Abstract
Inhaled nitric oxide (iNO) therapy for the treatment of newborns with hypoxemic respiratory failure and pulmonary hypertension has dramatically changed management strategies for this critically ill population.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Suggested Reading
Abman SH, Hansmann G, Archer SL, et al. Pediatric pulmonary hypertension: guidelines from the American heart association and American thoracic society. Circulation. 2015;132:1–66.
Ballard RA, Truog WE, Cnaan A, et al. Inhaled nitric oxide in preterm infants undergoing mechanical ventilation. N Engl J Med. 2006;205:343–53.
Clark RH, Kueser TJ, Walker MW, et al. Low-dose inhaled nitric oxide treatment of persistent pulmonary hypertension of the newborn. N Engl J Med. 2000;342:469–74.
Cole FS, Alleyne C, Barks JD, et al. NIH Consensus Development Conference statement: inhaled nitric-oxide therapy for premature infants. Pediatrics. 2011;127:363–9.
Davidson D, Barefield ES, Kattwinkel J, et al. Safety of withdrawing inhaled nitric oxide therapy in persistent pulmonary hypertension. Pediatrics. 1999;104:231–6.
Gerlach H, Rossaint R, Pappert D, Falke KJ. Time-course and dose-response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome. Eur J Clin Invest. 1993;23:499–502.
Gersony WM. Neonatal pulmonary hypertension: pathophysiology, classification and etiology. Clin Perinatol. 1984;11:517–24.
Hallman M. Molecular interactions between nitric oxide and lung surfactant. Biol Neonate. 1997;71:44–8.
Kinsella JP, Abman SH. Clinical approach to inhaled nitric oxide therapy in the newborn. J Pediatr. 2000;136:717–26.
Kinsella JP, Neish SR, Shaffer E, Abman SH. Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn. Lancet. 1992;340:819–20.
Kinsella JP, Truog WE, Walsh WF, et al. Randomized, multicenter trial of inhaled nitric oxide and high frequency oscillatory ventilation in severe persistent pulmonary hypertension of the newborn. J Pediatr. 1997;131:55–62.
Kinsella JP, Walsh WF, Bose CL, et al. Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial. Lancet. 1999;354:1061–5.
Kinsella JP, Cutter GR, Walsh WF, et al. Early inhaled nitric oxide therapy in premature newborns with respiratory failure. N Engl J Med. 2006;205:354–64.
Kinsella JP, Steinhorn RH, Krishnan US, et al. Recommendations for the use of inhaled nitric oxide therapy in premature newborns with severe pulmonary hypertension. J Pediatr. 2016;170:312–4. PMID: 26703869.
Kinsella JP, Steinhorn RH, Mullen MP, et al. The left ventricle in congenital diaphragmatic hernia: implications for the management of pulmonary hypertension. J Pediatr. 2018;197:17–22. PMID: 29628412.
Lakshminrusimha S, Kinsella JP, Krishnan US, et al. Just say no to iNO in preterms-really? J Pediatr. 2020;218:243–52. PMID: 31810629.
Levin DL, Heymann MA, Kitterman JA, et al. Persistent pulmonary hypertension of the newborn. J Pediatr. 1976;89:626.
Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med. 1997;336:597–604.
Roberts JD, Polaner DM, Lang P, Zapol WM. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet. 1992;340:818–9.
Schreiber MD, Gin-Mestan K, Marks JD, et al. Inhaled nitric oxide in premature infants with the respiratory distress syndrome. N Engl J Med. 2003;349:2099–107.
Wessel DL, Adatia I, Van Marter LJ, et al. Improved oxygenation in a randomized trial of inhaled nitric oxice for persistent pulmonary hypertension of the newborn. Pediatrics. 1997;100:e7.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Kinsella, J.P. (2022). Inhaled Nitric Oxide Therapy. In: Donn, S.M., Mammel, M.C., van Kaam, A.H. (eds) Manual of Neonatal Respiratory Care. Springer, Cham. https://doi.org/10.1007/978-3-030-93997-7_63
Download citation
DOI: https://doi.org/10.1007/978-3-030-93997-7_63
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-93996-0
Online ISBN: 978-3-030-93997-7
eBook Packages: MedicineMedicine (R0)