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Complications of Surgical Management of Skull Base and Sinonasal Malignancies

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Sinonasal and Skull Base Malignancies

Abstract

The mainstay of treatment for sinonasal and skull base malignancies includes surgical resection with or without adjuvant therapy. Depending on the extent of the tumor, surgical removal can be extremely challenging because of the proximity of the paranasal sinuses to the orbit, intracranial cavity, and major neurovascular structures. Traditionally, an open approach was used to achieve surgical resection of these malignancies. Over the last 30 years, there have been significant advances in sinonasal and skull base surgery. With improvements in anatomical knowledge, surgical technique, and skull base reconstruction, the endoscopic endonasal approach has now become an accepted surgical approach in the management of certain sinonasal malignancies. This has added to the armamentarium of options available for surgical control of these complex tumors.

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References

  1. Silverberg E, Grant R. Cancer statistics, 1970. CA Cancer J Clin. 1970;20:11–23.

    Article  CAS  PubMed  Google Scholar 

  2. Roush G. Epidemiology of cancer of the nose and paranasal sinuses: current concepts. Head Neck Surg. 1979;2:3–11.

    Article  CAS  PubMed  Google Scholar 

  3. Kuijpens J, Louwman M, Peters R, et al. Trends in sinonasal cancer in the Netherlands: more squamous cell cancer, less adenocarcinoma. A population-based study 1973–2009. Eur J Cancer. 2012;48:2369–74.

    Article  PubMed  Google Scholar 

  4. Haerle S, Gullane P, Witterick I, Zweifel C, Gentili F. Sinonasal carcinomas: epidemiology, pathology, and management. Neurosurg Clin N Am. 2013;24(1):34–49.

    Article  Google Scholar 

  5. Ayiomamitis A, Parker L, Havas T. The epidemiology of malignant neoplasms of the nasal cavities, the paranasal sinuses and the middle ear in Canada. Arch Otorhinolaryngol. 1988;244:367–71.

    Article  CAS  PubMed  Google Scholar 

  6. Lu VM, Ravindran K, Phan K, et al. Surgical outcomes of endoscopic versus open resection for primary sinonasal malignancy: a meta-analysis. Am J Rhinol Allergy. 2019;33(5):608–16.

    Article  PubMed  Google Scholar 

  7. Ganly I, Patel S, Bilsky M, Shah J, Kraus D. Complications of craniofacial resection for malignant tumors of the skull base: report of an international collaborative study. Otolaryngol Head Neck Surg. 2009;140:218–23.

    Google Scholar 

  8. Kutlay M, Durmaz A, Özer İ, et al. Extended endoscopic endonasal approach to the ventral skull base lesions. Clin Neurol Neurosurg. 2018;167:129–40.

    Article  PubMed  Google Scholar 

  9. Hagemann J, Roesner J, Helling S, et al. Long-term outcome for open and endoscopically resected sinonasal tumors. Otolaryngol Head Neck Surg. 2019;160(5):862–9.

    Article  PubMed  Google Scholar 

  10. Kassam AB, Prevedello DM, Carrau RL, et al. Endoscopic endonasal skull base surgery: analysis of complications in the authors’ initial 800 patients. J Neurosurg. 2010;114(6):1544–68.

    Article  PubMed  Google Scholar 

  11. Gardner PA, Tormenti MJ, Pant H, Fernandez-Miranda JC, Snyderman CH, Horowitz MB. Carotid artery injury during endoscopic endonasal skull base surgery: incidence and outcomes. Neurosurgery. 2013;73(SUPPL. 2):261–70.

    Google Scholar 

  12. Cappabianca P, Cavallo L, Colao A, de Divitiis E. Surgical complications associated with the endscopic endonasal transsphenoidal approach for pituitary adenomas. J Neurosurg. 2002;97:293–8.

    Article  PubMed  Google Scholar 

  13. Dehdashti A, Ganna A, Karabatsou K, Gentili F. Pure endoscopic endonasal approach for pituitary adenomas: early surgical results in 200 patients and comparison with previous microsurgical series. Neurosurgery. 2008;62:1006–17.

    PubMed  Google Scholar 

  14. Fatemi N, Dusick J, de Paiva NM, Kelly D. The endonasal microscopic approach for pituitary adenomas and other parasellar tumors: a 10-year experience. Neurosurgery. 2008;63:244–56.

