Abstract
As in most cell types, intracellular Ca2+ regulates many fundamental physiological functions in sperm and its progenitors. Ca2+ permeable and voltage-dependent channels in their plasma membrane deeply influence the intracellular Ca2+ concentration. Notably, the role of traditional voltage-dependent Ca2+ channels (CaVs) in spermatogenesis, sperm maturation, motility, and preparation for egg fusion is not well defined. Sperm possesses a unique and very complex Ca2+ channel regulated by intracellular pH, Ca2+, and voltage called CatSper that is key for fertilization and influences motility, and possibly the acrosome reaction (AR). This exocytotic singular event encompasses the fusion of the acrosome vesicle in the posterior region of the head to the plasma membrane preparing this cell to fuse and fertilize the egg. Though CaVs and CatSper may participate in this reaction, it is still a pending question. In this chapter, we examine the characteristics of these Ca2+ channels and their involvement in sperm physiology.
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Darszon, A., Ferreira, J.J., López-González, I., Orta, G., Treviño, C.L., Santi, C.M. (2022). Voltage-Dependent Calcium Channels (CaVs) and CatSper in Spermatogenic and Sperm Cells. In: Zamponi, G.W., Weiss, N. (eds) Voltage-Gated Calcium Channels . Springer, Cham. https://doi.org/10.1007/978-3-031-08881-0_23
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