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Selenium Concentrations and Multiple Trauma/Trace Elements in Trauma: A Focus on Selenium

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Biomarkers in Trauma, Injury and Critical Care

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Abstract

Systematic inflammatory response and compensatory anti-inflammatory response caused by hemorrhage, ischemia, and reperfusion injury occur simultaneously in the acute phase of an injury, creating a sepsis-like state by releasing endogenous damage-associated molecular patterns into the systemic circulation in injured patients. Oxidative stress is increased in this immune-inflammatory activation status, and when it is exacerbated, multi-organ dysfunction is induced accordingly. Defense mechanisms exist in the body to protect cells (especially mitochondria). Antioxidants and antioxidant enzymes reduce oxidative stress. Vitamins and trace elements are required as cofactors for the functioning of antioxidants, and reductions in micronutrients have been reported in several critically ill conditions. In this chapter, we will focus on studying the effects of selenium deficiency and trace element supplementation in trauma patients.

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Abbreviations

ATP:

Adenosine triphosphate

CARS:

Compensatory anti-inflammatory immune response

CI:

Confidence intervals

DAMPs:

Endogenous damage-associated molecular patterns

HMGB1:

High mobility group box protein-1

ICU:

Intensive care unit

NOS:

Nitric oxide species

PAMPs:

Pathogen-associated molecular patterns

RCT:

Randomized control trial

ROS:

Reactive oxygen species

RRs:

Risk ratios

SIRS:

Systemic inflammatory response syndrome

SOD:

Superoxide dismutase

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Author information

Authors and Affiliations

  1. Department of Surgery, National Health Insurance Service Ilsan Hospital, Goyang, South Korea

    Ji Young Jang

  2. Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea

    Jae Gil Lee

Authors
  1. Ji Young Jang
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  2. Jae Gil Lee
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Correspondence to Jae Gil Lee .

Editor information

Editors and Affiliations

  1. College of Medicine, King Saud bin Abdulaziz University of Health Sciences, Riyadh, Saudi Arabia

    Rajkumar Rajendram

  2. School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK

    Victor R. Preedy

  3. School of Life Sciences, University of Westminster, London, UK

    Vinood B. Patel

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Jang, J.Y., Lee, J.G. (2023). Selenium Concentrations and Multiple Trauma/Trace Elements in Trauma: A Focus on Selenium. In: Rajendram, R., Preedy, V.R., Patel, V.B. (eds) Biomarkers in Trauma, Injury and Critical Care. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Cham. https://doi.org/10.1007/978-3-031-07395-3_34

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