Abstract
The gut microbiome is recognized as an important component in determining the health status of ageing individuals due to its role in modulating digestive functions, immunity and resistance to pathogen infections, and cognitive functions. Microbial data from long-lived individuals showed the progressive transition to a peculiar elderly-type microbiome, often related to immunosenescence, inflammageing, and frailty, along with the emergence of some possibly ageing-supportive features. Here, we extensively describe the characteristics of such a microbiome configuration, with a focus on the concomitant ageing-associated unavoidable physiological modifications, in order to bring out the close connections between the human host and its microbial counterpart.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Alemán JO, Bokulich NA, Swann JR, Walker JM, De Rosa JC, Battaglia T, Costabile A, Pechlivanis A, Liang Y, Breslow JL, Blaser MJ, Holt PR (2018) Fecal microbiota and bile acid interactions with systemic and adipose tissue metabolism in diet-induced weight loss of obese postmenopausal women. J Transl Med 16(1):244. https://doi.org/10.1186/s12967-018-1619-z.PMID:30176893;PMCID:PMC6122649
Araos R, Battaglia T, Ugalde JA, Rojas-Herrera M, Blaser MJ, D’Agata EMC (2019) Fecal microbiome characteristics and the resistome associated with acquisition of multidrug-resistant organisms among elderly subjects. Front Microbiol 10:2260. https://doi.org/10.3389/fmicb.2019.02260
Balamurugan R, George G, Kabeerdoss J, Hepsiba J, Chandragunasekaran AM, Ramakrishna BS (2010) Quantitative differences in intestinal Faecalibacterium prausnitzii in obese Indian children. Br J Nutr 103(3):335–338. https://doi.org/10.1017/S0007114509992182 Epub 2009 Oct 23 PMID: 19849869
Barone M, D’Amico F, Fabbrini M, Rampelli S, Brigidi P, Turroni S (2021) Over-feeding the gut microbiome: a scoping review on health implications and therapeutic perspectives. World J Gastroenterol 27(41):7041–7064. https://doi.org/10.3748/wjg.v27.i41.7041.PMID:34887627;PMCID:PMC8613651
Bartosch S, Fite A, Macfarlane GT, McMurdo ME (2004) Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota. Appl Environ Microbiol 70(6):3575–3581. https://doi.org/10.1128/AEM.70.6.3575-3581.2004.PMID:15184159;PMCID:PMC427772
Beaumont M, Goodrich JK, Jackson MA, Yet I, Davenport ER, Vieira-Silva S, Debelius J, Pallister T, Mangino M, Raes J, Knight R, Clark AG, Ley RE, Spector TD, Bell JT (2016) Heritable components of the human fecal microbiome are associated with visceral fat. Genome Biol 17(1):189. https://doi.org/10.1186/s13059-016-1052-7.PMID:27666579;PMCID:PMC5036307
Biagi E, Nylund L, Candela M, Ostan R, Bucci L, Pini E, Nikkïla J, Monti D, Satokari R, Franceschi C, Brigidi P, De Vos W (2010) Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS ONE 5(5):e10667. https://doi.org/10.1371/journal.pone.0010667.Erratum.In:PLoSOne.2010;5(6).doi:10.1371/annotation/df45912f-d15c-44ab-8312-e7ec0607604d.PMID:20498852;PMCID:PMC2871786
Biagi E, Candela M, Fairweather-Tait S, Franceschi C, Brigidi P (2012) Aging of the human metaorganism: the microbial counterpart. Age (dordr) 34(1):247–267. https://doi.org/10.1007/s11357-011-9217-5
Biagi E, Franceschi C, Rampelli S, Severgnini M, Ostan R, Turroni S, Consolandi C, Quercia S, Scurti M, Monti D, Capri M, Brigidi P, Candela M (2016) Gut Microbiota and Extreme Longevity. Curr Biol 26(11):1480–1485. https://doi.org/10.1016/j.cub.2016.04.016 Epub 2016 May 12 PMID: 27185560
