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Immediate and Delayed Reactions to Beta-Lactams

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Drug Eruptions

Part of the book series: Updates in Clinical Dermatology ((UCD))

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Abstract

Beta-lactams are the leading causes of immediate and nonimmediate drug hypersensitivity reactions. Such drug allergy labels often lead to increased costs, healthcare utilization as well as microbial resistance with the use of alternative antibiotics. Sensitization patterns have evolved over time, in line with changing prescription patterns. Diagnostic approach to beta-lactam hypersensitivity reactions involves a detailed clinical history, skin tests, and drug provocation tests. Various in vitro tests such as specific IgE detection and quantification, basophil activation tests, histamine release tests, lymphocyte transformation tests, and Elispot may play a complementary role. An accurate diagnosis and evaluation of beta-lactam allergy should be considered as part of a strategy in antimicrobial stewardship in order to reduce the excessive use of broad-spectrum alternatives resulting in bacterial resistance.

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References

  • Aberer W, Bircher A, Romano A, Blanca M, Campi P, Fernandez J, et al. Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations. Allergy. 2003;58(9):854–63.

    Article  CAS  PubMed  Google Scholar 

  • Andrade P, Brinca A, Goncalo M. Patch testing in fixed drug eruptions—a 20-year review. Contact Dermatitis. 2011;65(4):195–201.

    Article  PubMed  Google Scholar 

  • Antunez C, Martin E, Cornejo-Garcia JA, Blanca-Lopez N, R-Pena R, Mayorga C, et al. Immediate hypersensitivity reactions to penicillins and other betalactams. Curr Pharm Des. 2006;12(26):3327–33.

    Article  CAS  PubMed  Google Scholar 

  • Ariza A, Garcia-Martin E, Salas M, Montanez MI, Mayorga C, Blanca-Lopez N, et al. Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole. Sci Rep. 2016;6:23845.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Atanaskovic-Markovic M, Gaeta F, Medjo B, Gavrovic-Jankulovic M, Cirkovic Velickovic T, Tmusic V, et al. Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up. Pediatr Allergy Immunol. 2016;27(5):533–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Barbaud A, Goncalo M, Bruynzeel D, Bircher A. Guidelines for performing skin tests with drugs in the investigation of cutaneous adverse drug reactions. Contact Dermatitis. 2001;45(6):321–8.

    Article  CAS  PubMed  Google Scholar 

  • Barbero N, Fernandez-Santamaria R, Mayorga C, Martin-Serrano A, Salas M, Bogas G, et al. Identification of an antigenic determinant of clavulanic acid responsible for IgE-mediated reactions. Allergy. 2019;74(8):1490–501.

    CAS  PubMed  Google Scholar 

  • Beeler A, Zaccaria L, Kawabata T, Gerber BO, Pichler WJ. CD69 upregulation on T cells as an in vitro marker for delayed-type drug hypersensitivity. Allergy. 2008;63(2):181–8.

    CAS  PubMed  Google Scholar 

  • Bigby M. Rates of cutaneous reactions to drugs. Arch Dermatol. 2001;137(6):765–70.

    CAS  PubMed  Google Scholar 

  • Blanca M. Allergic reactions to penicillins. A changing world? Allergy. 1995;50(10):777–82.

    Article  CAS  PubMed  Google Scholar 

  • Blanca M, Mayorga C, Torres MJ, Reche M, Moya MC, Rodriguez JL, et al. Clinical evaluation of Pharmacia CAP system RAST FEIA amoxicilloyl and benzylpenicilloyl in patients with penicillin allergy. Allergy. 2001;56(9):862–70.

    Article  CAS  PubMed  Google Scholar 

  • Blanca M, Romano A, Torres MJ, Fernandez J, Mayorga C, Rodriguez J, et al. Update on the evaluation of hypersensitivity reactions to betalactams. Allergy. 2009;64(2):183–93.

    Article  CAS  PubMed  Google Scholar 

  • Bousquet PJ, Co-Minh HB, Arnoux B, Daures JP, Demoly P. Importance of mixture of minor determinants and benzylpenicilloyl poly-l-lysine skin testing in the diagnosis of β-lactam allergy. J Allergy Clin Immunol. 2005;115(6):1314–6.

