Abstract
Organizing pneumonia (OP) and usual interstitial pneumonia (UIP) are two histopathologic patterns of interstitial lung disease and are each associated with different clinical presentations. Recognition of either pattern is important, especially because UIP is the typical histopathologic pattern of idiopathic pulmonary fibrosis (IPF), which has significant prognostic and treatment implications. OP and UIP have histologic features that can be conflated at first glance, namely, the so-called Masson bodies of OP and the often-seen “fibroblastic foci” of UIP pattern. Careful examination of the pattern and distribution of fibrosis and findings of honeycomb change are helpful in establishing a pathologic diagnosis of UIP. Clinical and radiologic correlations are also important in forming an accurate differential diagnosis. OP is nonspecific and can be seen in a variety of diseases (including acute exacerbations of UIP). The diagnosis of cryptogenic organizing pneumonia (COP) can only be made in the absence of other findings and etiologies for lung disease.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Khan A, Al-Ghanem S, Al-Jahdali H, Bamefleh H. Bronchiolitis obliterans organizing pneumonia: pathogenesis, clinical features, imaging and therapy review. Ann Thorac Med. 2008;3(2):67.
Cordier J. Cryptogenic organising pneumonia. Eur Respir J. 2006;28(2):422–46.
King TE, Mortenson RL. Cryptogenic organizing pneumonitis. The North American experience. Chest. 1992;102(1):8S.
Travis W, Costabel U, Hansell D, King T, Lynch D, Nicholson A, et al. An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 2013;188(6):733–48.
Freudenberger T. Association between acute and chronic graft-versus-host disease and bronchiolitis obliterans organizing pneumonia in recipients of hematopoietic stem cell transplants. Blood. 2003;102(10):3822–8.
Armanios M. Telomerase and idiopathic pulmonary fibrosis. Mutat Res. 2012;730(1–2):52–8.
Raghu G, Remy-Jardin M, Myers J, Richeldi L, Ryerson C, Lederer D, et al. Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT clinical practice guideline. Am J Respir Crit Care Med. 2018;198(5):e44–68.
King T, Bradford W, Castro-Bernardini S, Fagan E, Glaspole I, Glassberg M, et al. A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med. 2014;370(22):2083–92.
Richeldi L, du Bois R, Raghu G, Azuma A, Brown K, Costabel U, et al. Efficacy and safety of Nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014;370(22):2071–82.
Cavazza A, Rossi G, Carbonelli C, Spaggiari L, Paci M, Roggeri A. The role of histology in idiopathic pulmonary fibrosis: an update. Respir Med. 2010;104:S11–22.
Kim SJ, Lee KS, Ryu YH, Yoon YC, Choe KO, Kim TS, et al. Reversed halo sign on high-resolution CT of cryptogenic organizing pneumonia: diagnostic implications. Am J Roentgenol. 2003;180(5):1251–4.
Maturu VN, Agarwal R. Reversed halo sign: a systematic review. Respir Care. 2014;59(9):1440–9.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Mau, B., Johnson, L.N., Xu, H. (2022). Organizing Pneumonia Versus Usual Interstitial Pneumonia. In: Xu, H., Ricciotti, R.W., Mantilla, J.G. (eds) Practical Lung Pathology. Practical Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-031-14402-8_40
Download citation
DOI: https://doi.org/10.1007/978-3-031-14402-8_40
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-14401-1
Online ISBN: 978-3-031-14402-8
eBook Packages: MedicineMedicine (R0)