Bolyen E, Rideout JR, Dillon MR, Bokulich NA, Abnet CC, Al-Ghalith GA, Alexander H, Alm EJ, Arumugam M, Asnicar F, Bai Y, Bisanz JE, Bittinger K, Brejnrod A, Brislawn CJ, Brown CT, Callahan BJ, Caraballo-Rodríguez AM, Chase J, Cope EK, Da Silva R, Diener C, Dorrestein PC, Douglas GM, Durall DM, Duvallet C, Edwardson CF, Ernst M, Estaki M, Fouquier J, Gauglitz JM, Gibbons SM, Gibson DL, Gonzalez A, Gorlick K, Guo J, Hillmann B, Holmes S, Holste H, Huttenhower C, Huttley GA, Janssen S, Jarmusch AK, Jiang L, Kaehler BD, Kang KB, Keefe CR, Keim P, Kelley ST, Knights D, Koester I, Kosciolek T, Kreps J, Langille MGI, Lee J, Ley R, Liu YX, Loftfield E, Lozupone C, Maher M, Marotz C, Martin BD, McDonald D, McIver LJ, Melnik AV, Metcalf JL, Morgan SC, Morton JT, Naimey AT, Navas-Molina JA, Nothias LF, Orchanian SB, Pearson T, Peoples SL, Petras D, Preuss ML, Pruesse E, Rasmussen LB, Rivers A, Robeson MS 2nd, Rosenthal P, Segata N, Shaffer M, Shiffer A, Sinha R, Song SJ, Spear JR, Swafford AD, Thompson LR, Torres PJ, Trinh P, Tripathi A, Turnbaugh PJ, Ul-Hasan S, van der Hooft JJJ, Vargas F, Vázquez-Baeza Y, Vogtmann E, von Hippel M, Walters W, Wan Y, Wang M, Warren J, Weber KC, Williamson CHD, Willis AD, Xu ZZ, Zaneveld JR, Zhang Y, Zhu Q, Knight R, Caporaso JG (2019 Aug) Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat Biotechnol 37(8):852–857. https://doi.org/10.1038/s41587-019-0209-9.Erratum.In:NatBiotechnol.2019Sep;37(9):1091.PMID:31341288;PMCID:PMC7015180
Bruno P, Caselli M, de Gennaro G, Iacobellis S, Tutino M (2008) Monitoring of volatile organic compounds in non-residential indoor environments. Indoor Air 18(3):250–256. https://doi.org/10.1111/j.1600-0668.2008.00528.x Epub 2008 Apr 21 PMID: 18429995
Bruno P, Caselli M, de Gennaro G, Scolletta L, Trizio L, Tutino M (2008) Assessment of the impact produced by the traffic source on VOC level in the urban area of Canosa di Puglia (Italy). Water Air Soil Pollut 193:37–50. https://doi.org/10.1007/s11270-008-9666-3
Buczynska AJ, Krata A, Stranger M, Locateli Godoi AF, Kontozova-Deutsch V, Bencs L, Naveau I, Roekens E, Van Grieken R (2009) Atmospheric BTEX-concentrations in an area with intensive street traffic. Atmos Environ 43:311–318. https://doi.org/10.1016/j.atmosenv.2008.09.071
Claesson MJ, Jeffery IB, Conde S, Power SE, O’Connor EM, Cusack S, Harris HM, Coakley M, Lakshminarayanan B, O’Sullivan O, Fitzgerald GF, Deane J, O’Connor M, Harnedy N, O’Connor K, O’Mahony D, van Sinderen D, Wallace M, Brennan L, Stanton C, Marchesi JR, Fitzgerald AP, Shanahan F, Hill C, Ross RP, O’Toole PW (2012) Gut microbiota composition correlates with diet and health in the elderly. Nature 488(7410):178–184. https://doi.org/10.1038/nature11319 PMID: 22797518
Claesson MJ, Wang Q, O'Sullivan O, Greene-Diniz R, Cole JR, Ross RP, O'Toole PW (2010) Comparison of two next-generation sequencing technologies for resolving highly complex microbiota composition using tandem variable 16S rRNA gene regions. Nucleic Acids Res 38(22):e200. https://doi.org/10.1093/nar/gkq873. Epub 2010 Sep 29. PMID: 20880993; PMCID: PMC3001100
Collino S, Montoliu I, Martin FP, Scherer M, Mari D, Salvioli S, Bucci L, Ostan R, Monti D, Biagi E, Brigidi P, Franceschi C, Rezzi S (2013) Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism. PLoS One 8(3):e56564. https://doi.org/10.1371/journal.pone.0056564. Epub 2013 Mar 6. Erratum in: PLoS One. 2013;8(8). https://doi.org/10.1371/annotation/5fb9fa6f-4889-4407-8430-6dfc7ecdfbdd. PMID: 23483888; PMCID: PMC3590212
D’Amico F, Soverini M, Zama D, Consolandi C, Severgnini M, Prete A, Pession A, Barone M, Turroni S, Biagi E, Brigidi P, Masetti R, Rampelli S, Candela M (2019) Gut resistome plasticity in pediatric patients undergoing hematopoietic stem cell transplantation. Sci Rep 9:5649. https://doi.org/10.1038/s41598-019-42222-w
Duvallet C, Gibbons SM, Gurry T, Irizarry RA, Alm EJ (2017) Meta-analysis of gut microbiome studies identifies disease-specific and shared responses. Nat Commun 8(1):1784. https://doi.org/10.1038/s41467-017-01973-8.PMID:29209090;PMCID:PMC5716994
Eren AM, Borisy GG, Huse SM, Mark Welch JL. Oligotyping analysis of the human oral microbiome. Proc Natl Acad Sci USA 111(28):E2875–84. https://doi.org/10.1073/pnas.1409644111. Epub 2014 Jun 25. PMID: 24965363; PMCID: PMC4104879
Esplugues A, Ballester F, Estarlich M, Llop S, Fuentes-Leonarte V, Mantilla E, Iñiguez C (2010) Indoor and outdoor air concentrations of BTEX and determinants in a cohort of one-year old children in Valencia, Spain. Sci Total Environ 409(1):63–69. https://doi.org/10.1016/j.scitotenv.2010.09.039 Epub 2010 Oct 20 PMID: 20965548
Fassarella M, Blaak EE, Penders J, Nauta A, Smidt H, Zoetendal EG (2021) Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health. Gut 70(3):595–605. https://doi.org/10.1136/gutjnl-2020-321747 Epub 2020 Oct 13 PMID: 33051190
Forslund K, Sunagawa S, Kultima JR, Mende DR, Arumugam M, Typas A, Bork P (2013) Country-specific antibiotic use practices impact the human gut resistome. Genome Res 23(7):1163–9. https://doi.org/10.1101/gr.155465.113. Epub 2013 Apr 8. PMID: 23568836; PMCID: PMC3698509
Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A (2018) Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol 14(10):576–590. https://doi.org/10.1038/s41574-018-0059-4 PMID: 30046148
Gasparrini AJ, Wang B, Sun X, Kennedy EA, Hernandez-Leyva A, Ndao IM, Tarr PI, Warner BB, Dantas G (2019) Persistent metagenomic signatures of early-life hospitalization and antibiotic treatment in the infant gut microbiota and resistome. Nat Microbiol 4:2285–2297. https://doi.org/10.1038/s41564-019-0550-2
Ghosh TS, Rampelli S, Jeffery IB, Santoro A, Neto M, Capri M, Giampieri E, Jennings A, Candela M, Turroni S, Zoetendal EG, Hermes GDA, Elodie C, Meunier N, Brugere CM, Pujos-Guillot E, Berendsen AM, De Groot LCPGM, Feskins EJM, Kaluza J, Pietruszka B, Bielak MJ, Comte B, Maijo-Ferre M, Nicoletti C, De Vos WM, Fairweather-Tait S, Cassidy A, Brigidi P, Franceschi C, O'Toole PW (2020) Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries. Gut 69(7):1218–1228. https://doi.org/10.1136/gutjnl-2019-319654. Epub 2020 Feb 17. PMID: 32066625; PMCID: PMC7306987
Giarratano A, Green SE, Nicolau DP (2018) Review of antimicrobial use and considerations in the elderly population. Clin Interv Aging 17(13):657–667. https://doi.org/10.2147/CIA.S133640.PMID:29713150;PMCID:PMC5909780
Guigoz Y, Doré J, Schiffrin EJ (2008) The inflammatory status of old age can be nurtured from the intestinal environment. Curr Opin Clin Nutr Metab Care 11(1):13–20. https://doi.org/10.1097/MCO.0b013e3282f2bfdf PMID: 18090652