    PubMed  Google Scholar 

  15. Feiz-Erfan I, Han P, Spetzler R, et al. The radical transbasal approach for resec- tion of anterior and midline skull base lesions. J Neurosurg. 2005;103(3):485–90.

    Article  PubMed  Google Scholar 

  16. Sekhar L, Pranatartiharan R, Chanda A, Wright D. Chordomas and chondrosarcomas of the skull base: results and complications of surgical management. Neurosurg Focus. 2001;10(3):E2.

    Article  CAS  PubMed  Google Scholar 

  17. Gardner P, Snyderman C, Fernandez-Miranda J, Jankowitz B. Management of major vascular injury during endoscopic endonasal skull base surgery. Otolaryngol Clin N Am. 2016;49:819–28.

    Article  Google Scholar 

  18. Wang W-H, Lieber S, Lan M. Nasopharyngeal muscle patch for the management of internal carotid artery injury in endoscopic endonasal surgery. J Neurosurg. 2019;18:1–6.

    Google Scholar 

  19. Padhye V, Valentine R, Sacks R, et al. Coping with catastrophe: the value of endoscopic vascular injury training. Int. 2015;5(3):247–52.

    Google Scholar 

  20. Valentine R, Wormald P. A vascular catastrophe during endonasal surgery: an endoscopic sheep model. Skull Base. 2011;1(212):109–14.

    Article  Google Scholar 

  21. Valentine R, Wormald P. Controlling the surgical field during a large endoscopic vascular injury. Laryngoscope. 2011;121(3):562–6.

    Article  PubMed  Google Scholar 

  22. Couldwell WT, Weiss M, Rabb C, Liu J, Apfelbaum R, Fukushima T. Variations on the standard transsphenoidal approach to the sellar region, with emphasis on the extended approaches and parasellar approaches: surgical experience in 105 cases. Neurosurgery. 2004;55(3):539–50.

    Article  PubMed  Google Scholar 

  23. Yin C, Chen B. Tension pneumocephalus from skull base surgery: a case report and review of the literature. Surg Neurol Int. 2018;9:128.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Chou S, Ning M, Buonanno F. Focal intraparenchymal tension pneumocephalus. Neurology. 2006;67:1465.

    Article  Google Scholar 

  25. Horowitz B. An unusual complication following mastoid surgery. J Laryngol Otol. 1964;78:128–34.

    Article  CAS  PubMed  Google Scholar 

  26. Aksoy F, Dogan R, Ozturan O, Tu S. Tension pneumocephalus: an extremely small defect leading to an extremely serious problem. Am J Otolaryngol. 2013;34(6):749–52.

    Article  PubMed  Google Scholar 

  27. Goldmann R. Pneumocephalus as a consequence of barotrauma. JAMA. 1986;255:3154–6.

    Article  CAS  PubMed  Google Scholar 

  28. Hong B, Biertz F, Raab P, et al. Normobaric hyperoxia for treatment of pneumocephalus after posterior fossa surgery in the semisitting position: a prospective randomized controlled trial. PLoS One. 2015;10:e0125710.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  29. Neligan P, Mulholland S, Irish J, et al. Flap selection in cranial base reconstruction. Plast Reconstr Surg. 1996;98(7):1159–66.

    Article  CAS  PubMed  Google Scholar 

  30. Zanation AM, Thorp BD, Parmar P, Harvey RJ. Reconstructive options for endoscopic Skull Base surgery. Otolaryngol Clin N Am. 2011;44(5):1201–22.

    Article  Google Scholar 

  31. Naunheim M, Goyal N, Dedmon M. An algorithm for surgical approach to the anterior skull base. J Neurol Surg B. 2016;77:364–70.

    Article  Google Scholar 

  32. Shemesh R, Alon EE, Gluck I, Yakirevitch A. Endoscopic surgery for delayed sinonasal complications of radiation therapy for nasopharyngeal carcinoma: a subjective outcome. Int J Radiat Oncol Biol Phys. 2018;100(5):1222–7.

    Article  PubMed  Google Scholar 

  33. Gallia GL, Asemota AO, Blitz AM, et al. Endonasal endoscopic resection of olfactory neuroblastoma: an 11-year experience. J Neurosurg. 2018;131:1–7.

