Skip to main content

Ovarian Cancer in the Pediatric Population

  • Chapter
  • First Online:
Advances in Diagnosis and Management of Ovarian Cancer
  • 311 Accesses

Abstract

Ovarian neoplasms are uncommon in children: the most common histopathology is a germ cell tumor. The pathology for the majority of pediatric ovarian tumors, typically germ cell tumors, differs from that of adult ovarian neoplasms, which are often epithelial tumors. Surgical staging and extent of surgical extirpation differ between children and adults, given such dissimilar pathologies. For pediatric ovarian malignancies, staging and surgical resection is focused on and localized to the actual visible extent of the tumor and its direct contiguous involvement in other structures. In contrast, adults require an extirpative approach taken to ensure staging of all potential peritoneal structures and to remove all potential sites harboring tumor, given the spread of epithelial tumors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Hassan E, Creatsas G, Deligeorolgu E, Michalas S. Ovarian tumors during childhood and adolescence. A clinicopathological study. Eur J Gynaecol Oncol. 1999;20:124.

    PubMed  CAS  Google Scholar 

  2. Piver MS, Patton T. Ovarian cancer in children. Semin Surg Oncol. 1986;2:163.

    Article  PubMed  CAS  Google Scholar 

  3. Madenci AL, Levine BS, Laufer MR, et al. Preoperative risk stratification of children with ovarian tumors. J Pediatr Surg. 2016;51(9):1507–12.

    Article  PubMed  Google Scholar 

  4. Hermans AJ, Kluivers KB, Janssen LM, et al. Adnexal mases in children, adolescents and women of reproductive age in the Netherlands; a nationwide population-based cohort study. Gynecol Oncol. 2016;143(1):93–7.

    Article  PubMed  Google Scholar 

  5. Cass DL, Hawkins E, Brandt ML, Chintagumpala M, Bloss RS, Milewicz AL, Minifee PK, Wesson DE, Nuchtern JG, et al. Surgery for ovarian masses in infants, children, adolescents: 102 consecutive patients treated in a 15 year period. J Pediatr Surg. 2001;36:693.

    Article  PubMed  CAS  Google Scholar 

  6. Zhang M, Jiang W, Li G, et al. Ovarian masses in children and adolescents - an analysis of 521 clinical cases. J Pediatr Adolesc Gynecol. 2014;27(3):e73–7.

    Article  PubMed  Google Scholar 

  7. Brookfield KF, Cheung MC, Koniaris L, Sola J, Fischer AC. A population-based analysis of 1037 malignant ovarian tumors in the pediatric population. J Surg Res. 2009;156(1):45–9.

    Article  PubMed  Google Scholar 

  8. Oltmann S, Garcia N, Huang R, Hicks B, Fischer AC. Can we preoperatively risk stratify ovarian masses for malignancy? J Pediatr Surg. 2010;45(1):130–4.

    Article  PubMed  Google Scholar 

  9. Morowitz M, Huff D, von Allmen D. Epithelial ovarian tumors in children: a retrospective analysis. J Pediatr Surg. 2003;38:331–5; discussion 331–5.

    Article  PubMed  Google Scholar 

  10. Oltmann SC, Fischer AC, Barber R, Fischer A, Barber R, Huang R, et al. Pediatric ovarian malignancy presenting as ovarian torsion: incidence and relevance. J Pediatr Surg. 2010;45:135–9.

    Article  PubMed  Google Scholar 

  11. Gutherie BD, Adler MD, Powell EC. Incidence and trends of pediatric ovarian torsion hospitalizations in the United States, 2000–2006. Pediatrics. 2010;125:532–8.

    Article  Google Scholar 

  12. Cass DL. Ovarian torsion. Semin Pediatr Surg. 2005;14:86–92.

    Article  PubMed  Google Scholar 

  13. Naiditch JA, Barsness KA. The positive and negative predictive value of the abdominal color Doppler ultrasound for diagnosing ovarian torsion in pediatric patients. J Pediatr Surg. 2013;48(6):1283–7.

    Article  PubMed  Google Scholar 

  14. Fischer AC. Ovarian masses and torsion. In: Ledbetter DJ, Johnson PRV, editors. Endocrine surgery in children. New York: Springer; 2011.

