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Fibrosing Mediastinitis

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FDG-PET/CT and PET/MR in Cardiovascular Diseases

Abstract

Fibrosing mediastinitis is a rare disorder characterized by progressive mediastinal fibrosis. The purpose of this chapter is to provide an overview of the etiology and epidemiology of this condition. In addition, the imaging features of fibrosing mediastinitis on CT, MRI, and FDG-PET are reviewed, and the potential role of FDG-PET imaging in this pathology is discussed.

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References

  1. Loyd JE, Tillman BF, Atkinson JB, Des Prez RM. Mediastinal fibrosis complicating histoplasmosis. Medicine (Baltimore). 1988;67(5):295–310.

    Article  CAS  Google Scholar 

  2. Seferian A, Steriade A, Jaïs X, Planché O, Savale L, Parent F, et al. Pulmonary hypertension complicating fibrosing mediastinitis. Medicine (Baltimore). 2015;94(44):e1800.

    Article  Google Scholar 

  3. Rossi GM, Emmi G, Corradi D, Urban ML, Maritati F, Landini F, et al. Idiopathic mediastinal fibrosis: a systemic immune-mediated disorder. A case series and a review of the literature. Clin Rev Allergy Immunol. 2017;52(3):446–59.

    Article  CAS  Google Scholar 

  4. Morrone N, Gama e Silva Volpe VL, Dourado AM, Mitre F, Coletta EN. Bilateral pleural effusion due to mediastinal fibrosis induced by radiotherapy. Chest. 1993;104(4):1276–8.

    Article  CAS  Google Scholar 

  5. Hage CA, Azar MM, Bahr N, Loyd J, Wheat LJ. Histoplasmosis: up-to-date evidence-based approach to diagnosis and management. Semin Respir Crit Care Med. 2015;36(5):729–45.

    Article  Google Scholar 

  6. Sherrick AD, Brown LR, Harms GF, Myers JL. The radiographic findings of fibrosing mediastinitis. Chest. 1994;106(2):484–9.

    Article  CAS  Google Scholar 

  7. Weinstein J, Aronberg D, Sagel S. CT of fibrosing mediastinitis: findings and their utility. Am J Roentgenol. 1983;141(2):247–51.

    Article  CAS  Google Scholar 

  8. Garrana SH, Buckley JR, Rosado-de-Christenson ML, Martínez-Jiménez S, Muñoz P, Borsa JJ. Multimodality imaging of focal and diffuse fibrosing mediastinitis. Radiographics. 2019;39(3):651–67.

    Article  Google Scholar 

  9. Kushihashi T, Munechika H, Motoya H, Hamada K, Satoh I, Naitoh H, et al. CT and MR findings in tuberculous mediastinitis. J Comput Assist Tomogr. 1995;19(3):379–82.

    Article  CAS  Google Scholar 

  10. Akman C, Kantarci F, Cetinkaya S. Imaging in mediastinitis: a systematic review based on aetiology. Clin Radiol. 2004;59(7):573–85.

    Article  CAS  Google Scholar 

  11. Kan Y, Yuan L, Wang W, Yang J. Unexpected Fibrosing Mediastinitis Shown on FDG PET/CT in a Patient With IgG4-Related Disease. Clin Nucl Med. 2017;42:818–19.

    Google Scholar 

  12. Sharma P, Mukherjee A, Karunanithi S, Bal C, Kumar R. Potential role of 18F-FDG PET/CT in patients with fungal infections. Am J Roentgenol. 2014;203(1):180–9.

    Article  Google Scholar 

  13. Pelletier-Galarneau M, Martineau P, Zuckier LS, Pham X, Lambert R, Turpin S. 18F-FDG-PET/CT imaging of thoracic and extrathoracic tuberculosis in children. Semin Nucl Med. 2017;47(3):304–18.

    Article  Google Scholar 

  14. Martineau P, Pelletier-Galarneau M, Juneau D, Leung E, Birnie D, Beanlands RSB. Molecular imaging of cardiac sarcoidosis. Curr Cardiovasc Imaging Rep. 2018;11(3):6–17.

    Article  Google Scholar 

  15. Ikeda K, Nomori H, Mori T, Kobayashi H, Iwatani K, Yoshimoto K, et al. Successful steroid treatment for fibrosing mediastinitis and Sclerosing cervicitis. Ann Thorac Surg. 2007;83(3):1199–201.

    Article  Google Scholar 

  16. Takalkar AM, Bruno GL, Makanjoula AJ, El-Haddad G, Lilien DL, Payne DK. A potential role for F-18 FDG PET/CT in evaluation and management of fibrosing mediastinitis. Clin Nucl Med. 2007;32(9):703–6.

    Article  Google Scholar 

  17. Westerly BD, Johnson GB, Maldonado F, Utz JP, Specks U, Peikert T. Targeting B lymphocytes in progressive fibrosing mediastinitis. Am J Respir Crit Care Med. 2014;190(9):1069–71.

    Article  Google Scholar 

  18. Chong S, Kim TS, Kim B-T, Cho EY. Fibrosing mediastinitis mimicking malignancy at CT: negative FDG uptake in integrated FDG PET/CT imaging. Eur Radiol. 2007;17(6):1644–6.

    Article  Google Scholar 

  19. Imran MB, Kubota K, Yoshioka S, Yamada S, Sato T, Fukuda H, et al. Sclerosing mediastinitis: findings on Fluorine-18 Fluorodeoxyglucose positron emission tomography. Clin Nucl Med. 1999;24(5):305–8.

    Article  CAS  Google Scholar 

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Correspondence to Matthieu Pelletier-Galarneau .

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Pelletier-Galarneau, M., Tan, S., Harel, F., Martineau, P. (2022). Fibrosing Mediastinitis. In: Pelletier-Galarneau, M., Martineau, P. (eds) FDG-PET/CT and PET/MR in Cardiovascular Diseases. Springer, Cham. https://doi.org/10.1007/978-3-031-09807-9_11

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  • DOI: https://doi.org/10.1007/978-3-031-09807-9_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-09806-2

  • Online ISBN: 978-3-031-09807-9

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