Hartmann EM, Hickey R, Hsu T, Betancourt Román CM, Chen J, Schwager R, Kline J, Brown GZ, Halden RU, Huttenhower C, Green JL (2016) Antimicrobial chemicals are associated with elevated antibiotic resistance genes in the indoor dust microbiome. Environ Sci Technol 50(18):9807–15. https://doi.org/10.1021/acs.est.6b00262. Epub 2016 Sep 7. PMID: 27599587; PMCID: PMC5032049
He Y, Wu W, Zheng HM, Li P, McDonald D, Sheng HF, Chen MX, Chen ZH, Ji GY, Zheng ZD, Mujagond P, Chen XJ, Rong ZH, Chen P, Lyu LY, Wang X, Wu CB, Yu N, Xu YJ, Yin J, Raes J, Knight R, Ma WJ, Zhou HW (2018) Author correction: regional variation limits applications of healthy gut microbiome reference ranges and disease models. Nat Med 24(12):1940. https://doi.org/10.1038/s41591-018-0219-z.Erratumfor:NatMed.2018Oct;24(10):1532-1535 PMID: 30250144
Helmink BA, Khan MAW, Hermann A, Gopalakrishnan V, Wargo JA (2019 Mar) The microbiome, cancer, and cancer therapy. Nat Med 25(3):377–388. https://doi.org/10.1038/s41591-019-0377-7 Epub 2019 Mar 6 PMID: 30842679
Holeček M (2018 May) Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements. Nutr Metab (lond) 3(15):33. https://doi.org/10.1186/s12986-018-0271-1.PMID:29755574;PMCID:PMC5934885
Hu Y, Yang X, Qin J, Lu N, Cheng G, Wu N, Pan Y, Li J, Zhu L, Wang X, Meng Z, Zhao F, Liu D, Ma J, Qin N, Xiang C, Xiao Y, Li L, Yang H, Wang J, Yang R, Gao GF, Wang J, Zhu B (2013) Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota. Nat Commun 4:2151. https://doi.org/10.1038/ncomms3151 PMID: 23877117
Huseyin CE, O’Toole PW, Cotter PD, Scanlan PD (2017) Forgotten fungi-the gut mycobiome in human health and disease. FEMS Microbiol Rev 41(4):479–511. https://doi.org/10.1093/femsre/fuw047 PMID: 28430946
Integrative HMP (iHMP) Research Network Consortium (2019) The integrative human microbiome project. Nature 569(7758):641–648. https://doi.org/10.1038/s41586-019-1238-8. Epub 2019 May 29. PMID: 31142853; PMCID: PMC6784865
Jeffery IB, Lynch DB, O'Toole PW (2016) Composition and temporal stability of the gut microbiota in older persons. ISME J 10(1):170–82. https://doi.org/10.1038/ismej.2015.88. Epub 2015 Jun 19. PMID: 26090993; PMCID: PMC4681863
Koh A, De Vadder F, Kovatcheva-Datchary P, Bäckhed F (2016) From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 165(6):1332–1345. https://doi.org/10.1016/j.cell.2016.05.041 PMID: 27259147
Kondo T, Kishi M, Fushimi T, Kaga T (2009) Acetic acid upregulates the expression of genes for fatty acid oxidation enzymes in liver to suppress body fat accumulation. J Agric Food Chem 57(13):5982–5986. https://doi.org/10.1021/jf900470c PMID: 19469536
Kropp C, Le Corf K, Relizani K, Tambosco K, Martinez C, Chain F, Rawadi G, Langella P, Claus SP, Martin R (2021) The Keystone commensal bacterium Christensenella minuta DSM 22607 displays anti-inflammatory properties both in vitro and in vivo. Sci Rep 11(1):11494. https://doi.org/10.1038/s41598-021-90885-1.PMID:34075098;PMCID:PMC8169850
Kundu P, Blacher E, Elinav E, Pettersson S (2017) Our gut microbiome: the evolving inner self. Cell 171(7):1481–1493. https://doi.org/10.1016/j.cell.2017.11.024 PMID: 29245010
Leung K, Thuret S (2015) Gut microbiota: a modulator of brain plasticity and cognitive function in ageing. Healthcare (basel) 3(4):898–916. https://doi.org/10.3390/healthcare3040898.PMID:27417803;PMCID:PMC4934620