    Google Scholar 

  15. Celik A, Ergun O, Aldemir H, Aldemir H, Ozcan C, Ozok G, et al. Long-term results of conservative management of adnexal torsion in children. J Pediatr Surg. 2005;40(4):704–8.

    Article  PubMed  Google Scholar 

  16. Aziz D, Davis V, Allen L, Langer J. Ovarian torsion in children: is oophorectomy necessary? J Pediatr Surg. 2004;39(5):750–3.

    Article  PubMed  Google Scholar 

  17. Dasgupta R, Renaud E, Goldin AB, et al. Ovarian torsion in pediatric and adolescent patients – a systematic review. J Pediatr Surg. 2018;53(7):1387–91.

    Article  PubMed  Google Scholar 

  18. Vogtlander MF, Rijntjes-Jacobs EG, van den Hoonaard TL, Versteegh FG. Neonatal ovarian cysts. Acta Paediatr. 2003;92:498–501.

    Article  PubMed  CAS  Google Scholar 

  19. Luzzatto C, Midrio P, Toffolutti T, Suma V. Neonatal ovarian cysts: management and follow up. Pediatr Surg Int. 2000;16:56–9.

    Article  PubMed  CAS  Google Scholar 

  20. Dolgin SE. Ovarian masses in the newborn. Semin Pediatr Surg. 2000;9:121–7.

    Article  PubMed  CAS  Google Scholar 

  21. Campbell BA, Garg RS, Garg K, Garg V, Othersen HB Jr, Smith CD. Perinatal cysts: a nonsurgical approach. J Pediatr Surg. 1992;27:1618–9.

    Article  PubMed  CAS  Google Scholar 

  22. Chiaramonte C, Piscopo A, Cataliotti F. Ovarian cysts in newborns. Pediatr Surg Int. 2001;17:171–4.

    Article  PubMed  CAS  Google Scholar 

  23. Brandt ML, Luks FI, Filiatrault D, Garel L, Desjardins JG, Youssef S. Surgical indications in antenatally diagnosed ovarian cysts. J Pediatr Surg. 1991;26:276–81.

    Article  PubMed  CAS  Google Scholar 

  24. Smorgick N, Melcer Y, Sarig-Meth T, et al. High risk of recurrent torsion in the premenarchal girls with torsion of normal adnexa. Fertil Steril. 2016;105(6):1561–5.

    Article  PubMed  Google Scholar 

  25. Brandt ML, Helmrath MA. Ovarian cysts in infants and children. Semin Pediatr Surg. 2005;14:78–85.

    Article  PubMed  Google Scholar 

  26. Barton S, Laufer MR. Recurrent bilateral serous cystadenomas in a premenarchal girl: a case report and literature review. J Pediatr Adolesc Gynecol. 2010;23(1):e27–9.

    Article  PubMed  CAS  Google Scholar 

  27. Magrina JF, Cornella JL. Office management of ovarian cysts. Mayo Clin Proc. 1997;72:653–6.

    Article  PubMed  CAS  Google Scholar 

  28. Lipitz S, Seidman DS, Menczer J, Bider D, Oelsner G, Moran O, Shaley J. Recurrence rate after fluid aspiration from sonographically benign-appearing ovarian cysts. J Reprod Med. 1992;37(10):845–8.

    PubMed  CAS  Google Scholar 

  29. Lala SV, Strubel N. Ovarian neoplasms of childhood. Pediatr Radiol. 2019;49:1463–75.

    Article  PubMed  Google Scholar 

  30. Bernstein L, Smith MA, Liu L. Cancer incidence and survival among children and adolescents: United States SEER Program 1975–1995, National Cancer Institute, SEER Program, Vol NIH Pub No.99-4649. In: Ries LAG, Smith MA, Gurny JC, et al., editors. . Bethesda, MD: Cancer Statistics Branch, Cancer Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute; 1999. p. 125–38.

    Google Scholar 

  31. Teilum G. Classification of endodermal sinus tumour (mesoblastoma vitellinum) and so-called “embryonal carcinoma” of the ovary. Acta Pathol Microbiol Scand. 1965;64(4):407–29.

    Article  PubMed  CAS  Google Scholar 

  32. Strickland J and Laufer MR. Adnexal masses. In: Goldstein’s pediatric & adolescent gynecology. Emans SJH, Laufer MR, DiVasta AD, 7th Edition. Wolters Kluwer, Philadelphia; 2020. p. 529–547.

