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An Examination of Mechanisms by which Synonymous Mutations may Alter Protein Levels, Structure and Functions

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Single Nucleotide Polymorphisms

Abstract

In this chapter, we review mechanisms by which synonymous codon variations influence gene expression at the mRNA or protein levels. These changes may alter the structure and function of the encoded proteins, leading to diseases, altered disease phenotype, or interfering with protein-drug interactions. In order to appreciate the significance of synonymous mutations, we first look at the concept of codon redundancy and the steps of protein biogenesis which can be influenced by synonymous codon variations.

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  1. Department of Cell, Developmental and Integrative Biology (CDIB), The University of Alabama at Birmingham, Birmingham, AL, USA

    Yiming Zhang & Zsuzsa Bebok

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    Chava Kimchi-Sarfaty

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Zhang, Y., Bebok, Z. (2022). An Examination of Mechanisms by which Synonymous Mutations may Alter Protein Levels, Structure and Functions . In: Sauna, Z.E., Kimchi-Sarfaty, C. (eds) Single Nucleotide Polymorphisms. Springer, Cham. https://doi.org/10.1007/978-3-031-05616-1_6

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