Abstract
Treatment of adults with serious mental illness is hampered by the difficulty of trying to undo the ravages that years of mental illness cause. Over the past several decades, first-episode psychosis (FEP) treatment has been developed and implemented widely throughout the country. This chapter will describe the scientific foundations of early treatment for psychosis including a description of the evidence indicating that longer duration of untreated psychosis is a strong predictor of worse short-term and long-term outcomes. The chapter will also cover the evidence supporting the effectiveness of specialized early treatment focused on recovery as well as the scientific and policy factors that led to the unusually rapid dissemination of FEP treatment throughout the country.
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References
Addington J., Heinssen R. K., Robinson D. G., Schooler N. R., & Marcy P. et al. (2015). Duration of untreated psychosis in community treatment settings in the United States. Psychiatric services, 66(7), 753–56. https://doi.org/10.1176/appi.ps.201400124
Addington D. E., Norman R., Bond G. R., Sale T., Melton R., et al. (2016). Development and testing of the First-Episode Psychosis Services Fidelity Scale. Psychiatric Services, 67(9), 1023–25. https://doi-org.ezproxy.cul.columbia.edu/10.1176/appi.ps.201500398
AlegrÃa, M., Mulvaney-Day, N., Woo, M., Torres, M., Gao, S., & Oddo, V. (2007). Correlates of past-year mental health service use among Latinos: results from the National Latino and Asian American Study. American journal of public health, 97(1), 76–83. https://doi.org/10.2105/AJPH.2006.087197
Anglin D. M., Lui F., Schneider M., Ellman L. M. (2020). Changes in perceived neighborhood ethnic density among racial and ethnic minorities over time and psychotic-like experiences. Schizophrenia research, 216, 330–8. https://doi.org/10.1016/j.schres.2019.11.034
Bello I., Lee R., Malinovsky I., Watkins L., Nossel I., et al. (2017). OnTrackNY: the development of a coordinated specialty care program for individuals experiencing early psychosis. Psychiatric services, 68(4), 318–20. https://doi.org/10.1176/appi.ps.201600512
Bennett, M. E., & Bellack, A. S. (2017). OnTrackNY: Recovery coach manual. Retrieved from http://www.ontrackny.org/portals/1/Files/Resources/RecoveryCoach_2015.01.21.pdf
Bourque, F., van der Ven, E., Malla A. (2011). A meta-analysis of the risk for psychotic disorders among first- and second-generation immigrants. Psychological medicine, 41(5), 897–910. https://doi.org/10.1017/S0033291710001406
Cabassa, L. J., Piscitelli, S., Haselden, M., Lee, R. J., Essock, S. M., & Dixon, L. B. (2018). Understanding Pathways to Care of Individuals Entering a Specialized Early Intervention Service for First-Episode Psychosis. Psychiatric services, 69(6), 648-656. https://doi.org/10.1176/appi.ps.201700018
Cloutier M., Aigbogun, M. S., Guerin, A., Nitulescu, R., Ramanakumar, A. V., et al. (2013). The economic burden of schizophrenia in the United States in 2013. Journal of clinical psychiatry 77(6):764–71. https://doi.org/10.4088/JCP.15m10278
Compton, Michael T, M.D., M.P.H., & Shim, Ruth, M.D., M.P.H. (2014). This issue: The Social Determinants of Mental Health. Psychiatric annals, 44(1), 17–20. https://doi.org/10.3928/00485713-20140108-03
Craig, T.K., Garety, P,. Power, P., Rahaman, N., Colbert, S., et al. (2004). The Lambeth Early Onset (LEO) team: randomised controlled trial of the effectiveness of specialised care for early psychosis. BMJ, 329, 1067–72. https://doi.org/10.1136/bmj.38246.594873.7C
Dixon, L. (2017a). What it will take to make coordinated specialty care available to anyone experiencing early schizophrenia: getting over the hump. JAMA psychiatry, 74(1), 7–8. https://doi.org/10.1001/jamapsychiatry.2016.2665
Dixon, L. (2017b). Coordinated specialty care for first-episode psychosis: an example of financing for specialty programs. Philadelphia: Scattergood Found. http://www.scattergoodfoundation.org/sites/default/files/%20Coordinated_Specialty_Care_for_First-Episode_Psychosis.pdf.
Dixon, L. B., Goldman, H. H, Bennett, M. E, et al. (2015). Implementing coordinated specialty care for early psychosis: The RAISE connection program. Psychiatric services, 66(7), 691-698. https://doi.org/10.1176/appi.ps.201400281
Dixon, L. B., Goldman, H. H, Srihari, V., & Kane, J. (2018). Transforming the treatment of schizophrenia in the United States: the RAISE initiative. Annual review of clinical psychology, 14, 237-258. https://doi.org/10.1146/annurev-clinpsy-050817-084934
Feagin, J., & Bennefield, Z. (2014). Systemic racism and U.S. health care. Soc sci med., 103, 7–14. https://doi.org/10.1016/j.socscimed.2013.09.006
Friis, S., Vaglum, P., Haahr, U., Johannessen, J. O., Larsen, T. K, et al. (2005). Effect of an early detection programme on duration of untreated psychosis: part of the Scandinavian TIPS study. British journal of psychiatry 48(Suppl.), S29–32. https://doi.org/10.1192/bjp.187.48.s29
Guo, X., Zhai, J., Liu, Z., et al. (2010). Effect of antipsychotic medication alone vs combined with psychosocial intervention on outcomes of early-stage schizophrenia: a randomized, 1-year study. Arch general psychiatry, 67(9), 895-904. https://doi.org/10.1001/archgenpsychiatry.2010.105
Heinssen, R. K., Goldstein, A. B., & Azrin, S. T. (2014). Evidence-based treatment for first-episode psychosis: Components of coordinated specialty care. Available at http://www.nimh.nih.gov/health/topics/schizophrenia/raise/coordinated-specialty-care-for-first-episode-psychosis-resources.shtml.
Hernandez, M., Hernandez, M. Y., Lopez, D., Barrio, C., Gamez, D., & López, S. R. (2019). Family processes and duration of untreated psychosis among US Latinos. Early intervention in psychiatry, 13(6), 389–1395. https://doi.org/10.1111/eip.12779
Howes, O. D., Whitehurst, T., Shatalina, E., Townsend, L., Onwordi, E.C., Mak, T.L.A., Arumuham, A., O’Brien, O., Lobo, M., Vano, L., Zahid, U., Butler, E. and Osugo, M. (2021), The clinical significance of duration of untreated psychosis: an umbrella review and random-effects meta-analysis. World psychiatry, 20, 75-95. https://doi.org/10.1002/wps.20822
Jonas, K. G., Fochtmann, L. J., Perlman, G., Tian, Y., Kane, J. M., Bromet, E. J., & Kotov, R. (2020). Lead-Time Bias Confounds Association Between Duration of Untreated Psychosis and Illness Course in Schizophrenia. The American journal of psychiatry, 177(4), 327–334. https://doi.org/10.1176/appi.ajp.2019.19030324
Kane, J. M., Robinson, D. G., Schooler, N. R., et al. (2015). Comprehensive versus usual community care for first-episode psychosis: 2-year outcomes from the NIMH RAISE early treatment program. American journal of psychiatry, 173(4), 362-372. https://doi.org/10.1176/appi.ajp.2015.15050632.
