Abstract
Recent advances in treatment and prevention using novel approaches are opening the door for a seismic shift in healthcare. In this chapter, we report advances in four key areas of personalised medicine: tissue engineering, regenerative medicine, gene therapy, and nanomedicine. We include examples of products currently in the market, barriers to translating these novel therapies to the clinic, and the outlook for emerging therapies.
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Abreu, T. R., Fonseca, N. A., Gonçalves, N., & Moreira, J. N. (2020). Current challenges and emerging opportunities of CAR-T cell therapies. Journal of Controlled Release, 319, 246–261.
Adams, D., Gonzalez-Duarte, A., O’Riordan, W. D., Yang, C. C., Ueda, M., Kristen, A. V., Tournev, I., Schmidt, H. H., Coelho, T., Berk, J. L., Lin, K. P., Vita, G., Attarian, S., Planté-Bordeneuve, V., Mezei, M. M., Campistol, J. M., Buades, J., Brannagan, T. H., Kim, B. J., Oh, J., Parman, Y., Sekijima, Y., Hawkins, P. N., Solomon, S. D., Polydefkis, M., Dyck, P. J., Gandhi, P. J., Goyal, S., Chen, J., Strahs, A. L., Nochur, S. V., Sweetser, M. T., Garg, P. P., Vaishnaw, A. K., Gollob, J. A., Suhr, O. B. (2018). Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis. New England Journal of Medicine, 379(1), 11–21.
Anselmo, A. C., & Mitragotri, S. (2016). Nanoparticles in the clinic. Bioengineering and Translation Medicine, 1(1), 10–29.
Anselmo, A. C., & Mitragotri, S. (2019). Nanoparticles in the clinic: An update. Bioengineering and Translation Medicine, 4(3), e10143.
Balkrishna, A., Arya, V., Rohela, A., Kumar, A., Verma, R., Kumar, D., Nepovimova, E., Kuca, K., Thakur, N., Thakur, N., & Kumar, P. (2021). Nanotechnology interventions in the management of COVID-19: Prevention, diagnosis and virus-like particle vaccines. Vaccine, 9(10), 1129.
Bressler, N. M., & Bressler, S. B. (2000). Photodynamic therapy with verteporfin (Visudyne): Impact on ophthalmology and visual sciences [Review]. Investigative Ophthalmology and Visual Science, 41(3), 624–628.
Brokowski, C., & Adli, M. (2020). Ethical considerations in therapeutic clinical trials involving novel human germline-editing technology. CRISPR Journal, 3(1), 18–26.
Bulaklak, K., & Gersbach, C. A. (2020). The once and future gene therapy. Nature Communications, 11(1), 5820.
Cevher, E., Sezer, A. D., & Çağlar, E. (2012). Gene delivery systems: Recent progress in viral and non-viral therapy. In A. D. Sezer (Ed.), Recent advances in novel drug carrier systems (pp. 437–470). INTECH.
Emancipator, K. (2020). Keytruda and PD-L1: A real-world example of co-development of a drug with a predictive biomarker. AAPS Journal, 23(1), 5.
Gadekar, V., Borade, Y., Kannaujia, S., Rajpoot, K., Anup, N., Tambe, V., Kalia, K., & Tekade, R. K. (2021). Nanomedicines accessible in the market for clinical interventions. Journal of Controlled Release, 330, 372–397.
Germain, M., Caputo, F., Metcalfe, S., Tosi, G., Spring, K., Åslund, A. K. O., Pottier, A., Schiffelers, R., Ceccaldi, A., & Schmid, R. (2020). Delivering the power of nanomedicine to patients today. Journal of Controlled Release, 326, 164–171.
Han, F., Wang, J., Ding, L., Hu, Y., Li, W., Yuan, Z., Guo, Q., Zhu, C., Yu, L., Wang, H., Zhao, Z., Jia, L., Li, J., Yu, Y., Zhang, W., Chu, G., Chen, S., & Li, B. (2020). Tissue engineering and regenerative medicine: Achievements, future, and sustainability in Asia [Review]. Frontiers in Bioengineering and Biotechnology, 8, 83.
Hernandez-Alcoceba, R., Poutou, J., Ballesteros-Briones, M. C., & Smerdou, C. (2016). Gene therapy approaches against cancer using in vivo and ex vivo gene transfer of interleukin-12. Immunotherapy, 8(2), 179–198.
Hersi, A.-F., Eriksson, S., Ramos, J., Abdsaleh, S., Wärnberg, F., & Karakatsanis, A. (2019). A combined, totally magnetic technique with a magnetic marker for non-palpable tumour localization and superparamagnetic iron oxide nanoparticles for sentinel lymph node detection in breast cancer surgery. European Journal of Surgical Oncology, 45(4), 544–549.