    Google Scholar 

  34. Ganly I, Pagel S, Singh B, et al. Complications of craniofacial ressection for malignant tumors of the skull base: report of an international collaborative study. Head Neck. 2005;27(6):445–51.

    Article  PubMed  Google Scholar 

  35. Hanna E, Ibrahim S, Roberts D, Kupferman M, DeMonte F, Levine N. Endoscopic resection of sinonasal cancers with and without craniotomy: oncologic results. Arch Otolaryngol Head Neck Surg. 2009;135(12):1219–24.

    Article  PubMed  Google Scholar 

  36. Jackson I, Adham M, Marsh W. Use of the galeal frontalis myofascial flap in craniofacial surgery. Plast Reconstr Surg. 1986;77(6):905–10.

    Article  CAS  PubMed  Google Scholar 

  37. Synderman C, Janecka I, Sekhar L, Sen C, Eibling D. Anterior cranial base reconstruction: role of galeal and pericranial flaps. Laryngoscope. 1990;100(6):607–14.

    Google Scholar 

  38. Hadad G, Bassagasteguy L, Carrau R, et al. A novel reconstructive technique after endoscopic expanded endonasal approaches: vascular pedicle nasoseptal flap. Laryngoscope. 2006;116(10):1882–6.

    Article  PubMed  Google Scholar 

  39. Harvey R, Smith J, Wise S, et al. Intracranial complications before and after endoscopic skull base reconstruction. Am J Rhinol. 2008;22(5):516–21.

    Article  PubMed  Google Scholar 

  40. Gray ST, Lin A, Curry WT, et al. Delayed complications after anterior craniofacial resection of malignant skull base tumors. J Neurol Surg B Skull Base. 2014;75(2):110–6.

    PubMed  Google Scholar 

  41. D’Anza B, Tien D, Stokken J, Recinos P, Woodard T, Sindwani R. Role of lumbar drains in contemporary endonasal skull base surgery: meta-analysis and systematic review. Am J Rhinol Allergy. 2016;30(6):430–5.

    Article  PubMed  Google Scholar 

  42. Ahmed OH, Marcus S, Tauber JR, Wang B, Fang Y, Lebowitz RA. Efficacy of perioperative lumbar drainage following endonasal endoscopic cerebrospinal fluid leak repair: a meta-analysis. Otolaryngol Head Neck Surg. 2017;156(1):52–60.

    Article  PubMed  Google Scholar 

  43. Governale L, Fein N, Logsdon J, Black P. Techniques and complicationsof external lumbar drainage for normal pressure hydrocephalus. Neurosurgery. 2008;63:379–84.

    PubMed  Google Scholar 

  44. Zuckerman J, DelGaudio J. Utility of preoperative high- resolution CT and intraoperative image guidance in identification of cerebrospinal fluid leaks for endoscopic repair. Am J Rhinol. 2008;22:151–4.

    Article  PubMed  Google Scholar 

  45. Woodworth BA, Prince A, Chiu AG, et al. Spontaneous CSF leaks: a paradigm for definitive repair and management of intracranial hypertension. YMHN. 2008;138(6):715–20.

    Google Scholar 

  46. Stokken J, Recinos P, Woodard T, Sindwani R. The utility of lumbar drains in modern endoscopic skull base surgery. Curr Opin Otolaryngol Head Neck Surg. 2015;23(1):78–82.

    PubMed  Google Scholar 

  47. Raza SM, Banu MA, Donaldson A, Patel KS, Anand VK, Schwartz TH. Sensitivity and specificity of intrathecal fluorescein and white light excitation for detecting intraoperative cerebrospinal fluid leak in endoscopic skull base surger: a prospective study. J Neurosurg. 2016;124(3):621–6.

    Article  CAS  PubMed  Google Scholar 

  48. Dumont A, Nemergut EC, Jane JA, Laws ER. Postoperative care following pituitary surgery. J Intensive Care Med. 2005;20:127–40.

    Article  PubMed  Google Scholar 

  49. van Aken M, Feelders R, de Marie S, et al. Cerebrospinal fluid leakage during transsphenoidal surgery: postoperative external lumbar drainage reduces the risk for meningitis. Pituitary. 2004;7:89–93.

    Article  PubMed  Google Scholar 

  50. Korinek A, Baugnon T, Golmard J, et al. Risk factors for adult nosocomial meningitis after craniotomy role of antibiotic prophylaxis. Neurosurgery. 2006;59:126–33.

