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Do Antipsychotics Lead to Cognitive Impairment in Dementia? A Meta-analysis of Randomized Placebo-Controlled Trials

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Abstract

In this meta-analysis, the investigators reviewed the use of antipsychotics for treating behavioral and psychological symptoms in dementia (BPSD) and the potential side effect of decline in cognitive function from ten randomized placebo-controlled trials (RCTs).

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References

  1. Wolf A, Leucht S, Pajonk FG. Do antipsychotics lead to cognitive impairment in dementia? A meta-analysis of randomised placebo-controlled trials. Eur Arch Psychiatry Clin Neurosci. 2017;267(3):187–98.

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  2. Sultzer DL, Davis SM, Tariot PN, Dagerman KS, Lebowitz BD, Lyketsos CG, Rosenheck RA, Hsiao JK, Lieberman JA, Schneider LS, CATIE-AD Study Group. Clinical symptom responses to atypical antipsychotic medications in Alzheimer’s disease: phase 1 outcomes from the CATIE-AD effectiveness trial. Am J Psychiatry. 2008;165(7):844–54.

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Correspondence to Tracey Holsinger .

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Kim, S., Holsinger, T. (2022). Do Antipsychotics Lead to Cognitive Impairment in Dementia? A Meta-analysis of Randomized Placebo-Controlled Trials. In: Tampi, R.R., Tampi, D.J., Young, J.J., Balasubramaniam, M., Joshi, P. (eds) Essential Reviews in Geriatric Psychiatry. Springer, Cham. https://doi.org/10.1007/978-3-030-94960-0_5

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  • DOI: https://doi.org/10.1007/978-3-030-94960-0_5

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-94959-4

  • Online ISBN: 978-3-030-94960-0

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