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Novel Method of Preparation Biocompatible Porous Materials Based on Modified Chitosan with High Mechanical Properties

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Intelligent Biotechnologies of Natural and Synthetic Biologically Active Substances (ICAETT 2021)

Part of the book series: Lecture Notes in Networks and Systems ((LNNS,volume 408))

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Abstract

A new method to obtain three-dimensional porous matrixes based on chitosan by treating its aqueous solutions with hydrocarbonates has been developed. During the reaction, pore formation occurs simultaneously, due to the release of carbon dioxide and the transition from the salt form of chitosan into the basic form, leading to the formation of a three-dimensional porous matrix. The structure is characterized by an interconnected pore system, with average pore size about 100–150 μm and average porosity about 82–85%. The material is biodegradable, biocompatible, exhibits high cell adhesion to fibroblasts and promotes their proliferation.

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Acknowledgments

This work was supported by the Fund for Assistance to the Development of Small Forms of Enterprises in the Scientific and Technical Sphere (Fund for Assistance to Innovation), within the framework of the UMNIK program (contract code 0064501).

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Authors and Affiliations

  1. National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia

    Ivan Lednev, Larisa Smirnova, Vitaliy Korokin & Diana Fukina

Authors
  1. Ivan Lednev
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  2. Larisa Smirnova
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  3. Vitaliy Korokin
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  4. Diana Fukina
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Corresponding author

Correspondence to Ivan Lednev .

Editor information

Editors and Affiliations

  1. Research Laboratory of Applied Issues, Belarusian State University, Minsk, Belarus

    Vladimir Kurchenko

  2. Department of Applied Biotechnology, North-Caucasus Federal University, Stavropol, Russia

    Alexei Lodygin

  3. R. Misericórdia Lagar dos Cortiços, Polytechnic Institute of Coimbra, Coimbra, Portugal

    Rui Manuel Machado da Costa

  4. Department of Informational Systems, Stavropol State Agrarian University, Stavropol, Russia

    Irina Samoylenko

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Lednev, I., Smirnova, L., Korokin, V., Fukina, D. (2022). Novel Method of Preparation Biocompatible Porous Materials Based on Modified Chitosan with High Mechanical Properties. In: Kurchenko, V., Lodygin, A., Machado da Costa, R.M., Samoylenko, I. (eds) Intelligent Biotechnologies of Natural and Synthetic Biologically Active Substances. ICAETT 2021. Lecture Notes in Networks and Systems, vol 408. Springer, Cham. https://doi.org/10.1007/978-3-030-96641-6_16

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  • DOI: https://doi.org/10.1007/978-3-030-96641-6_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-96640-9

  • Online ISBN: 978-3-030-96641-6

  • eBook Packages: EngineeringEngineering (R0)

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