    Article  PubMed  Google Scholar 

  51. Kono Y, Prevedello D, Snyderman C, et al. One thousand endoscopic skull base surgical procedures demystifying the infection potential: incidence and description of postoperative meningitis and brain abscesses. Infect Control Hops Epidemiol. 2011;32:77–83.

    Article  Google Scholar 

  52. Johans S, Burkett D, Swong K, et al. Antibiotic prophylaxis and infection prevention for endoscopic endonasal skull base surgery: our protocol, results, and review of the literature. J Clin Neurosci. 2018;47:249–53.

    Article  PubMed  Google Scholar 

  53. Horowitz G, Fliss D, Margalit N, et al. Association between cerebrospinal fluid leak and meningitis after skull base surgery. Otolaryngol Head Neck Surg. 2011;145:689–93.

    Article  PubMed  Google Scholar 

  54. Roxbury C, Lobo B, Kshettry V, et al. Perioperative management in endoscopic endonasal skull-base surgery: a survey of the North American Skull Base Society. Int Forum Allergy Rhinol. 2018;8(5):631–40.

    Article  PubMed  Google Scholar 

  55. Lange J, Peeden E, Stringer S. Are prophylactic systemic antibiotis necessary with nasal packing? A systematic review. Am J Rhinol Allergy. 2017;31(4):240–7.

    Article  PubMed  Google Scholar 

  56. Deng ZY, Tang AZ. Bacteriology of postradiotherapy chronic rhinosinusitis in nasopharyngeal carcinoma patients and chronic rhinosinusitis. Eur Arch Oto-Rhino-Laryngol. 2009;266(9):1403–7.

    Article  Google Scholar 

  57. Fu T, Monteiro E, Almeida J, et al. Costs and perioperative outcomes associated with open versus endoscopic resection of sinonasal malignancies with skull base involvement. J Neurol Surg B. 2017;78:430–40.

    Article  Google Scholar 

  58. Ganly I, Patel SG, Singh B, et al. Craniofacial resection for malignant melanoma of the skull base: report of an International Collaborative tudy. Arch Otolaryngol Head Neck Surg. 2006;132(1):73–8.

    Article  PubMed  Google Scholar 

  59. Gil Z, Patel SG, Bilsky M, Shah JP, Kraus DH. Complications after craniofacial resection for malignant tumors: are complication trends changing? Otolaryngol Head Neck Surg. 2009;140(2):218–23.

    Article  PubMed  Google Scholar 

  60. Neel GS, Nagel TH, Hoxworth JM, et al. Management of orbital involvement in sinonasal and ventral skull base malignancies. Otolaryngol Clin N Am. 2017;50(2):347–64.

    Article  Google Scholar 

  61. Ransom E, Chiu A. Prevention and management of complications in intracranial endoscopic skull base surgery. Otolaryngol Clin NA. 2010;43(4):875–95.

    Article  Google Scholar 

  62. Pelausa E, Smith K, Dempsey I. Orbital complications in functional endoscopic sinus surgery. J Otolaryngol. 1995;24(3):154–9.

    CAS  PubMed  Google Scholar 

  63. May M, Levine H, Mester S, Schaitkin B. Complications of endoscopic sinus surgery: analysis of 2108 patients—incidence and prevention. Laryngoscope. 1994;104(9):1080–3.

    Article  CAS  PubMed  Google Scholar 

  64. Andersen P, Kraus D, Arbit E, Shah J. Management of the orbit during anterior fossa craniofacial resection. Arch Otolaryngol Head Neck Surg. 1996;122(12):1305–7.

    Article  CAS  PubMed  Google Scholar 

  65. Rotsides J, Franco A, Albader A, et al. Nasolacrimal duct management during endoscopic sinus and skull base surgery. Ann Otol Rhinol Laryngol. 2019;128(10):932–7.

    Article  PubMed  Google Scholar 

  66. Gray S, Lin A, Curry W, et al. Delayed complications after anterior craniofacial resection of malignant skull base tumors. J Neurol Surg B Skull Base. 2014;75:110–6.

    PubMed  Google Scholar 

  67. Yeo N, Wang J, Chung Y, et al. Contributing factors to prevent prolonged epiphora after maxillectomy. Arch Otolaryngol Head Neck Surg. 2010;136(3):229–33.

    Article  PubMed  Google Scholar 

  68. Himwich W, Spurgeon H. Pulse pressure contours in cerebral arteries. Acta Neurol Scand. 1968;44(1):43–56.

    Article  CAS  PubMed  Google Scholar 

  69. Nakissa N, Rubin P, Strohl R, et al. Ocular and orbital complications following radiation therapy of paranasal sinus maljgnancies and review of literature. Cancer. 1983;51:980–6.

    Article  CAS  PubMed  Google Scholar 

  70. Blodi F. The late effects of x-radiation on the cornea. Trans Am Opthalmol Soc. 1958;56:413–50.

    CAS  Google Scholar 

  71. Durkin S, Roos D, Higgs B, et al. Ophthalmic and adnexal complications of radiotherapy. Acta Ophthalmol Scand. 2006;85:240–50.

    Article  Google Scholar 

  72. Bhenswala P, Schlosser R, Nguyen S, et al. Sinonasal quality-of-life outcomes after endoscopic endonasal skull base surgery. Int Forum Allergy Rhinol. 2019;9(10):1105–18.

    Article  PubMed  Google Scholar 

  73. Gallagher M, Durnford A, Wahab S, et al. Patient-reported nasal morbidity following endoscopic endonasal skull base surgery. Br J Neurosurg. 2014;28(5):622–5.

    Article  PubMed  Google Scholar 

  74. de Almeida J, Snyderman C, Gardner P, et al. Nasal morbidity following endoscopic skull base surgery: a prospective cohort study. Head Neck. 2011;33(4):547–51.

    Article  PubMed  Google Scholar 

  75. Kuhn F, Citardi M. Advances in postoperative care following functional endoscopic sinus surgery. Otolaryngol Clin N Am. 1997;30:479–90.

    Article  CAS  Google Scholar 

  76. Chabot J, Patel C, Hughes M, et al. Nasoseptal flap necrosis: a rare complication of endoscopic endonasal surgery. J Neurosurg. 2018;128(5):1463–72.

    Article  PubMed  Google Scholar 

  77. Lavigne P, Faden D, Wang E, Synderman C. Complications of nasoseptal flap reconstruction: a systematic review. J Neurol Surg B Skull Base. 2018;79(Suppl 4):S291–9.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Huang CC, Huang SF, Lee TJ, Ng SH, Chang JTC. Postirradiation sinus mucosa disease in nasopharyngeal carcinoma patients. Laryngoscope. 2007;117(4):737–42.

    Article  PubMed  Google Scholar 

  79. Surico G, Muggeo P, Mappa L, et al. Impairment of nasal mucociliary clearance after radiotherapy for childhood head cancer. Head Neck. 2001;23:461–6.

    Article  CAS  PubMed  Google Scholar 

  80. Lou P, Chen W, Tai C. Delayed irradiation effects on nasal epithelium in patients with nasopharyngeal carcinoma. An ultrastructural study. Ann Otol Rhinol Laryngol. 1999;108(5):474–80.

    Article  CAS  PubMed  Google Scholar 

  81. Kuhar H, Tajudeen B, Heilingoetter A, et al. Distinct histopathologic features of radiation-induced chronic sinusitis. Int Forum Allergy Rhinol. 2017;7(10):990–8.

    Article  PubMed  Google Scholar 

  82. Maxfield A, Chambers K, Sedaghat A, et al. Mucosal thickening occurs in contralateral paranasal sinuses following sinonasal malignancy treatment. J Neurol Surg Part B Skull Base. 2017;78(4):331–6.

    Article  Google Scholar 

  83. Gray ST, Sadow PM, Lin DT, Sedaghat AR. Endoscopic sinus surgery for chronic rhinosinusitis in patients previously treated for sinonasal malignancy. Laryngoscope. 2016;126(February):304–15.

    Article  PubMed  Google Scholar 

  84. Bleier B, Wang E, Vandergrift W 3rd, Schlosser R. Mucocele rate after endoscopic skull base reconstruction using vascularized pedicled flaps. Am J Rhinol Allergy. 2011;25(3):186–7.

    Article  PubMed  Google Scholar 

  85. Vaezeafshar R, Hwang P, Harsh G, Turner J. Mucocele formation under pedicled nasoseptal flap. Am J Otolaryngol. 2012;33(5):634–6.

    Article  PubMed  Google Scholar 

  86. Husain Q, Sanghvi S, Kovalerchik O, et al. Assessment of mucocele formation after endoscopic nasoseptal flap reconstruction of skull base defects. Allergy Rhinol (Providence). 2013;4(1):e27–31.

    Article  Google Scholar 

  87. Nyquest C, Anand V, Singh A, Schwartz T. Janus flap: bilateral nasoseptal flap for anterior skull base reconstruction. Otolaryngol Head Neck Surg. 2010;142:327–31.

    Article  Google Scholar 

  88. McCoul E, Anand V, Singh A, et al. Long-term effectiveness of a reconstructive protocol using the nasoseptal flap after endoscopic skull base surgery. World Neurosurg. 2014;81(1):136–43.

    Article  PubMed  Google Scholar 

  89. Soudry E, Psaltis A, Lee K, et al. Complication associated with the pedicled nasoseptal flap for skull base reconstruction. Laryngoscope. 2015;125(01):80–5.

    Article  PubMed  Google Scholar 

  90. Dolci R, Miyake M, Tateno D, et al. Postoperative otorhinolaryngologic complications in transnasal endoscopic surgery to assess the skull base. Braz J Otorhinolaryngol. 2017;83:349–55.

    Article  PubMed  Google Scholar 

  91. Janakiram T, Karunasagar A. Sphenoid mucocele: a complication of skull base reconstruction with nasoseptal flap – a critical review and our experience. Indian J Otolaryngol Head Neck Surg. 2019;71(Suppl 3):2151–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. Moriyama H, Hesaka H, Tachibana T, et al. Mucoceles of ethmoid and sphenoid sinus with visual disturbance. Arch Otolaryngol Head Neck Surg. 1992;118:142–6.

    Article  CAS  PubMed  Google Scholar 

  93. Lee L, Huang C, Lee T. Prolonged visual disturbance seconadry to isolated sphenoid sinus disease. Laryngoscope. 2004;114(6):986–90.

    Article  PubMed  Google Scholar 

  94. Sethi D, Lau D, Chan C. Sphenoid sinus mucocele presenting with isolated oculomotor nerve palsy. J Laryngol Otol. 1997;111:471–3.

    Article  CAS  PubMed  Google Scholar 

  95. Kosling S, Hinter M, Brandt S, et al. Mucoceles of the sphenoid sinus. Eur J Radiol. 2004;51:1–5.

    Article  CAS  PubMed  Google Scholar 

  96. Hantzakos A, Dowley A, Yung M. Sphenoid sinus mucocele: late complication of sphenoidotomy. J Laryngol Otol. 2003;117:561–3.

    Article  PubMed  Google Scholar 

  97. Delfini R, Missori P, Iannetti G, et al. Mucocles of the paranasal sinuses with intracranial andn intraorbital extension: report of 28 cases. Neurosurgery. 1993;32:901–6.

    Article  CAS  PubMed  Google Scholar 

  98. Wang L, Kim J, Heilman C. Intracranial mucocele as a complication of endoscopic repair of cerebrospinal fluid rhinorrhea: case report. Neurosurgery. 1999;45(5):1243–5.

    Article  CAS  PubMed  Google Scholar 

  99. Har-El G. Endoscopic management of 108 sinus mucoceles. Laryngoscope. 2001;111:2131–4.

    Article  CAS  PubMed  Google Scholar 

  100. Lund V. Endoscopic management of paranasal sinus mucoceles. J Laryngol Otol. 1998;112:36–40.

    Article  CAS  PubMed  Google Scholar 

  101. Benkhatar H, Khettab I, Sultanik P, et al. Mucocele development after endoscopic sinus surgery for nasal polyposis: a long-term analysis. Ear Nose Throat J. 2018;97(9):284–94.

    Article  PubMed  Google Scholar 

  102. Patel Z, DelGaudio J. Olfaction following endoscopic skull base surgery. Curr Opin Otolaryngol Head Neck Surg. 2016;24(1):70–4.

    Article  PubMed  Google Scholar 

  103. Kim B, Kang S, Kim S, et al. Olfactory changes after endoscopic endonasal transsphenoidal approach for skull base tumors. Laryngoscope. 2014;124(11):2470–5.

