Abstract
Cutaneous melanoma is dramatically increasing in frequency, and it represents quite an aggressive tumor when evolving to the metastatic stage. High-resolution ultrasound (US) is playing a growing role in assessing newly diagnosed cutaneous melanoma in the locoregional staging prior to the sentinel lymph node biopsy procedure and in the melanoma patient follow-up. Primary melanoma assessment with US requires a rigorous methodology to allow a sonographic measurement of tumor thickness adequately reflecting pathological measurement. Several challenging aspects exist. Appropriate equipment setting and adequate knowledge of the very peculiar way of spread of melanoma and the related grayscale and color Doppler features are mandatory. US can be valuable in assessing superficial melanoma metastases’ response to newly developed local or systemic therapies. Finally, US may guide percutaneous procedures in the melanoma patient, both diagnostic and therapeutic.
To the memory of Christiane Voit, passionate melanoma ultrasound expert
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Abbreviations
- CLND:
-
Complete lymph node dissection
- CT:
-
Computed tomography
- EFOV:
-
Extended field-of-view
- FNAC:
-
Fine needle aspiration cytology
- L/T:
-
Longitudinal-to-transverse ratio
- PET:
-
Positron-emission tomography
- SLN:
-
Sentinel lymph node
- SLNB:
-
Sentinel lymph node biopsy
- US:
-
Ultrasound
References
Garbe C, Amaral T, Peris K, et al. European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics—update 2019. Eur J Cancer. 2020;126:141–58.
Hartman RI, Lin JY. Cutaneous melanoma: a review in detection, staging, and management. Hematol Oncol Clin North Am. 2019;33:25–38.
Botar-Jid CM, Cosgarea R, Bolboacă SD, et al. Assessment of cutaneous melanoma by use of very-high-frequency ultrasound and real-time elastography. AJR. 2016;206:699–704.
Catalano O, Alfabete Roldan F, Varelli C, et al. Skin cancer: findings and role of high-resolution ultrasound. J Ultrasound. 2019;22:423–31.
Michielin O, van Akkooi ACJ, Ascierto PA, et al. Cutaneous melanoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2019;30:1884–901.
Leonardi GC, Falzone L, Salemi R, et al. Cutaneous melanoma: from pathogenesis to therapy (review). Int J Oncol. 2018;52:1071–80.
Wouters MW, Michielin O, Basitane E, et al. ECCO essential requirements for quality cancer care: melanoma. Crit Rev Oncol Hematol. 2018;122:164–78.
Guy GP Jr, Thomas CC, Thompson T, et al. Vital signs: melanoma incidence and mortality trends and projections - United States, 1982-2030. MMWR Morb Mortal Wkly Rep. 2015;64:591–6.
Schadendorf D, van Akkooi ACJ, Berking C, et al. Melanoma. Lancet. 2018;392:971–84.
Elder DE, Bastian BC, Cree IA, et al. The 2018 World Health Organization classification of cutaneous, mucosal, and uveal melanoma: detailed analysis of 9 distinct subtypes defined by their evolutionary pathway. Arch Pathol Lab Med. 2020;144:500–22.
Fernández Canedo I, de Troya MM, Fúnez Liébana R, et al. Preoperative 15-MHz ultrasound assessment of tumor thickness in malignant melanoma. Actas Dermosifiliogr. 2013;104:227–31.
Scolyer RA, Judge MJ, Evans A, et al. Data set for pathology reporting of cutaneous invasive melanoma: recommendations from the international collaboration on cancer reporting (ICCR). Am J Surg Pathol. 2013;37:1797–814.
Swetter SM, Tsao H, Bichakjian CK, et al. Guidelines of care for the management of primary cutaneous melanoma. J Am Acad Dermatol. 2019;80:208–50.
Thompson JF, Haydu LE, Sanki A, et al. Ultrasound assessment of lymph nodes in the management of early-stage melanoma. J Surg Oncol. 2011;104:354–60.
