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Tissue-Based Biomarkers of Tumor-Vascular Interactions

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Biomarkers of the Tumor Microenvironment

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Abstract

The vascular systems are key components of the tumor microenvironment and angiogenesis is recognized as a hallmark of cancer. Although studies have indicated that the prognosis of certain cancer patients might be improved by targeting tumor-associated blood vessels, there is a lack of markers that can predict the clinical response to such anti-tumor therapy and thereby stratify patients for optimal management. Microvessel density (MVD) and other angiogenesis markers are known to be effective prognostic factors, but information on response prediction is virtually lacking. In addition to the use of novel endothelial proteins and markers for improved tumor imaging and targeting strategies, the potential practical value of selected histologic indicators for better stratification and predictive purposes needs to be more deeply explored and validated in future studies.

Tumor-associated vessels are unevenly distributed with variation in diameter and shape. They show increased endothelial proliferation (e.g., by Ki67 expression) and are more immature with decreased pericyte coverage. These atypical vessels are more prone to invasion by tumor cells as an early marker of vascular dissemination

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  1. Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, Bergen, Norway

    Lars A. Akslen

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  1. Centre for Cancer Biomarkers CCBIO Department of Clinical Medicine, University of Bergen, Bergen, Norway

    Lars A. Akslen

  2. Department of Surgery, Harvard Medical School, Vascular Biology Program, Boston Children’s Hospital, Boston, USA

    Randolph S. Watnick

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Akslen, L.A. (2022). Tissue-Based Biomarkers of Tumor-Vascular Interactions. In: Akslen, L.A., Watnick, R.S. (eds) Biomarkers of the Tumor Microenvironment. Springer, Cham. https://doi.org/10.1007/978-3-030-98950-7_2

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