    Article  PubMed  Google Scholar 

  104. Ho W-k. Change in olfaction after radiotherapy for nasopharyngeal cancer – a prospective study. Am J Otolaryngol Head Neck Med Surg. 2002;23(4):209–14.

    Google Scholar 

  105. Upadhyay S, Buohliqah L, Dolci R, et al. Periodic olfactory assessment in patients undergoing skull base surgery with preservation of the olfactory strip. Laryngoscope. 2017;127(09):1970–5.

    Article  PubMed  Google Scholar 

  106. Soyka M, Serra C, Regli L, et al. Long-term olfactory outcome after nasoseptal flap reconstructions in midline skull base surgery. Am J Rhinol Allergy. 2017;31(5):334–7.

    Article  PubMed  Google Scholar 

  107. Rotenberg B, Saunders S, Duggal N. Olfactory outcomes after endoscopic transsphenoidal pituitary surgery. Laryngoscope. 2011;121:1611–3.

    Article  PubMed  Google Scholar 

  108. Tam S, Duggal N, Rogenberg B. Olfactory outcomes following endoscopic pituitary surgery with or without septal flap reconstruction: a randomized controlled trial. Int Forum Allergy Rhinol. 2013;3:62–5.

    Article  PubMed  Google Scholar 

  109. Álvarez-Camacho M, Gonella S, Campbell S, Scrimger RA, Wismer WV. A systematic review of smell alterations after radiotherapy for head and neck cancer. Cancer Treat Rev. 2017;54:110–21.

    Article  PubMed  Google Scholar 

  110. Koren I, Hadar T, Rappaport Z, Yaniv E. Endoscopic transnasal transsphenoidal microsurgery versus the sublabial approach for the treatment of pituitary tumors: endonasal complications. Laryngoscope. 1999;109(11):1838–40.

    Article  CAS  PubMed  Google Scholar 

  111. Pant H, Bhatki A, Snyderman C, et al. Quality of life following endonasal skull base surgery. Skull Base. 2010;20(1):35–40.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Alon E, Lipschitz N, Bedrin L, et al. Delayed sino-nasal complications of radiotherapy for nasopharyngeal carcinoma. Otolaryngol Head Neck Surg. 2014;151(2):354–8.

    Article  PubMed  Google Scholar 

  113. Waldron J, O’Sullivan B, Gullane P, et al. Carcinoma of the maxillary antrum: a retrospective analysis of 110 cases. Radiother Oncol. 2000;57(2):167–73.

    Article  CAS  PubMed  Google Scholar 

  114. Cianchetti M, Varvares M, Deschler D, et al. Risk of sinonasal-cutaneous fistula after treatment for advanced sinonasal cancer. J Surg Oncol. 2012;105(3):261–5.

    Article  PubMed  Google Scholar 

  115. Hua Y, Chen M, Qian C, et al. Postradiation nasopharyngeal necrosis in the patients with nasopharyngeal carcinoma. Head Neck. 2009;31(6):807–12.

    Article  PubMed  Google Scholar 

  116. Huang X, Zheng Y, Zhang X, et al. Diagnosis of management of skull base osteoradionecrosis after radiotherapy for nasopharyngeal carcinoma. Laryngoscope. 2006;116(9):1626–31.

    Article  PubMed  Google Scholar 

  117. Han P, Wang X, Liang F, et al. Osteoradionecrosis of the skull base in nasopharyngeal carcinoma: incidence and risk factors. Int J Radiat Oncol Biol Phys. 2018;102(3):552–5.

    Article  PubMed  Google Scholar 

  118. Liu J, Ning X, Sun X, et al. Endoscopic sequestrectomy for skull base osteoradionecrosis in nasopharyngeal carcinoma patients: a 10-year experience. Int J Clin Oncol. 2019;24(3):248–55.

    Article  PubMed  Google Scholar 

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Maxfield, A.Z., Workman, A., Gray, S.T. (2022). Complications of Surgical Management of Skull Base and Sinonasal Malignancies. In: Saba, N.F., Lin, D.T. (eds) Sinonasal and Skull Base Malignancies. Springer, Cham. https://doi.org/10.1007/978-3-030-97618-7_10

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  • DOI: https://doi.org/10.1007/978-3-030-97618-7_10

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  • Publisher Name: Springer, Cham

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