    Article  CAS  PubMed  Google Scholar 

  • Cars O, Molstad S, Melander A. Variation in antibiotic use in the European Union. Lancet. 2001;357(9271):1851–3.

    Article  CAS  PubMed  Google Scholar 

  • Caubet JC, Kaiser L, Lemaitre B, Fellay B, Gervaix A, Eigenmann PA. The role of penicillin in benign skin rashes in childhood: a prospective study based on drug rechallenge. J Allergy Clin Immunol. 2011;127:218–22.

    Article  CAS  PubMed  Google Scholar 

  • Chaves P, Torres MJ, Aranda A, Lopez S, Canto G, Blanca M, et al. Natural killer-dendritic cell interaction in lymphocyte responses in hypersensitivity reactions to betalactams. Allergy. 2010;65(12):1600–8.

    Article  CAS  PubMed  Google Scholar 

  • Chiriac AM, Rerkpattanapipat T, Bousquet PJ, Molinari N, Demoly P. Optimal step doses for drug provocation tests to prove beta-lactam hypersensitivity. Allergy. 2017;72(4):552–61.

    Article  CAS  PubMed  Google Scholar 

  • Chiriac AM, Wang Y, Schrijvers R, Bousquet PJ, Mura T, Molinari N, et al. Designing predictive models for Beta-lactam allergy using the drug allergy and hypersensitivity database. J Allergy Clin Immunol Pract. 2018;6(1):139–48 e2.

    Article  PubMed  Google Scholar 

  • Co Minh HB, Bousquet PJ, Fontaine C, Kvedariene V, Demoly P. Systemic reactions during skin tests with beta-lactams: a risk factor analysis. J Allergy Clin Immunol. 2006;117(2):466–8.

    Article  PubMed  Google Scholar 

  • De Week AL, Sanz ML, Gamboa PM, Aberer W, Sturm G, Bilo MB, et al. Diagnosis of immediate-type beta-lactam allergy in vitro by flow-cytometric basophil activation test and sulfidoleukotriene production: a multicenter study. J Investig Allergol Clin Immunol. 2009;19(2):91–109.

    PubMed  Google Scholar 

  • Demoly P, Romano A, Botelho C, Bousquet-Rouanet L, Gaeta F, Silva R, et al. Determining the negative predictive value of provocation tests with beta-lactams. Allergy. 2010;65(3):327–32.

    Article  CAS  PubMed  Google Scholar 

  • Demoly P, Adkinson NF, Brockow K, Castells M, Chiriac AM, Greenberger PA, et al. International consensus on drug allergy. Allergy. 2014;69(4):420–37.

    Article  CAS  PubMed  Google Scholar 

  • Dona I, Blanca-Lopez N, Torres MJ, Garcia-Campos J, Garcia-Nunez I, Gomez F, et al. Drug hypersensitivity reactions: response patterns, drug involved, and temporal variations in a large series of patients. J Investig Allergol Clin Immunol. 2012;22(5):363–71.

    CAS  PubMed  Google Scholar 

  • Dona I, Barrionuevo E, Blanca-Lopez N, Torres MJ, Fernandez TD, Mayorga C, et al. Trends in hypersensitivity drug reactions: more drugs, more response patterns, more heterogeneity. J Investig Allergol Clin Immunol. 2014;24(3):143–53; quiz 1 p following 53.

    CAS  PubMed  Google Scholar 

  • Dona I, Romano A, Torres MJ. Algorithm for betalactam allergy diagnosis. Allergy. 2019;74(9):1817–9.

    Article  PubMed  Google Scholar 

  • Eberlein B, Leon Suarez I, Darsow U, Rueff F, Behrendt H, Ring J. A new basophil activation test using CD63 and CCR3 in allergy to antibiotics. Clin Exp Allergy. 2010;40(3):411–8.

    Article  CAS  PubMed  Google Scholar 

  • Ferech M, Coenen S, Dvorakova K, Hendrickx E, Suetens C, Goossens H. European surveillance of antimicrobial consumption (ESAC): outpatient penicillin use in Europe. J Antimicrob Chemother. 2006;58(2):408–12.

