Abstract
Motor units, which comprise a motoneuron and the set of muscle fibers it innervates, are the fundamental neuromuscular transducers for all motor commands. The one to one relationship between a motoneuron and its innervated muscle fibers allow motoneuron firing patterns to be readily measured in humans. In this chapter, we summarize the current understanding of the cellular basis for the generation of firing patterns in human motor units. We provide a brief review of landmark insights from classic studies and then proceed to consider the features of motor unit firing patterns that are most likely to be sensitive estimators of motoneuron inputs and properties. In addition, we discuss recent advances in technology for recording human motor unit firing patterns and highly realistic computer simulations of motoneurons. The final section presents our recent efforts to use the power of supercomputers for implementation of the motoneuron models, with a goal of achieving a true “reverse engineering” approach that maximizes the insights from motor unit firing patterns into the synaptic structure of motor commands.
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Khurram, O.U., Pearcey, G.E.P., Chardon, M.K., Kim, E.H., García, M., Heckman, C.J. (2022). The Cellular Basis for the Generation of Firing Patterns in Human Motor Units. In: O'Donovan, M.J., Falgairolle, M. (eds) Vertebrate Motoneurons. Advances in Neurobiology, vol 28. Springer, Cham. https://doi.org/10.1007/978-3-031-07167-6_10
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