Overview
- Provides latest understanding about the blood-brain barrier and its role within the neurovascular unit
- Covers many different methods to study pharmacokinetics and pharmacodynamics of the blood-brain barrier
- Describes the pivotal role of the blood-brain barrier for the etiology of CNS diseases and therapeutic approaches
Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 273)
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About this book
This book presents a comprehensive collection of current knowledge and leading research about the blood-brain barrier. The chapters are organized in four main parts providing basic information and novel insights about the physiology of the blood-brain barrier, the challenges related to finding and developing drugs crossing the blood-brain barrier, experimental methods to study the blood-brain barrier and the role of the blood-brain barrier in disease mechanisms and its consequences for drug development. In the first part the readers will discover the structure, function and developmental aspects of the blood-brain barrier and gain novel insights into the complexity and functionality of the neurovascular unit and energy metabolism of brain endothelial cells. Chapters of the second part focus on translational challenges from the bench to the bedside in CNS drug development, shed light on the importance to understand the brain distribution of drugs related to their efficacy, elaborate on general pharmacokinetic considerations for CNS drugs and introduce current and novel drug delivery strategies to overcome the blood-brain barrier. The experimental part of the book covers mathematical and in vitro models as well as animal and human methods in blood-brain barrier research. Specific emphasis is set on the description of the methods, the role of species differences for data interpretation, novel human models based on stem cells with the potential for personalized medicine and technical considerations and tips helpful for readers interested in working with these models. In the fourth part particular attentions is given to the blood-brain barrier, its changes and participation during disease progression. Chapters summarize alterations of the blood-brain barrier that are present in common disorders such as Alzheimer’s disease, multiple sclerosis, stroke, traumatic brain injury, epilepsy and brain tumors. Present therapies will be discussed and the consequences for novel treatment approaches that need to bypass the blood-brain-barrier will be explored. In addition, experts discuss the question in how far changes at the blood-brain barrier are causally linked to disease progressions and consequently could serve as therapeutic targets. This collection is designed to appeal to a wide readership from students through basic and applied scientist to pharmacologists, medical doctors and stakeholders from the pharmaceutical industry and regulatory affairs. Due its comprehensive content the book has the potential to become a standard work in the field of blood-brain barrier research.
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Keywords
Table of contents (15 chapters)
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Background on the Blood-Brain Barrier
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Challenges with Findings Drugs to Cross the Blood-Brain Barrier
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Experimental Methods to Study Drug Transport across the Blood-Brain Barrier In Vitro and In Vivo
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The Blood-Brain Barrier and Diseases: Novel Treatment Approaches from a Blood-Brain Barrier Perspective
Editors and Affiliations
Bibliographic Information
Book Title: Physiology, Pharmacology and Pathology of the Blood-Brain Barrier
Editors: Zameel Cader, Winfried Neuhaus
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/978-3-030-99654-3
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2022
Hardcover ISBN: 978-3-030-99653-6Published: 14 June 2022
Softcover ISBN: 978-3-030-99656-7Published: 15 June 2023
eBook ISBN: 978-3-030-99654-3Published: 13 June 2022
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: VIII, 364
Number of Illustrations: 70 b/w illustrations, 30 illustrations in colour
Topics: Pharmacology/Toxicology, Human Physiology, Drug Resistance, Pathology, Neurosciences