Scripps Research Institute, La Jolla, CA, USA

    Donna L. Gruol

  2. Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  3. Service de Neurologie, CHU-Charleroi, Charleroi, Belgium

    Mario Manto

  4. Clinical Translational Research, Santa Lucia Foundation, Rome, Italy

    Marco Molinari

  5. Ataxia Center, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Jeremy D. Schmahmann

  6. Department of Physiology, Zhejiang University School of Medicine, Hangzho, China

    Ying Shen

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Hadjivassiliou, M., Mitoma, H. (2023). Immune-Mediated Cerebellar Ataxias. In: Gruol, D.L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J.D., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-15070-8_87

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