Leusch F, Bartkow M (2010). A short primer on benzene, toluene, ethylbenzene and xylenes (BTEX) in the environment and hydraulic fracturing fluids. Smart Water Research Centre, Griffith University, Queensland, Australia. https://environment.des.qld.gov.au/management/coal-seam-gas/pdf/btex-report.pdf
Li J, Cao J, Zhu YG, Chen QL, Shen F, Wu Y, Xu S, Fan H, Da G, Huang RJ, Wang J, de Jesus AL, Morawska L, Chan CK, Peccia J, Yao M (2018) Global survey of antibiotic resistance genes in air. Environ Sci Technol 52(19):10975–10984. https://doi.org/10.1021/acs.est.8b02204 Epub 2018 Jul 25 PMID: 30043612
Liang SY, Mackowiak PA (2007) Infections in the elderly. Clin Geriatr Med 23(2):441–456, viii. https://doi.org/10.1016/j.cger.2007.01.010. PMID: 17462528
Lu Y, Fan C, Li P, Lu Y, Chang X, Qi K (2016) Short Chain fatty acids prevent high-fat-diet-induced obesity in mice by regulating G protein-coupled receptors and gut microbiota. Sci Rep 28(6):37589. https://doi.org/10.1038/srep37589.PMID:27892486;PMCID:PMC5124860
Lynch SV, Pedersen O (2016) The human intestinal microbiome in health and disease. N Engl J Med 375(24):2369–2379. https://doi.org/10.1056/NEJMra1600266 PMID: 27974040
Mahnert A, Moissl-Eichinger C, Zojer M, Bogumil D, Mizrahi I, Rattei T, Martinez JL, Berg G (2019) Man-made microbial resistances in built environments. Nat Commun 10(1):968. https://doi.org/10.1038/s41467-019-08864-0.PMID:30814504;PMCID:PMC6393488
Massolo L, Rehwagen M, Porta A, Ronco A, Herbarth O, Mueller A (2010) Indoor-outdoor distribution and risk assessment of volatile organic compounds in the atmosphere of industrial and urban areas. Environ Toxicol 25(4):339–349. https://doi.org/10.1002/tox.20504 PMID: 19449388
Mueller S, Saunier K, Hanisch C, Norin E, Alm L, Midtvedt T, Cresci A, Silvi S, Orpianesi C, Verdenelli MC, Clavel T, Koebnick C, Zunft HJ, Doré J, Blaut M (2006) Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol 72(2):1027–1033. https://doi.org/10.1128/AEM.72.2.1027-1033.2006.PMID:16461645;PMCID:PMC1392899
Nayfach S, Roux S, Seshadri R, Udwary D, Varghese N, Schulz F, Wu D, Paez-Espino D, Chen IM, Huntemann M, Palaniappan K, Ladau J, Mukherjee S, Reddy TBK, Nielsen T, Kirton E, Faria JP, Edirisinghe JN, Henry CS, Jungbluth SP, Chivian D, Dehal P, Wood-Charlson EM, Arkin AP, Tringe SG, Visel A; IMG/M Data Consortium, Woyke T, Mouncey NJ, Ivanova NN, Kyrpides NC, Eloe-Fadrosh EA (2021) A genomic catalog of Earth's microbiomes. Nat Biotechnol 39(4):499–509. https://doi.org/10.1038/s41587-020-0718-6. Epub 2020 Nov 9. Erratum in: Nat Biotechnol. 2020 Nov 18;: Erratum in: Nat Biotechnol. 2021 Apr 1;: PMID: 33169036; PMCID: PMC8041624
Nicoletti C (2015) Age-associated changes of the intestinal epithelial barrier: local and systemic implications. Expert Rev Gastroenterol Hepatol 9(12):1467–1469. https://doi.org/10.1586/17474124.2015.1092872 Epub 2015 Sep 22 PMID: 26395417
Noto D, Fayer F, Cefalù AB, Altieri I, Palesano O, Spina R, Valenti V, Pitrone M, Pizzolanti G, Barbagallo CM, Giordano C, Averna MR (2016) Myristic acid is associated to low plasma HDL cholesterol levels in a Mediterranean population and increases HDL catabolism by enhancing HDL particles trapping to cell surface proteoglycans in a liver hepatoma cell model. Atherosclerosis 246:50–56. https://doi.org/10.1016/j.atherosclerosis.2015.12.036 Epub 2015 Dec 28 PMID: 26756970