    Article  CAS  PubMed  Google Scholar 

  • Fernandez TD, Torres MJ, Blanca-Lopez N, Rodriguez-Bada JL, Gomez E, Canto G, et al. Negativization rates of IgE radioimmunoassay and basophil activation test in immediate reactions to penicillins. Allergy. 2009;64(2):242–8.

    Article  CAS  PubMed  Google Scholar 

  • Fernandez TD, Mayorga C, Salas M, Barrionuevo E, Posadas T, Ariza A, et al. Evolution of diagnostic approaches in betalactam hypersensitivity. Expert Rev Clin Pharmacol. 2017;10(6):671–83.

    Article  CAS  PubMed  Google Scholar 

  • Fontaine C, Mayorga C, Bousquet PJ, Arnoux B, Torres MJ, Blanca M, et al. Relevance of the determination of serum-specific IgE antibodies in the diagnosis of immediate beta-lactam allergy. Allergy. 2007;62(1):47–52.

    Article  CAS  PubMed  Google Scholar 

  • Gadde J, Spence M, Wheeler B, Adkinson NF Jr. Clinical experience with penicillin skin testing in a large inner-city STD clinic. JAMA. 1993;270(20):2456–63.

    Article  CAS  PubMed  Google Scholar 

  • Garcia-Ortega P, Marin A. Usefulness of the basophil activation test (BAT) in the diagnosis of life-threatening drug anaphylaxis. Allergy. 2010;65(9):1204.

    CAS  PubMed  Google Scholar 

  • Gastaminza G, Audicana MT, Fernandez E, Anda M, Ansotegui IJ. Palmar exfoliative exanthema to amoxicillin. Allergy. 2000;55(5):510–1.

    Article  CAS  PubMed  Google Scholar 

  • Gomes ER, Demoly P. Epidemiology of hypersensitivity drug reactions. Curr Opin Allergy Clin Immunol. 2005;5(4):309–16.

    Article  PubMed  Google Scholar 

  • Gomes ER, Brockow K, Kuyucu S, Saretta F, Mori F, Blanca-Lopez N, et al. Drug hypersensitivity in children: report from the pediatric task force of the EAACI drug allergy interest group. Allergy. 2016;71(2):149–61.

    Article  CAS  PubMed  Google Scholar 

  • Green GR, Rosenblum AH, Sweet LC. Evaluation of penicillin hypersensitivity: value of clinical history and skin testing with penicilloyl-polylysine and penicillin G. A cooperative prospective study of the penicillin study group of the American Academy of allergy. J Allergy Clin Immunol. 1977;60(6):339–45.

    Article  CAS  PubMed  Google Scholar 

  • Hausermann P, Harr T, Bircher AJ. Baboon syndrome resulting from systemic drugs: is there strife between SDRIFE and allergic contact dermatitis syndrome? Contact Dermatitis. 2004;51(5–6):297–310.

    Article  CAS  PubMed  Google Scholar 

  • Haw WY, Polak ME, McGuire C, Erlewyn-Lajeunesse M, Ardern-Jones MR. In vitro rapid diagnostic tests for severe drug hypersensitivity reactions in children. Ann Allergy Asthma Immunol. 2016;117(1):61–6.

    Article  CAS  PubMed  Google Scholar 

  • Hierro Santurino B, Mateos Conde J, Cabero Moran MT, Miron Canelo JA, Armentia MA. A predictive model for the diagnosis of allergic drug reactions according to the medical history. J Allergy Clin Immunol Pract. 2016;4(2):292–300 e3.

    Article  PubMed  Google Scholar 

  • Hjortlund J, Mortz CG, Skov PS, Bindslev-Jensen C. Diagnosis of penicillin allergy revisited: the value of case history, skin testing, specific IgE and prolonged challenge. Allergy. 2013;68(8):1057–64.

    Article  CAS  PubMed  Google Scholar 

  • Hunziker T, Kunzi UP, Braunschweig S, Zehnder D, Hoigne R. Comprehensive hospital drug monitoring (CHDM): adverse skin reactions, a 20-year survey. Allergy. 1997;52(4):388–93.

    Article  CAS  PubMed  Google Scholar 

  • Jeffres MN, Narayanan PP, Shuster JE, Schramm GE. Consequences of avoiding beta-lactams in patients with beta-lactam allergies. J Allergy Clin Immunol. 2016;137(4):1148–53.

