Skip to main content

Luteal Phase

  • Chapter
  • First Online:
Natural Cycle and Minimal Stimulation IVF
  • 298 Accesses

Abstract

Ovulation, followed by the transformation of the follicle into the corpus luteum, marks the beginning of the luteal phase. Luteal progesterone transforms the endometrium and enables the implantation of the embryo or, if pregnancy does not occur, its regulated shedding. The function of the corpus luteum and its maintenance is controlled by luteinizing hormone (LH), and, if pregnancy occurs, by the trophoblastic human chorionic gonadotropin, hCG. The function of the corpus luteum, the luteolysis and its maintenance at the onset of pregnancy require a sensitive interaction between pituitary gonadotropin secretion, LH/hCG induced steroid hormone synthesis, and the expression of luteotropic and luteolytic factors. A disturbance of this interaction leads to an insufficient luteal function with a reduction in the chance of pregnancy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Richards JS. Genetics of ovulation. Semin Reprod Med. 2007;25:235–42.

    Article  CAS  Google Scholar 

  2. Kohen P, Castro O, Palomino A, Muñoz A, Christenson LK, Sierralta W, Carvallo P, Strauss JF 3rd, Devoto L. The steroidogenic response and corpus luteum expression of the steroidogenic acute regulatory protein after human chorionic gonadotropin administration at different times in the human luteal phase. J Clin Endocrinol Metab. 2003;88:3421–30.

    Article  CAS  Google Scholar 

  3. Fraser HM, Dickson SE, Lunn SF, Wulff C, Morris KD, Carroll VA, Bicknell R. Suppression of luteal angiogenesis in the primate after neutralization of vascular endothelial growth factor. Endocrinology. 2000;141:995–1000.

    Article  CAS  Google Scholar 

  4. Devoto L, Kohen P, Muñoz A, Strauss JF 3rd. Human corpus luteum physiology and the luteal-phase dysfunction associated with ovarian stimulation. Reprod Biomed Online. 2009;18(Suppl 2):19–24.

    Article  Google Scholar 

  5. Strauss JF 3rd, Kallen CB, Christenson LK, Watari H, Devoto L, Arakane F, Kiriakidou M, Sugawara T. The steroidogenic acute regulatory protein (StAR): a window into the complexities of intracellular cholesterol trafficking. Recent Prog Horm Res. 1999;54:369–94.

    CAS  PubMed  Google Scholar 

  6. Kiriakidou M, McAllister JM, Sugawara T, Strauss JF 3rd. Expression of steroidogenic acute regulatory protein (StAR) in the human ovary. J Clin Endocrinol Metab. 1996;81:4122–8.

    CAS  PubMed  Google Scholar 

  7. Devoto L, Kohen P, Vega M, Castro O, González RR, Retamales I, Carvallo P, Christenson LK, Strauss JF. Control of human luteal steroidogenesis. Mol Cell Endocrinol. 2002;186:137–41.

    Article  CAS  Google Scholar 

  8. von Wolff M, Kohl Schwartz A, Stute P, Fäh M, Otti G, Schürch R, Rohner S. Follicular flushing in natural cycle IVF does not affect the luteal phase—a prospective controlled study. Reprod Biomed Online. 2017;35:37–41.

    Article  Google Scholar 

  9. Devoto L, Vega M, Navarro V, Sir T, Alba F, Castro O. Regulation of steroid hormone synthesis by human corpora lutea: failure of follicle-stimulating hormone to support steroidogenesis in vivo and in vitro. Fertil Steril. 1989;51:628–33.

    Article  CAS  Google Scholar 

  10. Csapo AI, Pulkkinen MO, Wiest WG. Effects of luteectomy and progesterone replacement therapy in early pregnant patients. Am J Obstet Gynecol. 1973;115:759–65.

    Article  CAS  Google Scholar 

  11. Baerwald AR, Adams GP, Pierson RA. Characterization of ovarian follicular wave dynamics in women. Biol Reprod. 2003;69:1023–31.

    Article  CAS  Google Scholar 

  12. le Nestour E, Marraoui J, Lahlou N, Roger M, de Ziegler D, Bouchard P. Role of estradiol in the rise in follicle-stimulating hormone levels during the luteal-follicular transition. J Clin Endocrinol Metab. 1993;77:439–42.

    PubMed  Google Scholar 

  13. Ellinwood WE, Norman RL, Spies HG. Changing frequency of pulsatile luteinizing hormone and progesterone secretion during the luteal phase of the menstrual cycle of rhesus monkeys. Biol Reprod. 1984;31:714–22.

    Article  CAS  Google Scholar 

  14. Cameron JL, Stouffer RL. Gonadotropin receptors of the primate corpus luteum. II. Changes in available luteinizing hormone- and chorionic gonadotropin-binding sites in macaque luteal membranes during the nonfertile menstrual cycle. Endocrinology. 1982;110:2068–73.

    Article  CAS  Google Scholar 

  15. Tesone M, Stouffer RL, Borman SM, Hennebold JD, Molskness TA. Vascular endothelial growth factor (VEGF) production by the monkey corpus luteum during the menstrual cycle: isoform-selective messenger RNA expression in vivo and hypoxia-regulated protein secretion in vitro. Biol Reprod. 2005;73:927–34.

    Article  CAS  Google Scholar 

  16. Hild-Petito S, Stouffer RL, Brenner RM. Immunocytochemical localization of estradiol and progesterone receptors in the monkey ovary throughout the menstrual cycle. Endocrinology. 1988;123:2896–905.

    Article  CAS  Google Scholar 

  17. Stouffer RL, Bishop CV, Bogan RL, Xu F, Hennebold JD. Endocrine and local control of the primate corpus luteum. Reprod Biol. 2013;13:259–71.

    Article  Google Scholar 

  18. Bull JR, Rowland SP, Scherwitzl EB, Scherwitzl R, Danielsson KG, Harper J. Real-world menstrual cycle characteristics of more than 600,000 menstrual cycles. NPJ Digit Med. 2019;2:83. https://doi.org/10.1038/s41746-019-0152-7.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael von Wolff .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

von Wolff, M. (2022). Luteal Phase. In: von Wolff, M. (eds) Natural Cycle and Minimal Stimulation IVF . Springer, Cham. https://doi.org/10.1007/978-3-030-97571-5_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-97571-5_8

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-97570-8

  • Online ISBN: 978-3-030-97571-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics