Abstract
The aim of this chapter would be to help the clinician, with the support of imaging, in the diagnosis of patients whith degenerative changes of the cervical spine, and to make differential diagnoses with other specific diseases.
The knowledge of the anatomy of the osteo-discal-ligamentous complex, with particular focus to the intervertebral joints, that represent the primary targets of degeneration and cause of symptoms, is fundamental, as is the capability of how to choose the best imaging modality, in order to make a correct diagnostic evaluation of the cervical spine and also to follow and understand the evolution of the disease. In this scenario, MRI certainly represents the best imaging modality, especially in the cervical segment where other investigation methods, such as radiography and computed tomography, do not have the same diagnostic accuracy.
In this chapter the basic findings in the degenerative diseases (disk degeneration, spondylosis, cervical facet joint arthropathy and the ligament degeneration), and how to recognize the evolution towards the phase of instability of the cervical spine will be explained. We will also illustrate the main findings, combining data from Rx, TC and MRI, of the degenerative disease of cranio-cervical junction and cervical axial segments with the support of images from clinical cases, focusing on the cervical disk herniation and the spinal stenosis.
Finally, specific degenerative disease that may have elements in common with each other but which require specific therapies will be discussed. The clinician will therefore find the major pathological signs in the various imaging modalities about the rheumatoid arthritis, the Crowned dens syndrome, the retro-odontoid pseudotumor, the diffuse idiopathic skeletal hyperostosis, the ossification of the posterior longitudinal ligament and flaval ligaments, the destructive spondyloarthropaty in long-term hemodialyzed patients and the calcium pyrophosphate deposition disease.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Pistolesi GF. Bergamo Andreis IA: L’imaging diagnostico del rachide. Ed Libreria Cortina Verona: Verona; 1987.
Ross J. Neuroimaging clinics of North America. Philadelphia: WB Sanders; 1995.
Maigne JY, Deligne L. Computed tomography follow-up study of 21 cases of nonoperatively treated cervical intervertebral soft disk herniation. Spine. 1994;19:189–91.
Milligram MA, Rand N. Cervical spine anatomy. Spine State Art Rev. 2000;14(3):521–32.
Johnson R. Anatomy of the cervical spine and its related structures. In: Torg JS, editor. Athletic injuries to the head, neck, and face. 2nd ed. St Louis: Mosby-Year Book; 1991. p. 371–83.
Ross JS, Moore KR, Borg B, et al. Diagnostic imaging: spine. 2nd ed. Salt Lake City: Amirsys; 2010.
Colosimo C, Pileggi M, Pedicelli A, Perotti G, Costantini AM. Diagnostic imaging of degenerative spine diseases. Technical approach. In: Minimally invasive surgery of lumbar spine. London: Springer; 2014.
Fullenlove T, Williams AJ. Comparative roentgen findings in symptomatics and asymptomatics backs. Radiology. 1957;68:572–4.
Gehweiler JA, Daffner RH. Low back pain: the controversy of radiologic evaluation. AJR Am J Roentgenol. 1983;140:109–12.
Wood KB, Popp CA, Transfeldt EE, Geissele AE. Radiographic evaluation of instability in spondylolisthesis. Spine. 1994;19:1697–703.
Rothman SLG, Glenn WV. Multiplanar CT of the spine. Chapters 1–4, p. 1–112, chapters 16– 17, p. 477–504. Baltimore: University Park Press; 1985.
Hirsch C, Shajowicz F. Studies on structural changes in the lumbar anulus fibrosus. Acta Orthop Scand. 1952;22:184–231.
Yu S, Haughton VM, Sether LA, et al. Criteria for classifying normal and degenerated lumbar intervertebral discs. Radiology. 1989;170:523–6.
Virgin WJ. Experimental investigations into the physical properties of the intervertebral disc. J Bone Joint Surg. 1951;33:607–11.
Nachemson A. Some mechanicalproperties of the lumbar intevertebral discs. Bull Hosp Joint Dis. 1962;23:130–43.
Modic MT, Steinberg PM, et al. Degenerative disc disease assessment of changes in vertebral marrow with imaging. Radiology. 1988;166:193–9.
Giunti A, Laus M. Le Radicolopatie Spinali. Bologna: Aulo Gaggi Editore; 1992.
Alizada M, Li RR, Hayatullah G. Cervical instability in cervical spondylosis patients. Orthopäde. 2018;47:977–85. https://doi.org/10.1007/s00132-018-3635-3.
Rydman E, Bankler S, Ponzer S, Järnbert-Pettersson H. Quantifying cervical spondylosis: reliability testing of a coherent CT-based scoring system. BMC Med Imaging. 2019;19(1):45.
Panjabi MM, Krag MH, White AA, Southwick WO. Effects of preload on load displacement curves of the lumbar spine. Orthop Clin North Am. 1977;8:181–92.
Kirkaldy-Willis WH. The pathology and pathogenesis of low back pain. In: Kirkaldy-Willis WH, editor. Managing low back pain. New York: Churchill Livingstone; 1983. p. 23–43.
Weyreuther M, Heyde CE, Westphal M, Zierski J, Weber U. MRI atlas, orthopedics and neurosurgery, the spine. Heidelberg: Springer; 2007.
Kramer J. Intervertebral disc disease. 2nd ed. New York: Thieme; 1992.
Wiltse LL, Berger PE, McCulloch JA. A system for reporting the size and location of lesions in the spine. Spine. 1997;22(13):1534–7.
Scott AW. Magnetic resonance imaging of the brain and spine, vol. 2. Philadelphia: Lippincott Williams & Wilkins; 2009. p. 1491.
Kang Y, Lee JW, Koh YH, et al. New MRI grading system for the cervical canal stenosis. AJR Am J Roentgenol. 2011;197(1):W134–40.
Yue WM, et al. The Torg-Pavlov ratio in cervical spondylotic myelopathy: a comparative study between patients with cervical spondylotic myelopathy and a nonspondylotic, nonmyelopathic population. Spine. 2001;26(16):1760–4.
Tsuruda JS, Norman D, Dillon W, et al. Three-dimensional gradient-recalled MR imaging as a screening tool for the diagnosis of cervical radiculopathy. AJNR Am J Neuroradiol. 1989;10:1263–71.
Takahashi M, Yasuyuki Y, Yuji S, et al. Chronic cervical cord compression: clinical significance of increased signal intensity on MR images. Radiology. 1989;173:219–24.
Julkunen H, Heinonen OP, Knekt P, Maatela J. The epidemiology of hyperostosis of the spine together with its symptoms and related mortality in a general population. Scand J Rheumatol. 1975;4:23–7.
Cassim B, Mody GM, Rubin DL. The prevalence of diffuse idiopathic skeletal hyperostosis in African blacks. Br J Rheumatol. 1990;29:131–2.
Resnick D, Shaul RS, Robins JM. Diffuse idiopathic skeletal hyperostosis (DISH): Forestier’s disease with extraspinal manifestation. Radiology. 1975;115:513–24.
Resnick D, Niwayama G. Radiographic and pathological features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology. 1976;119:559–68.
Kuperus JS, de Gendt EEA, Oner FC, de Jong PA, Buckens SCFM, van der Merwe AE, Maat GJR, Regan EA, Resnick DL, Mader R, Verlaan JJ. Classification criteria for diffuse idiopathic skeletal hyperostosis: a lack of consensus. Rheumatology (Oxford). 2017;56(7):1123–34.
Cammisa M, De Serio A, Guglielmi G. Diffuse idiopathic skeletal hyperostosis. Eur J Radiol. 1998;27(Suppl 1):S7–11.
Kuperus JS, Oudkerk SF, Foppen W, Mohamed Hoesein FA, Gielis WP, Waalwijk J, Regan EA, Lynch DA, Oner FC, de Jong PA, Verlaan JJ. Criteria for early-phase diffuse idiopathic skeletal hyperostosis: development and validation. Radiology. 2019;291(2):420–6.