    Article  CAS  PubMed  Google Scholar 

  • Kano Y, Hirahara K, Mitsuyama Y, Takahashi R, Shiohara T. Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption. Allergy. 2007;62(12):1439–44.

    Article  CAS  PubMed  Google Scholar 

  • Kardaun SH, Sekula P, Valeyrie-Allanore L, Liss Y, Chu CY, Creamer D, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study. Br J Dermatol. 2013;169(5):1071–80.

    Article  CAS  PubMed  Google Scholar 

  • Kato K, Kawase A, Azukizawa H, Hanafusa T, Nakagawa Y, Murota H, et al. Novel interferon-gamma enzyme-linked immunoSpot assay using activated cells for identifying hypersensitivity-inducing drug culprits. J Dermatol Sci. 2017;86(3):222–9.

    Article  CAS  PubMed  Google Scholar 

  • Kuruvilla M, Khan DA. Anaphylaxis to drugs. Immunol Allergy Clin N Am. 2015 May;35(2):303–19.

    Article  Google Scholar 

  • Lacombe-Barrios J, Salas M, Gomez F, Dona I, Ariza A, Mayorga C, et al. The addition of Benzylpenicillin does not increase the skin test sensitivity obtained with classic beta-lactam determinants. J Investig Allergol Clin Immunol. 2016;26(1):52–4.

    CAS  PubMed  Google Scholar 

  • Lammintausta K, Kortekangas-Savolainen O. The usefulness of skin tests to prove drug hypersensitivity. Br J Dermatol. 2005;152(5):968–74.

    Article  CAS  PubMed  Google Scholar 

  • Lazaro Bengoa E, Madurga Sanz M, de Abajo Iglesias FJ. Trends in antibiotic consumption in Spain, 1985-2000. Med Clin (Barc). 2002;118(15):561–8.

    Google Scholar 

  • Lee CE, Zembower TR, Fotis MA, Postelnick MJ, Greenberger PA, Peterson LR, et al. The incidence of antimicrobial allergies in hospitalized patients: implications regarding prescribing patterns and emerging bacterial resistance. Arch Intern Med. 2000;160(18):2819–22.

    Article  CAS  PubMed  Google Scholar 

  • Levine BB. Immunologic mechanisms of penicillin allergy. A haptenic model system for the study of allergic diseases of man. N Engl J Med. 1966;275(20):1115–25.

    Article  CAS  PubMed  Google Scholar 

  • Levine BB, Ovary Z. Studies on the mechanism of the formation of the penicillin antigen. III. The N-(D-alpha-benzylpenicilloyl) group as an antigenic determinant responsible for hypersensitivity to penicillin G. J Exp Med. 1961;114:875–904.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lin YF, Yang CH, Sindy H, Lin JY, Rosaline Hui CY, Tsai YC, et al. Severe cutaneous adverse reactions related to systemic antibiotics. Clin Infect Dis. 2014;58(10):1377–85.

    Article  CAS  PubMed  Google Scholar 

  • Lochmatter P, Beeler A, Kawabata TT, Gerber BO, Pichler WJ. Drug-specific in vitro release of IL-2, IL-5, IL-13 and IFN-gamma in patients with delayed-type drug hypersensitivity. Allergy. 2009;64(9):1269–78.

    Article  CAS  PubMed  Google Scholar 

  • Macy E, Ngor EW. Safely diagnosing clinically significant penicillin allergy using only penicilloyl-poly-lysine, penicillin, and oral amoxicillin. J Allergy Clin Immunol Pract. 2013;1(3):258–63.

    Article  PubMed  Google Scholar 

  • Macy E, Schatz M, Lin C, Poon KY. The falling rate of positive penicillin skin tests from 1995 to 2007. Perm J. 2009 Spring;13(2):12–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Martin M, Wurpts G, Ott H, Baron JM, Erdmann S, Merk HF, et al. In vitro detection and characterization of drug hypersensitivity using flow cytometry. Allergy. 2010;65(1):32–9.

