Abstract
Regenerative medicine is the most recent and emerging branch of medical science. It deals with functional restoration of tissues or organs in patients suffering from severe injuries or chronic disease when the body’s own regenerative responses do not suffice (Mason and Dunnill, Reg Med. 3(1):11–15, 2018). Regenerative medicine is a branch of translational research which takes advantage of the body’s self-repairing properties in order to establish, restore or enhance normal function. Until recently scientists primarily worked with two kinds of stem cells from animal and humans; embryonic stem cells and non-embryonic or adult stem cells. Its scope now includes cell therapies, therapeutic tissue-engineering products, human cell and tissue products and combinations.
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References
Kaiser LR. The future of multi- hospital systems. Top Health Care Finance. 1992;18(4):82–45.
Kumar R, Sharma A, Varadwaj K. Stem cells: an overview with respect to cardiovascular and renal disease. J Nat BioMed. 2010;1(1):45–52.
Kleiderman E, Boily A, Hasilo C, Knoppers BM. Overcoming barriers to facilitate the regulation of multi-centre regnerative medicine clinical trials. Stem Cell Res Ther. 2018;9(1):307–15.
Lacci KM, Dardik A. Platelet- rich plasma: support for its use in wound healing. Yale J Biol Med. 2010;83(1):1–9.
Alves R, Grimalt R. A randomized placebo-controlled, double- blinded, half-head study to assess the efficacy of platelet-rich plasma on the treatment of androgenetic alopecia. Dermatol Surg. 2016;42:491–7.
Dohan Ehrenfest DM, Andia I, Zumstein MA, Zhang CA, Pinto NR, Bieleeki T. Classification of platelet concentrates (Platelet-Rich Plasma, PRP; Platelet-Rich Fibrin, PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspective. Ligaments Tendons J. 2014;4(1):3–9.
Isaac C, Gharaibeh B, Witt M, Wright VJ, Huard J. Biologic approaches to enhance rotator cuff healing after injury. J Shoulder Elb Surg. 2012;21:181–90.
Sweeney J, Grossman BJ. Blood collection, storage and component preparation methods. In: Breeher M, editor. Technical manual. 14th ed. Bethesda MD: Am. Assoc. Blood Banks (AABB); 2002. p. 955–8.
Navani A, Manchikanti L, Albers SL, Latchaw RE, Sanapati J, Kaye AD, Atluri S, Jordan S, Gupta A, Cedeno D, Vallejo A, Fellows B, Knezevic NN, Pappolla M, Diwan S, Trescot AM, Soin A, Kaye AM, Aydin SM, Calodney AK, Candido KD, Bakshi S, Benyamin RM, Vallejo R, Watanabe A, Beall D, Stitik TP, Foye PM, Helander EM, Hirsch JA. Responsible, safe, and effective use of biologics in the management of low back pain: American Society of Interventional Pain Physicians (ASIPP) guidelines. Pain Physician. 2019;22:S1–S74.
Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofacial Surg. 2004;62:489–96.
Scherer SS, Tobalem M, Vigato E, Heit Y, Modorressi A, Heinz B. Non -activated versus thrombin-activated platelets in wound healing and fibroblast -to- myofibroblast differentiation in Vivo and in Vitro. Plast Reconstruction Surg. 2012;129:46e–54e.
Rubio D, Garcia-Castro J, Martin MC, de la Fuentes R, Cigudosa JC, Lloyd AC. Spontaneous human adult stem cell transformation. Cancer Res. 2005;65:3033–9.
Montgomery SR, Petrigliano FA, Gamradt SC. Biologic augmentation of rotator cuff repair. Curr Rev Musculoskeletal Med. 2011;4:221.
Evans CH, Chevalier X, Wehling P. Autologous conditioned serum. Phys Med Rehabil Clin N Am. 2016, nOV;27(4):893–908.
Ntege EH, Sunami H, Shimizu Y. Advances in regenerative therapy: a review of the literature and future directions. Regen Ther. 2020;14:136–53.
