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Analgesic Effects of Botulinum Neurotoxins: Data from Animal Studies Volunteers

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Botulinum Toxin Treatment of Pain Disorders

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Abstract

Recent discoveries of the new pain receptors and channels as well as pain modulators and transmitters have improved our knowledge of pain pathophysiology. Animal data on botulinum neurotoxins (BoNTs) indicate that application of this toxin via injection can modify and diminish the function of several mechanisms that generate or maintain pain.

The first part of this chapter describes the pathophysiology of pain in light of the new knowledge recently gained in this area. The second part provides a brief review of the literature on how treatment with BoNTs can improve pain behavior in animals and lower perception of pain in asymptomatic human volunteers; the therapeutic impact of BoNTs on pain receptors, channels, and mediators is also discussed.

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Authors and Affiliations

  1. Professor Emeritus of Neurology, Yale University School of Medicine, New Haven, CT, USA

    Bahman Jabbari MD, FANN

  2. Clinical Professor of Neurology, University of California, Irvine, CA, USA

    Bahman Jabbari MD, FANN

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Jabbari, B. (2022). Analgesic Effects of Botulinum Neurotoxins: Data from Animal Studies Volunteers. In: Botulinum Toxin Treatment of Pain Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-99650-5_3

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