Abstract
Primary synovial sarcoma (SS) and solitary fibrous tumor (SFT) are both uncommon pulmonary mesenchymal neoplasms. Clinically and morphologically, monophasic SS can closely mimic SFT. Both SS and SFT are predominantly pleural-based tumors composed of monotonous spindle cells accompanied by staghorn-like blood vessels. Immunohistochemically, both tumors can express EMA, CD99, BCL2, and other nonspecific markers. Pulmonary SS is an aggressive neoplasm with a poor survival rate, while SFT generally follows an indolent behavior with most patients cured by complete resection. Thus, correct diagnosis is crucial for patient care. In this chapter, we describe the clinical and pathologic features of SS and SFT, and summarize the histologic, immunohistochemical, and molecular features that are helpful in distinguishing between these two neoplasms.
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Zhu, H. (2022). Synovial Sarcoma Versus Solitary Fibrous Tumor. In: Xu, H., Ricciotti, R.W., Mantilla, J.G. (eds) Practical Lung Pathology. Practical Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-031-14402-8_25
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DOI: https://doi.org/10.1007/978-3-031-14402-8_25
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