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Grafting

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Essentials of Cerebellum and Cerebellar Disorders

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Abstract

Neurotransplantation is as a potential therapeutic method for diseases of the nervous system, including the cerebellum. Experiments on laboratory animals have shown many promising results, but also potential risks and limitations, with many questions remaining unanswered. We discuss the main goals of neurotransplantation as a treatment of cerebellar disorders, potential graft effect mechanisms, types of grafts with their advantages and disadvantages, and problems of graft development and functional integration.

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Authors and Affiliations

  1. Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University, Plzen, Czech Republic

    Jan Cendelin & Zdenka Purkartova

  2. Laboratory of Neurodegenerative Disorders, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Plzen, Czech Republic

    Jan Cendelin

Authors
  1. Jan Cendelin
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  2. Zdenka Purkartova
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Corresponding author

Correspondence to Jan Cendelin .

Editor information

Editors and Affiliations

  1. Neuroscience Department, The Scripps Research Institute, La Jolla, CA, USA

    Donna L. Gruol

  2. Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  3. Service de Neurologie, CHU-Charleroi, Charleroi, Belgium

    Mario Manto

  4. Clinical Translational Research, Santa Lucia Foundation, Rome, Italy

    Marco Molinari

  5. Ataxia Center, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Jeremy D. Schmahmann

  6. Department of Physiology, Zhejiang University School of Medicine, Hangzho, China

    Ying Shen

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Cendelin, J., Purkartova, Z. (2023). Grafting. In: Gruol, D.L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J.D., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-15070-8_109

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