Abstract
Localized in vivo magnetic resonance spectroscopy (MRS) is useful for obtaining information on brain metabolism. Many neurological diseases are associated with more or less specific changes of metabolite concentrations, which can be determined from integral peak intensities in MR spectra. The normal neurochemical profile and its changes in pathological conditions including spinocerebellar ataxias, other neurological diseases, and psychiatric disorders were measured in vivo on series of patients and compared with normal values obtained on control subjects. It was shown that changes in cerebellar concentrations of some metabolites could be used as markers for the diagnosis and follow-up of diseases.
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References
Altindag E, Kara B, Baykan B et al (2009) MR spectroscopy findings in Lafora disease. J Neuroimaging 19(4):359–365. https://doi.org/10.1111/j.1552-6569.2008.00325.x
Aoki Y, Kasai K, Yamasue H (2012) Age-related change in brain metabolite abnormalities in autism: a meta-analysis of proton magnetic resonance spectroscopy studies. Transl Psychiatry 2(1):e69. https://doi.org/10.1038/tp.2011.65
BenAmor L (2014) 1H-magnetic resonance spectroscopy study of stimulant medication effect on brain metabolites in French Canadian children with attention deficit hyperactivity disorder. Neuropsychiatr Dis Treat 10:47–54. https://doi.org/10.2147/NDT.S52338
Boddaert N, Romano S, Funalot B et al (2008) 1H MRS spectroscopy evidence of cerebellar high lactate in mitochondrial respiratory chain deficiency. Mol Genet Metab 93(1):85–88. https://doi.org/10.1016/j.ymgme.2007.09.003
Bustillo JR, Upston J, Mayer EG et al (2020) Glutamatergic hypo-function in the left superior and middle temporal gyri in early schizophrenia: a data-driven three-dimensional proton spectroscopic imaging study. Neuropsychopharmacology 45(11):1851–1859. https://doi.org/10.1038/s41386-020-0707-y
Chen LP, Dai HY, Dai ZZ et al (2014) Anterior cingulate cortex and cerebellar hemisphere neurometabolite changes in depression treatment: a 1H magnetic resonance spectroscopy study. Psychiatry Clin Neurosci 68(5):357–364. https://doi.org/10.1111/pcn.12138
Costa MO, Lacerda MT, Garcia Otaduy MC et al (2002) Proton magnetic resonance spectroscopy: normal findings in the cerebellar hemisphere in childhood. Pediatr Radiol 32(11):787–792. https://doi.org/10.1007/s00247-002-0777-5
Dichgans M, Herzog J, Freilinger T et al (2005) 1H-MRS alterations in the cerebellum of patients with familial hemiplegic migraine type 1. Neurology 64(4):608–613. https://doi.org/10.1212/01.WNL.0000151855.98318.50
Endres D, Tebartz van Elst L, Maier SJ et al (2019) Neurochemical sex differences in adult ADHD patients: an MRS study. Biol Sex Differ 10(1):50. https://doi.org/10.1186/s13293-019-0264-4
Hadjivassiliou M, Wallis LI, Hoggard N et al (2012) MR spectroscopy and atrophy in gluten, Friedreich’s and SCA6 ataxias. Acta Neurol Scand 126(2):138–143. https://doi.org/10.1111/j.1600-0404.2011.01620.x
Harno H, Heikkinen S, Kaunisto MA et al (2005) Decreased cerebellar total creatine in episodic ataxia type 2: a 1H MRS study. Neurology 64(3):542–544. https://doi.org/10.1212/01.WNL.0000150589.26350.3D
Heikkilä O, Mäkimattila S, Timonen M et al (2010) Cerebellar glucose during fasting and acute hyperglycemia in nondiabetic men and in men with type 1 diabetes. Cerebellum 9:336–344
Ichikawa K, Kikuchi M, Takeshita S et al (2009) A case of chronic recurrent cerebellar ataxia responding to steroid therapy. Brain Dev 31(1):83–85. https://doi.org/10.1016/j.braindev.2008.04.010
Iltis I, Hutter D, Bushara KO et al (2010) 1H MR spectroscopy in Friedreich’s ataxia and ataxia with oculomotor apraxia type 2. Brain Res 1358:200–210. https://doi.org/10.1016/j.brainres.2010.08.030
Ipser JC, Syal S, Bentley J et al (2012) 1H-MRS in autism spectrum disorders: a systematic meta-analysis. Metab Brain Dis 27(3):275–287. https://doi.org/10.1007/s11011-012-9293-y
Kahl KG, Atalaya S, Maudsley AA et al (2020) Altered neurometabolism in major depressive disorder: a whole brain 1H magnetic resonance spectroscopic imaging study at 3T. Prog Neuro-Psychopharmacol Biol Psychiatry 101:109916. https://doi.org/10.1016/j.pnpbp.2020.109916