    Article  CAS  PubMed  Google Scholar 

  • Mayorga C, Celik G, Rouzaire P, Whitaker P, Bonadonna P, Rodrigues-Cernadas J, et al. In vitro tests for drug hypersensitivity reactions: an ENDA/EAACI drug allergy interest group position paper. Allergy. 2016;71(8):1103–34.

    Article  CAS  PubMed  Google Scholar 

  • Mayorga C, Fernandez TD, Montanez MI, Moreno E, Torres MJ. Recent developments and highlights in drug hypersensitivity. Allergy. 2019a;74(12):2368–81.

    Article  PubMed  Google Scholar 

  • Mayorga C, Ebo DG, Lang DM, Pichler WJ, Sabato V, Park MA, et al. Controversies in drug allergy: in vitro testing. J Allergy Clin Immunol. 2019b;143(1):56–65.

    Article  CAS  PubMed  Google Scholar 

  • Mirakian R, Ewan PW, Durham SR, Youlten LJ, Dugue P, Friedmann PS, et al. BSACI guidelines for the management of drug allergy. Clin Exp Allergy. 2009;39(1):43–61.

    Article  CAS  PubMed  Google Scholar 

  • Misirlioglu ED, Toyran M, Capanoglu M, Kaya A, Civelek E, Kocabas CN. Negative predictive value of drug provocation tests in children. Pediatr Allergy Immunol. 2014;25(7):685–90.

    Article  PubMed  Google Scholar 

  • Montanez MI, Mayorga C, Bogas G, Barrionuevo E, Fernandez-Santamaria R, Martin-Serrano A, et al. Epidemiology, mechanisms, and diagnosis of drug-induced anaphylaxis. Front Immunol. 2017;8:614.

    Article  PubMed  PubMed Central  Google Scholar 

  • Padial A, Antunez C, Blanca-Lopez N, Fernandez TD, Cornejo-Garcia JA, Mayorga C, et al. Non-immediate reactions to beta-lactams: diagnostic value of skin testing and drug provocation test. Clin Exp Allergy. 2008;38(5):822–8.

    Article  CAS  PubMed  Google Scholar 

  • Papay J, Yuen N, Powell G, Mockenhaupt M, Bogenrieder T. Spontaneous adverse event reports of Stevens-Johnson syndrome/toxic epidermal necrolysis: detecting associations with medications. Pharmacoepidemiol Drug Saf. 2012;21(3):289–96.

    Article  PubMed  Google Scholar 

  • Picard M, Begin P, Bouchard H, Cloutier J, Lacombe-Barrios J, Paradis J, et al. Treatment of patients with a history of penicillin allergy in a large tertiary-care academic hospital. J Allergy Clin Immunol Pract. 2013;1(3):252–7.

    Article  PubMed  Google Scholar 

  • Pichler WJ, Tilch J. The lymphocyte transformation test in the diagnosis of drug hypersensitivity. Allergy. 2004;59(8):809–20.

    Article  CAS  PubMed  Google Scholar 

  • Pineda F, Ariza A, Mayorga C, Arribas F, Gonzalez-Mendiola R, Blanca-Lopez N, et al. Role of histamine release test for the evaluation of patients with immediate hypersensitivity reactions to clavulanic acid. Int Arch Allergy Immunol. 2015;168(4):233–40.

    Article  CAS  PubMed  Google Scholar 

  • Pinho A, Coutinho I, Gameiro A, Gouveia M, Goncalo M. Patch testing - a valuable tool for investigating non-immediate cutaneous adverse drug reactions to antibiotics. J Eur Acad Dermatol Venereol. 2017;31(2):280–7.

    Article  CAS  PubMed  Google Scholar 

  • Polak ME, Belgi G, McGuire C, Pickard C, Healy E, Friedmann PS, et al. In vitro diagnostic assays are effective during the acute phase of delayed-type drug hypersensitivity reactions. Br J Dermatol. 2013;168(3):539–49.

    Article  CAS  PubMed  Google Scholar 

  • Ponvert C, Perrin Y, Bados-Albiero A, Le Bourgeois M, Karila C, Delacourt C, et al. Allergy to betalactam antibiotics in children: results of a 20-year study based on clinical history, skin and challenge tests. Pediatr Allergy Immunol. 2011;22(4):411–8.

