Abstract
BK polyomavirus (BKPyV) and cytomegalovirus (CMV) are major viral pathogens that portend adverse allograft/recipient outcomes. Viral co-infection is synergistic, with BKPyV and CMV stimulating viral cell entry, replication, and immune modulation leading to allograft injury via viral infection and/rejection. Here we describe a case of BK polyomavirus and cytomegalovirus co-infection in a kidney transplant recipient to enhance understanding of and guide management of this unique post-transplant complication.
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References
Hirsch HH, Yakhontova K, Lu M, Manzetti J. BK polyomavirus replication in renal tubular epithelial cells is inhibited by Sirolimus, but activated by tacrolimus through a pathway involving FKBP-12. Am J Transplant. 2016;16(3):821–32.
Srivastava A, Bodnar J, Osman F, Jorgenson MR, Astor BC, Mandelbrot DA, et al. Serum albumin level before kidney transplant predicts post-transplant BK and possibly cytomegalovirus infection. Kidney Int Rep. 2020;5(12):2228–37.
Kristoffersen AK, Johnsen JI, Seternes OM, Rollag H, Degré M, Traavik T. The human polyomavirus BK T antigen induces gene expression in human cytomegalovirus. Virus Res. 1997;52(1):61–71.
Goldstein SC, Tralka TS, Rabson AS. Mixed infection with human cytomegalovirus and human polyomavirus (BKV). J Med Virol. 1984;13(1):33–40.
Pari GS, St Jeor SC. Human cytomegalovirus major immediate early gene product can induce SV40 DNA replication in human embryonic lung cells. Virology. 1990;179(2):785–94.
Herrera S, Bernal-Maurandi J, Cofan F, Ventura P, Marcos MA, Linares L, et al. BK virus and cytomegalovirus coinfections in kidney transplantation and their impact on allograft loss. J Clin Med. 2021;10(17)
Jehn U, Schütte-Nütgen K, Bautz J, Pavenstädt H, Suwelack B, Thölking G, et al. Clinical features of BK-polyomavirus and cytomegalovirus co-infection after kidney transplantation. Sci Rep. 2020;10(1):22406.
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Bhunia, K., Swanson, K.J. (2022). Concomitant BK Polyoma Virus and Cytomegalovirus Infection in a Kidney Transplant Recipient. In: Aziz, F., Parajuli, S. (eds) Complications in Kidney Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-031-13569-9_29
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DOI: https://doi.org/10.1007/978-3-031-13569-9_29
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