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The Medial Prefrontal Cortex (mPFC) and Addictions

A New Narrative

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Handbook of Substance Misuse and Addictions

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Abstract

Although currently we now possess much information on how the prefrontal cortex (PFC) integrates and processes incoming information, we do not have the exact mechanisms and connections underlying its proper functioning yet. The main clue to solve this puzzle may come from its incoming connections, for example, those arising from the dorsal raphe nucleus (DRN) and the ventral tegmental area (VTA). These two areas are extensively related to the reward system, and its innervation of the PFC probably modulates decision-making, mood modulation, and addiction (Russo and Nestler 2013). Taking this into account, we postulate that PFC undergoes a critical period when these inputs compete for target innervation. By the end of this critical period, the incoming connection weight from VTA and DRN establishes a certain PFC configuration that later in life can make this region more resilient or vulnerable to addiction and neuropsychiatric disorders. Furthermore, we hypothesize that drug abuse during this critical period may also modify these inputs and, therefore, its resilience.

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Authors and Affiliations

  1. Neurobiology Unit, Program in Neurosciences and University Institute of Biotechnology and Biomedicine (BIOTECMED), Universitat de València, Burjassot, Spain

    Marta Perez-Rando & Ramón Guirado

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  1. Marta Perez-Rando
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  2. Ramón Guirado
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Correspondence to Ramón Guirado .

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Editors and Affiliations

  1. School of Life Sciences, University of Westminster, London, UK

    Vinood B. Patel

  2. School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK

    Victor R. Preedy

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Perez-Rando, M., Guirado, R. (2022). The Medial Prefrontal Cortex (mPFC) and Addictions. In: Patel, V.B., Preedy, V.R. (eds) Handbook of Substance Misuse and Addictions. Springer, Cham. https://doi.org/10.1007/978-3-030-92392-1_25

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