Kane, J., & Birnbaum, M. (2017). 178.2 Developing Strategies to Reduce DUP in the Age of Social Media and the Internet. Schizophrenia bulletin, 43(Suppl 1), S94–S95. https://doi.org/10.1093/schbul/sbx021.254
Kessler, R. C., Demler, O., Frank, R. G., Olfson, M., Pincus, H. A., Walters, E. E., Wang, P., Wells, K. B., & Zaslavsky, A. M. (2005). Prevalence and treatment of mental disorders, 1990 to 2003. The New England journal of medicine, 352(24), 2515–2523. https://doi.org/10.1056/NEJMsa043266
Ku, B. S., Pauselli, L., Manseau, M., & Compton, M. T. (2020). Neighborhood-level predictors of age at onset and duration of untreated psychosis in first-episode psychotic disorders. Schizophrenia research, 218, 247–254. https://doi.org/10.1016/j.schres.2019.12.036
Lewis-Fernandez, R., Jiménez-Solomon, O., Diaz, S., Bello, I., Malinovsky, I. et al., (2018). OnTrackNY: Delivering Competent Care in FEP. Retrieved from https://ontrackny.org/Portals/1/Files/Resources/OnTrackNY%20Cultural%20Competency%20Guide_%20Final%205.29.18.pdf?ver=2018-06-07-11044
Lieberman J. A., Dixon L. B., Goldman H. H. (2013). Early detection and intervention in schizophrenia: a new therapeutic model. JAMA, 310(7), 689–90. https://doi.org/10.1001/jama.2013.8804
Lloyd-Evans, B., Crosby, M., Stockton, S., Pilling, S., Hobbs, L., Hinton, M., & Johnson, S. (2011). Initiatives to shorten duration of untreated psychosis: systematic review. The British journal of psychiatry: the journal of mental science, 198(4), 256–263. https://doi.org/10.1192/bjp.bp.109.075622
López, S. R., Gamez, D., Mejia, Y., Calderon, V., Lopez, D., Ullman, J. B., & Kopelowicz, A. (2018). Psychosis Literacy Among Latinos With First-Episode Psychosis and Their Caregivers. Psychiatric services, 69(11), 1153–1159. https://doi.org/10.1176/appi.ps.201700400
Marshall, M., Lewis, S., Lockwood, A., Drake, R., Jones, P., & Croudace, T. (2005). Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Archives of general psychiatry, 62(9), 975–983. https://doi.org/10.1001/archpsyc.62.9.975
Narita, Z., Knowles, K., Fedina, L., Oh, H., Stickley, A., Kelleher, I., & DeVylder, J. (2020). Neighborhood change and psychotic experiences in a general population sample. Schizophrenia research, 216, 316–321. https://doi.org/10.1016/j.schres.2019.11.036
Petersen, L., Thorup, A., Øqhlenschlaeger, J., Christensen, T. Ø., Jeppesen, P., Krarup, G., Jørrgensen, P., Mortensen, E. L., & Nordentoft, M. (2008). Predictors of remission and recovery in a first-episode schizophrenia spectrum disorder sample: 2-year follow-up of the OPUS trial. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 53(10), 660–670. https://doi.org/10.1177/070674370805301005
Rosenberg, S. D., Lu, W., Mueser, K. T., Jankowski, M. K., & Cournos, F. (2007). Correlates of adverse childhood events among adults with schizophrenia spectrum disorders. Psychiatric services, 58(2), 245–253. https://doi.org/10.1176/ps.2007.58.2.245
Schwartz, R. C., & Blankenship, D. M. (2014). Racial disparities in psychotic disorder diagnosis: A review of empirical literature. World J Psychiatry, 4(4),133–140. https://doi.org/10.5498/wjp.v4.i4.133. PMID: 25540728. PMCID: PMC4274585.
Srihari, V. H., Tek, C., Kucukgoncu, S., Phutane, V. H., Breitborde, N. J., Pollard, J., Ozkan, B., Saksa, J., Walsh, B. C., & Woods, S. W. (2015). First-Episode Services for Psychotic Disorders in the U.S. Public Sector: A Pragmatic Randomized Controlled Trial. Psychiatric services, 66(7), 705–712. https://doi.org/10.1176/appi.ps.201400236
Srihari, V. H., Ferrara, M., Li, F., Kline, E., Gülöksüz, S., Pollard, K. M., Cahill, J. D., Mathis, W. S., Sykes, L. Y., Walsh, B. C., McDermott, G., Seidman, L. J., Gueorguieva, R., Woods, S. W., Tek, C., Keshavan, M. S. (2022). Reducing the Duration of Untreated Psychosis (DUP) in a US Community: A quasi-experimental trial. Schizophrenia Bulletin Open, 3(1), sgab057. https://doi.org/10.1093/schizbullopen/sgab057
Woods, S. W., Yung, A. R., McGorry, P. D., & McGlashan, T. H. (2020). Duration of Untreated Psychosis: Getting Both the Timing and the Sample Right. The American journal of psychiatry, 177(12), 1183. https://doi.org/10.1176/appi.ajp.2020.20040389
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Bello, I., Nossel, I., Dixon, L.B. (2022). Early Psychosis and the Prevention and Mitigation of Serious Mental Illness. In: Sowers, W.E., McQuistion, H.L., Ranz, J.M., Feldman, J.M., Runnels, P.S. (eds) Textbook of Community Psychiatry. Springer, Cham. https://doi.org/10.1007/978-3-031-10239-4_43
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