    Article  CAS  PubMed  Google Scholar 

  • Porebski G, Pecaric-Petkovic T, Groux-Keller M, Bosak M, Kawabata TT, Pichler WJ. In vitro drug causality assessment in Stevens-Johnson syndrome—alternatives for lymphocyte transformation test. Clin Exp Allergy. 2013;43(9):1027–37.

    Article  CAS  PubMed  Google Scholar 

  • Rodriguez-Pena R, Lopez S, Mayorga C, Antunez C, Fernandez TD, Torres MJ, et al. Potential involvement of dendritic cells in delayed-type hypersensitivity reactions to beta-lactams. J Allergy Clin Immunol. 2006;118(4):949–56.

    Article  CAS  PubMed  Google Scholar 

  • Romano A, Di Fonso M, Papa G, Pietrantonio F, Federico F, Fabrizi G, et al. Evaluation of adverse cutaneous reactions to aminopenicillins with emphasis on those manifested by maculopapular rashes. Allergy. 1995;50(2):113–8.

    Article  CAS  PubMed  Google Scholar 

  • Romano A, Viola M, Mondino C, Pettinato R, Di Fonso M, Papa G, et al. Diagnosing nonimmediate reactions to penicillins by in vivo tests. Int Arch Allergy Immunol. 2002;129(2):169–74.

    Article  CAS  PubMed  Google Scholar 

  • Romano A, Gaeta F, Valluzzi RL, Caruso C, Rumi G, Bousquet PJ. The very limited usefulness of skin testing with penicilloyl-polylysine and the minor determinant mixture in evaluating nonimmediate reactions to penicillins. Allergy. 2010;65(9):1104–7.

    CAS  PubMed  Google Scholar 

  • Romano A, Gaeta F, Valluzzi RL, Caruso C, Alonzi C, Viola M, et al. Diagnosing nonimmediate reactions to cephalosporins. J Allergy Clin Immunol. 2012;129(4):1166–9.

    Article  PubMed  Google Scholar 

  • Romano A, Gaeta F, Valluzzi RL, Alonzi C, Maggioletti M, Zaffiro A, et al. Absence of cross-reactivity to carbapenems in patients with delayed hypersensitivity to penicillins. Allergy. 2013;68(12):1618–21.

    Article  CAS  PubMed  Google Scholar 

  • Romano A, Gaeta F, Valluzzi RL, Maggioletti M, Caruso C, Quaratino D. Cross-reactivity and tolerability of aztreonam and cephalosporins in subjects with a T cell-mediated hypersensitivity to penicillins. J Allergy Clin Immunol. 2016;138(1):179–86.

    Article  CAS  PubMed  Google Scholar 

  • Romano A, Atanaskovic-Markovic M, Barbaud A, Bircher AJ, Brockow K, Caubet JC, et al. Towards a more precise diagnosis of hypersensitivity to beta-lactams—an EAACI position paper. Allergy. 2020;75(6):1300–15.

    Article  PubMed  Google Scholar 

  • Roujeau JC, Haddad C, Paulmann M, Mockenhaupt M. Management of nonimmediate hypersensitivity reactions to drugs. Immunol Allergy Clin N Am. 2014;34(3):473–87, vii.

    Article  Google Scholar 

  • Rubio M, Bousquet PJ, Gomes E, Romano A, Demoly P. Results of drug hypersensitivity evaluations in a large group of children and adults. Clin Exp Allergy. 2012;42(1):123–30.

    Article  CAS  PubMed  Google Scholar 

  • Sacco KA, Bates A, Brigham TJ, Imam JS, Burton MC. Clinical outcomes following inpatient penicillin allergy testing: a systematic review and meta-analysis. Allergy. 2017;72(9):1288–96.

    Article  CAS  PubMed  Google Scholar 

  • Salas M, Fernandez-Santamaria R, Mayorga C, Barrionuevo E, Ariza A, Posadas T, et al. Use of the basophil activation test may reduce the need for drug provocation in amoxicillin-clavulanic allergy. J Allergy Clin Immunol Pract. 2018;6(3):1010–18.e2.