    Google Scholar 

  33. Kim MJ, Kim NY, Lee DY, et al. Clinical characteristics of ovarian teratoma: age-focused retrospective analysis of 580 cases. Am J Obstet Gynecol. 2011;205(1):32.e1–4.

    Article  Google Scholar 

  34. Norris HJ, Zirkin HJ, Benson WL. Immature (malignant) teratoma of the ovary: a clinical and pathologic study of 58 cases. Cancer. 1976;37:2359–72.

    Article  PubMed  CAS  Google Scholar 

  35. Mahajan P, Weldon CB, Frazier AL, Laufer MR. Gynecologic cancers in chidren and adolescents. In: Emans SJH, Laufer MR, DiVasta AD, editors. Goldstein’s pediatric & adolescent gynecology. 7th ed. Philadelphia: Wolters Kluwer; 2020. p. 556–74.

    Google Scholar 

  36. Cushing B, Giller R, Ablin A, Cohen L, Cullen J, Hawkins E. Surgical resection alone is effective treatment for ovarian immature teratoma in children and adolescents: a report of the pediatric oncology group and the children’s cancer group. Am J Obstet Gynecol. 1999;181:353–8.

    Article  PubMed  CAS  Google Scholar 

  37. O’Connor DM, Norris HJ. The influence of grade on the outcome of stage I ovarian immature (malignant) teratomas and the reproducibility of grading. Int J Gynecol Pathol. 1994;13:283–9.

    Article  PubMed  Google Scholar 

  38. Pashankar F, Hale JP, Dang H, et al. Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Consortium. Cancer. 2016;122(2):230–7.

    Article  PubMed  Google Scholar 

  39. Pawinski A, Favalli G, Ploch E, Sahmoud T, van Oosterom AT, Pecorelli S. PVB chemotherapy in patients with recurrent or advanced dysgerminoma: a phase II study of the EORTC Gynaecological Cancer Cooperative Group. Clin Oncol. 1998;10(5):301–5.

    Article  CAS  Google Scholar 

  40. Ayhan A, Tuncer ZS, Yanik F, Bükülmez O, Yanik A, Küçükali T. Malignant germ cell tumors of the ovary: Hacettepe hospital experience. Acta Obstet Gynecol Scand. 1995;74(5):384–90.

    Article  PubMed  CAS  Google Scholar 

  41. Scully RE. Gonadoblastoma: a review of 74 cases. Cancer. 1970;25:1340–56.

    Article  PubMed  CAS  Google Scholar 

  42. Gordon A, Lipton D, Woodruff D. Dysgerminoma: a review of 158 cases from the Emil Novak ovarian tumor registry. Obstet Gynecol. 1981;58:497–504.

    PubMed  CAS  Google Scholar 

  43. Kurman RJ, Norris HJ. Endodermal sinus tumor of the ovary: a clinical and pathologic analysis of 71 cases. Cancer. 1976;38:2404–19.

    Article  PubMed  CAS  Google Scholar 

  44. Gershenson DM, Del Junco G, Herson J, Rutledge FN. Endodermal sinus tumor of the ovary: the MD Anderson experience. Obstet Gynecol. 1983;61:194–202.

    PubMed  CAS  Google Scholar 

  45. Gribbon M, Ein SH, Mancer K. Pediatric malignant ovarian tumors: a 43-year review. J Pediatr Surg. 1992;27:480–4.

    Article  PubMed  CAS  Google Scholar 

  46. Belchis D, Mowry J, Davis J. Infantile choriocarcinoma. Re-examination of a potentially curable entity. Cancer. 1993;72:2028–32.

    Article  PubMed  CAS  Google Scholar 

  47. Flam F, Lundstrom V, Silfversward C. Choriocarcinoma in mother and child: case report. Br J Obstet Bynaecol. 1989;96:241–4.

    Article  CAS  Google Scholar 

  48. Takeda A, Ishizuka T, Goto T, Goto S, Ohta M, Tomoda Y, Hoshino M. Polyembryoma of ovary producing alpha-fetoprotein and HCG: immunoperoxidase and electron microscopic study. Cancer. 1982;49(9):1878–89.

