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Local B-Cell and T-Cell Populations in the Pathophysiology of Chronic Rhinosinusitis with Nasal Polyposis

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Nasal Physiology and Pathophysiology of Nasal Disorders

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Abstract

Endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) are distinguished by different inflammatory patterns that highlight the heterogeneous pathophysiologic pathways of disease. These endotypes have increasingly been characterized by the local T-cell and B-cell populations within the tissue of nasal polyps. T cells demonstrate a significant amount of plasticity, giving rise to a variety of specific T-cell subsets, including T helper 1 cells, T helper 2 cells, T helper 17 cells, T follicular helper cells, and regulatory T cells. Each of these differentiated T cells influence the downstream signaling of effector mechanisms that ultimately shape the clinical manifestations of CRSwNP. Nasal polyps furthermore function as tertiary lymphoid organs, relying on the activity of local B cells and their associated immunoglobulins to produce various inflammatory patterns. Despite the increasing evidence of the importance of local T-cell and B-cell populations in the pathophysiology of CRSwNP, the potential to improve the clinical management of CRSwNP on diagnostic and therapeutic fronts emphasizes the need for continued research into the immunologic factors that drive this complex disease.

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Authors and Affiliations

  1. Department of Otolaryngology—Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, VA, USA

    Kent K. Lam

  2. Department of Otorhinolaryngology—Head and Neck Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA

    Amber U. Luong

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Correspondence to Amber U. Luong .

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Editors and Affiliations

  1. Department of Otoloaryngology Head and Neck Surgery, University of Health Sciences, Istanbul Training and Research Hospital, Istanbul, Turkey

    Özlem Önerci Celebi

  2. Faculty of Medicine, Hacettepe University, Ankara, Turkey

    T. Metin Önerci

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Lam, K.K., Luong, A.U. (2023). Local B-Cell and T-Cell Populations in the Pathophysiology of Chronic Rhinosinusitis with Nasal Polyposis. In: Celebi, Ö.Ö., Önerci, T.M. (eds) Nasal Physiology and Pathophysiology of Nasal Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-12386-3_5

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  • DOI: https://doi.org/10.1007/978-3-031-12386-3_5

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