    Article  PubMed  Google Scholar 

  • Sampson HA, Munoz-Furlong A, Campbell RL, Adkinson NF Jr, Bock SA, Branum A, et al. Second symposium on the definition and management of anaphylaxis: summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol. 2006;117(2):391–7.

    Article  PubMed  Google Scholar 

  • Sanchez-Quintero MJ, Torres MJ, Blazquez AB, Gomez E, Fernandez TD, Dona I, et al. Synergistic effect between amoxicillin and TLR ligands on dendritic cells from amoxicillin-delayed allergic patients. PLoS One. 2013;8(9):e74198.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sanz ML, Gamboa PM, Antepara I, Uasuf C, Vila L, Garcia-Aviles C, et al. Flow cytometric basophil activation test by detection of CD63 expression in patients with immediate-type reactions to betalactam antibiotics. Clin Exp Allergy. 2002;32(2):277–86.

    Article  CAS  PubMed  Google Scholar 

  • Sastre J, Manso L, Sanchez-Garcia S, Fernandez-Nieto M. Medical and economic impact of misdiagnosis of drug hypersensitivity in hospitalized patients. J Allergy Clin Immunol. 2012;129(2):566–7.

    Article  PubMed  Google Scholar 

  • Shiohara T, Kano Y. A complex interaction between drug allergy and viral infection. Clin Rev Allergy Immunol. 2007;33(1–2):124–33.

    Article  CAS  PubMed  Google Scholar 

  • Sidoroff A. Acute generalized exanthematous pustulosis. Chem Immunol Allergy. 2012;97:139–48.

    Article  PubMed  Google Scholar 

  • Silviu-Dan F, McPhillips S, Warrington RJ. The frequency of skin test reactions to side-chain penicillin determinants. J Allergy Clin Immunol. 1993;91(3):694–701.

    Article  CAS  PubMed  Google Scholar 

  • Soria A, Autegarden E, Amsler E, Gaouar H, Vial A, Frances C, et al. A clinical decision-making algorithm for penicillin allergy. Ann Med. 2017;49(8):710–7.

    Article  PubMed  Google Scholar 

  • Stahl Skov P, Norn S, Weeke B. A new method for detecting histamine release. Agents Actions. 1984;14(3–4):414–6.

    Article  CAS  PubMed  Google Scholar 

  • Stern RS. Clinical practice. Exanthematous drug eruptions. N Engl J Med. 2012;366(26):2492–501.

    Article  CAS  PubMed  Google Scholar 

  • Thong BY, Leong KP, Tang CY, Chng HH. Drug allergy in a general hospital: results of a novel prospective inpatient reporting system. Ann Allergy Asthma Immunol. 2003;90(3):342–7.

    Article  PubMed  Google Scholar 

  • Torres MJ, Blanca M. The contribution of major and minor determinants from benzylpenicillin to the diagnosis of immediate allergy to beta-lactams. J Allergy Clin Immunol. 2006;117(1):220–1; author reply 1.

    Article  CAS  PubMed  Google Scholar 

  • Torres MJ, Blanca M. The complex clinical picture of beta-lactam hypersensitivity: penicillins, cephalosporins, monobactams, carbapenems, and clavams. Med Clin North Am. 2010;94(4):805–20, xii.

    Article  CAS  PubMed  Google Scholar 

  • Torres MJ, Romano A, Mayorga C, Moya MC, Guzman AE, Reche M, et al. Diagnostic evaluation of a large group of patients with immediate allergy to penicillins: the role of skin testing. Allergy. 2001;56(9):850–6.

    Article  CAS  PubMed  Google Scholar 

  • Torres MJ, Mayorga C, Leyva L, Guzman AE, Cornejo-Garcia JA, Juarez C, et al. Controlled administration of penicillin to patients with a positive history but negative skin and specific serum IgE tests. Clin Exp Allergy. 2002;32(2):270–6.

    Article  CAS  PubMed  Google Scholar 

  • Torres MJ, Blanca M, Fernandez J, Romano A, de Weck A, Aberer W, et al. Diagnosis of immediate allergic reactions to beta-lactam antibiotics. Allergy. 2003;58(10):961–72.