    Article  PubMed  CAS  Google Scholar 

  49. Koksal Y, Reisli I, Gunel E, Caliskan U, Bulun A, Kale G. Galactorrhea-associated granulosa cell tumor in a child. Pediatr Hematol Oncol. 2004;21:101–6.

    Article  PubMed  Google Scholar 

  50. Chan LF, Storr HL, Scheimberg I, Perry LA, Banerjee K, Miraki-Moud F. Pseudo-precocious puberty caused by a juvenile granulosa cell tumour secreting androstenedione, inhibin and insulin-like growth factor-I. J Pediatr Endocrinol Metab. 2004;17:679–84.

    Article  PubMed  CAS  Google Scholar 

  51. Lazar EL, Stolar CJ. Evaluation and management of pediatric solid ovarian tumors. Semin Pediatr Surg. 1998;7:29–34.

    Article  PubMed  CAS  Google Scholar 

  52. Schultz KAP, Harris AK, Schneider DT, et al. Ovarian sex cord-stromal tumors. J Oncol Pract. 2016;12:940–6.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Tetu B, Ordonez NG, Silva EG. Sertoli-Leydig cell tumor of the ovary with alpha-fetoprotein production. Arch Pathol Lab Med. 1986;110:65–8.

    PubMed  CAS  Google Scholar 

  54. Gershenson DM, Copeland LI, Kavanagh JJ, Stringer CA, Saul PB, Wharton JT. Treatment of metastatic stromal tumors of the ovary with cisplatin, doxorubicin, and cyclophosphamide. Obstet Gynecol. 1987;70:765–9.

    PubMed  CAS  Google Scholar 

  55. Schneider DT, Janig U, Calaminus G, Göbel U, Harms D. Ovarian sex cord-stromal tumors: a clinicopathological study of 72 cases from the Kiel Pediatric Tumor Registry. Virchows Arch. 2003;443:549–60.

    Article  PubMed  Google Scholar 

  56. Breen JL, Maxon WS. Ovarian tumors in children and adolescents. Clin Obstet Gynecol. 1977;20:607–23.

    Article  PubMed  CAS  Google Scholar 

  57. Tsai JY, Saigo PE, Brown C, La Quaglia MP. Diagnosis, pathology, staging, treatment, and outcome of epithelial ovarian neoplasia in patients age <21 years. Cancer. 2001;91:2065–70.

    Article  PubMed  CAS  Google Scholar 

  58. Deprest J, Moerman P, Corneillie P, Ide P. Ovarian borderline mucinous tumor in a premenarchal girl: review on ovarian epithelial cancer in young girls. Gynecol Oncol. 1992;45(2):219–24.

    Article  PubMed  CAS  Google Scholar 

  59. Leake JF, Currie JL, Rosenshein NB, Woodruff JD. Long-term follow-up of serous ovarian tumors of low malignant potential. Gynecol Oncol. 1992;47(2):150–8.

    Article  PubMed  CAS  Google Scholar 

  60. Elchalal U, Dgani R, Piura B, Anteby SO, Anteby SO, Zalel Y, Czernobilsky B, Schenker JG. Current concepts in management of epithelial ovarian tumors of low malignant potential. Obstet Gynecol Surv. 1995;50(1):62–70.

    Article  PubMed  CAS  Google Scholar 

  61. Barakat RR. Borderline tumors of the ovary. Obstet Gynecol Clin N Am. 1994;21(1):93–105.

    Article  CAS  Google Scholar 

  62. Skinner MA, Schlatter M, Heifetz S, Skinner MA. Ovarian neoplasms in children. Arch Surg. 1993;128:849–54.

    Article  PubMed  CAS  Google Scholar 

  63. Kr S, Wakhlu A, Kokai GK, McDowell H, Jones MO. Ovarian adenocarcinoma in premenarchal girls. J Pediatr Surg. 2001;36:511–5.

    Article  Google Scholar 

  64. Chakrabarti B, Bhaduri B, Barik S, Gupta D, Chakravorty S. Primary ovarian lymphoma in a child. J Indian Med Assoc. 2011;109(9):679–80.

    PubMed  Google Scholar 

  65. Heaton DC, Duff GB. Ovarian relapse in a young woman with acute lymphoblastic leukaemia. Am J Hematol. 1989;30(1):42–3.