Ulrich J, van Akkooi AJ, Eggermont AM, et al. New developments in melanoma: utility of ultrasound imaging (initial staging, follow-up and pre-SLNB). Expert Rev Anticancer Ther. 2011;11:1693–701.
Gershenwald JE, Scolyer RA, Hess KR, et al. Melanoma staging: evidence-based changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67:472–92.
Catalano O, Voit C. Locoregional staging of melanoma. In: Wortsman X, GBE J, editors. Dermatologic ultrasound - clinical and histologic correlations. Berlin: Springer; 2014.
Wortsman X, Wortsman J. Clinical usefulness of variable-frequency ultrasound in localized lesions of the skin. J Am Acad Dermatol. 2010;62:247–56.
Catalano O, Wortsman X. Dermatology ultrasound. Imaging technique, tips and tricks, high-resolution anatomy. Ultrasound Q. 2020;36:321–7.
Wortsman X. Common applications of dermatologic sonography. J Ultrasound Med. 2012a;31:97–111.
Uematsu T, Kasami M, Kiyohara Y. B-mode ultrasound imaging, Doppler imaging, and real-time elastography in cutaneous malignant melanoma and lymph node metastases. Healthcare (Basel). 2013;1:84–95.
Uren RF, Sanki A, Thompson JF. The utility of ultrasound in patients with melanoma. Expert Rev Anticancer Ther. 2007;7:1633–42.
Catalano O, Sandomenico F, Siani A. Value of the extended field of view modality in the sonographic imaging of cutaneous melanoma: a pictorial essay. Dermatol Surg. 2010a;36:1300–4.
Wortsman X. Sonography of the primary cutaneous melanoma: a review. Radiol Res Pract. 2012b;2012:814396.
Corvino A, Sandomenico F, Corvino F, et al. Utility of a gel stand-off pad in the detection of Doppler signal on focal nodular lesions of the skin. J Ultrasound. 2020;23:45–53.
Hambardzumyan M, Hayrapetyan A. Ultrasound analytic criteria for diagnosing cutaneous malignant melanoma. J Dermatol Res. 2018;3:32–6.
Catalano O. Cancer measurement at ultrasound: state of the art. Ultrasound Q. 2017;33:116–24.
Andrekute K, Valiukeviciene S, Raisutis R, et al. Automated estimation of melanocytic skin tumor thickness by ultrasonic radiofrequency data. J Ultrasound Med. 2016;35:857–65.
Catalano O, Nunziata A, Saturnino PP, et al. Epitrochlear lymph nodes: anatomy, clinical aspects, and sonography features. Pictorial essay. J Ultrasound. 2010c;13:168–74.
Blum A, Schmid-Wendtner MH, Mauss-Kiefer V, et al. Ultrasound mapping of lymph node and subcutaneous metastases in patients with cutaneous melanoma: results of a prospective multicenter study. Dermatology. 2006;212:47–52.
Solivetti FM, Di Luca SA, Pirozzi G, et al. Sonographic evaluation of clinically occult in-transit and satellite metastases from cutaneous malignant melanoma. Radiol Med. 2006;111:702–8.
Catalano O, Siani A. Cutaneous melanoma: role of ultrasound in the assessment of locoregional spread. Curr Probl Diagn Radiol. 2010;39:30–6.
Catalano O, Setola SV, Vallone P, e t al. Sonography for locoregional staging and follow-up of cutaneous melanoma. J Ultrasound Med. 2010d;29:791–802.
Marone U, Caracò C, Chiofalo MG, et al. Resection in the popliteal fossa for metastatic melanoma. World J Surg Oncol. 2007;5:8.
Uren RF, Howman-Giles R, Thompson JF, et al. Interval nodes: the forgotten sentinel nodes in patients with melanoma. Arch Surg. 2000;135:1168–72.
