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Brain and Spinal Cord Tumors Among the Life-Threatening Health Problems: An Introduction

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Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 1

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1394))

Abstract

As one of the global concerns, cancers, including brain and spinal cord tumors, are responsible for mortalities and irreversible morbidities in the affected patients. Although advancements in molecular pathology and imaging of tumors may have influenced the incidence rate due to higher diagnosis in early stages, exposure to environmental risk factors could be another explanation for increased incidence of these tumors over the past decades. Similar to many other tumors, the CNS tumors begin in cellular dimension with activation of different molecular pathways. Several genetic, epigenetic, and immunologic pathways and processes are already discovered to play roles in pathophysiology of these tumors, which mostly will eventually become symptomatic. Each of these tumors may exhibit imaging characteristics, making it possible to list a series of differential diagnosis before histopathologic examination. Advances in molecular pathology have resulted in better understanding and categorization of CNS tumors, leading to better decision-making on the most appropriate therapeutic approach for each category, as well as proposing new therapeutic modalities to treat these tumors. As an introduction to the 2-volume book, this chapter addressed different types of human brain and spinal cord tumors based on the fifth version of WHO classification of CNS tumors.

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Authors and Affiliations

  1. Department of Neurosurgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Arad Iranmehr, Mohamad Namvar & Sara Hanaei

  2. Department of Immunology, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Nima Rezaei

  3. Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Nima Rezaei & Sara Hanaei

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  1. Arad Iranmehr
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Correspondence to Sara Hanaei .

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  1. Department of Immunology, School of Medicine, Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Nima Rezaei

  2. Department of Neurosurgery, Imam Khomeini Hospital Complex, Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Sara Hanaei

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Iranmehr, A., Namvar, M., Rezaei, N., Hanaei, S. (2023). Brain and Spinal Cord Tumors Among the Life-Threatening Health Problems: An Introduction. In: Rezaei, N., Hanaei, S. (eds) Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 1. Advances in Experimental Medicine and Biology, vol 1394. Springer, Cham. https://doi.org/10.1007/978-3-031-14732-6_1

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