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Embryonic Neurogenesis in the Mammalian Brain

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Neurogenetics

Part of the book series: Learning Materials in Biosciences ((LMB))

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Abstract

The mammalian brain is probably the most fascinating and complex organ that has evolved over millions of years. In this chapter, we learn about some key genetic factors that control mammalian brain development with a focus on the cerebral cortex. Selected topics highlight oscillatory expression of neurogenic and proneural factors, the relationship between cell cycle control and cell fate and the spatiotemporal generation of neurons in the layered cortex. In a second part, we introduce the neural stem and progenitor cell types in the mammalian neocortex that potentially are the key recent inventions to distinguish higher evolved gyrencephalic from more primitive lissencephalic brains. We discuss the concepts and cellular mechanisms that might have led to neocortex expansion during evolution toward the primate brain.

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Acknowledgment

We are grateful to Dr Rita Sousa-Nunes for comments and suggestions for this chapter.

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Authors and Affiliations

  1. Department of Biology, University of Fribourg, Fribourg, Switzerland

    Dotun Adeleye Adeyinka & Boris Egger

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  1. Dotun Adeleye Adeyinka
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  2. Boris Egger
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Correspondence to Boris Egger .

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Editors and Affiliations

  1. Department of Biology, University of Fribourg, Fribourg, Switzerland

    Boris Egger

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Adeyinka, D.A., Egger, B. (2023). Embryonic Neurogenesis in the Mammalian Brain. In: Egger, B. (eds) Neurogenetics . Learning Materials in Biosciences. Springer, Cham. https://doi.org/10.1007/978-3-031-07793-7_9

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