Hambardzumyan M, Hayrapetyan A. Differential diagnosis of malignant melanoma and benign cutaneous lesions by ultrasound analysis. Sci Med J. 2020;2:2.
Catalano O, Voit C, Sandomenico F, et al. Previously reported sonographic appearances of regional melanoma metastases are not likely due to necrosis. J Ultrasound Med. 2011;30:1041–9.
Catalano O, Caracò C, Mozzillo N, et al. Locoregional spread of cutaneous melanoma: sonography findings. AJR. 2010b;194:735–45.
Botar Jid C, Bolboacă SD, Cosgarea R, et al. Doppler ultrasound and strain elastography in the assessment of cutaneous melanoma: preliminary results. Med Ultrason. 2015;17:509–14.
Hinz T, Wenzel J, Schmid-Wendtner MH. Real-time tissue elastography: a helpful tool in the diagnosis of cutaneous melanoma? J Am Acad Dermatol. 2011;5:424–6.
Chami L, Lassau N, Chebil M, Robert C. Imaging of melanoma: usefulness of ultrasonography before and after contrast injection for diagnosis and early evaluation of treatment. Clin Cosmet Investig Dermatol. 2011;4:1–6.
Dinnes J, Bamber J, Chuchu N, et al. High-frequency ultrasound for diagnosing skin cancer in adults. Cochrane Database Syst Rev. 2018;12:CD013188.
Bessoud B, Lassau N, Koscielny S, et al. High-frequency sonography and color Doppler in the management of pigmented skin lesions. Ultrasound Med Biol. 2003;29:875–9.
Harland C, Kale S, Jackson P, et al. Differentiation of common benign pigmented skin lesions from melanoma by high resolution ultrasound. Br J Dermatol. 2000;143:281–9.
Jasaitiene D, Valiukeviciene S, Linkeviciute G. Principles of high-frequency ultrasonography for investigation of skin pathology. J Eur Acad Dermatol Venereol. 2011;25:375–82.
Machet L, Belot V, Naouri M, et al. Preoperative measurement of thickness of cutaneous melanoma using high-resolution 20 MHz ultrasound imaging: a monocenter prospective study and systematic review of the literature. Ultrasound Med Biol. 2009;35:1411–20.
Piłat P, Borzęcki A, Jazienicki M, et al. Skin melanoma imaging using ultrasonography: a literature review. Postepy Dermatol Alergol. 2018;35:238–42.
Gamblicher T, Moussa G, Bahrenberg K, et al. Preoperative ultrasonic assessment of thin melanocytic skin lesions using a 100-MHz ultrasound transducer: a comparative study. Dermatol Surg. 2007;33:818–24.
Guitera P, Li LX, Crotty K, et al. Melanoma histological Breslow thickness predicted by 75-MHz ultrasonography. Br J Dermatol. 2008;159:364–9.
Music MM, Hertl K, Kadivec M, et al. Pre-operative ultrasound with a 12-15 MHz linear probe reliably differentiates between melanoma thicker and thinner than 1 mm. J Eur Acad Dermatol Venereol. 2010;24:1105–8.
Weichenthal M, Mohr P, Breitbart EW. The velocity of ultrasound in human primary melanoma tissue - implications for the clinical use of high-resolution sonography. BMC Dermatol. 2001;1:1.
Chaput L, Laurent E, Pare A, et al. One-step surgical removal of cutaneous melanoma with surgical margins based on preoperative ultrasound measurement of tumor thickness of the melanoma. Eur J Dermatol. 2018;28:202–8.
Lassau N, Koscielny S, Avril MF, et al. Prognostic value of angiogenesis evaluated with high-frequency and color Doppler sonography for preoperative assessment of melanomas. AJR. 2002;178:1547–51.
Lassau N, Lamuraglia M, Koscielny S, et al. Prognostic value of angiogenesis evaluated with high-frequency and colour Doppler sonography for preoperative assessment of primary cutaneous melanomas: correlation with recurrence after a 5 year follow-up period. Cancer Imaging. 2006;6:24–9.