Lostalé-Seijo, I., & Montenegro, J. (2018). Synthetic materials at the forefront of gene delivery. Nature Reviews Chemistry, 2(10), 258–277.
Lu, R.-M., Hwang, Y.-C., Liu, I. J., Lee, C.-C., Tsai, H.-Z., Li, H.-J., & Wu, H.-C. (2020). Development of therapeutic antibodies for the treatment of diseases. Journal of Biomedical Science, 27(1), 1.
Manjunath, N., Yi, G., Dang, Y., & Shankar, P. (2013). Newer gene editing technologies toward HIV gene therapy. Viruses, 5(11), 2748–2766.
Mao, A. S., & Mooney, D. J. (2015). Regenerative medicine: Current therapies and future directions. Proceedings of the National Academy of Sciences, 112(47), 14452–14459.
McCabe, C., & Sipp, D. (2016). Undertested and overpriced: Japan issues first conditional approval of stem cell product. Cell Stem Cell, 18(4), 436–437.
Moore, J. P. (2021). Approaches for optimal use of different COVID-19 vaccines: Issues of viral variants and vaccine efficacy. JAMA, 325(13), 1251–1252.
Munawar, A., Ong, Y., Schirhagl, R., Tahir, M. A., Khan, W. S., & Bajwa, S. Z. (2019). Nanosensors for diagnosis with optical, electric and mechanical transducers. RSC Advances, 9(12), 6793–6803.
Nayerossadat, N., Maedeh, T., & Ali, P. A. (2012). Viral and nonviral delivery systems for gene delivery. Advanced Biomedical Research, 1, 127.
Sankar, P. L., & Parker, L. S. (2017). The precision medicine Initiative’s all of us research program: An agenda for research on its ethical, legal, and social issues. Genetics in Medicine, 19(7), 743–750.
Schilsky, R. L. (2010). Personalized medicine in oncology: The future is now. Nature Reviews Drug Discovery, 9(5), 363–366.
Schmidt, C. (2012). Gintuit cell therapy approval signals shift at US regulator. Nature Biotechnology, 30(6), 479.
Sipp, D. (2015). Conditional approval: Japan lowers the bar for regenerative medicine products. Cell Stem Cell, 16(4), 353–356.
Sung, Y. K., & Kim, S. W. (2019). Recent advances in the development of gene delivery systems. Biomaterials Research, 23(1), 8.
Tachibana, M., Amato, P., Sparman, M., Woodward, J., Sanchis, D. M., Ma, H., Gutierrez, N. M., Tippner-Hedges, R., Kang, E., & Lee, H.-S. (2013). Towards germline gene therapy of inherited mitochondrial diseases. Nature, 493(7434), 627–631.
Thomas, G., Boudon, J., Maurizi, L., Moreau, M., Walker, P., Severin, I., Oudot, A., Goze, C., Poty, S., Vrigneaud, J.-M., Demoisson, F., Denat, F., Brunotte, F., & Millot, N. (2019). Innovative magnetic nanoparticles for PET/MRI bimodal imaging. ACS Omega, 4(2), 2637–2648.
Tijsterman, M., Ketting, R. F., & Plasterk, R. H. (2002). The genetics of RNA silencing. Annual Review of Genetics, 36(1), 489–519.
Tombal, B., & Berges, R. (2006). Eligard®: Advantages for optimal testosterone control. European Urology Supplements, 5(18), 900–904.
Vinatier, C., & Guicheux, J. (2016). Cartilage tissue engineering: From biomaterials and stem cells to osteoarthritis treatments. Annals of Physical and Rehabilitation Medicine, 59(3), 139–144.
Wagner, V., Dullaart, A., Bock, A.-K., & Zweck, A. (2006). The emerging nanomedicine landscape. Nature Biotechnology, 24(10), 1211–1217.
Wilson, B. J., & Nicholls, S. G. (2015). The human genome project, and recent advances in personalized genomics. Risk Management and Healthcare Policy, 8, 9–20.
Zaulyanov, L., & Kirsner, R. S. (2007). A review of a bi-layered living cell treatment (Apligraf©) in the treatment of venous leg ulcers and diabetic foot ulcers. Clinical Interventions in Aging, 2(1), 93–98.
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Parhizkar, M., Tsaoulidis, D. (2022). The Outlook for Novel Pharmaceutics. In: Ehsani, S., Glauner, P., Plugmann, P., Thieringer, F.M. (eds) The Future Circle of Healthcare. Future of Business and Finance. Springer, Cham. https://doi.org/10.1007/978-3-030-99838-7_16
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DOI: https://doi.org/10.1007/978-3-030-99838-7_16
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