Oki K, Toyama M, Banno T, Chonan O, Benno Y, Watanabe K (2016) Comprehensive analysis of the fecal microbiota of healthy Japanese adults reveals a new bacterial lineage associated with a phenotype characterized by a high frequency of bowel movements and a lean body type. BMC Microbiol 16(1):284. https://doi.org/10.1186/s12866-016-0898-x.PMID:27894251;PMCID:PMC5127096
Qato DM, Wilder J, Schumm LP, Gillet V, Alexander GC (2016) Changes in prescription and over-the-counter medication and dietary supplement use among older adults in the United States, 2005 vs 2011. JAMA Intern Med 176(4):473–482. https://doi.org/10.1001/jamainternmed.2015.8581.PMID:26998708;PMCID:PMC5024734
Rampelli S, Soverini M, D'Amico F, Barone M, Tavella T, Monti D, Capri M, Astolfi A, Brigidi P, Biagi E, Franceschi C, Turroni S, Candela M (2020) Shotgun metagenomics of gut microbiota in humans with up to extreme longevity and the increasing role of xenobiotic degradation. mSystems 5(2):e00124–20. https://doi.org/10.1128/mSystems.00124-20. PMID: 32209716; PMCID: PMC7093822
Sato Y, Atarashi K, Plichta DR, Arai Y, Sasajima S, Kearney SM, Suda W, Takeshita K, Sasaki T, Okamoto S, Skelly AN, Okamura Y, Vlamakis H, Li Y, Tanoue T, Takei H, Nittono H, Narushima S, Irie J, Itoh H, Moriya K, Sugiura Y, Suematsu M, Moritoki N, Shibata S, Littman DR, Fischbach MA, Uwamino Y, Inoue T, Honda A, Hattori M, Murai T, Xavier RJ, Hirose N, Honda K (2021) Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians. Nature 599(7885):458–464. https://doi.org/10.1038/s41586-021-03832-5 Epub 2021 Jul 29 PMID: 34325466
Shkoporov AN, Clooney AG, Sutton TDS, Ryan FJ, Daly KM, Nolan JA, McDonnell SA, Khokhlova EV, Draper LA, Forde A, Guerin E, Velayudhan V, Ross RP, Hill C (2019) The human gut virome is highly diverse, stable, and individual specific. Cell Host Microbe 26(4):527-541.e5. https://doi.org/10.1016/j.chom.2019.09.009 PMID: 31600503
Sommer MOA, Dantas G, Church GM (2009) Functional characterization of the antibiotic resistance reservoir in the human microflora. Science 325(5944):1128–1131. https://doi.org/10.1126/science.1176950.PMID:19713526;PMCID:PMC4720503
Song MY, Chun H (2021) Species and characteristics of volatile organic compounds emitted from an auto-repair painting workshop. Sci Rep 11(1):16586. https://doi.org/10.1038/s41598-021-96163-4.PMID:34400724;PMCID:PMC8368184
Stark AH, Crawford MA, Reifen R (2008) Update on alpha-linolenic acid. Nutr Rev 66(6):326–332. https://doi.org/10.1111/j.1753-4887.2008.00040.x PMID: 18522621
Tavella T, Turroni S, Brigidi P, Candela M, Rampelli S (2021a) The human gut resistome up to extreme longevity. mSphere 6(5):e0069121. https://doi.org/10.1128/mSphere.00691-21. Epub 2021a Sep 8. PMID: 34494880; PMCID: PMC8550338
Tavella T, Rampelli S, Guidarelli G, Bazzocchi A, Gasperini C, Pujos-Guillot E, Comte B, Barone M, Biagi E, Candela M, Nicoletti C, Kadi F, Battista G, Salvioli S, O'Toole PW, Franceschi C, Brigidi P, Turroni S, Santoro A (2021b) Elevated gut microbiome abundance of Christensenellaceae, Porphyromonadaceae and Rikenellaceae is associated with reduced visceral adipose tissue and healthier metabolic profile in Italian elderly. Gut Microbes 13(1):1–19. https://doi.org/10.1080/19490976.2021b.1880221.PMID: 33557667; PMCID: PMC7889099
Turroni S, Brigidi P, Cavalli A, Candela M (2018) Microbiota-host transgenomic metabolism, bioactive molecules from the inside. J Med Chem 61(1):47–61. https://doi.org/10.1021/acs.jmedchem.7b00244 Epub 2017 Aug 3 PMID: 28745893
van Tongeren SP, Slaets JP, Harmsen HJ, Welling GW (2005) Fecal microbiota composition and frailty. Appl Environ Microbiol 71(10):6438–6442. https://doi.org/10.1128/AEM.71.10.6438-6442.2005.PMID:16204576;PMCID:PMC1265947
Villa CR, Ward WE, Comelli EM (2017) Gut microbiota-bone axis. Crit Rev Food Sci Nutr 57(8):1664–1672. https://doi.org/10.1080/10408398.2015.1010034 PMID: 26462599
Visconti A, Le Roy CI, Rosa F, Rossi N, Martin TC, Mohney RP, Li W, de Rinaldis E, Bell JT, Venter JC, Nelson KE, Spector TD, Falchi M (2019) Interplay between the human gut microbiome and host metabolism. Nat Commun 10(1):4505. https://doi.org/10.1038/s41467-019-12476-z.PMID:31582752;PMCID:PMC6776654
de Vos WM, Tilg H, Van Hul M, Cani PD (2022) Gut microbiome and health: mechanistic insights. Gut gutjnl-2021–326789. https://doi.org/10.1136/gutjnl-2021-326789. Epub ahead of print. PMID: 35105664
Vujkovic-Cvijin I, Sklar J, Jiang L, Natarajan L, Knight R, Belkaid Y (2020) Host variables confound gut microbiota studies of human disease. Nature 587(7834):448–454. https://doi.org/10.1038/s41586-020-2881-9. Epub 2020 Nov 4. PMID: 33149306; PMCID: PMC7677204
Waters JL, Ley RE (2019 Oct 28) The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health. BMC Biol 17(1):83. https://doi.org/10.1186/s12915-019-0699-4.PMID:31660948;PMCID:PMC6819567
Wilmanski T, Diener C, Rappaport N, Patwardhan S, Wiedrick J, Lapidus J, Earls JC, Zimmer A, Glusman G, Robinson M, Yurkovich JT, Kado DM, Cauley JA, Zmuda J, Lane NE, Magis AT, Lovejoy JC, Hood L, Gibbons SM, Orwoll ES, Price ND (2021) Gut microbiome pattern reflects healthy ageing and predicts survival in humans. Nat Metab 3(2):274–286. https://doi.org/10.1038/s42255-021-00348-0. Epub 2021 Feb 18. Erratum in: Nat Metab. 2021 Apr;3(4):586. PMID: 33619379; PMCID: PMC8169080.Copy
Wu L, Zeng T, Zinellu A, Rubino S, Kelvin DJ, Carru C (2019) A cross-sectional study of compositional and functional profiles of gut microbiota in sardinian centenarians. mSystems 4(4):e00325–19. Published 2019 Jul 9. doi:https://doi.org/10.1128/mSystems.00325-19
Wutthi-In M, Cheevadhanarak S, Yasom S, Kerdphoo S, Thiennimitr P, Phrommintikul A, Chattipakorn N, Kittichotirat W, Chattipakorn S (2020) Gut microbiota profiles of treated metabolic syndrome patients and their relationship with metabolic health. Sci Rep 10(1):10085. https://doi.org/10.1038/s41598-020-67078-3.PMID:32572149;PMCID:PMC7308281
Yao L, Seaton SC, Ndousse-Fetter S, Adhikari AA, DiBenedetto N, Mina AI, Banks AS, Bry L, Devlin AS (2018) A selective gut bacterial bile salt hydrolase alters host metabolism. Elife 17(7):e37182. https://doi.org/10.7554/eLife.37182.PMID:30014852;PMCID:PMC6078496
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Rampelli, S., Turroni, S., Candela, M. (2023). Ageing and Human Gut Microbiome: The Taxonomic and Functional Transition Towards an Elderly-Type Microbiome. In: Marotta, F. (eds) Gut Microbiota in Aging and Chronic Diseases. Healthy Ageing and Longevity, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-031-14023-5_2
Download citation
DOI: https://doi.org/10.1007/978-3-031-14023-5_2
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-14022-8
Online ISBN: 978-3-031-14023-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)