Omega-6 Fatty Acids

Huang, Xin; Zhao, Jie V.

doi:10.1007/978-3-031-07389-2_25

Xin Huang⁵ &
Jie V. Zhao⁵

Part of the book series: Biomarkers in Disease: Methods, Discoveries and Applications ((BDMDA))

872 Accesses

Abstract

Omega-6 fatty acids are involved in a series of biological processes including inflammation, immune function, and carcinogenesis. Omega-6 fatty acids are closely related to multiple chronic diseases, such as cardiovascular disease, diabetes, asthma, autoimmune diseases, and cancer, however, the evidence is controversial. Omega-6 fatty acids are also responsive to dietary intake and therefore serve as biomarkers for dietary intake. This chapter provides a narrative review of omega-6 fatty acids as biomarkers for major chronic diseases, summarizes the usefulness and limitations of omega-6 fatty acids as biomarkers in epidemiological research and clinical applications, with implicatoins for using omega-6 fatty acids as biomarkers for disease prediction, dietary interventions and primary health care.

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Abbreviations

5-HETE:: 5 hydroxyeicosatetraenoic
AA:: Arachidonic acid
CHD:: Coronary heart disease
CVD:: Cardiovascular disease
D5D:: Delta-5-desaturase
D6D:: Delta-6-desaturase
DGLA:: Dihomo-γ-linolenic acid
GLA:: γ-linolenic acid
IL:: Interleukin
JIA:: Juvenile idiopathic arthritis
LA:: Linoleic acid
LT:: Leukotrienes
LXA4:: Lipoxin A4
MI:: Myocardial infarction
MS:: Multiple sclerosis
PUFAs:: Polyunsaturated fatty acids
RA:: Rheumatoid arthritis
SLE:: Systemic lupus erythematosus
T2D:: Type 2 diabetes
TNF-α:: Tumor necrosis factor-α

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School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Xin Huang & Jie V. Zhao

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School of Life Sciences, University of Westminster, London, UK
Vinood B. Patel
Department of Nutrition and Dietetics, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK
Victor R. Preedy

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Huang, X., Zhao, J.V. (2022). Omega-6 Fatty Acids. In: Patel, V.B., Preedy, V.R. (eds) Biomarkers in Nutrition . Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Cham. https://doi.org/10.1007/978-3-031-07389-2_25

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DOI: https://doi.org/10.1007/978-3-031-07389-2_25
Published: 15 October 2022
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-07388-5
Online ISBN: 978-3-031-07389-2
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