Huang Y, Leung VYL, Lu WW, Luk KDK. The effects of micro-environment in mesenchymal stem cell based regeneration of intervertebral disk. Spine J. 2013;13:352–62.
Nolta JA, Galipeau J, Phinney DG. Improving mesenchymal stem/stromal cell potency and survival. Proceedings from the International Society of Cell Therapy (ISCT) MSC preconference held in May 2018, Palais de Congres de Montréal, Organized by the ISCT MSC Scientific Committee. Cytotherapy. 2020;22:123–6.
Phinney DG, Galipeau J. Manufacturing mesenchymal stromal cells for clinical applications: a survey of Good Manufacturing Practices at U.S. academic centers. Cytotherapy. 2019;21:782–92.
Buchheit T, Huh Y, Maixner W, Cheng J, Ji R-R. Neuroimmune modulation of pain and regenerative pain medicine. J Clin Investig. 2020;130(5):2164–76.
Bora P, Majumdar AS. Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation. Stem Cell Res Ther. 2017;8:145–55.
Rodbell M. Localization of lipoprotein lipase in fat cells of rat adipose tissue. J Biol Chem. 1964;289(3):753–5.
Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7(2):211–28.
Xia K, Zhu J, Hua J, Gong Z, Yu C, Zhou X, et al. Intradiscal Injection of Induced Pluripotent Stem Cell-Derived nucleus pulposus-like cell-seeeded polymeric microspheres promotes rat disc regeneration. Stem Cells Int. 2019;2019:6806540.
Sanjurjo-Rodriguez C, Castro-Vinuelas R, Pineiro-Ramil M, Rodriguez-Fernandez S, Fuentes-Boquete I, Blanco FJ, Diaz-Prado S. Versatility of induced pluripotent stem cells (iPSCs) for improving the knowledge on musculoskeletal diseases. Int J Mol Sci. 2020;21:6124–51.
Wang F, Qin Z, Lu H, He S, Luo J, Jin C, Song X. Clinical translation of gene medicine. J Gene Med. 2019;21(7):e3108–16.
Mobasheri A, Richardson SM. Cell and gene therapy for spine regeneration: mammalian protein production platforms for overproduction of therapeutic proteins and growth factors. Neurosurg Clin N Am. 2020;31(1):131–9.
Rabago D, Best TM, Beamsley M, Patterson J. A systematic review of prolotherapy for chronic musculoskeletal pain. Clin J Sports Med. 2005;15(5):E376–86.
Becker C, Heidersdorf S, Drewlo S, Zirke de Rodriguez S, Kramer J, Willburger RE. Efficacy of epidural perineural injections with autologous conditioned serum for lumbar radicular compression: an investigator-initiated, prospective, double-blind, reference-controlled study. Spine. 2007;32(17):1803–8.
Goni VG, Jhala SS, Gopinathan NR, Behera P, Batra YK, Arjun RHH, et al. Efficacy of epidural perineural injection of autologous conditioned serum in unilateral cervical radiculopathy. Spine. 2015;40(16):E915–21.
Sivakamasundari V, Lufkin T. Stemming the degeneration: IVD stem cells and stem cell regenerative therapy for degenerative disk disease. Adv Stem Cells. 2013;2013:724547.
Sanapati J, Manchikanti L, Atluri S, Jordan S, Albers SL, Pappolla MA, Kaye AD, Candido KD, Pampati V, Hirsch JA. Do regenerative medicine therapies provide long-term relief in chronic low back pain: a Systematic review and meta-analysis. Pain Physician. 2018;21:515–40.
Pettine KA, Suzuki RK, Sand TT, Murphy MB. Autologous bone marrow concentrate intradiscal injection for the treatment of degenerative disc disease with three-year follow-up. Int Orthop. 2017;41:2097–103.
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Nwazota, N., Hegazi, A. (2022). Regenerative Therapies. In: Noe, C.E. (eds) Multidisciplinary Spine Care. Springer, Cham. https://doi.org/10.1007/978-3-031-04990-3_30
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DOI: https://doi.org/10.1007/978-3-031-04990-3_30
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