Keung EZ, Gershenwald JE. The eighth edition American joint Committee on cancer (AJCC) melanoma staging system: implications for melanoma treatment and care. Expert Rev Anticancer Ther. 2018;18:775–84.
Morton DL, Thompson JF, Cochran AJ, et al. Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med. 2014;370:599–609.
Valsecchi ME, Silbermins D, de Rosa N, et al. Lymphatic mapping and sentinel lymph node biopsy in patients with melanoma: a meta-analysis. J Clin Oncol. 2011;29:1479–87.
Morton DL, Wen DR, Wong JH, et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg. 1992;127:392–9.
Wong SL, Balch CM, Hurley P, et al. Sentinel lymph node biopsy for melanoma: American Society of Clinical Oncology and Society of Surgical Oncology joint clinical practice guideline. J Clin Oncol. 2012;30:2912–8.
Gonzalez A. Sentinel lymph node biopsy: past and present implications for the management of cutaneous melanoma with nodal metastasis. Am J Clin Dermatol. 2018;19(Suppl 1):24–30.
Namikawa K, Yamazaki N, Nakai Y, et al. Prediction of additional lymph node positivity and clinical outcome of micrometastases in sentinel lymph nodes in cutaneous melanoma: a multi-institutional study of 450 patients in Japan. J Dermatol. 2012;39:130–7.
van Akkooi AC, Verhoef C, Eggermont AM. Importance of tumor load in the sentinel node in melanoma: clinical dilemmas. Nat Rev Clin Oncol. 2010b;7:446–54.
Karim RZ, Scolyer RA, Li W, et al. False negative sentinel lymph node biopsies in melanoma may result from deficiencies in nuclear medicine, surgery, or pathology. Ann Surg. 2008;247:1003–10.
Lam TK, Uren RF, Scolyer RA, et al. False-negative sentinel node biopsy because of obstruction of lymphatics by metastatic melanoma: the value of ultrasound in conjunction with preoperative lymphoscintigraphy. Melanoma Res. 2009;19:94–9.
Satzger I, Meier A, Hoy L, et al. Sentinel node dissection delays recurrence and prolongs melanoma-related survival: an analysis of 673 patients from a single center with long-term follow-up. Ann Surg Oncol. 2011;18:514–20.
Gershenwald JE, Andtbacka RH, Prieto VG, et al. Microscopic tumor burden in sentinel lymph nodes predicts synchronous nonsentinel lymph node involvement in patients with melanoma. J Clin Oncol. 2008;26:4296–303.
Reeves ME, Delgado R, Busam KJ, et al. Prediction of nonsentinel lymph node status in melanoma. Ann Surg Oncol. 2003;10:27–31.
Brown RE, Ross MI, Edwards MJ, et al. The prognostic significance of nonsentinel lymph node metastasis in melanoma. Ann Surg Oncol. 2010;17:3330–5.
Faries MB, Thompson JF, Cochran AJ, et al. Completion dissection or observation for sentinel-node metastasis in melanoma. N Engl J Med. 2017;376:2211–22.
Leiter U, Stadler R, Mauch C, et al. Complete lymph node dissection versus no dissection in patients with sentinel lymph node biopsy positive melanoma (DeCOG-SLT): a multicentre, randomised, phase 3 trial. Lancet Oncol. 2016;17:757–67.
Hocevar M, Bracko M, Pogacnik A, et al. The role of preoperative ultrasonography in reducing the number of sentinel lymph node procedures in melanoma. Melanoma Res. 2004;14:533–6.
Catalano O. Critical analysis of the ultrasonographic criteria for diagnosing lymph node metastasis in patients with cutaneous melanoma: a systematic review. J Ultrasound Med. 2011;30:547–60.
Chai CY, Zager JS, Szabunio MM, et al. Preoperative ultrasound is not useful for identifying nodal metastasis in melanoma patients undergoing sentinel node biopsy: preoperative ultrasound in clinically node-negative melanoma. Ann Surg Oncol. 2012;19:1100–6.
Pilko G, Zgajnar J, Music M, et al. Lower tumour burden and better overall survival in melanoma patients with regional lymph node metastases and negative preoperative ultrasound. Radiol Oncol. 2012;46:60–8.
Hinz T, Voth H, Ahmadzadehfar H, et al. Role of high-resolution ultrasound and PET/CT imaging for preoperative characterization of sentinel lymph nodes in cutaneous melanoma. Ultrasound Med Biol. 2013b;39:30–6.
Olmedo D, Brotons-Seguí M, Del Toro C, et al. Use of lymph node ultrasound prior to sentinel lymph node biopsy in 384 patients with melanoma: a cost-effectiveness analysis. Actas Dermosifiliogr. 2017;108:931–8.
van Rijk MC, Jelle Teertstra H, Peterse JL, et al. Ultrasonography and fine-needle aspiration cytology in the preoperative evaluation of melanoma patients eligible for sentinel node biopsy. Ann Surg Oncol. 2006;13:1511–6.
De Giorgi V, Gori A, Grazzini M, et al. Contrast-enhanced ultrasound: a filter role in AJCC stage I/II melanoma patients. Oncology. 2010;79:370–5.
Sanki A, Uren RF, Moncrieff M, et al. Targeted high-resolution ultrasound is not an effective substitute for sentinel lymph node biopsy in patients with primary cutaneous melanoma. J Clin Oncol. 2009;27:5614–9.
Starritt EC, Uren RF, Scolyer RA, et al. Ultrasound examination of sentinel nodes in the initial assessment of patients with primary cutaneous melanoma. Ann Surg Oncol. 2005;12:18–23.
Stoffels I, Dissemond J, Poeppel T, et al. Advantages of preoperative ultrasound in conjunction with lymphoscintigraphy in detecting malignant melanoma metastases in sentinel lymph nodes: a retrospective analysis in 221 patients with malignant melanoma AJCC stages I and II. J Eur Acad Dermatol Venereol. 2012;26:79–85.
Voit C, Kron M, Schäfer G, et al. Ultrasound-guided fine needle aspiration cytology prior to sentinel lymph node biopsy in melanoma patients. Ann Surg Oncol. 2006;13:1682–9.
Voit CA, van Akkoi AC, Schäfer-Hesterberg G, et al. Rotterdam criteria for sentinel node (SN) tumor burden and the accuracy of ultrasound (US)-guided fine-needle aspiration cytology (FNAC): can US-guided FNAC replace SN staging in patients with melanoma? J Clin Oncol. 2009;27:4994–5000.
Voit CA, Gooskens SL, Siegel P, et al. Ultrasound-guided fine needle aspiration cytology as an addendum to sentinel lymph node biopsy can perfect the staging strategy in melanoma patients. Eur J Cancer. 2014;50:2280–8.
van Akkooi AC, Voit CA, Verhoef C, et al. Potential cost-effectiveness of US-guided FNAC in melanoma patients as a primary procedure and in follow-up. Ann Surg Oncol. 2010a;17:660–2.
Dinnes J, Ferrante di Ruffano L, Takwoingi Y, et al. Ultrasound, CT, MRI, or PET-CT for staging and re-staging of adults with cutaneous melanoma. Cochrane Database Syst Rev. 2019;7:CD012806.
Nazarian LN, Alexander AA, Kurtz AB, et al. Superficial melanoma metastases: appearances on gray-scale and color Doppler sonography. AJR. 1998;170:459–63.
Corvino A, Corvino F, Catalano O, et al. The tail and the string sign: new sonographic features of subcutaneous melanoma metastasis. Ultrasound Med Biol. 2017;43:370–4.
Alexander AA, Nazarian LN, Capuzzi DM Jr, er al. Color Doppler sonographic detection of tumor flow in superficial melanoma metastases: histologic correlation. J Ultrasound Med. 1998;17:123–6.
Cohen J, Riishede I, Carlsen JF, et al. Can strain elastography predict malignancy of soft tissue tumors in a tertiary sarcoma center? Diagnostics (Basel). 2020;10:148.
Li S, Liu L, Lv G. Diagnostic value of strain elastography for differentiating benign and malignant soft tissue masses. Oncol Lett. 2017;14:2041–4.
Marone U, Catalano O, Caracò C, et al. Can high-resolution ultrasound avoid the sentinel lymph-node biopsy procedure in the staging process of patients with stage I-II cutaneous melanoma? Ultraschall Med. 2012;33:E179–85.
Voit C, van Akkooi AC, Schafer-Hesterberg G, et al. Ultrasound morphology criteria predict metastatic disease of the sentinel nodes in patients with melanoma. J Clin Oncol. 2010;28:847–52.
Tregnaghi A, De Candia A, Calderone M, et al. Ultrasonographic evaluation of superficial lymph node metastases in melanoma. Eur J Radiol. 1997;24:216–21.
Voit CA, Oude Ophuis CM, Ulrich J, et al. Ultrasound of the sentinel node in melanoma patients: echo-free island is a discriminatory morphologic feature for node positivity. Melanoma Res. 2016;26:267–71.
Rubaltelli L, Beltrame V, Tregnaghi A, et al. Contrast-enhanced ultrasound for characterizing lymph nodes with focal cortical thickening in patients with cutaneous melanoma. AJR. 2011;196:W8–12.
Saiag P, Bernard M, Beauchet A, et al. Ultrasonography using simple diagnostic criteria vs palpation for the detection of regional lymph node metastases of melanoma. Arch Dermatol. 2005;41:183–9.
Hinz T, Hoeller T, Wenzel J, et al. Real-time tissue elastography as promising diagnostic tool for diagnosis of lymph node metastases in patients with malignant melanoma: a prospective single-center experience. Dermatology. 2013a;226:81–90.
Ogata D, Uematsu T, Yoshikawa S, et al. Accuracy of real-time ultrasound elastography in the differential diagnosis of lymph nodes in cutaneous malignant melanoma (CMM): a pilot study. Int J Clin Oncol. 2014;19:716–21.
Francken AB, Bastiaannet E, Hoekstra HJ. Follow-up in patients with localised primary cutaneous melanoma. Lancet Oncol. 2005;6:608–21.
Francken AB, Shaw HM, Accortt NA, et al. Detection of first relapse in cutaneous melanoma patients: implications for the formulation of evidence-based follow-up guidelines. Ann Surg Oncol. 2007;14:1924–33.
Bafounta ML, Beauchet A, Chagnon S, et al. Ultrasonography or palpation for detection of melanoma nodal invasion: a meta-analysis. Lancet Oncol. 2004;5:673–80.
Machet L, Nemeth-Normand F, Giraudeau B, et al. Is ultrasound lymph node examination superior to clinical examination in melanoma follow-up? A monocentre cohort study of 373 patients. Br J Dermatol. 2005;152:66–70.
Voit C, Mayer T, Kron M, et al. Efficacy of ultrasound B-scan compared with physical examination in follow-up of melanoma patients. Cancer. 2001a;91:2409–16.
Solivetti FM, Desiderio F, Guerrisi A, et al. HF ultrasound vs PET-CT and telethermography in the diagnosis of in-transit metastases from melanoma: a prospective study and review of the literature. J Exp Clin Cancer Res. 2014a;33:96.
Ribero S, Podlipnik S, Osella-Abate S, et al. Ultrasound-based follow-up does not increase survival in early-stage melanoma patients: a comparative cohort study. Eur J Cancer. 2017;85:59–66.
Podlipnik S, Carrera C, Sanchez M, et al. Performance of diagnostic tests in an intensive follow-up protocol for patients with American joint Committee on cancer (AJCC) stage IIB, IIC, and III localized primary melanoma: a prospective cohort study. J Am Acad Dermatol. 2016;75:516–24.
Blum A, Schlagenhauff B, Stroebel W, et al. Ultrasound examination of regional lymph nodes significantly improves early detection of locoregional metastases during the follow-up of patients with cutaneous melanoma. Results of a prospective study of 1288 patients. Cancer. 2000;88:2534–9.
Xing Y, Bronstein Y, Ross MI, et al. Contemporary diagnostic imaging modalities for the staging and surveillance of melanoma patients: a meta-analysis. J Natl Cancer Inst. 2011;103:129–42.
Solivetti FM, Elia F, Santaguida MG, et al. The role of ultrasound and ultrasound-guided fine needle aspiration biopsy of lymph nodes in patients with skin tumours. Radiol Oncol. 2014b;48:29–34.
Covarelli P, Burini G, Barberini F, et al. The integrated role of ultrasonography in the diagnosis of soft tissue metastases from melanoma: preliminary report of a single-center experience and literature review. In Vivo. 2013;27:827–33.
Hall BJ, Schmidt RL, Sharma RR, et al. Fine-needle aspiration cytology for the diagnosis of metastatic melanoma. Systematic review and meta-analysis. Am J Clin Pathol. 2013;140:635–42.
Schäfer-Hesterberg G, Schoengen A, Sterry W, et al. Use of ultrasound to early identify, diagnose and localize metastases in melanoma patients. Expert Rev Anticancer Ther. 2007;7:1707–16.
Voit CA, van Akkooi AC, Eggermont AM, et al. Fine needle aspiration cytology of palpable and nonpalpable lymph nodes to detect metastatic melanoma. J Natl Cancer Inst. 2011;103:1771–7.
Bohelay G, Battistella M, Pagès C, et al. Ultrasound-guided core needle biopsy of superficial lymph nodes: an alternative to fine-needle aspiration cytology for the diagnosis of lymph node metastasis in cutaneous melanoma. Melanoma Res. 2015;25:519–27.
Shirley R, Uppal R, Vadodoria S, et al. Ultrasound-guided wire localisation for surgical excision of deep seated metastatic deposit of malignant melanoma. J Plast Reconstr Aesthet Surg. 2009;62:e411–2.
Voit C, Proebstle TM, Winter H, et al. Presurgical ultrasound-guided anchor-wire marking of soft tissue metastases in stage III melanoma patients. Dermatol Surg. 2001b;27:129–32.
Borgognoni L, Pasciteli L, Gerlini G, et al. Efficacy of electrochemotherapy in the treatment of cutaneous melanoma metastases and rare non-melanoma skin cancer. Anticancer Res. 2020;40:6485–92.
Kunte C, Letulé V, Gehl J, et al. Electrochemotherapy in the treatment of metastatic malignant melanoma: a prospective cohort study by InspECT. Br J Dermatol. 2017;176:1475–85.
Simioni A, Valpione S, Granziera E, et al. Ablation of soft tissue tumours by long needle variable electrode-geometry electrochemotherapy: final report from a single-arm, single-Centre phase-2 study. Sci Rep. 2020;10:2291.
Lassau N, Chami L, Peronneau P. Imaging of melanoma: accuracy of ultrasonography before and after contrast injection for diagnostic and early evaluation of treatments. Bull Cancer. 2007;94:93–8.
Goldmacher GV, Khilnani AD, Andtbacka RHI, et al. Response criteria for intratumoral immunotherapy in solid tumors: itRECIST. J Clin Oncol. 2020;38:2667–76.
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Catalano, O. (2022). Ultrasound of Cutaneous Melanoma: Primary Tumor Assessment and Locoregional Staging. In: Wortsman, X. (eds) Textbook of Dermatologic Ultrasound. Springer, Cham. https://doi.org/10.1007/978-3-031-08736-3_10
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