    Article  PubMed  CAS  Google Scholar 

  66. Cacciaguerra S, Miano AE, Di Benedetto A, Vasquez E, Magro G, Fraggetta F. Gastric carcinoma with ovarian metastases in an adolescent. Pediatr Surg Int. 1998;14(1–2):98–9.

    Article  PubMed  CAS  Google Scholar 

  67. Surti U, Hoffner L, Chakravarti A, Ferrell RE. Genetics and biology of human ovarian teratomas: I. Cytogenetic analysis and mechanism of origin. Am J Hum Genet. 1990;47:635–43.

    PubMed  PubMed Central  CAS  Google Scholar 

  68. Parrington JM, West LE, Povey S. The origin of ovarian teratomas. J Med Genet. 1984;21:4–12.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  69. Ohama K, Nomura K, Okamato E, Fukuda Y, Ihara T, Fujiwara A. Origin of immature teratoma of the ovary. Am J Obstet Gynecol. 1985;152:896–900.

    Article  PubMed  CAS  Google Scholar 

  70. King ME, DiGiovanni LM, Yung JF, Clarke-Pearson DL. Immature teratoma of the ovary grade 3, with karyotype analysis. Int J Gynecol Pathol. 1990;9(2):178–84.

    Article  PubMed  CAS  Google Scholar 

  71. Ihara T, Ohama K, Satoh H, Fujii T, Nomura K, Fujiwara A. Histologic grade and karyotype of immature teratoma of the ovary. Cancer. 1984;54(12):2988–94.

    Article  PubMed  CAS  Google Scholar 

  72. Ulbright TM. Gonadal teratomas: a review and speculation. Adv Anat Pathol. 2004;11:10–23.

    Article  PubMed  Google Scholar 

  73. Hoffner L, Deka R, Chakravarti A. Cytogenetics and origins of pediatric germ cell tumors. Cancer Genet Cytogenet. 1994;74:54–8.

    Article  PubMed  CAS  Google Scholar 

  74. Hoffner L, Shen-Schwarz S, Deka R, Chakravarti A, Surti U. Genetics and biology of human ovarian teratomas: III. Cytogenetics and origins of malignant ovarian germ cell tumors. Cancer Genet Cytogenet. 1992;62:58–65.

    Article  PubMed  CAS  Google Scholar 

  75. Thompson FH, Emerson J, Alberts D, Liu Y, Guan XY, Burgess A, et al. Clonal chromosome abnormalities in 54 cases of ovarian carcinoma. Cancer Genet Cytogenet. 1994;73:33–45.

    Article  PubMed  CAS  Google Scholar 

  76. Rutgers JL, Scully RE. Pathology of the testis in intersex syndromes. Semin Diagn Pathol. 1987;4:275–91.

    PubMed  CAS  Google Scholar 

  77. Billmire D, Vinocur C, Rescorla F, Cushing B, London W, Schlatter M, et al. Outcome and staging evaluation in malignant germ cell tumors of the ovary in children and adolescents: an intergroup study. J Pediatr Surg. 2004;39:424–9.

    Article  PubMed  CAS  Google Scholar 

  78. Templeman C, Fallat ME, Blinchevsky A, Hertweck SP. Noninflammatory ovarian masses in girls and young women. Obstet Gynecol. 2000;96:229–33.

    PubMed  CAS  Google Scholar 

  79. Niedziela M. Virilizing ovarian tumor in a 14-year-old female with prior familial multinodular goiter. Pediatr Blood Cancer. 2008;51:543–5.

    Article  PubMed  Google Scholar 

  80. Calaminus G, Wessalowski R, Harms D, Göbel U. Juvenile granulosa cell tumors of the ovary in children and adolescents: results from 33 patients registered in a prospective cooperative study. Gynecol Oncol. 1997;65:447–52.

    Article  PubMed  CAS  Google Scholar 

  81. Hayes-Jordan A. Surgical management of the incidentally identified ovarian mass. Semin Pediatr Surg. 2005;14:106–10.

    Article  PubMed  Google Scholar 

  82. Madenci AL, Vandewalle RJ, Dieffenbach BV, Laufer MR, Boyd TK, Voss SD, Frazier AL, Billmire DF, Rescorla FJ, Weil BR, Weldon CB. Multicenter pre-operative assessment of pediatric ovarian malignancy. J Pediatr Surg. 2019;54(9):1921–5.

    Article  PubMed  Google Scholar 

  83. Brown MF, Hebra A, McGeehin K, Ross AJ III. Ovarian masses in children: a review of 91 cases of malignant and benign masses. J Pediatr Surg. 1993;28:930–2.

    Article  PubMed  CAS  Google Scholar 

  84. Von Allmen D. Malignant lesions of the ovary in childhood. Semin Pediatr Surg. 2005;14:100–5.

    Article  Google Scholar 

  85. Childrens Oncology Group. Treatment of children with germ cell tumors handbook. 2004. www.childrensoncologygroup.org.

  86. Pectasides D, Pestasides E, Kassanos D. Germ cell tumors of the ovary. Cancer Treat Rev. 2008;34:427–41.

    Article  PubMed  CAS  Google Scholar 

  87. Thalberg SA. New gynecologic cancer staging. Obstet Gynecol. 1990;76(1):158.

    PubMed  CAS  Google Scholar 

  88. Benedet JL, Bender H, Jones H III, Ngan HY, Pecorelli S. FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology. Int J Gynaecol Obstet. 2000;70(2):209–62.

    Article  PubMed  CAS  Google Scholar 

  89. Terenziani M, D’Angelo P, Bisogno G, Boldrini R, Cecchetto G, Collini P, et al. Teratoma with a malignant somatic component in pediatric patients: the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience. Pediatr Blood Cancer. 2010;54(4):532–7.

    Article  PubMed  Google Scholar 

  90. Topuz S, Iyibozkurt AC, Akhan SE, Keskin N, Yavuz E, Salihoglu Y, et al. Malignant germ cell tumors of the ovary: a review of 41 cases and risk factors for recurrence. Eur J Gynaecol Oncol. 2008;29(6):635–7.

    PubMed  CAS  Google Scholar 

  91. Thomas GM, Dembo AJ, Hacker NF, DePetrillo AD. Current therapy for dysgerminoma of the ovary. Obstet Gynecol. 1987;70(2):268–75.

    PubMed  CAS  Google Scholar 

  92. Templeman CL, Hertweck SP, Scheetz JP, Perlman SE, Fallat ME. The management of mature cystic teratoma in children and adolescents: a retrospective analysis. Hum Reprod. 2000;15:2669–72.

    Article  PubMed  CAS  Google Scholar 

  93. Azizkhan RG, Caty MG. Teratomas in childhood. Curr Opin Pediatr. 1996;8:287–92.

    Article  PubMed  CAS  Google Scholar 

  94. Yanai-Inbar I, Scully RE. Relations of ovarian dermoid cysts and immature teratomas: an analysis of 350 cases of immature teratoma and 10 cases of dermoid cyst with microscopic foci of immature tissue. Int J Gynecol Pathol. 1987;6:203–12.

    Article  PubMed  CAS  Google Scholar 

  95. Rogers PC, Olson TA, Cullen JW, Billmire DF, Marina N, Rescorla F, et al. Treatment of children and adolescents with stage II testicular and stages I and II ovarian malignant germ cell tumors: a pediatric intergroup study - POG 9048 and COG 8891. J Clin Oncol. 2004;22:3563–9.

    Article  PubMed  Google Scholar 

  96. Frazier AI, Stoneham S, Rodriguez-Galindo C, et al. Comparison of carboplatin versus cisplatin in the treatment of pediatric extracranial malignant germ cell tumors: a report of the Malignant Germ Cell International Consortium. Eur J Cancer. 2018;98:30–7.

    Article  PubMed  CAS  Google Scholar 

  97. Shah R, Xia C, Krailo M, et al. Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults? Gynecol Oncol. 2018;150:253–60.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anne C. Fischer MD, PhD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Fischer, A.C. (2022). Ovarian Cancer in the Pediatric Population. In: Farghaly, S.A. (eds) Advances in Diagnosis and Management of Ovarian Cancer. Springer, Cham. https://doi.org/10.1007/978-3-031-09169-8_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-09169-8_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-09168-1

  • Online ISBN: 978-3-031-09169-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics