Abstract
In contrast with the original Motor Learning Theory that included a single form of plasticity at the parallel fiber—Purkinje cell synapse, recent experimental work has revealed multiple forms of long-term synaptic and non-synaptic plasticity (some of which are bidirectional) distributed among the cerebellar cortex and deep cerebellar nuclei. Thus, understanding cerebellar plasticity requires now that the spatiotemporal interplay of these multiple mechanisms is analyzed during specific behaviors. A recent set of experimental and modeling investigations has opened a new view on how the multiple forms of long-term synaptic plasticity might cooperate to generate cerebellar learning and memory in sensorimotor control tasks.
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Acknowledgments
We thank Simona Tritto for technical assistance. This work received funding from the European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Framework Partnership Agreement No. 650003 (HBP FPA) to ED.
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D’Angelo, E. (2023). Distributed Plasticity in the Cerebellar Circuit. In: Gruol, D.L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J.D., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-15070-8_39
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