Krahe J, Binkofski F, Schulz JB et al (2020) Neurochemical profiles in hereditary ataxias: a meta-analysis of magnetic resonance spectroscopy studies. Neurosci Biobehav Rev 108:854–865. https://doi.org/10.1016/j.neubiorev.2019.12.019
Lai S, Zhonga S, Shan Y et al (2019) Altered biochemical metabolism and its lateralization in the cortico-striatocerebellar circuit of unmedicated bipolar II depression. J Affect Disord 259:82–90. https://doi.org/10.1016/j.jad.2019.07.021
Lirng JF, Wang PS, Chen HC et al (2012) Differences between spinocerebellar ataxias and multiple system atrophy-cerebellar type on proton magnetic resonance spectroscopy. PLoS One 7(10):e47925
Long L, Song Y, Zhang L et al (2015) A case-control proton magnetic resonance spectroscopy study confirms cerebellar dysfunction in benign adult familial myoclonic epilepsy. Neuropsychiatr Dis Treat 11:485–491. https://doi.org/10.2147/NDT.S77910
Minati L, Aquino D, Bruzzone MG et al (2010) Quantitation of normal metabolite concentrations in six brain regions by in-vivo 1H-MR spectroscopy. J Med Phys 35(3):154–163. https://doi.org/10.4103/0971-6203.62128
Öz G, Tkáč I (2011) Short-echo, single-shot, full-intensity proton magnetic resonance spectroscopy for neurochemical profiling at 4 T: validation in the cerebellum and brainstem. Magn Reson Med 65(49):901–910. https://doi.org/10.1002/mrm.22708
Öz G, Hutter D, Tkáč I et al (2010) Neurochemical alterations in spinocerebellar ataxia type 1 and their correlations with clinical status. Mov Disord 25(9):1253–1261. https://doi.org/10.1002/mds.23067
Öz G, Iltis I, Hutter D et al (2011) Distinct neurochemical profiles of spinocerebellar ataxias 1, 2, 6, and cerebellar multiple system atrophy. Cerebellum 10(2):208–217. https://doi.org/10.1007/s12311-010-0213-6
Öz G, Harding IH, Krahe J et al (2020) MR imaging and spectroscopy in degenerative ataxias: toward multimodal, multisite, multistage monitoring of neurodegeneration. Curr Opin Neurol 33(4):451–461. https://doi.org/10.1097/WCO.0000000000000834
Perlov E, Tebarzt van Elst L, Buechert M et al (2010) H1-MR-spectroscopy of cerebellum in adult attention deficit/hyperactivity disorder. J Psychiatr Res 44(14):938–943. https://doi.org/10.1016/j.jpsychires.2010.02.016
Piras F, Piras F, Banaj N et al (2019) Cerebellar GABAergic correlates of cognition-mediated verbal fluency in physiology and schizophrenia. Acta Psychiatr Scand 139(6):582–594. https://doi.org/10.1111/acps.13027
Piras F, Vecchio D, Assogna F et al (2020) Cerebellar GABA levels and cognitive interference in Parkinson’s disease and healthy comparators. J Pers Med 11(1):16. https://doi.org/10.3390/jpm11010016
Striano P, Caranci F, Di Benedetto R et al (2009) 1H-MR spectroscopy indicates prominent cerebellar dysfunction in benign adult familial myoclonic epilepsy. Epilepsia 50(6):1491–1497. https://doi.org/10.1111/j.1528-1167.2008.01900.x
Tomiyasu M, Aida N, Mitani T et al (2012) Acute hemicerebellitis in a pediatric patient: a case report of a serial MR spectroscopy study. Acta Radiol 53(2):223–227. https://doi.org/10.1258/ar.2011.110339
Tomiyasu M, Aida N, Endo M et al (2013) Neonatal brain metabolite concentrations: an in vivo magnetic resonance spectroscopy study with a clinical MR system at 3 tesla. PLoS One 8(11):e82746. https://doi.org/10.1371/journal.pone.0082746
Weber-Fahr W, Englisch S, Esser A et al (2013) Altered phospholipid metabolism in schizophrenia: a phosphorus 31 nuclear magnetic resonance spectroscopy study. Psychiatry Res 214(3):365–373. https://doi.org/10.1016/j.pscychresns.2013.06.011
Zaaraoui W, Reuter F, Rico A et al (2011) Occurrence of neuronal dysfunction during the first 5 years of multiple sclerosis is associated with cognitive deterioration. J Neurol 258(5):811–819. https://doi.org/10.1007/s00415-010-5845-4
Zielman R, Teeuwisse WM, Bakels F et al (2014) Biochemical changes in the brain of hemiplegic migraine patients measured with 7 tesla 1H-MRS. Cephalalgia 34(12):959–967. https://doi.org/10.1177/0333102414527016
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Mlynárik, V. (2023). MR Spectroscopy. In: Gruol, D.L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J.D., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-15070-8_52
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DOI: https://doi.org/10.1007/978-3-031-15070-8_52
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