    Article  CAS  PubMed  Google Scholar 

  • Torres MJ, Padial A, Mayorga C, Fernandez T, Sanchez-Sabate E, Cornejo-Garcia JA, et al. The diagnostic interpretation of basophil activation test in immediate allergic reactions to betalactams. Clin Exp Allergy. 2004;34(11):1768–75.

    Article  CAS  PubMed  Google Scholar 

  • Torres MJ, Ariza A, Fernandez J, Moreno E, Laguna JJ, Montanez MI, et al. Role of minor determinants of amoxicillin in the diagnosis of immediate allergic reactions to amoxicillin. Allergy. 2010;65(5):590–6.

    Article  CAS  PubMed  Google Scholar 

  • Torres MJ, Romano A, Blanca-Lopez N, Doña I, Canto G, Ariza A, et al. Immunoglobulin E-mediated hypersensitivity to amoxicillin: in vivo and in vitro comparative studies between an injectable therapeutic compound and a new commercial compound. Clin Exp Allergy. 2011;41(11):1595–601.

    Article  CAS  PubMed  Google Scholar 

  • Torres MJ, Montanez MI, Ariza A, Salas M, Fernandez TD, Barbero N, et al. The role of IgE recognition in allergic reactions to amoxicillin and clavulanic acid. Clin Exp Allergy. 2016;46(2):264–74.

    Article  CAS  PubMed  Google Scholar 

  • Torres MJ, Celik GE, Whitaker P, Atanaskovic-Markovic M, Barbaud A, Bircher A, et al. A EAACI drug allergy interest group survey on how European allergy specialists deal with beta-lactam allergy. Allergy. 2019;74(6):1052–62.

    Article  PubMed  Google Scholar 

  • Van Boeckel TP, Gandra S, Ashok A, Caudron Q, Grenfell BT, Levin SA, et al. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis. 2014;14(8):742–50.

    Article  PubMed  Google Scholar 

  • Versporten A, Coenen S, Adriaenssens N, Muller A, Minalu G, Faes C, et al. European surveillance of antimicrobial consumption (ESAC): outpatient cephalosporin use in Europe (1997-2009). J Antimicrob Chemother. 2011a;66 Suppl 6:vi25–35.

    PubMed  Google Scholar 

  • Versporten A, Coenen S, Adriaenssens N, Muller A, Minalu G, Faes C, et al. European surveillance of antimicrobial consumption (ESAC): outpatient penicillin use in Europe (1997-2009). J Antimicrob Chemother. 2011b;66 Suppl 6:vi13–23.

    PubMed  Google Scholar 

  • Wenande EC, Skov PS, Mosbech H, Poulsen LK, Garvey LH. Inhibition of polyethylene glycol-induced histamine release by monomeric ethylene and diethylene glycol: a case of probable polyethylene glycol allergy. J Allergy Clin Immunol. 2013;131(5):1425–7.

    Article  CAS  PubMed  Google Scholar 

  • Zawodniak A, Lochmatter P, Yerly D, Kawabata T, Lerch M, Yawalkar N, et al. In vitro detection of cytotoxic T and NK cells in peripheral blood of patients with various drug-induced skin diseases. Allergy. 2010;65(3):376–84.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain

    María José Torres Jaén & Adriana Ariza Veguillas

  2. Allergy Unit, Hospital Regional Universitario de Málaga, Málaga, Spain

    María José Torres Jaén

  3. Centro Andaluz de Nanomedicina y Biotecnología-BIONAND, Málaga, Spain

    María José Torres Jaén

  4. Departamento de Medicina, Universidad de Málaga, Málaga, Spain

    María José Torres Jaén

Authors
  1. María José Torres Jaén
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  2. Adriana Ariza Veguillas
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Editors and Affiliations

  1. Department of Dermatology and Allergy Centre, Singapore General Hospital, Singapore, Singapore

    Haur Yueh Lee

  2. Department of Dermatology, King’s College Hospital, London, UK

    Daniel Creamer

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Torres Jaén, M.J., Ariza Veguillas, A. (2022). Immediate and Delayed Reactions to Beta-Lactams. In: Lee, H.Y., Creamer, D. (eds) Drug Eruptions. Updates in Clinical Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-031-09388-3_22

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  • DOI: https://doi.org/10.1007/978-3-031-09388-3_22

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