Resnick D, Guerra J Jr, Robinson CA, Vint VC. Association of diffuse idiopathic skeletal hyperostosis (DISH) and calcification and ossification of the posterior longitudinal ligament. AJR Am J Roentgenol. 1978;131(6):1049–53.
Hanakita J, Suwa H, Namure S, et al. The significance of the cervical soft disk herniation in the ossification of the posterior longitudinal ligament. Spine. 1994;19:412–8.
Lee DH, Cho JH, Kim NH, Kim S, Choi J, Hwang CJ, Lee CS. Radiological risk factors for progression of ossification of posterior longitudinal ligament following laminoplasty. Spine J. 2018;18(7):1116–21.
Doi T, Sakamoto R, Horii C, Okamoto N, Nakajima K, Hirai S, Oguchi F, Kato S, Taniguchi Y, Matsubayashi Y, Hayashi N, Tanaka S, Oshima Y. Risk factors for progression of ossification of the posterior longitudinal ligament in asymptomatic subjects. J Neurosurg Spine. 2020:1–7. https://doi.org/10.3171/2020.3.SPINE2082.
Leone A, Sundaram M, Cerase A, Magnavita N, Tazza L, Marano P. Destructive spondyloarthropathy of the cervical spine in long-term hemodialyzed patients: a five-year clinical radiological prospective study. Skeletal Radiol. 2001;30:431–41. Int Skeletal Soc (ISS)
Nagamachi A, Takahashi M, Mima N, Adachi K, Inoue K, Jha SC, Nitta A, Morimoto M, Takasago T, Iwame T, Wada K, Tezuka F, Yamashita K, Hayashi H, Miyagi R, Nishisyo T, Tonogai I, Goto T, Takata Y, Sakai T, Higashino K, Chikawa T, Sairyo K. Radiographic changes of cervical destructive spondyloarthropathy in long-term hemodialysis patients: a 9-year longitudinal observational study. J Med Investig. 2017;64(1.2):68–73.
Scutellari PN, Galeotti R, Leprotti S, Ridolfi M, Franciosi R, Antinolfi G. The crowned dens syndrome. Evaluation with CT imaging. Radiol Med. 2007;112(2):195–207. English, Italian
Stiskal MA, Neuhold A, Szolar DH, et al. Rheumatoid arthritis of the craniocervical region by MR imaging: detection and characterization. Am J Roentgenol. 1995;165(3):585–92.
Del Grande M, Del Grande F, Carrino J, Bingham CO, Louie GH. Cervical spine involvement early in the course of rheumatoid arthritis. Semin Arthritis Rheum. 2014;43(6):738–44.
Kobayashi K, Imagama S, Ando K, Nishida Y, Ishiguro N. Post-operative regression of retro-odontoid pseudotumors treated with and without fusion. Eur Spine J. 2018;27(12):3105–12.
Kakutani K, Doita M, Yoshikawa M, Okamoto K, Maeno K, Yurube T, Sha N, Kurosaka M, Nishida K. C1 laminectomy for retro-odontoid pseudotumor without atlantoaxial subluxation: review of seven consecutive cases. Eur Spine J. 2013;22(5):1119–26.
Shi J, Ermann J, Weissman BN, Smith SE, Mandell JC. Thinking beyond pannus: a review of retro-odontoid pseudotumor due to rheumatoid and non-rheumatoid etiologies. Skelet Radiol. 2019;48(10):1511–23.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Di Lella, G.M., Costantini, A.M., Monelli, E., Guerri, G., Leone, A., Colosimo, C. (2022). Diagnostic Imaging in the Degenerative Diseases of the Cervical Spine. In: Menchetti, P.P.M. (eds) Cervical Spine. Springer, Cham. https://doi.org/10.1007/978-3-030-94829-0_3
Download citation
DOI: https://doi.org/10.1007/978-3-030-94829-0_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-94828-3
Online ISBN: 978-3-030-94829-0
eBook Packages: MedicineMedicine (R0)