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Diabetes Mellitus and Microbiota: Knowledge and Perspectives

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Gut Microbiota in Aging and Chronic Diseases

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 17))

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Abstract

Diabetes mellitus is a global epidemic disease constantly increasing, due to genetic predisposition and behavioral risk factors, with etiological mechanisms not completely defined. Moreover, diabetes can induce critical complications that damage the heart, vessels, kidney, eye and nerves, with important alterations in the quality and quantity of life. Gut microbiota represents a topic of growing interest in clinical research and several studies have focused their attention on the possible interplay between metabolic diseases and alteration in gut microbiota. A different composition in bacterial phyla and species among patients with type 1 and type 2 diabetes mellitus and healthy people has been observed, with some differences in patients with complications. The purpose of this chapter is to show current knowledge on the composition of gut microbiota in diabetic patients, the relationship between diabetic treatments and gut microbiota and the possible advantages in the prevention and therapy of diabetes through the action on the microbiota by the use of prebiotics, probiotics and fecal transplant.

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Authors and Affiliations

  1. Diabetes Care Unit Fondazione Policlinico Universitario, Agostino Gemelli IRCCs-Catholic University, Rome, Italy

    Gaetano Emanuele Rizzo, Alessandro Rizzi, Linda Tartaglione, Maria Laura Leo, Luca Viti, Mauro Di Leo & Dario Pitocco

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  1. Gaetano Emanuele Rizzo
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  2. Alessandro Rizzi
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  3. Linda Tartaglione
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  4. Maria Laura Leo
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Correspondence to Dario Pitocco .

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  1. ReGenera R&D International for Aging Intervention, Milan, Italy

    Francesco Marotta

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Rizzo, G.E. et al. (2023). Diabetes Mellitus and Microbiota: Knowledge and Perspectives. In: Marotta, F. (eds) Gut Microbiota in Aging and Chronic Diseases. Healthy Ageing and Longevity, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-031-14023-5_7

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